A copolymer including a structural unit represented by General Formula (1) below, and a structural unit represented by General Formula (2) below,

##STR00001##

where, in General Formula (1), R.sup.1 is a hydrogen atom or a methyl group, L.sup.1 is an alkylene group having 2 or greater carbon atoms but 5 or less carbon atoms, and X is a hydrogen atom or a cation,

##STR00002##

where, in General Formula (2), R.sup.2 is a hydrogen atom or a methyl group and L.sup.2 is an alkylene group having 2 or greater carbon atoms but 18 or less carbon atoms.

A copolymer including a structural unit represented by General Formula (1) below, and a structural unit represented by General Formula (2) below,

##STR00001##

where, in General Formula (1), R.sup.1 is a hydrogen atom or a methyl group, L.sup.1 is an alkylene group having 2 or greater carbon atoms but 5 or less carbon atoms, and X is a hydrogen atom or a cation,

##STR00002##

where, in General Formula (2), R.sup.2 is a hydrogen atom or a methyl group and L.sup.2 is an alkylene group having 2 or greater carbon atoms but 18 or less carbon atoms.

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

A curable composition comprising the components (i) 0 to 60 wt % non-ionic crosslinker(s); (ii) 20 to 85 wt % curable ionic compound(s) comprising an anionic group and at least one ethylenically unsaturated group; (iii) 15 to 45 wt % solvent(s); (iv) 0 to 10 wt % of photoinitiator(s); and (v) 2 to 45 wt % of structure modifier(s); wherein the molar ratio of component (v):(ii) is 0.25 to 0.65. The compositions are useful for preparing membranes for (reverse) electrodialysis.

Disclosed is a self-invertible inverse latex comprising an aqueous phase containing: a) a crosslinked anionic polyelectrolyte (P) including: —at least one first monomer unit derived from 2-methyl-2-[(1-oxo-2-propenyl) amino] 1-propanesulfonic acid in the form of a free or partially or totally salified acid; —at least one second monomer unit derived from at least one monomer selected from the elements of the group consisting of acrylic acid, methacrylic acid, 2-carboxyethyl acrylic acid, itaconic acid, maleic acid, 3-methyl 3-[(1-oxo-2-propenyl) amino] butanoic acid, the carboxylic function of said monomers being in the free, partially salified or totally salified acid form; and —at least one third monomer unit derived from a polyethylenic crosslinking monomer (AR); b) ethylenediamine disuccinic acid in the form of trisodium salt.

The present invention relates to radiation curable compositions, comprising (A1) at least one water-soluble reactive diluent (A1); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a), a slightly water-soluble reactive diluent (B1b) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (A1) and (A2) is greater than 20% by weight, especially 30% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2); radiation curable composition, comprising (A1′) at least one slightly water-soluble reactive diluent (B1b); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (B1b) and (A2) is greater than 40% by weight, especially 50% by weight based on the amount of components (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A2), (B1a), (B1b) and (B2). The radiation curable compositions can be cleaned by pure water with no assistance of any solvent or detergent. The printed three-dimensional products have clean, smooth, tack-free surface after washing with water and sufficient post-curing. The fully cured three-dimensional products are high-temperature resistant and have excellent mechanical performance above glass transition temperature, e.g. 200° C.

The present invention relates to radiation curable compositions, comprising (A1) at least one water-soluble reactive diluent (A1); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a), a slightly water-soluble reactive diluent (B1b) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (A1) and (A2) is greater than 20% by weight, especially 30% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2); radiation curable composition, comprising (A1′) at least one slightly water-soluble reactive diluent (B1b); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (B1b) and (A2) is greater than 40% by weight, especially 50% by weight based on the amount of components (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A2), (B1a), (B1b) and (B2). The radiation curable compositions can be cleaned by pure water with no assistance of any solvent or detergent. The printed three-dimensional products have clean, smooth, tack-free surface after washing with water and sufficient post-curing. The fully cured three-dimensional products are high-temperature resistant and have excellent mechanical performance above glass transition temperature, e.g. 200° C.

The present invention relates to radiation curable compositions, comprising (A1) at least one water-soluble reactive diluent (A1); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a), a slightly water-soluble reactive diluent (B1b) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (A1) and (A2) is greater than 20% by weight, especially 30% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A1), (A2), (B1a), (B1b) and (B2); radiation curable composition, comprising (A1′) at least one slightly water-soluble reactive diluent (B1b); (A2) at least one water-soluble reactive oligomer (A2); (B) at least one reactive component selected from the group consisting of a water insoluble reactive diluent (B1a) and a water insoluble, or slightly water-soluble reactive oligomer (B2); and (C) optionally a photoinitiator (C), wherein the amount of component (B1b) and (A2) is greater than 40% by weight, especially 50% by weight based on the amount of components (A2), (B1a), (B1b) and (B2) and the amount of components (B1a), (B1b) and (B2) is greater than 10% by weight, especially 20% by weight based on the amount of components (A2), (B1a), (B1b) and (B2). The radiation curable compositions can be cleaned by pure water with no assistance of any solvent or detergent. The printed three-dimensional products have clean, smooth, tack-free surface after washing with water and sufficient post-curing. The fully cured three-dimensional products are high-temperature resistant and have excellent mechanical performance above glass transition temperature, e.g. 200° C.