The monofunctional branched poly(ethylene glycol) (PEG) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched PEG has a general formula shown in formula (2), wherein X.sub.1 and X.sub.2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n.sub.1 and n.sub.2 are each independently an integer selected from 1 to 1000, n.sub.3 is an integer selected from 11 to 1000, L.sub.1, L.sub.2 are each independently a linking group, p is 0 or 1, q is 0 or 1, R.sub.1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, D is a bio-related substance, Z is a linking group, and Z can react with the bio-related substance to form a residue group L.sub.3. The PEG-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo.

##STR00001##

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

The disclosure provides a multi-arm multi-claw polyethylene glycol derivative suitable for click chemistry reactions of general formula I, wherein R is a polyethylene glycol residue having a linear-chain structure, a Y-type structure or a multi-branched structure, R.sub.1, R.sub.2 and R.sub.3 are linking groups, P is an terminal group of non-azido non-alkynyl group, D is —N.sub.3 or —C≡CH, l is selected from an integer of 1 to 20, and m is selected from an integer of 0 to 19. ##STR00001##

The present invention relates to aqueous pigment preparations, comprising (A) at least one organic and/or inorganic pigment and/or filler (B) at least one dispersant of the formula (I) or (II), or mixtures of dispersants of the formulas (I) and (II), where n is an integer greater than or equal to 1, preferably 1 to 5, more preferably 1 to 2, z is an integer greater than or equal to 1, preferably 1 to 10, more preferably 1 to 4, R1 is an aliphatic, linear or branched hydrocarbon radical having 1 to 10 carbon atoms or a hydrogen atom or the structural unit -O-X or the structural unit —CH.sub.2—O—X, and structural unit X corresponds to the formula (III) in which a is an integer from 1 to 10, b is an integer from 0 to 10, c is an integer from 1 to 50, m is 1 or 2, and R2 is an aliphatic, linear or branched hydrocarbon radical having 1 to 10 carbon atoms, (C) optionally wetting agents, (D) optionally further surfactants and/or dispersants, (E) optionally one or more organic solvents and/or one or more hydrotropic substances and/or mixtures thereof, (F) optionally further additives customary for the production of aqueous pigment dispersions, and (G) water.

The invention relates to compositions containing compounds of formula (I), formula (II), or mixtures thereof, in which n is an integer greater than or equal to 1, R.sup.1, an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, a hydrogen atom, the structural unit —O—X, or the structural unit —CH.sub.2—O—X, X corresponds to formula (III), in which a is an integer from 2 to 6, b is an integer from 0 to 3, c is an integer from 20 to 28, m is 1 or 2, R.sup.2 is an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, Y is hydrogen, —SO.sub.3M, —SO.sub.2M, —PO.sub.3M.sub.2, or —CH.sub.2COOM, and M is a cation. The compounds of formula (I), of formula (II), or mixtures thereof are preferably suitable to act as a dispersing agent. ##STR00001##

The invention relates to compositions containing compounds of formula (I), formula (II), or mixtures thereof, in which n is an integer greater than or equal to 1, R.sup.1, an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, a hydrogen atom, the structural unit —O—X, or the structural unit —CH.sub.2—O—X, X corresponds to formula (III), in which a is an integer from 2 to 6, b is an integer from 0 to 3, c is an integer from 20 to 28, m is 1 or 2, R.sup.2 is an aliphatic, linear or branched hydrocarbon group having 1 to 10 carbon atoms, Y is hydrogen, —SO.sub.3M, —SO.sub.2M, —PO.sub.3M.sub.2, or —CH.sub.2COOM, and M is a cation. The compounds of formula (I), of formula (II), or mixtures thereof are preferably suitable to act as a dispersing agent.

##STR00001##

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

A medical hydrogel is formed by in-situ crosslinking an aldehyde-terminated multi-arm star polyethylene glycol and a polyamino compound. The aldehyde group and the multi-arm star polyethylene glycol are linked by a chemical bond such as an ether bond, an amide bond, a urethane bond, an imine bond, or a urea bond. The aldehyde group at the end of the multi-arm polyethylene glycol reacts with the amino group in the polyamino compound to produce Schiff base for crosslinking so that the medical injectable gel is formed. The prepared gel has a short gelling time, a desired gel burst strength, and a good stability in an aqueous solution.

The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease.

The disclosure provides a multi-arm multi-claw polyethylene glycol derivative suitable for click chemistry reactions of general formula I, wherein R is a polyethylene glycol residue having a linear-chain structure, a Y-type structure or a multi-branched structure, R.sub.1, R.sub.2 and R.sub.3 are linking groups, P is an terminal group of non-azido non-alkynyl group, D is N.sub.3 or CCH, l is selected from an integer of 1 to 20, and m is selected from an integer of 0 to 19.