The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.

An intravascular multi-side hole catheter containing a bioscaffold capable of housing therapeutic cells is provided. The catheter comprises a plurality of side holes distributed along the length of the catheter in a spiraling corkscrew pattern. The bioscaffold inside the catheter is designed with a plurality of macropores capable of encapsulating therapeutic cells for cellular therapy. Upon placement of the catheter in a vein, the side holes allow blood to flow though the catheter thereby supplying oxygen and nutrients to any loaded cellular cargo and also providing for the removal of waste products. Methods of producing the intravascular catheter and methods of using the intravascular catheter in cellular therapy, including for delivery of insulin-secreting cells such as beta cells or stem cell-derived islets into blood vessels for treating type 1 diabetes are also disclosed.

A resin microparticle production method includes a step of pulverizing resin particles having a thermoplastic resin as a forming material and having a BET specific surface area of equal to or more than 5 m.sup.2/g using an impact type pulverizer.

The present invention relates to a porous layer structure containing a base material and a polyurethane porous layer formed on the base material, wherein a moisture permeability A of the porous layer structure measured by JIS L1099 A-1 (calcium chloride method) is 2000 to 10000 g/(m.sup.2.Math.24h), a moisture permeability loss rate obtained by a predetermined formula from a moisture permeability B of the base material alone measured by JIS L1099 A-1 (calcium chloride method) and the moisture permeability A is 75% or less, and a peel strength at a bonding surface between the base material and the polyurethane porous layer is 0.7 kgf/inch or more.

This disclosure provides for processes to form a porous crosslinked polyphenoxide resin, using a templating process which can increase the porosity, pore size, active sites, and the like of the resin, as compared with a non-templated crosslinked polyphenoxide resin. The process includes contacting a phenol or polyphenol compound with formaldehyde and an aqueous base in the presence of a basic particulate template to form a templated crosslinked polyphenol resin. The templated crosslinked polyphenol resin can then be contacted with an aqueous acid to remove the basic particulate template and form a porous crosslinked polyphenol resin. This porous crosslinked polyphenol resin can subsequently be contacted with a metal-containing base to form a promoter for acrylate and acrylic acid formation from CO.sub.2 and ethylene coupling.

Multiple processes for preparing porous articles are described. The porous articles can be in a wide array of shapes and configurations. The methods include providing a soluble material in particulate form and forming a packed region from the material. The methods also include contacting a flowable polymeric material with the packed region such that the polymeric material is disposed in voids in the packed region. The polymeric material is then at least partially solidified. The soluble material is then removed such as by solvent washing to thereby produce desired porous articles. Also described are systems for performing the various processes.

A method of manufacturing a flexible intrinsically antimicrobial absorbent porosic composite controlling for an effective pore size using removable pore-forming substances and physically incorporated, non-leaching antimicrobials. A flexible intrinsically antimicrobial absorbent porosic composite controlled for an effective pore size composited physically incorporated, high-surface area, non-leaching antimicrobials, optionally in which the physically incorporated non-leaching antimicrobial exposes nanopillars on its surface to enhance antimicrobial activity. A kit that enhances the effectiveness of the intrinsically antimicrobial absorbent porosic composite by storing the composite within an antimicrobial container.

A method of manufacturing a flexible intrinsically antimicrobial absorbent porosic composite controlling for an effective pore size using removable pore-forming substances and physically incorporated, non-leaching antimicrobials. A flexible intrinsically antimicrobial absorbent porosic composite controlled for an effective pore size composited physically incorporated, high-surface area, non-leaching antimicrobials, optionally in which the physically incorporated non-leaching antimicrobial exposes nanopillars on its surface to enhance antimicrobial activity. A kit that enhances the effectiveness of the intrinsically antimicrobial absorbent porosic composite by storing the composite within an antimicrobial container.

A foam composition that includes a polymer material such as polyurethane or polyurea and a leachable water-soluble fine powder is provided. This composition can be used in a relatively simple process to obtain a foam body (porous body) that is uniform only at the surface or uniform throughout. The foam body can be suitably used as a golf ball member in golf balls required to have good controllability on approach shots. Also provided is a method for producing a foam member, which method includes the steps of molding the foam composition to obtain a solid molded body, and then leaching out and removing the water-soluble fine powder so as to obtain a foam-molded body.

A method of manufacturing a flexible intrinsically antimicrobial absorbent porosic composite controlling for an effective pore size using removable pore-forming substances and physically incorporated, non-leaching antimicrobials. A flexible intrinsically antimicrobial absorbent porosic composite controlled for an effective pore size composited physically incorporated, high-surface area, non-leaching antimicrobials, optionally in which the physically incorporated non-leaching antimicrobial exposes nanopillars on its surface to enhance antimicrobial activity. A kit that enhances the effectiveness of the intrinsically antimicrobial absorbent porosic composite by storing the composite within an antimicrobial container.