C08K3/18

SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

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SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

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Heat-storage composition

A heat storage composition (20) of the present invention includes a matrix resin (21) and heat storage inorganic particles (22). The heat storage inorganic particles (22) are composed of a material that undergoes an electronic phase transition and has a latent heat of 1 J/cc or more for the electronic phase transition. The amount of the heat storage inorganic particles is 10 to 2000 parts by weight with respect to 100 parts by weight of the matrix resin. The heat conductivity of the heat storage composition is 0.3 W/m.Math.K or more. The heat storage composition may further include heat conductive particles (23, 24). The heat storage inorganic particles are preferably metal oxide particles containing vanadium as the main metal component. The heat storage composition has high heat storage properties and high heat conduction properties, and is used as a heat storage silicone material provided between a heat generating component and a case. Since heat from the heat generating component is temporarily stored in the heat storage composition so that the heat conduction is delayed, the heat is diffused during the delay to eliminate partial heating, thereby resulting in uniform heat dissipation.

ORGANOSILICON COMPOUND, METHOD FOR PRODUCING SAME AND METAL SURFACE TREATMENT AGENT USING SAME
20170226136 · 2017-08-10 · ·

An organosilicon compound represented by general formula (1). The present invention is able to provide an organosilicon compound which has excellent adhesion during processing and high bonding strength, while exhibiting antirust corrosion resistance at high levels, and which is useful as a metal surface treatment agent.

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(In the formula, R represents a hydrolyzable group; R′ represents an alkyl group; A represents an alkylene group; R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, or R.sup.3 and R.sup.4 among the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties may combine together to form an aliphatic or aromatic ring skeleton, and in cases where a ring skeleton is not formed, each one of the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties independently represents a hydrogen atom or an alkyl group; and m represents a number of 1-3.)

ORGANOSILICON COMPOUND, METHOD FOR PRODUCING SAME AND METAL SURFACE TREATMENT AGENT USING SAME
20170226136 · 2017-08-10 · ·

An organosilicon compound represented by general formula (1). The present invention is able to provide an organosilicon compound which has excellent adhesion during processing and high bonding strength, while exhibiting antirust corrosion resistance at high levels, and which is useful as a metal surface treatment agent.

##STR00001##

(In the formula, R represents a hydrolyzable group; R′ represents an alkyl group; A represents an alkylene group; R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, or R.sup.3 and R.sup.4 among the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties may combine together to form an aliphatic or aromatic ring skeleton, and in cases where a ring skeleton is not formed, each one of the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties independently represents a hydrogen atom or an alkyl group; and m represents a number of 1-3.)

Switchable water-based paint or coating compositions

The present application provides switchable, homogeneous paint composition and methods of painting and/or forming films or coatings using the composition. The composition includes a liquid having an aqueous solution and dissolved acid gas (e.g., carbonated water), and a switchable polymer. The switchable polymer converts from a protonated, water-soluble form in the liquid to a water-insoluble unprotonated form following removal or substantial removal of the liquid and acid gas.

Switchable water-based paint or coating compositions

The present application provides switchable, homogeneous paint composition and methods of painting and/or forming films or coatings using the composition. The composition includes a liquid having an aqueous solution and dissolved acid gas (e.g., carbonated water), and a switchable polymer. The switchable polymer converts from a protonated, water-soluble form in the liquid to a water-insoluble unprotonated form following removal or substantial removal of the liquid and acid gas.

Thermally conductive composition
11236259 · 2022-02-01 · ·

The thermally conductive composition comprises a thermally conductive filler dispersed in a liquid matrix.

Thermally conductive composition
11236259 · 2022-02-01 · ·

The thermally conductive composition comprises a thermally conductive filler dispersed in a liquid matrix.

DAMPING-IMPARTING COMPOSITION HAVING HIGH IMPACT DURABILITY AT LOW TEMPERATURE
20170267842 · 2017-09-21 ·

The present invention relates to a thermally curable composition comprising: (a1) a solid rubber in an amount of 2.5% by mass or more, (a2) an olefinic double bond-containing polymer which is liquid or pasty at 22° C. in an amount of less than 5% by mass, (a3) a hydrocarbon resin in an amount of, in total with said component (a2), 5% by mass or more and 20% by mass or less, and (a4) a liquid polydiene in an amount of 15% by mass or more based on the total mass of the composition as a component (a); and at least one selected from the group consisting of the following (b1) to (b3): (b1) sulfur and one or more accelerator(s), (b2) peroxidic vulcanization system or disulfidic vulcanization system, and (b3) quinones, quinone dioximes or dinitrosobenzene, as a vulcanization system (b).