This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.

Provided is a flame-retardant resin composition containing a thermoplastic resin and a polysaccharide, wherein the polysaccharide includes an acidic polysaccharide composed of one or more selected from the group consisting of a polysaccharide having an acidic functional group, a derivative of the polysaccharide having an acidic functional group in which a site other than the acidic functional group is modified, and a salt thereof; and a total number of the acidic functional group and the salt thereof per monosaccharide unit in the acidic polysaccharide is in the range of 0.2 to 1.5.

Provided is a flame-retardant resin composition containing a thermoplastic resin and a polysaccharide, wherein the polysaccharide includes an acidic polysaccharide composed of one or more selected from the group consisting of a polysaccharide having an acidic functional group, a derivative of the polysaccharide having an acidic functional group in which a site other than the acidic functional group is modified, and a salt thereof; and a total number of the acidic functional group and the salt thereof per monosaccharide unit in the acidic polysaccharide is in the range of 0.2 to 1.5.

Compositions for coating microneedles with aluminum-adjuvanted vaccines are provided comprising an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension; a vaccine in an amount effective to stimulate an immune response in a mammal; a sugar, sugar alcohol, or combinations thereof; and a thickener. Some embodiments of the compositions have a viscosity of 500 to 30,000 cps when measured at 100 s.sup.−1 and temperature of 25 C. Microneedle devices coated with the compositions, as well as methods of forming the compositions and coating the microneedles, and methods of maximizing the aluminum content of vaccine-coated microneedle arrays are also provided.

Compositions for coating microneedles with aluminum-adjuvanted vaccines are provided comprising an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension; a vaccine in an amount effective to stimulate an immune response in a mammal; a sugar, sugar alcohol, or combinations thereof; and a thickener. Some embodiments of the compositions have a viscosity of 500 to 30,000 cps when measured at 100 s.sup.−1 and temperature of 25 C. Microneedle devices coated with the compositions, as well as methods of forming the compositions and coating the microneedles, and methods of maximizing the aluminum content of vaccine-coated microneedle arrays are also provided.

The disclosure relates to products including a polysaccharide derivative wherein the polysaccharide derivative includes a polysaccharide substituted with at least one of: a) at least one sulfate group; b) at least one sulfonate group; c) at least one thiosulfate group; or d) a combination thereof; wherein the polysaccharide is poly alpha-1,3-glucan, poly alpha-1,6-glucan, poly alpha-1,3-1,6-glucan, or a mixture thereof; and the polysaccharide derivative has a degree of substitution of about 0.001 to about 3. The products can be useful as anti-deposition and/or anti-graying agents in laundry detergents, and in home care applications.

The disclosure relates to products including a polysaccharide derivative wherein the polysaccharide derivative includes a polysaccharide substituted with at least one of: a) at least one sulfate group; b) at least one sulfonate group; c) at least one thiosulfate group; or d) a combination thereof; wherein the polysaccharide is poly alpha-1,3-glucan, poly alpha-1,6-glucan, poly alpha-1,3-1,6-glucan, or a mixture thereof; and the polysaccharide derivative has a degree of substitution of about 0.001 to about 3. The products can be useful as anti-deposition and/or anti-graying agents in laundry detergents, and in home care applications.

A biodegradable aliphatic-aromatic polyester for the production of packaging films, having a Poisson's ratio (RVE) between 800 and 1700, comprising units of at least one dicarboxylic acid and at least one diol, in which Mn≥40000 and Mw/q≤90000, in which q is the percentage by weight of polyester oligomers having a molecular weight≤10000.

A biodegradable aliphatic-aromatic polyester for the production of packaging films, having a Poisson's ratio (RVE) between 800 and 1700, comprising units of at least one dicarboxylic acid and at least one diol, in which Mn≥40000 and Mw/q≤90000, in which q is the percentage by weight of polyester oligomers having a molecular weight≤10000.

Described herein are methods for evaluating polymer compositions comprising polymers modified with a small molecule compound (e.g., afibrotic compound), including methods for determining the concentration levels of said compounds.