Patent classifications
C
CHEMISTRY; METALLURGY
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C12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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C12N
MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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15/00
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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C12N15/63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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C12N15/79
Vectors or expression systems specially adapted for eukaryotic hosts
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C12N15/8509
for producing genetically modified animals, e.g. transgenic
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C12N2015/8527
for producing animal models, e.g. for tests or diseases
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C12N2015/8536
Animal models for genetic diseases
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C12N2015/8545

PORCINE THY1 GENE PROMOTER SPECIFICALLY EXPRESSED IN NEURONS
20180258446 · 2018-09-13 ·

A Thy1 gene promoter specifically expressed in neurons and a recombinant vector including the Thy1 gene promoter are provided. The Thy1 gene promoter may be utilized to regulate an expression of a target gene in preparation of an animal model similar to a human.

Animal Model With Rapid Onset Of Alzheimer's Amyloid Beta Plaque Pathology
20240408246 · 2024-12-12 ·

Provided herein are compositions comprising a nucleic acid encoding amyloid-beta precursor protein and/or a nucleic acid encoding presenilin-1, cells comprising the compositions, animals comprising the compositions, methods of making the cells and animals, methods of modeling Alzheimer's disease, methods of assessing a therapeutic candidate for the treatment of Alzheimer's disease or amelioration of a symptom or phenotype of Alzheimer's disease, and methods of assessing a therapeutic candidate for the prevention of Alzheimer's disease or prevention of a symptom or phenotype of Alzheimer's disease.

EXPRESSION CASSETTE AND VECTOR COMPRISING ALZHEIMER'S DISEASE-RELATED MUTANT GENES AND CELL LINE TRANSFORMED BY MEANS OF SAME
20170112109 · 2017-04-27 · ·

The present invention relates to expression cassette and vector comprising Alzheimer's disease-related genes and a cell line transformed by means of same, and more specifically, the expression cassette according to the present invention comprises amyloid precursor protein (APP), Tau protein, and presenilin-1 (PS1) genes associated with Alzheimer's disease so that mutant genes thereof can be simultaneously expressed. Additionally, the present invention relates to a cell line transformed by means of the expression cassette or vector comprising said genes, and further, to an animal model transformed by means of the vector or cell line.