The present invention relates to yeast cells engineered for the production of E8,E10-dodecadienyl coenzyme A, codlemone (E8,E10-dodecadien-1-ol), and optionally its derivatives E8,E10-dodecadienyl acetate and/or E8,E10-dodecadienal. Methods for production of E8,E10-dodecadienyl coenzyme A, codlemone (E8,E10-do-decadien-1-ol), and optionally its derivatives E8,E10-dodecadienyl acetate and/or E8,E10-dodecadienal are also provided. Nucleic acid constructs useful for obtaining such yeast cells are also provided.

The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

The present invention relates to the production of aromatic hexanols and compositions containing them. In particular provided herein are methods of producing hexenols comprising: a) contacting a hydroperoxide of a polyunsaturated fatty acid with a modified hydroperoxide lyase to form a hexenal; and b) reducing the hexenal to a hexenol in the presence of a hydride donor, a ketoreductase, and a co-factor wherein the contacting and reducing steps are carried out at essentially the same time in the substantial absence of baker's yeast.

The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

The present invention relates to the production of aromatic hexanols and compositions containing them. In particular provided herein are methods of producing hexenols comprising: a) contacting a hydroperoxide of a polyunsaturated fatty acid with a modified hydroperoxide lyase to form a hexenal; and b) reducing the hexenal to a hexenol in the presence of a hydride donor, a ketoreductase, and a co-factor wherein the contacting and reducing steps are carried out at essentially the same time in the substantial absence of baker's yeast.

Herein are provided methods for increasing enzymatic activity of desaturases and fatty acyl reductases by co-expressing NAD(P)H cytochrome b5 reductases (EC 1.6.2.2, Ncb5or), as well as to methods for production of compounds comprised in pheromones, in particular moth pheromones, such as saturated and desaturated fatty alcohols, and saturated and desaturated fatty alcohol acetates and fatty acids, and derivatives thereof, in a cell.

The present invention relates to microorganisms for producing monoterpene indole al-kaloids (MIAs) and derivatives thereof de novo, including halogenated MIAs and halo-genated derivatives thereof. Also provided herein are methods for producing MIAs and derivatives thereof de novo, in particular halogenated MIAs and derivatives thereof, in a 5 microorganism, as well as useful nucleic acids, vectors and host cells for performing the present methods.