The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.

The present invention relates to polypeptides, specifically polypeptides having transgalactosylating activity and nucleic acids encoding these, and their uses in e.g. dairy product.

The present invention relates to new improved peptide or dimeric peptides exhibiting betagalactosidase enzyme activity wherein the peptide has a pH optimum at acidic conditions.

The present invention relates to an enzyme complex which the following (i) to (iv) are combined: (i) chimeric beta-agarase formed by a fusion of beta-agarase and the dockerin module of endo-β-1,4-glucanase-B; (ii) chimeric kappa-carrageenase formed by a fusion of kappa-carrageenase and the dockerin module of endo-β-1,4-glucanase-B; (iii) chimeric anhydro-galactosidase formed by a fusion of anhydro-galactosidase and the dockerin module of endoβ-1,4-glucanase-B; and (iv) mini cellulose-binding protein A, and to a method of degrading red algal biomass using the same. According to the present invention, an enzymatic degradation process is applied for the production of agar degradation products, deviating from conventional methods that relied on physical and chemical pretreatment processes. Thus, the present invention will greatly contribute to efficiently converting marine algae into valuable products by use of a convenient, cost-effective, highly efficient and environmentally friendly degradation system while controlling the products.

The present invention relates to polypeptides, specifically polypeptides having transgalactosylating activity and nucleic acids encoding these, and their uses in e.g. dairy product.

The present invention relates to an expansin-agarase enzyme complex and a method of degrading agar by using the same. The use of the enzyme complex according to the present invention can efficiently degrade agar obtained from marine biomass, and thus can efficiently provide not only galactose or glucose, necessary for ethanol production, but also useful biologically active substances, such as diose, triose, and oligosaccharides.

The present invention relates to a Streptomyces mutant strain in which a -agarase DagA enzyme is over-expressed and a method for developing the strain. In addition, the present invention relates to a method for producing neoagarohexaose or neoagarotetraose in vivo by using the Streptomyces mutant strain.

The present disclosure relates to an enzyme complex of arabinose isomerase, agarase and 3,6-anhydro galactosidase and a method for producing tagatose by degrading agar using the same. By using the enzyme complex according to the present disclosure, agar obtained from marine biomass can be degraded effectively and useful physiologically active substances such as tagatose can be obtained effectively therefrom.

Described herein are methods for treating a subject having or at risk of developing Parkinson's disease, by administering pluripotent cells that express glucocerebrosidase (GBA) or pluripotent cells that express GBA and one or more M2-promoting agents to the subject. Also disclosed are compositions comprising pluripotent cells expressing GBA, such as pluripotent cells expressing GBA and one or more M2-promoting agents.

The present invention provides a -agarase, a composition containing the same and applications thereof. The present -agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the present agarase is particularly modified for heterologous production by prokaryotic expression systems, and thereby is favorable for commercial use.