Patent classifications
C12Y504/02007
Engineered phosphopentomutase variant enzymes
- Scott J. Novick ,
- Xiang Yi ,
- Nikki Dellas ,
- Oscar Alvizo ,
- Jovana Nazor ,
- Da Duan ,
- Vesna Mitchell ,
- Jonathan Vroom ,
- Santhosh Sivaramakrishnan ,
- Nandhitha Subramanian ,
- Jeffrey C. Moore ,
- Mark Huffman ,
- Agustina Rodriguez-Granillo ,
- Deeptak Verma ,
- Grant S. Murphy ,
- Nicholas Marshall ,
- Jay Russell ,
- Keith A. CANADA
The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
ENGINEERED PHOSPHOPENTOMUTASE VARIANT ENZYMES
- Scott J. Novick ,
- Xiang Yi ,
- Nikki Dellas ,
- Oscar Alvizo ,
- Jovana Nazor ,
- Da Duan ,
- Vesna Mitchell ,
- Jonathan Vroom ,
- Santhosh Sivaramakrishnan ,
- Nandhitha Subramanian ,
- Jeffrey C. Moore ,
- Mark Huffman ,
- Agustina Rodriguez-Granillo ,
- Deeptak Verma ,
- Grant S. Murphy ,
- Nicholas Marshall ,
- Jay Russell ,
- Keith A. CANADA
The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
Compositions and uses thereof
The present invention relates to a composition comprising a probiotic extract, wherein the extract comprises a protein fraction derived from a secretion or lysate and having proteins of a molecular weight of up to 100 kDa. The composition may have a number of uses, such as for use in the prevention, management or treatment of bacterial infection or the enhancement and improvement of skin health.