The invention relates to a system for manufacturing by electrospinning a composite fibre structure; wherein the system comprises a first device of solution electrospinning comprising a first head biased to a first voltage, a second device of melt electrospinning comprising a second head electrically connected to ground, and a moveable collector configured to be either electrically connected to ground or biased to a second voltage. Wherein the system further comprises switching means configured to selectively assign the electrical status of the collector.

A sheet of substrate (7) travels along a first path in a first direction between a first collecting electrode (1) and a second spinning wire electrode (2); and the second spinning wire electrode (2) travels in a second direction (10) approximately perpendicular to the first direction at an approximately constant operational distance to the sheet of substrate (7). One or more secondary guiding means (4) guide the second spinning wire electrode (2) in a third direction at least partly parallel to the first direction i.e. parallel to the traveling direction of the sheet of substrate, and tertiary guiding means (5) guide the second spinning wire electrode (2) in a fourth direction (11) approximately perpendicular to the first direction and parallel but opposite the second direction (10) at a constant operational distance to the sheet of substrate (7).

A device for producing electrospun polymer short fibers has a dosing electrode (1) and a collector medium (3) opposite the dosing electrode (1) in the dosing direction (2). In order to create a device that enables continuous production of electrospun polymer short fibers, a cutting grid (5), which can be heated at least to the softening temperature of the polymer and which has a mesh size that corresponds to the minimum fiber length, is arranged upstream of the collector medium (3) in the dosing direction (2).

A fiber collection tool for collecting a fiber spun by electrospinning is described. The fiber collection tool has a size holdable by the hand of a user, and includes, in at least a portion of the surface thereof, an electroconductive section having a surface electrical resistivity of 10.sup.11 Ω/cm.sup.2 or less, or a hydrophilic section having a water contact angle of preferably from 15° to 90° at 25° C. A user collects, with the fiber collection tool, a fiber spun by the user by electrospinning using an electrospinning device having a size holdable by the hand of the user, and thereby produces a film including a deposit of the fiber on a surface of the fiber collection tool. The fiber collection tool, having the deposit formed thereon, is pressed against a surface of an object, and the deposit is transferred onto the surface of the object, to form a film including the fiber deposit on the surface of the object.

A fiber collection tool for collecting a fiber spun by electrospinning is described. The fiber collection tool has a size holdable by the hand of a user, and includes, in its interior, an electroconductive section. Preferably, the fiber collection tool further includes a surface section outside the electroconductive section. In a fiber deposit production method, a user collects, with the fiber collection tool, a fiber spun by the user by performing electrospinning using an electrospinning device having a size holdable by the hand of the user, and thereby produces a film including a deposit of the fiber on a surface of the fiber collection tool. The fiber collection tool, having the deposit formed thereon, is pressed against a surface of an object, and the deposit is transferred onto the surface of the object, to form a film including the fiber deposit on the surface of the object.

The present invention generally relates to a dual density air filtration media that comprises a plurality of nanofibers layers formed from nanofibers having different fiber diameters. Due to the presence of these multiple nanofiber layers with different nanofiber diameters, the resulting filtration media of the present invention comprises a gradient density. In particular, the present invention uses a novel combination of two or more layers of nanofibers made via an electrospinning process, wherein the nanofiber layers made up from different fiber sizes are strategically applied to a cellulose or synthetic base material or substrate, to thereby maximize the filtration efficiency and dust holding capacity of the resulting filtration media.

A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

According to an embodiment, an electrospinning apparatus includes: a transport roll; and a head unit. The transport roll is a roll that transports a substrate. The transport has a transport surface that is in contact with the substrate when transporting the substrate. The transport surface of the transport roll has a surface roughness Ra of 1.6 or less. The head unit ejects a raw material liquid of fiber toward the substrate transported by the transport roll to form a film of the fiber on the substrate.

Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix , as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.

The present invention relates to thin filters comprising melt electro spinning writing (MEW) fibers for capturing and culturing circulating tumor cells (CTCs). The invention further relates to processes for producing the filters, methods for capturing and culturing CTCs using the filters, kits and devices comprising the filters and uses of the filters.