A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.

Apparatus features a signal processor or signal processing module configured to: receive signaling containing information about a central air-core of an overflow pipe of a hydrocyclone where fluid flow is concentrated in an outer annular region of the overflow pipe that is against an inner wall of the overflow pipe during a normal operation of the hydrocyclone; and determine corresponding signaling containing information about a collapse of the central air-core of the overflow pipe of the hydrocyclone during an abnormal operation of the hydrocyclone, based upon the signaling received. The signaling contains information about a fluid flow rate of the fluid flow by detecting a change in the magnitude of a force and/or a moment on the probe.

Apparatus features a signal processor or signal processing module configured to: receive signaling containing information about a central air-core of an overflow pipe of a hydrocyclone where fluid flow is concentrated in an outer annular region of the overflow pipe that is against an inner wall of the overflow pipe during a normal operation of the hydrocyclone; and determine corresponding signaling containing information about a collapse of the central air-core of the overflow pipe of the hydrocyclone during an abnormal operation of the hydrocyclone, based upon the signaling received. The signaling contains information about a fluid flow rate of the fluid flow by detecting a change in the magnitude of a force and/or a moment on the probe.

A microfluidic device that reads a colloidal mixture and separates the colloids based upon size and shape. and in the case of polymer colloids such as DNA, it reads patterns of markers attached to DNA. The combination of different separated fractions and DNA markers (it mapping) constitutes the physical code.

A microfluidic device that reads a colloidal mixture and separates the colloids based upon size and shape. and in the case of polymer colloids such as DNA, it reads patterns of markers attached to DNA. The combination of different separated fractions and DNA markers (it mapping) constitutes the physical code.

A process for optically sorting a plurality of particles includes: providing a particle receiver; producing particles; receiving the particles by the particle receiver; receiving a light by the particle receiver; producing a standing wave optical interference pattern in an optical interference site of the particle receiver from the light; subjecting the particles to an optical gradient force from the standing wave optical interference pattern; deflecting the particles into a plurality of deflected paths to form the sorted particles from the particles; and propagating the sorted particles from the optical interference site through the deflected paths to optically sort the particles

The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.

Disclosed is a method for selecting a cancer treatment regimen for a subject.

The present disclosure provides improved systems and methods for automated cell identification/classification. More particularly, the present disclosure provides advantageous systems and methods for automated cell identification/classification using shearing interferometry with a digital holographic microscope. The present disclosure provides for a compact, low-cost, and field-portable 3D printed system for automatic cell identification/classification using a common path shearing interferometry with digital holographic microscopy. This system has demonstrated good results for sickle cell disease identification with human blood cells. The present disclosure provides that a robust, low cost cell identification/classification system based on shearing interferometry can be used for accurate cell identification. For example, by combining both the static features of the cell along with information on the cell motility, classification can be performed to determine the type of cell present in addition to the state of the cell (e.g., diseased vs. healthy).

The present disclosure provides improved systems and methods for automated cell identification/classification. More particularly, the present disclosure provides advantageous systems and methods for automated cell identification/classification using shearing interferometry with a digital holographic microscope. The present disclosure provides for a compact, low-cost, and field-portable 3D printed system for automatic cell identification/classification using a common path shearing interferometry with digital holographic microscopy. This system has demonstrated good results for sickle cell disease identification with human blood cells. The present disclosure provides that a robust, low cost cell identification/classification system based on shearing interferometry can be used for accurate cell identification. For example, by combining both the static features of the cell along with information on the cell motility, classification can be performed to determine the type of cell present in addition to the state of the cell (e.g., diseased vs. healthy).