A sensor for particle identification is provided. The subject sensor includes: a first chamber configured to be filled with an electrolytic solution; a first electrode provided inside the first chamber and configured to be connected to an external power supply for applying a voltage; a second chamber configured to be filled with the electrolytic solution; a second electrode provided inside the second chamber and configured to be connected to the external power supply; a data output means configured to output measurement data expressing an ion current generated between the first electrode and the second electrode; a partition separating the first chamber and the second chamber; and a presentation device for providing a unique identifier to an external computer device over a network.

Apparatus (3) for electrically measuring individual particles (4) flowing in a liquid (6), which apparatus (3) comprises: (i) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (ii) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); (iii) at least one other electrode arrangement (9) having at least one measurement electrode and at least one signal electrode (13); (iv) at least one signal conditioning electrode (10, 12, 14, 15, 17, 19) positioned adjacent to at least one of the measurement electrodes (16, 18) or at least one of the signal electrode (9); and (v) measuring means (20, 21) for measuring electrical signal changes; and the apparatus (3) being such that: (vi) the first and the other electrode arrangements (8, 9) are connected to the measuring means (20, 21) whereby individual particles passing between the first and other electrode arrangements (8, 9) cause a change in electrical signal which is measured; and (vii) the electrical potential of the signal conditioning electrode (10, 12, 14, 15, 17, 19) is controlled to substantially prevent current flow between the first electrode arrangement (8) and the other electrode arrangement (9).

A flow cell includes a first layer, a second layer, and a third layer. The first layer includes a first flow path and a first electrode. The second layer includes a second flow path and a second electrode. The third layer is formed between the first layer and the second layer, and includes a first connection hole connecting the first flow path and the second flow path. The first electrode is disposed in the first flow path at a first side opposite to a second side where a sample is provided to the first flow path with respect to the first connection hole. The second electrode is disposed in the second flow path at a third side opposite to a fourth side where a fluid is discharged from the second flow path with respect to the first connection hole.

A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).

Microfluidic impedance based lab on chip is a sensor module to measure the impedance of a single biological cell flowing in channel of micrometer size. In the present invention, the enhancement in the channel cross-section 30 micron [h]45 micron [w] leads to reduce the pressure drop significantly i.e., around 40 kPa at 100 microliter/min, which demands by cartridge based micro-pump for portable devices at Point of Care (PoC) location. Lab on chip of present invention is capable of withstanding 20 Vpp for several hours without degradation of electrodes and also capable to measure the particle with dimension down to 2 microns. Lab on chip of present invention was also used to count the platelet of the diluted blood samples without any pretreatment and comparable to the clinical lab report.

The present invention relates to a pipette tip comprising a thin holed membrane at its distal end, which is designed to be adapted with a system comprising at least an impedance analyser and a fluidic actuator to perform the dispensing and analysis of particles comprised within a conductive medium by exploiting the Coulter counter principle. The pipette tip can comprise attached or floating electrodes at its internal or external side for creating an electrical circuit. Also disclosed therein is a dispensing and analysis system, methods of using thereof and pipette tip's manufacturing methods.

There is provided a microparticle analysis apparatus including a sample channel configured to receive liquid containing a plurality of microparticles, a first pair of electrodes configured to form an alternating electric field in at least a part of the sample channel, a measuring part configured to measure impedance between the first pair of electrodes, an analyzing part configured to calculate property values of the microparticles from the impedance measured in the measuring part, and a determining part configured to determine whether data of the impedance measured in the measuring part is derived from the microparticles.

This disclosure provides a microfluidic system (e.g., microfluidic cartridge, microfluidic chip) comprising two or more microfluidic flow channels for impedance-based detection of a biological entity in a sample. The disclosed system enables simultaneous measurements of a sample in two or more microfluidic flow channels to minimize faulty results. It eliminates the need of lysing samples and measuring them multiple times that is more time-consuming, and could introduce some variations across samples and devices.

A flow cell includes a first layer, a second layer, and a third layer. The first layer includes a first flow path and a first electrode. The second layer includes a second flow path and a second electrode. The third layer is formed between the first layer and the second layer, and includes a first connection hole connecting the first flow path and the second flow path. The first electrode is disposed in the first flow path at a first side opposite to a second side where a sample is provided to the first flow path with respect to the first connection hole. The second electrode is disposed in the second flow path at a third side opposite to a fourth side where a fluid is discharged from the second flow path with respect to the first connection hole.

According to one embodiment, a particle inspection system includes a voltage driving circuit which applies a driving voltage for a particle inspection to a particle inspection chip, a current-voltage conversion circuit which converts, into a voltage signal, a current signal output from the particle inspection chip when the driving voltage is applied to the particle inspection chip, a detection circuit which detects, based on the voltage signal, whether the sample liquid is introduced into a detection region of the particle inspection chip, and an analysis circuit which analyzes the fine particle, in the sample liquid based on the voltage signal. The voltage driving circuit varies the driving voltage based on the detection result of the detection circuit.