A measuring cell includes a cavity for receiving a test sample to be used in a particle detection apparatus. The measuring cell is configured as an optical waveguide for guiding a light beam. The waveguide has a core which has a refractive index n.sub.K, extends along a longitudinal axis of the waveguide, has a cross-sectional area A.sub.K of less than 80 μm.sup.2 in a cross section perpendicular to the longitudinal axis, and which is surrounded by a cladding having a smaller refractive index than n.sub.K. The cavity forms a channel. The channel extends along the longitudinal axis, is formed inside of or in contact with the core, and has at least one open end with an opening area A.sub.H of less than 0.2 μm.sup.2.

Microfluidic cuvettes and a network of multiplexed channels including such cuvettes. The channels operationally share a main output channel defining an output of the network. A microfluidic channel includes an inlet, a cuvette, and an outlet that is coupled into the main output channel. The network is configured to provide a difference in resistances, to the fluid, by the main output channel and by an individual outlet is sufficient to prevent cross-contamination of different cuvettes, thereby operably isolating individual channels from one another. An individual cuvette is adapted to substantially prevent the formation of air-bubbles as part of the fluid flow through the cuvette and, therefore, to be fully filled and fully emptied. A system and method for photometric measurements of multiple fluid samples employing such network of channels.

The disclosure relates to a method for making carrier for use in single molecule detection. The method includes: providing a rigid substrate; coating a polymer layer on a surface of the rigid substrate, the polymer layer is in semisolid state; transferring a nano-scaled pattern of a template on a surface of the polymer layer by pressing the template on the surface of the polymer layer; obtaining a flexible substrate by removing the template; and applying a metal layer on the flexible substrate. The carrier for use in single molecule detection has a relative higher SERS and can enhance the Raman scattering.

A disposable injection moulded flow cell or cuvette for use in flow cytometer for in vitro assaying of human or animal whole blood and to an investigation method using the flow cytometer. The present disclosure provides a cuvette for use in an optical flow cytometer, comprising a cuboid sheath preparation area, a curved sample injection area with a rectangular cross section, a pyramidal shaped flow formation area, and a sample injector which is arranged in the transition area from the cuboid sheath preparation area to the curved sample injection area.

The present invention relates to a liquid immersion micro-channel measurement device and measurement method which are based on trapezoidal incident structure prism incident-type silicon, and according to one embodiment of the present invention, the liquid immersion micro-channel measurement device based on trapezoidal incident structure prism incident-type silicon comprises: a micro-channel structure including a support and at least one micro-channel, which is formed on the support and has a sample detection layer to which a first bioadhesive material for detecting a first sample is fixed; a quadrangular pyramid-shaped prism formed on the upper part of the micro-channel structure; a sample injection unit for injecting, into the micro-channel, a buffer solution containing the first sample; a polarized light generation unit for emitting incident light polarized through the prism on the micro-channel at an incident angle that satisfies a p-wave non-reflection condition; and a polarized light detection unit for detecting, from the polarized incident light, a polarization change in a first refection light reflected from the sample detection layer, wherein the prism completely reflects, from the polarized incident light incident on the prism, on an upper boundary surface of the prism, second reflection light reflected from a lower boundary surface of the prism and a boundary surface of the buffer solution injected into the micro-channel.

The gas detection apparatus comprises a figure of all or a part of n ellipsoids. When a region inside the ellipsoid E.sub.i and not including the ellipsoid E.sub.si is defined as a region R.sub.i, the ellipsoid E.sub.i including a light source region of the light emitting part is defined as an ellipsoid E.sub.s, the ellipsoid E.sub.i including a light receiving region of the light receiving part is defined as an ellipsoid E.sub.d, the region R.sub.i of the ellipsoid E.sub.s is defined as a region R.sub.in, and the region R.sub.i of the ellipsoid E.sub.d is defined as a region R.sub.out, 60% or more of the light source region is present in the region R.sub.in and 60% or more of the light receiving region is present in the region R.sub.out.

A fine particle measurement device includes a support stand (20) that has a groove (F) extending in a predetermined direction and is configured to support in the groove an observation container (10), which has an elongate shape and accommodates a liquid sample containing a fine particle therein such that an extending direction of the groove (F) coincides with a longitudinal direction of the observation container (10); and an imaging unit (40) that is configured to capture an image of the fine particle in the observation container (10) at a position where the support stand is out of a field of view, the observation container (10) being supported by the support stand (20).

An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.

A disposable injection moulded flow cell or cuvette for use in flow cytometer for in vitro assaying of human or animal whole blood and to an investigation method using the flow cytometer. The present disclosure provides a cuvette for use in an optical flow cytometer, comprising a cuboid sheath preparation area, a curved sample injection area with a rectangular cross section, a pyramidal shaped flow formation area, and a sample injector which is arranged in the transition area from the cuboid sheath preparation area to the curved sample injection area.

A measuring apparatus for measuring a spectrum of a gaseous sample includes a tunable laser light source to provide an illuminating light beam, a sample cell with an inner surface to provide scrambled light that is transmitted through the gaseous sample, a detector to detect intensity of transmitted scrambled light and a pressure control system to maintain an absolute pressure of the gaseous sample smaller than 50 kPa inside the sample cell to reduce spectral widths of spectral features of the gaseous sample. The measuring apparatus measures spectral transmittance values of the sample by modulating the spectral position of the illuminating light, and detecting the intensity of the transmitted light at different spectral positions. The divergence of the illuminating light beam in a transverse direction is greater than 30° to cause multiple consecutive reflections of the scrambled light from the inner surface.