Patent classifications
G01N2030/521
Materials transport device for diagnostic and tissue engineering applications
Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.
Method for detecting a gas sample using a carbon aerogel adsorbent
A method for detecting a gas sample includes the following steps of: providing a carbon aerogel sleeve; introducing a gas sample to the carbon aerogel sleeve, and then sequentially extracting, concentrating, activating, and re-concentrating the gas sample adsorbed by the carbon aerogel and detecting a concentration of the re-concentrated gas sample by a gas chromatograph-mass spectrometer (GC-MS); and extracting the carbon aerogel for several hours with reflux in a dichloromethane solvent and a n-hexane solvent several times per hour to remove the residual gas sample, and then drying the extracted carbon aerogel for reuse, wherein the dichloromethane solvent and the n-hexane solvent are at a volume ratio of 0.001-1000.
COLUMN OVEN
A column oven includes a substantially sealed space surrounded by wall surfaces made of a heat conductive material to accommodate an analytical column, a heater for heating the wall surfaces made of the heat conductive material, and a heat insulating material surrounding an outside of the wall surfaces made of the heat conductive material. That is, a space inside the column oven in which the analytical column is accommodated is formed as a substantially sealed structure surrounded by the heat conductive wall surfaces, and the wall surfaces surrounding the substantially sealed space are heated by the heater, thereby heating the substantially sealed space uniformly from circumferential directions.
METHOD FOR DETECTING A GAS SAMPLE USING A CARBON AEROGEL ADSORBENT
A method for detecting a gas sample includes the following steps of: providing a carbon aerogel sleeve; introducing a gas sample to the carbon aerogel sleeve, and then sequentially extracting, concentrating, activating, and re-concentrating the gas sample adsorbed by the carbon aerogel and detecting a concentration of the re-concentrated gas sample by a gas chromatograph-mass spectrometer (GC-MS); and extracting the carbon aerogel for several hours with reflux in a dichloromethane solvent and a n-hexane solvent several times per hour to remove the residual gas sample, and then drying the extracted carbon aerogel for reuse, wherein the dichloromethane solvent and the n-hexane solvent are at a volume ratio of 0.001-1000.
PACKING ASSEMBLY FOR CHROMATOGRAPHY MEDIA AND METHODS OF USE THEREOF
A packing assembly for forming a packed-bed for a chromatography device is described herein. The packing assembly includes a bottom plate and a first top plate. The first top plate has a top plate hole centrally positioned therein. The packing assembly also includes a middle plate. The middle plate has a middle plate hole centrally positioned therein. The middle plate hole is aligned with the top plate hole when the packing assembly is in an assembled state. The packing assembly also includes a second top plate. The second top plate has a protrusion extending outwardly. At least a portion of the protrusion has a same size and a same shape as the top plate hole to be received in the top plate hole when the packing assembly is in a packing state. Methods of packing chromatography media in a packing assembly and assembling a chromatography device are also described herein.
HIGH SURFACE AREA CHROMATOGRAPHIC DEVICE WITH LOW PRESSURE DROP
A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.
ENCAPSULATED PRE-ANALYTIC WORKFLOWS FOR FLOW-THROUGH DEVICES, LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRIC ANALYSIS
This invention relates to encapsulated workflow reagents comprising an encapsulating material and a workflow reagent encapsulated within the encapsulating material for sample and workflow preparation prior to chromatographic, spectroscopic or other analytical systems, use thereof, and devices comprising the same.
Micro-separator having stationary phase with three dimensional nano-structure and method for manufacturing the same
A disclosed micro-separator for gas chromatography includes a base substrate having a trench, a channel column disposed in the trench, and a cover member combined with the base substrate and covering the channel column. The channel column includes a stationary phase having pores ordered and three-dimensionally connected to each other.
Chromatography Media And Method
Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
Materials Transport Device for Diagnostic and Tissue Engineering Applications
Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.