The present disclosure pertains to compositions comprising anti-VEGF and methods for producing such compositions in chemically defined media and controlling amounts of certain oxidized aflibercept variants.

The present disclosure pertains to compositions comprising anti-VEGF and methods for producing such compositions in chemically defined media and controlling amounts of certain oxidized aflibercept variants.

An ion chromatography system includes a separation column configured to separate components of a solution; a non-destructive detector; and a concentrator configured to capture components of a check standard after they leave the conductivity non-destructive detector; and release the components of the check standard to the separation column.

The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.

The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.

The present disclosure pertains to compositions comprising anti-VEGF proteins.

The present disclosure pertains to compositions comprising anti-VEGF proteins.

Methods and system for protein characterization using online chromatography and electrospray ionization mass spectrometry are provided.

Methods and system for protein characterization using online chromatography and electrospray ionization mass spectrometry are provided.

The present invention relates to a gas-liquid separator for a chromatography system, comprising: (a) a separating region having an inlet nozzle, a baffle unit and a gas distribution unit; (b) a dividing region having a liquid outlet; and (c) a gas discharge region having a gas outlet; wherein the separating region is connected to the dividing region by a separating opening and the distance of the inlet nozzle from the baffle unit is greater than the smallest longitudinal extension of the separating opening and the inlet nozzle is configured such that a gas-liquid stream directed through the inlet nozzle can act on the baffle unit.

The present invention further relates to a chromatography system comprising a separator according to the invention and to a chromatography method wherein the separator is used.