The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

A nuclear waste cask with impact protection includes impact limiters comprising deformable energy-absorbing perforated sleeves. An impact amelioration system for nuclear fuel storage components includes impact limiter assemblies at the bottom cask to canister interface including impact limiter plugs frictionally engaging corresponding plug holes formed in the cask closure plate. A nuclear waste fuel storage system includes an unventilated cask including a heavy free-floating radiation shielding lid loosely coupled the top end of the cask in a movable manner via the anchor bosses which provides cask overpressurization protection. A nuclear waste cask includes an axially elongated rectangular cuboid cask body having a cavity for holding nuclear waste materials and cask locking mechanism including first locking protrusions on the lid which are selectively interlockable with mating second locking protrusions on the cask body to lock the lid to the cask body.

Various embodiments relate to devices for transporting high-assay low-enriched uranium (HALEU). A device may include at least one section, wherein each section of the at least one section includes a number of storage tubes. Each storage tube, which is configured to receive and hold a container, extends from adjacent a first end of the section toward second, opposite end of the section. Each section further includes a number of flux traps, wherein each storage tube of the number of storage tubes is at least partially surrounded by a flux trap of the number of flux traps Associated systems are also disclosed.

Various embodiments relate to devices for transporting high-assay low-enriched uranium (HALEU). A device may include at least one section, wherein each section of the at least one section includes a number of storage tubes. Each storage tube, which is configured to receive and hold a container, extends from adjacent a first end of the section toward second, opposite end of the section. Each section further includes a number of flux traps, wherein each storage tube of the number of storage tubes is at least partially surrounded by a flux trap of the number of flux traps Associated systems are also disclosed.

The present invention is directed to new and improved industrial containment bags wherein the improvement comprises providing methods and technologies for improving the integrity of such bags during processes designed for lifting, transporting storing and/or disposing of the same. In certain embodiments, the improvement includes providing methods and technologies for improving the sealing capabilities of the bag's closure systems. In other embodiments, the improvement includes providing methods and technologies for assessing the load balance of materials being contained in such industrial containment bags; and thereafter, compensating for any significant load imbalances. The present invention is also directed to methods of manufacturing, using, filling, lifting, transporting, storing, and/or disposing of such new and improved industrial containment bags.

The present invention is directed to new and improved industrial containment bags wherein the improvement comprises providing methods and technologies for improving the integrity of such bags during processes designed for lifting, transporting storing and/or disposing of the same. In certain embodiments, the improvement includes providing methods and technologies for improving the sealing capabilities of the bag's closure systems. In other embodiments, the improvement includes providing methods and technologies for assessing the load balance of materials being contained in such industrial containment bags; and thereafter, compensating for any significant load imbalances. The present invention is also directed to methods of manufacturing, using, filling, lifting, transporting, storing, and/or disposing of such new and improved industrial containment bags.

A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.

A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.

An underground ventilated system for storing nuclear waste materials. The system includes a storage module having an outer shell defining an internal cavity and an inner shell. A majority of the height of the outer shell may be disposed below grade. The outer shell may include a hermetically sealed bottom. First and second canisters are positioned in lower and upper portions within the cavity respectively in vertically stacked relationship. A centering and spacing ring assembly is interspersed between the first and second canisters to transfer the weight of the upper second canister to the lower first canister. The assembly may include centering lugs which laterally restrain the first and second canisters in case of a seismic event. A natural convection driven ventilated air system cools the canisters to remove residual decay heat to the atmosphere. In one non-limiting embodiment, the shells are made of steel.

A compression member for insertion into a pig for transporting a container of biohazardous materials includes a flange maintained in spaced relation with an annulus by pillars; and spaced apart pivotable grip components supported by the annulus and extending downwards from the annulus between respective ones of the pillars towards, but not into contact with, the flange, the pivotable grip components resiliently compressible inwardly against the container when the container is received within the compression member. In use, the compression member receives at least a closure portion of the container and, in turn, is itself received within a complementary annulus of the pig. When being received within the complementary annulus of the pig, the pivotable grip components are urged inwards towards the container thereby to grip the container and provide a spacer for between this portion of the container and the pig.