According to one embodiment, a particle beam therapy system comprising: a circular accelerator configured to accelerate charged particles; a beam transportation line configured to lead the charged particles accelerated by the circular accelerator to an irradiation room; a shielding wall that is disposed around a radiation controlled area and shields radiation to be generated from the circular accelerator and the beam transportation line, the radiation controlled area being an area where the circular accelerator and the beam transportation line are disposed; a specific portion that is provided at a position that separates the radiation controlled area from outside of the shielding wall and can form an additional opening portion of the irradiation room; and a blocking portion configured to close the specific portion and shield radiation passing through the specific portion.

The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

The invention relates to a door arrangement (1) for a door with a first enclosed volume, the arrangement permitting a sealed connection between the first enclosed volume and a second enclosed volume, and comprising a flange (2) defining passage opening and a passage axis (O) perpendicular to the opening plane, a door (4) pivotably mounted on the flange (2) and a chute for discharging (10) components which is movable between a discharge position in which the chute is positioned opposite the passage opening and a position in which the chute is spaced apart from the passage opening, the chute being attached to the flange (2) by means of a first double-jointed link mechanism (11) comprising a first link (12) arranged to permit a rotational movement about an axis (C) parallel to the passage axis (O) of the passage opening and a second link (13) arranged to permit a rotational movement about an axis (D) perpendicular to the passage axis (O) of the passage opening.

An assembly for transferring an element from or towards the inside of a closed contaminated enclosure having an opening. The transfer assembly includes a first door closing substantially sealingly the opening of the contaminated enclosure and a transfer box delimiting an enclosed space and having an opening closed by a second door configured to pivot towards the inside of the transfer box, the first door and the second door each having at least one coupling member configured to allow the coupling of the first door and of the second door and configured to allow the first door and the second door, coupled to one another, to pivot towards the inside of the transfer box.

An assembly for transferring an element from or towards the inside of a closed contaminated enclosure having an opening. The transfer assembly includes a first door closing substantially sealingly the opening of the contaminated enclosure and a transfer box delimiting an enclosed space and having an opening closed by a second door configured to pivot towards the inside of the transfer box, the first door and the second door each having at least one coupling member configured to allow the coupling of the first door and of the second door and configured to allow the first door and the second door, coupled to one another, to pivot towards the inside of the transfer box.

A container for ensuring the transport and the aseptic transfer of a biopharmaceutical product from or to a closed chamber provided with a leaktight joining device, includes: an annular flange delimiting an opening, a removable cover, built-in elements for locking/unlocking the removable cover and a peripheral envelope. The built-in locking/unlocking elements include a built-in functional locking/unlocking arrangement formed by a through-housing formed in the annular flange and a blind housing formed in the removable cover, and by a pin at an inner radial position and a pin at an outer radial position. The container is capable of being in an initial locking position, in an intermediate unlocking position and in a final locking position owing to the displacements of the pin at an inner radial position and the pin at an outer radial position in the blind hole of the removable cover and in the through-housing of the annular flange.

A container for ensuring the transport and the aseptic transfer of a biopharmaceutical product from or to a closed chamber provided with a leaktight joining device, includes: an annular flange delimiting an opening, a removable cover, built-in elements for locking/unlocking the removable cover and a peripheral envelope. The built-in locking/unlocking elements include a built-in functional locking/unlocking arrangement formed by a through-housing formed in the annular flange and a blind housing formed in the removable cover, and by a pin at an inner radial position and a pin at an outer radial position. The container is capable of being in an initial locking position, in an intermediate unlocking position and in a final locking position owing to the displacements of the pin at an inner radial position and the pin at an outer radial position in the blind hole of the removable cover and in the through-housing of the annular flange.

A transport and packaging container for a plurality of pharmaceutical containers and a method for transferring the pharmaceutical containers from the transport and packaging containers into a clean room are provided. By placing a side wall of the transport and packaging container in close proximity to or in contact with the side wall of the clean room and by opening the side wall of the transport and packaging container and a transfer port door of the clean room, the pharmaceutical containers can be transferred into the inside space of the clean room via the access opening.

The present invention concerns a hood for handling and confinement of at least two objects of slender shape, including an external enclosure and internal enclosures inside the external enclosure and at least one motor fixed above an internal enclosure and inside a barrel, the motor(s) being adapted to rotate the screw of the screw-nut mechanism of each internal enclosure and therefore the nut over a stroke A, and first and second mechanical control means, arranged in part above the cover of the external enclosure, respectively for manually guiding the internal enclosures in translation over a stroke A0 and manually pivoting the barrel in order to bring a holding member of one of the internal enclosures opposite the opening in the bottom of the external enclosure. Application to the handling and confinement of nuclear material sample holders.