VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECONSTITUTING AND/OR DILUTING OF INJECTABLE PRODUCTS

Abstract

This CIP, Continuation-in-part, presents constructive details of the material contained in the original document BR 10 2016 016091-0 and not specified until then, and the valve (3) can also be used in transfers, dilution and drip chamber and medicine bottles, vaccines and related, the valve (3) has five basic components: conical base (4), which receives in its interior the assembly of the second component, which is the conical movable part (7); the conical base (4) which receives in its core (16) the assembly of the third component which is a smaller diameter o-ring sealing ring (13); on the other hand, the conical movable part (7) receives in its lower groove (14) the assembly of the fourth component, which is a larger diameter o-ring sealing ring (12); the conical base (4) receives the assembly of the fifth component which is the cap (10), which protects the thread in the luer-lock pattern (8); the cover (10) prevents the separation of the conical movable part (7) in relation to the conical base (4); the movable conical part (7) has a surface (22) with an angulation (X), equal to that verified on the inner surface (27) of the conical base (4); the constructive variation of the valve (3a) is fixed to the mouthpiece (6a) of the bottle (F) through its conical base (4), this adjusted to the diameter of the bottle, keeping the valve system unchanged; in addition, the cover (10) of the valve (3a) presents a constructive variation (not shown) formed by a cylindrical body, internally threaded, provided with a lower ring connected to the cover body through a plurality of breaking points, welding points plastic or shrink.

Claims

1. “VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECOSTITUTING AND/OR DILUTION OF INJECTABLE PRODUCTS”, presents a valve (3) wherein have five basic components, the first being a conical base (4), which receives inside an assembly of the second component, which is a conical movable part (7); a conical base (4) receives in its core (16) an assembly of the third component which is a sealing ring of the type or smaller diameter ring (13); on the other hand, the conical movable part (7) receives in its lower groove (14) the assembly of the fourth component, which is a larger diameter o-ring sealing ring (12); a conical base (4) receives an assembly of the fifth component which is a cap (10), which protects a thread in the luer-lock pattern (8); the cover (10) also prevents the moving conical part (7) from separating from the conical base (4); a conical movable part (7) has a surface (22) with an angulation (X), equal to that verified on the inner surface (27) of the conical base (4); the constructive variation of the valve (3) defined as valve (3a), is fixed to the mouthpiece (6a) of the bottle (F) through its conical base (4), this adjusted to the diameter of the bottle, keeping the valve system unchanged.

2. “VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECOSTITUTING AND/OR DILUTION OF INJECTABLE PRODUCTS”, according to claim 1, whereom in that it has a lid (10a) in a constructive variation being formed by a cylindrical body (CC), internally threaded, provided with a lower ring (AI) connected to the body (CC) of the lid (10a) through of a plurality of rupture points (PR), plastic or shrink welding points, however, also in this case, the valve mechanism in question remains unchanged, keeping the same components: two conical plastic parts (4) and (7) which fit between each other and two o-ring type rubber seal rings, one with a larger diameter (12) and one with a smaller diameter (13).

3. “VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECOSTITUTING AND/OR DILUTION OF INJECTABLE PRODUCTS”, according to claim 1, wherein that it is used in bottles with agrochemicals (FA), with access to the content being made by connection with a syringe (S) or other device with thread in the luer-lock pattern (8).

4. “VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECOSTITUTING AND/OR DILUTION OF INJECTABLE PRODUCTS”, according to claim 1, Wherein that it is used in transfers (FIG. 11) to access the content of traditional bottles (FT).

5. “VALVE WITH ON-OFF MECHANISM FOR BAG USED FOR CONDITIONING, RECOSTITUTING AND/OR DILUTION OF INJECTABLE PRODUCTS”, according to claim 1, wherein that it is used in medical devices such as dilution and drip chambers (CA) (FIG. 12), replacing traditional burettes.

Description

DESCRIPTION OF DRAWINGS

[0027] he valve with on-off mechanism for bag used for packaging, reconstitution and/or dilution of products for injectable use, object of this Continuation In Part—CIP, is represented, in its entirety, through the drawings listed in follow where:

[0028] FIG. 1 shows a perspective view of the valve with an on-off mechanism for a bag used for packaging, reconstitution and/or dilution of products for injectable use, as deposited in the main document;

[0029] FIG. 2 shows a perspective view of the valve with an on-off mechanism for a bag used for packaging, reconstitution and/or dilution of products for injectable use, illustrating (in broken lines, the narrowing to be removed from the base conical, resetting the valve for use in vials;

[0030] FIG. 3 shows a perspective view of the constructive variant of the valve with on-off mechanism for a bag used for packaging, reconstitution and/or dilution of products for injectable use, without the narrowing and with the appropriate conical base to the diameter of the vial nozzle resetting the valve for use in vials;

[0031] FIG. 4 shows a sectional view of the model of the valve variant with on-off mechanism for a bag used for packaging, reconstitution and/or dilution of injectable products, for use in vials of medicines, vaccines and the like, cut this indicated by the cut line “A”-“A” in FIG. 3;

[0032] FIG. 5 shows an exploded perspective view of the variant of the valve with on-off mechanism for a bag used for packaging, reconstitution and/or dilution of injectable products, being applied in a generic model of a vial representative of vials of medicines, vaccines and related;

[0033] FIG. 6 shows an assembled perspective view with the lid closed, of the valve variant with on-off mechanism for bag used for packaging, reconstitution and/or dilution of products for injectable use, already applied in a model of representative bottle of bottles of medicines, vaccines and related;

[0034] FIG. 7 shows an assembled perspective view, with the lid open, of the valve variant with on-off mechanism for bag used for packaging, reconstitution and/or dilution of products for injectable use, applied in a bottle model representative of medicines, vaccines and related;

[0035] FIG. 8 shows a side view of the bottle with the valve cap open and the syringe with luer-lock pattern thread positioned to transfer the drug;

[0036] FIG. 9 shows a side view of the vial with the valve cap open and the syringe with luer-lock pattern thread already fitted to the vial valve;

[0037] FIG. 10 shows a perspective view of the valve model with on-off mechanism for a bag used for packaging, reconstitution and/or dilution of injectable products, for use in a generic model of a representative bottle of plastic bottles of agrochemicals;

[0038] FIG. 11 shows a perspective view of the access system to the content of conventional bottles with an on-off mechanism valve;

[0039] FIG. 12 shows a perspective view of a dilution and drip chamber with the valve model usable in vials provided for in this document;

[0040] FIG. 13 shows a perspective view of a conventional vial and a syringe with a needle, at the time of transfer of the drug or vaccine, for application to the patient, through a syringe;

[0041] FIG. 14 shows a traditional bottle with a constructive variation for the valve cap.

REFERENCE SIGNS

[0042] The valve with on-off mechanism for bag used for packaging, reconstitution and/or dilution of products for injectable use, will be better described, through the reference signs below: [0043] (3) valve shown in the original document; [0044] (3a) valve variant; [0045] (4) conical base; [0046] (5) narrowing shown on the valve of the original document; [0047] (6a) mouth of the bottle; [0048] (7) movable conical part; [0049] (8) standard luer-lock thread; [0050] (10) cover; [0051] (10a) alternative cover construction; [0052] (12) larger diameter o'ring ring; [0053] (13) smaller diameter o'ring ring; [0054] (14) lower groove; [0055] (16) core; [0056] (22) surface; [0057] (27) inner surface; [0058] (AI) lower ring; [0059] (CA) dilution and drip chamber [0060] (CC) cylindrical body of the cover; [0061] (F) bottle; [0062] (FA) agrochemical flask; [0063] (FT) traditional bottles; [0064] (PR) breakpoints; [0065] (S) syringe; and [0066] (x) angulation.

DETAILED DESCRIPTION OF THE INVENTION

[0067] The valve (3) with on-off mechanism for bag used for packaging, reconstitution and/or dilution of products for injectable use, object of this CIP, Continuation-in-part, is usable in transfers, dilution chamber and drip and vials for medicines, vaccines and the like, and the valve (3) is characterized by having five basic components, the first being the conical base (4), which receives inside the assembly of the second component that it is the conical movable part (7); the conical base (4) receives in its core (16) the assembly of the third component which is a smaller diameter o-ring sealing ring (13); on the other hand, the conical movable part (7) receives in its lower groove (14) the assembly of the fourth component, which is a larger diameter o-ring sealing ring (12); the conical base (4) receives the assembly of the fifth component which is the cover (10); the cover (10) also prevents the moving conical part (7) from separating from the conical base (4); the movable conical part (7) has a surface (22) with angulation (X), which angulation is the same as that found on the inner surface (27) of the conical base (4).

[0068] In the main patent document, the valve (3) presents a narrowing defined by a tubular terminal, provided for in the conical base. The constructive variation of this valve (3), defined as valve (3a), is fixed to the mouthpiece (6a) of the bottle (F) through its conical base (4), instead of being fixed to the tube (6) of the bag (1) (these last two items, not illustrated).

[0069] For the use of the valve (3a) in place of the rubber stoppers previously provided for in the medicine bottles, structurally the valve (3a) remains the same, if compared to the valve (3) presented in the original document, only the base conical (4) is adjusted to the diameter of the flask, eliminating only the narrowing (5) of said conical base (4), which originally, is used in the connection with the tube (6) of plastic bag (1) (these two last items not illustrated) however, the valve system does not change.

[0070] In addition, the cap (10) of the valve (3a) can present a constructive variation (10a) to adapt more easily to the bottle closing machine, and, also, in this case, the change of the cap structure does not change the valve system.

[0071] The constructive variant of the cover (10a) can be formed by a cylindrical body CC, internally threaded, provided with a lower ring (AI) connected to the cover body through a plurality of breaking points (PR), soldering points plastic or shrink, however, also in this case, the valve mechanism in question remains unchanged, keeping the same components: two conical plastic parts (4) and (7) that fit together and two rubber sealing rings of the type o′ring, one with larger diameter (12) and one with smaller diameter (13).

[0072] Many products existing in the pharmaceutical industry are likely to be composed by the valve closing system, benefiting from its functions in different market segments (human, animal, vegetable), particularly products that require health care.

[0073] An example within these different market segments are the bottles with agrochemicals (FA) (illustrated in FIG. 10), which can improve the safety of use by adopting the valve system as a lid, with access to the content being made by connection with syringe (S) or other device with standard luer-lock thread (8).

[0074] To demonstrate the breadth of use of the valve closing system, taking as examples only products that require sanitary care, it can be seen that the valve lends itself to different products, such as in transfers (FIG. 11) to access the content of traditional vials (FT) or in new medical devices such as dilution and drip chambers (CA) (FIG. 12), to replace traditional burettes.

[0075] With the valve (3a), object of this order, the preparation processes of the products, particularly the powders for injection, the subdivisions of doses will be substantially facilitated and the packaging of the products will be revolutionized.

[0076] A product now considered a single dose, can be subdivided in hospital pharmacies, which are equipped with laminar flow, safely, without perforations of rubber stoppers (FIG. 13); in the case of BULK presentations, containing several individual doses, access to these larger bottles will be greatly facilitated and the subdivisions of doses will also be equally safe.