Cosmetic and dermatological preparations containing carnitine for treating and actively preventing dry skin and other negative alterations in the physiological homeostasis of healthy skin

Abstract

A cosmetic or dermatological composition which comprises carnitine, a precursor thereof, a metabolite thereof and/or a derivative thereof.

Claims

1. A cosmetic or dermatological composition, wherein the composition comprises from 0.001% to 30% by weight of at least one substance which is a carboxylic acid ester of L-carnitine selected from propionyl-L-carnitine, L-carnitine fumarate, and L-carnitine galactarate or is an ester of carnitine with an alkanol and wherein the composition is present as at least one of an anhydrous preparation, an emulsion, a microemulsion, a multiple emulsion, a cream, a milk, a lotion, an ointment, a gel, a solid stick, and an aerosol.

2. The composition of claim 1, wherein the at least one substance is present in a concentration of from 0.05% to 10% by weight.

3. The composition of claim 1, wherein the at least one substance is present in a concentration of from 0.1% to 5.0% by weight.

4. The composition of claim 1, wherein the composition comprises from 0.05% to 10% by weight of at least one of propionyl-L-carnitine, L-carnitine fumarate, and L-carnitine galactarate.

5. The composition of claim 1, wherein the composition is a pH-buffered composition.

6. The composition of claim 1, wherein the composition has a pH of from 5 to 7.

7. The composition of claim 6, wherein the composition has a pH of from 5 to 6.

8. The composition of claim 1, wherein the composition comprises propionyl-L-carnitine.

9. The composition of claim 1, wherein the composition comprises L-carnitine fumarate.

10. The composition of claim 1, wherein the composition comprises L-carnitine galactarate.

11. The composition of claim 1, wherein the composition comprises an ester of carnitine with an alkanol.

12. A cosmetic or dermatological composition, wherein the composition has a pH of from 5 to 7 and comprises from 0.05% to 10% by weight of at least one substance which comprises a carboxylic acid ester of L-carnitine selected from propionyl-L-carnitine, L-carnitine fumarate, and L-carnitine galactarate or is an ester of carnitine with an alkanol.

13. The composition of claim 12, wherein the at least one substance is present in a concentration of from 0.1% to 5.0% by weight.

14. The composition of claim 12, wherein the composition is present as an emulsion.

15. The composition of claim 14, wherein the composition is present as an oil-in-water emulsion.

16. The composition of claim 12, wherein the composition has a pH of from 5 to 6.

17. The composition of claim 12, wherein the composition comprises propionyl-L-carnitine.

18. The composition of claim 12, wherein the composition comprises L-carnitine fumarate.

19. The composition of claim 12, wherein the composition comprises L-carnitine galactarate.

20. A cosmetic or dermatological composition, wherein the composition comprises from 0.1% to 5.0% by weight of at least one substance which is an ester of carnitine with a carboxylic acid, or an ester of carnitine with an alkanol, has a pH of from 5 to 6, and is present as at least one of an anhydrous preparation, an emulsion, a microemulsion, a multiple emulsion, a cream, a milk, a lotion, an ointment, a gel, a solid stick, and an aerosol, the at least one substance comprising at least one of propionyl-L-carnitine, L-carnitine fumarate, and L-carnitine galactarate.

21. The composition of claim 20, wherein the composition is present as an emulsion.

22. The composition of claim 21, wherein the composition is present as an oil-in-water emulsion.

23. The composition of claim 20, wherein the composition comprises propionyl-L-carnitine.

24. The composition of claim 20, wherein the composition comprises L-carnitine fumarate.

25. The composition of claim 20, wherein the composition comprises L-carnitine galactarate.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The examples below serve to illustrate the present invention without limiting it.

Example 1

(2) TABLE-US-00001 O/W cream % by wt. Glyceryl stearate 3.0000 Cetyl alcohol 3.0000 PEG-40 stearate 3.5000 Paraffinum liquidum 5.0000 C12-15 Alkyl benzoate 0.5000 Cyclomethicone 5.0000 Glycerol 5.0000 Sodium chloride 5.0000 Sodium Chloride 5.0000 L-carnitine 0.5000 Dyes/perfume q.s. Preservative Water ad 100.0000

(3) The constituents of the oil phase are combined together, then stirred at 60-70° C. with the likewise combined water phase, and then the mixture is homogenized. It is then cooled to room temperature.

Example 2

(4) TABLE-US-00002 O/W cream % by wt. Glyceryl stearate 2.4000 Cetyl alcohol 2.4000 Glyceryl stearate + PEG- 1.2000 100 stearate Paraffinum liquidum 15.0000 Xanthan gum 0.2000 Glycerol 3.0000 Glycerin 5.0000. TaurinAcetyl-L-carnitine 0.30000 Sodium chloride 55.0000 Sodium Chloride Diazolidinylurea 0.3000 Dyes/perfume q.s. Preservative Water ad 100.0000

(5) The constituents of the oil phase are combined together, then stirred at 60-70° C. with the likewise combined water phase, and then the mixture is homogenized. It is then cooled to room temperature.

Example 3

(6) TABLE-US-00003 O/W cream % by wt. Cetyl alcohol 2.4000 Steareth-21 1.2000 Steareth-2 2.4000 Paraffinum liquidum 15.0000 Xanthan gum 0.2000 Glycerol 5.0000 Urea 2.00005. Propionyl-L-carnitine 5.00000 Sodium Chloride Sodium chloride 5.0000 Diazolidinylurea 0.3000 Dyes/perfume q.s. Preservative Water ad 100.0000

(7) The constituents of the oil phase are combined together, then stirred at 60-70° C. with the likewise combined water phase, and then the mixture is homogenized. It is then cooled to room temperature.

Example 4

(8) TABLE-US-00004 O/W cream % by wt. Cetyl alcohol 2.4000 Steareth-21 1.2000 Steareth-2 2.4000 Octyldodecanol 0.1000 PPG-14 butyl ether 5.0000 Cyclomethicone 5.0000 Trisodium EDTA 1.5000 ol 3 L-carnitine fumarate 2.0 Sodium chloride 3.0000 Dyes/perfume q.s. Preservative Water ad 100.0000

(9) The constituents of the oil phase are combined together, then stirred at 60-70° C. with the likewise combined water phase, and then the mixture is homogenized. It is then cooled to room temperature.