REBAMIPIDE FOR USE IN PREVENTION AND/OR TREATMENT OF ARTERIAL STIFFNESS

Abstract

The present invention relates to the use of rebamipide in a method of prevention and/or treatment of arterial stiffness and associated diseases, such as hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, and chronic kidney disease. Rebamipide may also be used in a method of increasing arterial elasticity.

Claims

1. A method of prevention and/or treatment of arterial stiffness comprising administration of rebamipide.

2. A method of prevention and/or treatment of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, and chronic kidney disease comprising administration of rebamipide.

3. A method of increasing arterial elasticity comprising administration of rebamipide.

4. The method according to claim 1, wherein rebamipide is used in a person that has a normal blood lipid level.

5. The method according to claim 1, wherein rebamipide is administered in an oral pharmaceutical form, preferably selected from tablets, capsules, dragees, granules, microgranules (sachets), orodispersible tablets or films, sublingual tablets, crushed tablets, oral solutions, oral suspensions, syrups, mouthwashes, rinses; or in a rectal pharmaceutical form, preferably selected from suppositories and enemas; or in a form for parenteral administration such as injection or infusion.

6. The method according to claim 5, wherein the oral pharmaceutical form is a form with enteric release, preferably enteric sustained release or enteric controlled release.

7. The method according to claim 5, wherein rebamipide is administered in a daily dose of 1 to 5000 mg, more preferably from 50 to 2500 mg, even more preferably from 100 to 1000 mg, and most preferably from 600 to 900 mg.

8. The method according to claim 2, wherein rebamipide is used in a person that has a normal blood lipid level.

9. The method according to claim 3, wherein rebamipide is used in a person that has a normal blood lipid level.

10. The method according to claim 2, wherein rebamipide is administered in an oral pharmaceutical form, preferably selected from tablets, capsules, dragees, granules, microgranules (sachets), orodispersible tablets or films, sublingual tablets, crushed tablets, oral solutions, oral suspensions, syrups, mouthwashes, rinses; or in a rectal pharmaceutical form, preferably selected from suppositories and enemas; or in a form for parenteral administration such as injection or infusion.

11. The method according to claim 3, wherein rebamipide is administered in an oral pharmaceutical form, preferably selected from tablets, capsules, dragees, granules, microgranules (sachets), orodispersible tablets or films, sublingual tablets, crushed tablets, oral solutions, oral suspensions, syrups, mouthwashes, rinses; or in a rectal pharmaceutical form, preferably selected from suppositories and enemas; or in a form for parenteral administration such as injection or infusion.

12. The method according to claim 10, wherein the oral pharmaceutical form is a form with enteric release, preferably enteric sustained release or enteric controlled release.

13. The method according to claim 11, wherein the oral pharmaceutical form is a form with enteric release, preferably enteric sustained release or enteric controlled release.

14. The method according to claim 10, wherein rebamipide is administered in a daily dose of 1 to 5000 mg, more preferably from 50 to 2500 mg, even more preferably from 100 to 1000 mg, and most preferably from 600 to 900 mg.

15. The method according to claim 11, wherein rebamipide is administered in a daily dose of 1 to 5000 mg, more preferably from 50 to 2500 mg, even more preferably from 100 to 1000 mg, and most preferably from 600 to 900 mg.

Description

[0010] The present invention thus provides rebamipide or a pharmaceutical composition thereof for use in a method of prevention and/or treatment of arterial stiffness. Since this condition represents a serious risk factor for development and progression of other diseases and conditions, the method may further involve prevention and/or treatment of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, and/or chronic kidney disease.

[0011] It is of a great advantage that rebamipide's activity is not limited to plaque removal in atherosclerotic patients as previously thought but that the molecule rather targets several different mechanisms leading to increase in arterial elasticity and improvement of arterial health. This broadens its possible use also to normolipidemic persons, i.e. those that do not suffer from either atherosclerosis or hyperlipidemia. Thus, in a preferred embodiment, rebamipide is for use in a person having normal blood lipid level.

[0012] “Rebamipide”, as used herein, shall include all forms of this active ingredient, such as anhydrous form, hydrated or solvated form (e.g. hemihydrate form), crystalline forms; and pharmaceutically acceptable salts thereof.

[0013] “Prevention” or “preventive use” shall be understood herein as preventing or delaying the increase in arterial stiffness and/or associated diseases, such as hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, and chronic kidney disease.

[0014] “Treatment” shall be understood herein as a therapy that is able to abrogate, inhibit, slow or reverse the progression of arterial stiffness and/or associated diseases.

[0015] The present invention further provides rebamipide for use in a method of prevention and/or treatment of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, and/or chronic kidney disease by decreasing arterial stiffness.

[0016] The present invention further provides a method for prevention and/or treatment of arterial stiffness by administering a pharmaceutically effective dose of rebamipide or a pharmaceutical composition thereof to a subject in need of such treatment. The subject is preferably a human subject, in particular a person suffering from or being at risk of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, or chronic kidney disease.

[0017] The present invention further provides use of rebamipide for the manufacture of a medicament for prevention and/or treatment of arterial stiffness, in particular in a person suffering from or being at risk of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, or chronic kidney disease.

[0018] The present invention further provides rebamipide for use in a method of increasing arterial elasticity. The method comprises administration of rebamipide or a pharmaceutical composition thereof to a subject in need of such treatment. The subject is preferably a human subject, in particular a person suffering from or being at risk of hypertension, heart failure, myocardial infarction, stroke, peripheral arterial disease, renal failure, or chronic kidney disease.

[0019] In the therapeutic indications as described in the present invention, rebamipide may be used in oral pharmaceutical forms such as tablets, capsules, dragees, granules, microgranules (sachets), orodispersible tablets or films, sublingual tablets, crushed tablets, oral solutions, oral suspensions, syrups, mouthwashes, rinses; or in rectal pharmaceutical forms such as suppositories and enemas; or in a form for parenteral administration such as injection or infusion. Preferably, the oral pharmaceutical form such as tablets, capsules, dragees and granules may be a form with enteric release, such as enteric sustained release or enteric controlled release.

[0020] A typical daily dose of rebamipide may range from 1 to 5000 mg for an average human (70 kg weight), more preferably from 50 to 2500 mg, even more preferably from 100 to 1000 mg, and most preferably from 600 to 900 mg. When immediate release formulation of rebamipide is administered, the daily dose is typically divided into several doses, which are administered separately. The daily dose may be divided into two to six separate doses taken twice daily or three times per day or four times per day or five times per day or six times per day. In a preferred embodiment the daily dose is divided into three separate doses administered three times per day, e.g. 200 mg dose administered three times per day. Alternatively, the whole daily dose can be taken at once, especially if it is in the form of a sustained release formulation, e.g. 600 mg dose administered once daily.

[0021] Hereinafter, the present invention will be described more specifically by the following working example. However, the following working example is provided only for illustration and thus the present invention is not limited to it.

Example

[0022] Aging of cardiovascular system is associated with worsening of arterial cushion function resulting in higher pulse pressure (systolic-diastolic amplitude). Pulse wave velocity (PWV), i.e. velocity at which the blood pressure pulse propagates through the circulatory system, is the gold standard method for arterial stiffness quantification. It can be readily measured non-invasively in humans, is highly reproducible, and predicts future cardiovascular events and all-cause mortality independent of conventional cardiovascular risk factors.

[0023] Pulse wave travels along the arteries at a velocity rate, which varies according to wall elasticity: the less elastic the wall, the higher the velocity of PW propagation. PWV measures the time of travel of the pressure wave over a known distance and is calculated as the distance between the two positions of the pulse transducer divided by the time delay measured between pressure upstroke at each site.

[0024] To study the effect of rebamipide on arteries, a small study on patients suffering from arterial stiffness was performed. Patients having PWV higher than the normal value for their age category (see The Reference Values for Arterial Stiffness' Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: “establishing normal and reference values”. Eur Heart J 2010; 31(19):2338-2350) without any evidence of either atherosclerosis or hyperlipidemia were randomly divided into two groups taking either rebamipide 200 mg (two 100 mg tablets) or placebo three times a day for a period of 12 months. Carotid to femoral PWV (cfPWV) was measured in both groups at 0, 3, 6, 9 and 12 months.

[0025] Assessment carried out after the end of the study revealed that arterial stiffness was gradually decreasing in the rebamipide taking group, while the placebo group didn't experience any change over the course of the study. The difference between both groups reached statistical significance. The results obtained from the study indicate that the administration of rebamipide supports regeneration of the arteries leading to a decrease in arterial stiffness, thereby preventing hypertension, cardiovascular diseases and associated disorders.