Alkyl polyrhamnosides, process for the preparation thereof, and cosmetic and/or pharmaceutical composition comprising same

Abstract

Composition based on fatty alcohols and on alkyl polyrhamnosides; process for the preparation thereof; cosmetic or pharmaceutical composition comprising same; and use thereof as an emulsifier.

Claims

1. A composition (C.sub.1) comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 60% by mass of an alcohol of formula (I): R—OH, in which R represents a linear or branched, saturated or unsaturated hydrocarbon-based radical, which may include at least one hydroxyl function, and including from 14 to 22 carbon atoms or a mixture of alcohols of formula (I); (b)—an amount of greater than or equal to 40% and less than 100% by mass of a composition (C.sub.R) represented by formula (II): R—O-(Rham).sub.x-H, in which Rham represents a rhamnose residue, R is as defined in formula (I) and x, which indicates the average degree of polymerization of said Rham residue, represents a decimal number greater than 1.0 and less than or equal to 5; or a mixture of compositions (C.sub.R), and (c)—an amount of greater than 0% by mass and less than or equal to 5% by mass of rhamnose.

2. The composition (C.sub.1) as defined in claim 1, wherein, in formulae (I) and (II), R represents a saturated or unsaturated, linear or branched hydrocarbon-based radical including from 16 to 20 carbon atoms.

3. The composition (C.sub.1) as defined in claim 2, wherein, in formulae (I) and (II), R represents a saturated or unsaturated, linear or branched hydrocarbon-based radical including from 16 to 18 carbon atoms.

4. The composition (C.sub.1) as defined in claim 3, comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 60% by mass of a mixture (M.sub.1) comprising, per 100% of mass: from 30% by mass to 70% by mass of an alcohol of formula (I.sub.A): R.sub.A—OH, in which R.sub.A represents a hexadecyl radical, and from 70% by mass to 30% by mass of an alcohol of formula (I.sub.B): R.sub.B—OH, in which R.sub.B represents an octadecyl radical; (b)—an amount of greater than or equal to 40% and less than 100% by mass of a mixture (M.sub.CR1) comprising, per 100% of mass: from 30% to 70% by mass of a composition (C.sub.RA) represented by formula (II.sub.A): R.sub.A—O-(Rham).sub.y-H, in which Rham represents a rhamnose residue, R.sub.A is as defined in formula (I.sub.A) and y represents a decimal number greater than 1.0 and less than or equal to 5; and from 70% to 30% by mass of a composition (C.sub.RB) represented by formula (II.sub.B): R.sub.B—O—(Rham).sub.z-H, in which Rham represents a rhamnose residue, R.sub.B is as defined in formula (I.sub.B) and Z represents a decimal number greater than 1.0 and less than or equal to 5; and (c)—an amount of greater than 0% by mass and less than or equal to 5% by mass of rhamnose.

5. The composition (C.sub.1) as defined in claim 1, wherein, in formulae (I) and (II), R represents a saturated or unsaturated, linear or branched hydrocarbon-based radical including from 20 to 22 carbon atoms.

6. The composition (C.sub.1) as defined in claim 5, comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 60% by mass of a mixture (M.sub.2) comprising, per 100% of mass: from 30% by mass to 70% by mass of an alcohol of formula (I.sub.C): R.sub.C—OH, in which R.sub.C represents an eicosyl radical, and from 70% by mass to 30% by mass of an alcohol of formula (I.sub.D): R.sub.D—OH, in which R.sub.D represents a docosyl radical; (b)—an amount of greater than 40% by mass and less than 100% by mass of a mixture (M.sub.CR2) comprising, per 100% of mass: from 30% to 70% by mass of a composition (C.sub.RC) represented by formula (II.sub.C): R.sub.C—O—(Rham).sub.t-H, in which Rham represents a rhamnose residue, R.sub.C is as defined in formula (I.sub.C) and t represents a decimal number greater than 1.0 and less than or equal to 5; and from 70% to 30% by mass of a composition (C.sub.RD) represented by formula (II.sub.D): R.sub.D—O—(Rham).sub.u-H, in which Rham represents a rhamnose residue, R.sub.D is as defined in formula (I.sub.D) and u represents a decimal number greater than 1.0 and less than or equal to 5; and (c)—an amount of greater than 0% by mass and less than or equal to 5% by mass of rhamnose.

7. The composition (C.sub.1) as defined in claim 1, comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 40% by mass of said alcohol of formula (I) or of said mixture of alcohols of formula (I); (b)—an amount of greater than or equal to 60% by mass and less than 100% by mass of said composition (C.sub.R) or of said mixture of compositions (C.sub.R); and (c)—an amount of greater than 0% by mass and less than or equal to 5% by mass of rhamnose.

8. The composition (C.sub.1) as defined in claim 7, comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 20% by mass of said alcohol of formula (I) or of said mixture of alcohols of formula (I); (b)—an amount of greater than or equal to 80% by mass and less than 100% by mass of said composition (C.sub.R) or of said mixture of compositions (C.sub.R); (c)—an amount of greater than 0% by mass and less than or equal to 3% by mass of rhamnose.

9. The composition (C.sub.1) as defined in claim 1, wherein, in formula (II), x represents a decimal number greater than zero and less than or equal to 2.

10. A composition (C.sub.1) comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 60% by mass of an alcohol of formula (I): R—OH, in which R represents a linear or branched, saturated or unsaturated hydrocarbon-based radical, which may include at least one hydroxyl function, and including from 14 to 22 carbon atoms or a mixture of alcohols of formula (I); and (b)—an amount of greater than or equal to 40% and less than 100% by mass of a composition (C.sub.R) represented by formula (II): R—O-(Rham).sub.x-H, in which Rham represents a rhamnose residue, R is as defined in formula (I) and x, which indicates the average degree of polymerization of said Rham residue, represents a decimal number greater than 1.0 and less than or equal to 5; or a mixture of compositions (C.sub.R).

11. The composition (C.sub.1) as defined in claim 7, comprising, per 100% of mass: (a)—an amount of greater than 0% by mass and less than or equal to 20% by mass of said alcohol of formula (I) or of said mixture of alcohols of formula (I); and (b)—an amount of greater than or equal to 80% by mass and less than 100% by mass of said composition (C.sub.R) or of said mixture of compositions (C.sub.R).

12. The composition (C.sub.1) as defined in claim 2, wherein, in formula (II), x represents a decimal number greater than zero and less than or equal to 2.

13. A topical cosmetic or dermocosmetic emulsion of oil-in-water type (C), comprising, as emulsifier, an effective amount of composition (C.sub.1) as defined in claim 1.

14. A topical pharmaceutical or dermopharmaceutical emulsion of oil-in-water type (C′), comprising, as emulsifier, an effective amount of composition (C.sub.1) as defined in claim 1.

15. A process for preparing composition (C.sub.1) as defined in claim 1, comprising: a step a) of heating, with gentle stirring, alcohol of formula (I), or a mixture of said alcohols of formula (I), until reaching a higher temperature (T.sub.1) of at least 5° C. above a melting point of the alcohol or the mixture of alcohols to form a molten medium; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in a desired stoichiometric ratio to form a medium; a step c) of acetalization by adding, with stirring, to the medium obtained from step b), a catalytic amount of strong acid, while maintaining under partial vacuum and distilling off any water formed to form a reaction mixture; a step d) of filtering the reaction mixture obtained in step c) to form a solution, and, a step e) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

16. A method for preparing emulsions of oil-in-water type, comprising providing the composition (C.sub.1) as in claim 1, and forming an emulsion comprising the composition.

17. A process for preparing composition (C.sub.1) as defined in claim 1, comprising: a step a) of heating, with gentle stirring, alcohol of formula (I), or a mixture of said alcohols of formula (I), until reaching a higher temperature (T.sub.1) of at least 5° C. above a melting point of the alcohol or the mixture of alcohols to form a molten medium; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in a desired stoichiometric ratio to form a medium; a step c) of acetalization by adding, with stirring, to the medium obtained from step b), a catalytic amount of strong acid, while maintaining under partial vacuum and distilling off any water formed to form a reaction mixture; and a step d) of filtering the reaction mixture obtained in step c).

Description

DESCRIPTION OF THE PREFERRED EMBODIMENTS

(1) The following examples illustrate the invention without, however, limiting it.

(2) A)—Preparation of Compositions C.sub.1 According to the Invention and of Comparative Compositions C′.sub.1

(3) A1—Preparation of Compositions C.sub.1 According to the Invention

(4) The general procedure for the glycosylation reaction performed for preparing the compositions according to the invention is as follows:

(5) loading the fatty alcohol into a reactor equipped with a mechanical stirrer and a vacuum distillation assembly, loading rhamnose monohydrate in powder form in the stoichiometric proportions indicated in tables 1 and 2 below, stirring and heating until a “syrup” or “slurry” is obtained, placing under partial vacuum to remove the water contained in the rhamnose, adding the catalytic system, heating until the rhamnose has disappeared, if necessary, neutralizing the medium with sodium hydroxide/sodium borohydride mixture, depending on the viscosity of the reaction medium, if necessary, filtering the reaction medium.

(6) TABLE-US-00001 TABLE 1 Operating conditions Initial proportion of 1 molar eq. 1 molar eq. stearyl alcohol Initial proportion of 0.2 molar eq. 1.25 molar eq. rhamnose Catalyst H.sub.2SO.sub.4 on H.sub.2SO.sub.4/H.sub.3PO.sub.2 silica/H.sub.3PO.sub.2 Glycosylation 70° C. 105° C. temperature Characteristic of the composition obtained (mass %) Composition (C.sub.1A) Composition (C.sub.1B) Stearyl polyrhamnoside 17.0% 66.5% Mean degree of 1.13 1.28 polymerization (*) Stearyl alcohol 82.7% 33.5% Residual rhamnose  0.3%   0% Operating conditions Initial proportion of 1 molar 1 molar eq. stearyl alcohol Initial proportion of 1.25 molar eq. 2.00 molar eq. rhamnose Catalyst H.sub.2SO.sub.4 on H.sub.2SO.sub.4/H.sub.3PO.sub.2 silica/H.sub.3PO.sub.2 Glycosylation 70° C. 105° C. temperature Characteristic of the composition obtained (mass %) Composition (C.sub.1C) Composition (C.sub.1D) Stearyl polyrhamnoside 82.5% 75.0 Mean degree of 1.47 1.35 polymerization (*) Stearyl alcohol 16.2% 24.9% Residual rhamnose  1.3%  0.1% Operating conditions Initial proportion of 1 molar eq. 0 stearyl alcohol Initial proportion of 0 1 molar eq. oleyl alcohol Initial proportion of 2.0 molar eq. 1.25 molar eq. rhamnose Catalyst H.sub.2SO.sub.4 on H.sub.2SO.sub.4 on silica/H.sub.3PO.sub.2 silica/H.sub.3PO.sub.2 Glycosylation 70-80° C. 75° C. temperature Characteristic of the composition obtained (mass %) Composition (C.sub.1E) Composition (C.sub.1F) Stearyl polyrhamnoside 75.5%   0% Oleyl polyrhamnoside   0% 85.0% Mean degree of 1.37 1.44 polymerization (*) Stearyl alcohol   24%   0% Oleyl alcohol   0% 13.3% Residual rhamnose  0.5%  1.7%

(7) TABLE-US-00002 TABLE 2 Operating conditions Initial proportion of oleyl alcohol   1 molar eq. Initial proportion of rhamnose 2.0 molar eq. Catalyst H.sub.2SO.sub.4 on silica/H.sub.3PO.sub.2 Glycosylation temperature 75-85° C. Characteristic of the composition obtained (mass %) Composition (C.sub.1G) Oleyl polyrhamnoside   80% Mean degree of polymerization (*) 1.52 Oleyl alcohol   0% Residual rhamnose 18.8% (*) the mean degree of polymerization of the polyol rhamnosides is obtained from a gas chromatography, followed by: i) determining the mass percentages of each oligomer, ii) normalizing the mass proportions obtained to 100%, iii) converting into molar percentages the normalized mass percentages obtained, and iv) calculating the mean degree of polymerization on the basis of each molar percentage obtained, weighted by the number of rhamnose units in the oligomer under consideration.

(8) A2—Preparation of Comparative Compositions C′.sub.1

(9) The general procedure for the glycosylation reaction performed for preparing the comparative compositions is as follows:

(10) loading the fatty alcohol into a reactor equipped with a mechanical stirrer and a vacuum distillation assembly, loading glucose monohydrate in powder form in the stoichiometric proportions indicated in table 3 below, stirring and heating at 90° C. until a homogeneous “dispersion” is obtained, placing under partial vacuum to remove the water contained in the glucose, adding the catalytic system, heating until the glucose suspension has disappeared, if necessary, neutralizing the medium with sodium hydroxide/sodium borohydride mixture, depending on the viscosity of the reaction medium, if necessary, filtering the reaction medium.

(11) TABLE-US-00003 Operating conditions Initial proportion of 6 molar eq. 5 molar eq. cetearyl alcohol (**) Initial proportion of 1 molar eq. 1 molar eq. glucose Catalyst H.sub.2SO.sub.4/H.sub.3PO.sub.2 H.sub.2SO.sub.4/H.sub.3PO.sub.2 Glycosylation 105° C. 105° C. temperature Characteristic of the composition obtained (mass %) Composition (C.sub.1A′) Composition (C.sub.1B′) Cetearyl polyglucosides 19.0% 19.8% Mean degree of 1.15 1.15 polymerization (*) Cetearyl alcohol 81.0% 80.2% Residual glucose  <0.1%    <0.1%   Operating conditions Initial proportion of 2 molar eq. 1 molar eq. cetearyl alcohol Initial proportion of 1 molar eq. 1 molar eq. glucose Catalyst H.sub.2SO.sub.4/H.sub.3PO.sub.2 H.sub.2SO.sub.4/H.sub.3PO.sub.2 Glycosylation 105° C. 105° C. temperature Characteristic of the composition obtained (mass %) Composition (C.sub.1C′) Composition (C.sub.1D′) Cetearyl polyglucosides 13.2% Reaction impossible: Mean degree of 1.19 the reaction medium polymerization (***) sets to a solid Cetearyl alcohol 85.7% Residual glucose  1.1% (**) cetearyl alcohol is an equimolar mixture of hexadecyl alcohol (or cetyl alcohol) and of octadecyl alcohol (or stearyl alcohol). (***) the mean degree of polymerization of the cetearyl polyglucosides is obtained from a gas chromatography, followed by: i) determining the mass percentages of each oligomer, ii) normalizing the mass proportions obtained to 100%, iii) converting into molar percentages the normalized mass percentages obtained, and iv) calculating the mean degree of polymerization on the basis of each molar percentage obtained, weighted by the number of glucose units in the oligomer under consideration.
It may be noted here that the use of the process of direct glycosylation of fatty alcohols (in this instance cetearyl alcohols) with glucose, similar to that performed for the glycosylation reaction between the fatty alcohols and rhamnose, does not make it possible to obtain compositions according to the invention, irrespective of the molar stoichiometries used.
B)—Determination of the Emulsifvina Properties of Compositions According to the Invention
Emulsions of oil-in-water type ((E.sub.1) to (E.sub.4)) are prepared by mixing at 80° C. with stirring 20% by mass of oil and an effective amount of emulsifying composition according to the invention, and the results are compared with that of an oil-in-water emulsion (E.sub.T) prepared under the same conditions with Montanov™ 68 (composition (C.sub.1T) comprising 80% by mass of a mixture of cetyl and stearyl alcohols (50/50 by mass) and 20% by mass of cetearyl polyglucoside). On the basis of its structure, composition (C.sub.1T) is representative of compositions (C′.sub.1A) and (C′.sub.1B) as described above. The data are collated in the following table:

(12) TABLE-US-00004 O/W emulsion Emulsifier E.sub.1 E.sub.2 E.sub.3 E.sub.4 E.sub.T1 E.sub.T2 E.sub.T3 E.sub.T4 Composition (C.sub.1C)  2.5%  2.5%  3.0%  3.0%   0%   0%   0%   0% Composition (C.sub.1T)   0%   0%   0%   0%  2.5%  2.5%  3.0%  3.0% Oil Primol ™ 352   20%   0%   20%   0%   20%   0%   20%   0% Sweet almond oil   0%   20%   0%   20%   0%   20%   0%   20% Water 77.5% 77.5% 77.0% 77.0% 77.5% 77.5% 77.0% 77.0% Stability at seven days St*. St*. St*. St*. Exud.** Exud.** St*. St*. at room temperature *St.: Stable; **Exud.: Start of exudation
C) Formulations

(13) In the following formulas, the percentages are expressed by weight of the formulation.

(14) C.1 Makeup-Removing Fluid for the Face

(15) Formula

(16) TABLE-US-00005 Composition (C.sub.1B) 10.00% Methyl paraben  0.15% Phenoxyethanol  0.80% Sepicalm ™ S  1.00% Perfume/Fragrance  0.10% Water qs 100.00%
Procedure: Mix the various ingredients in the water with magnetic stirring, in the order indicated, and adjust the pH to about 7.
C.2 Infant Hair and Body Shampoo
Formula

(17) TABLE-US-00006 A Composition (C.sub.1C)  5.00% Proteol ™ APL  5.00% Sepicide ™ HB  0.50% Perfume/Fragrance  0.10% B Water 20.00% Capigel ™ 98  3.50% C Water qs 100.00% Sepicide ™ CI  0.30% Colorant qs Sodium hydroxide qs pH = 7.2
Procedure: Mix composition (C.sub.1C) with the Proteol™ APL and the Sepicide™ HB (Phase A). Dilute the Capigel™ 98 in a portion of the water and add it to phase A obtained previously (Phase B). Add the rest of the water to phase B, followed by the Sepicide™ CI and the colorant. Adjust the pH of the mixture to about 7.2 with sodium hydroxide.
C.3 Makeup-Removing Wipes for the Eyes
Formula

(18) TABLE-US-00007 A Composition (C.sub.1C) 3.00% B Sepicide ™ HB2 0.50% C Sepicalm ™ VG 0.50% Perfume/Fragrance 0.05% D Water qs 100.00%
Procedure: Mix the ingredients of phase B and those of phase C in phase A until the solution is clear. Add phase D.
C.4 Mild Foaming Gel
Formula

(19) TABLE-US-00008 A Composition (C.sub.1D) 8.50% Proteol ™ APL 3.00% EuxyI ™ PE9010 1.00% Perfume/Fragrance 0.10% B Water qs 100.00% Lactic acid qs pH = 6.0
Procedure: Dissolve the perfume and the preserving agent Euxyl™ PE9010 in the mixture composed of composition E.sub.4 and the Proteol™ APL (phase A). Add the water and adjust the pH to about 6.0 with lactic acid.
C.5 Regular-Use Shampoo
Formula

(20) TABLE-US-00009 A Composition (C.sub.1B)  12.80% Proteol ™ OAT  5.00% Euxyl ™ PE9010  1.00% Perfume/Fragrance  0.30% Water qs 100.00% B Montaline ™ C40  8.50% Lactic acid qs pH = 6.0
Procedure: Mix all the ingredients of phase A and, after homogenization, add the Montaline™ C40 and adjust the pH to about 6.0 with lactic acid.
C.6 Ultra-Mild Baby Shampoo
Formula

(21) TABLE-US-00010 A Composition (C.sub.1F) 10.00% Amisoft ™ CS-11  4.00% Perfume/Fragrance  0.10% Sepicide ™ HB  0.30% Sepicide ™ CI  0.20% Water qs 100.00% B Water 20.00% Capigel ™ 98  3.50% Tromethamine qs pH = 7.2
Procedure: Mix all the ingredients of phase A, in the order indicated, until a clear phase A is obtained. Separately, add the Capigel™ 98 to the water and then add this phase B thus prepared to phase A and adjust the pH to 7.2 using tromethamine.
C.7 Baby Cleansing Milk
Formula

(22) TABLE-US-00011 A Simulsol ™ 165 2.00% Montanov ™ 202 1.00% Lanal ™ 99 3.00% Dimethicone 1.00% Isohexadecane 3.00% B Water qs 100.00% C Sepiplus ™ 400 0.30% D Composition (C.sub.1B) 6.35% E Sepicide ™ HB 0.30% DMDM Hydantoin 0.20% Perfume/Fragrance 0.10%
Procedure: Heat, separately, phases A and B constituted by mixing the various constituents. Add phase C to the hot fatty phase and make the emulsion by pouring in the aqueous phase; homogenize for a few minutes with vigorous stirring (by means of a rotor/stator turbomixer). Next, add phase D to the hot emulsion and cool the emulsion with moderate stirring down to room temperature. Add phase E at 40° C.
C.8 Cleansing Powder Lotion for Sensitive Skin
Formula

(23) TABLE-US-00012 A Lipacide ™ C8G  0.95% Methyl paraben  0.10% Ethyl paraben  0.024% Propyl paraben 0.0119% Butyl paraben  0.024% Isobutyl paraben 0.0119% Water  20.00% Disodium EDTA  0.10% Triethanolamine  1.38% B Composition (C.sub.1D)  1.80% Perfume/Fragrance  0.10% C Sepicalm ™ S  0.28% Water qs 100.00% Lactic acid qs pH = 5.2 D Micropearl ™ M310  5.00%
Procedure: Dissolve the ingredients of phase A in the water at 80° C. Separately, dissolve the perfume in composition (E.sub.4) to prepare phase B. Add the cooled phase A to phase B, then introduce the Sepicalm™ S and the remaining water. Check the final pH and adjust to about 5.2 if necessary. Next, add the Micropearl™ M310.
C.9 Infant Shower Gel
Formula

(24) TABLE-US-00013 A Water 56.06% Sepimax ™ Zen  3.00% Sepiplus ™ S  0.80% B Proteol ™ OAT 20.80% Oramix ™ NS 10  9.30% Amonyl ™ 265 BA  5.10% C Composition (C.sub.1C)  2.00% Glyceryl glucoside  1.00% Phenoxyethanol & ethylhexyl glycerol  1.00% Perfume/Fragrance  0.90% Colorant  0.04%
Procedure: disperse the Sepimax™ ZEN in the water and stir using a mechanical stirrer equipped with a deflocculator, a counter-rotating impeller and an anchor paddle, until a perfectly smooth gel is obtained. Add the Sepiplus™ S and then stir until the mixture is homogeneous. Next, add the ingredients of phase B, homogenize and individually add the additives of phase C. Adjust the pH to 6.0-6.5.
C.10 BB Cream
Formula

(25) TABLE-US-00014 A Easynov ™ 2.30% Lanal ™ 99 1.00% Sepimat ™ H10W 1.00% Ethylhexyl methoxycinnamate 5.00% B Cyclomethicone 6.00% Triethoxycaprylsilane & alumina-silane & 8.00% titanium oxide Red iron oxide & triethoxycaprylsilane 0.24% Yellow iron oxide & triethoxycaprylsilane 0.66% Black iron oxide & triethoxycaprylsilane 0.09% Perfume/Fragrance 0.10% C Water qs  100% Sepinov ™ EMT10 1.20% D Composition (C.sub.1D) 2.00% Sepitonic ™ M3 1.00% Phenoxyethanol & ethylhexyl glycerol 1.00%

(26) Procedure: Prepare phase B by mixing the various ingredients and homogenize using a mixer equipped with a rotor-stator system at a spin speed of 4500 rpm, for a time of 6 minutes. Prepare phase C by adding the Sepinov™ EMT10 to the mixture of water and glycerol, and homogenize using a mixer equipped with a rotor-stator system at a spin speed of 4000 rpm for 4 minutes. Add phases A and B to phase C, and stir the resulting mixture using a mechanical stirrer equipped with an anchor paddle, at a speed of 30 rpm for 2 minutes, and then at a speed of 50 rpm for 20 minutes. Add the components of phase 5 one by one and stir at a speed of 50 rpm for 25 minutes.

(27) Sepicalm™ S: Mixture of N-cocoyl amino acids, sarcosine, potassium aspartate and magnesium aspartate as described in WO 98/09611;

(28) Proteol™ APL: Mixture of sodium salts of N-cocoyl amino acids, obtained by acylation of amino acids characteristic of apple juice;

(29) Sepicide™ HB: Mixture of phenoxyethanol, methyl paraben, ethyl paraben, propyl paraben and butyl paraben, which is a preserving agent;

(30) Capigel™ 98: Acrylate copolymer;

(31) Sepicide™ CI: Imidazoline urea, which is a preserving agent;

(32) Sepicide™ HB: Mixture of phenoxyethanol, methyl paraben, ethyl paraben, propyl paraben, butyl paraben and isobutyl paraben, which is a preserving agent;

(33) Sepicalm™ VG: Mixture of N-palmitoyl proline in sodium salt form and of extract of Nymphea alba blossom;

(34) Euxyl™ PE9010: Mixture of phenoxyethanol and ethylhexyl glycerol;

(35) Proteol™ OAT: Mixture of N-lauryl amino acids obtained by total hydrolysis of oat protein as described in WO 94/26694;

(36) Montaline™ C40: Chloride salt of monoethanolamine cocamidopropyl betainamide;

(37) Amisoft™ CS-11: Sodium salt of N-cocoyl glutamate;

(38) Simulsol™ 165: Mixture of PEG-100 stearate and glyceryl stearate;

(39) Montanov™ 202 (arachidyl alcohol, behenyl alcohol and arachidyl glucoside) is a self-emulsifying composition such as those described in EP 0 977 626;

(40) Lanol™99: Isononyl isononanoate;

(41) Sepiplus™ 400: Self-invertible inverse latex of polyacrylates in polyisobutene and including polysorbate 20, as described in WO 2005/040230;

(42) Lipacide™ C8G: Capryloylglycine sold by the company SEPPIC;

(43) Micropearl™ M310: Crosslinked polymethyl methacrylate polymer in powder form, used as a texture modifier;

(44) Sepimax™ Zen (INCI: Polyacrylate Crosspolymer-6): Thickening polymer in the form of a powder;

(45) Sepiplus™ S (INCI name: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer & Polyisobutene & PEG-7 Trimethylolpropane Coconut Ether): Self-invertible inverse latex;

(46) Amonyl™ 265 BA (INCI name: cocoyl betaine): Foaming amphoteric surfactant;

(47) Sepinov™ EMT10 (INCI name: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer): Thickening copolymer in the form of a powder;

(48) Easynov™ (INCI name: Octyldodecanol and Octyldodecyl Xyloside and PEG-30 Dipolyhydroxystearate): Emulsifying agent of lipophilic tendency;

(49) Sepimat™ H10 FW (INCI name: Methyl Methacrylate Crosspolymer and Squalane): Polymer used as texture agent;

(50) Sepitonic™ M3 (INCI name: Magnesium Aspartate and Zinc Gluconate and Copper Gluconate): Mixture used as free-radical scavenger and energizing agent for cells;

(51) Montanov™ L (INCI name: C14-22 Alcohols and C12-20 Alkylglucoside): Emulsifying agent;

(52) Montanov™ 82 (INCI name: Cetearyl Alcohol and Coco-glucoside): Emulsifying agent;

(53) Simulgel™ INS100 (INCI name: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer and isohexadecane and Polysorbate 60): Polymeric thickener.