NEBULIZER AND METHOD FOR PRODUCING A NEBULIZER

Abstract

The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

Claims

1. A nebulizer comprising an aerosol generator, a nebulizing chamber, and an outlet, wherein the aerosol generator is configured to release an aerosol into the nebulizing chamber and the outlet is configured to allow removal of the aerosol from the nebulizing chamber, wherein a wetting surface is provided in the nebulizing chamber, said wetting surface being provided on a plastic component.

2. The nebulizer according to claim 1, wherein the aerosol generator comprises a nozzle.

3. The nebulizer according to claim 1, wherein the nebulizing chamber comprises an aerosol guide, which connects the aerosol generator to the outlet, and the aerosol guide comprises the wetting surface.

4. The nebulizer according to claim 3, wherein a surface of the aerosol guide comprises the wetting surface.

5. The nebulizer according to claim 3, wherein an edge of the aerosol guide comprises the wetting surface.

6. The nebulizer according to claim 1, wherein the aerosol guide comprises a passage and the passage comprises the wetting surface.

7. The nebulizer according to claim 1, wherein the nebulizing chamber has a delimiting wall which comprises the wetting surface.

8. The nebulizer according to claim 1, wherein the nebulizing chamber comprises a filter area, and the filter area comprises the wetting surface.

9. The nebulizer according to claim 1, wherein the nebulizing chamber comprises a baffle surface, and the baffle surface comprises the wetting surface.

10. The nebulizer according to claim 1, wherein the nebulizing chamber comprises a reservoir, the aerosol generator is configured to cooperate with the reservoir, and the reservoir comprises the wetting surface.

11. A method for producing a nebulizer having a wetting surface, which comprises the steps of: producing a nebulizer comprising an aerosol generator, a nebulizing chamber and an outlet, said aerosol generator being configured to release an aerosol into the nebulizing chamber and said outlet being configured to allow removal of the aerosol from the nebulizing chamber; and providing a wetting surface in the nebulizing chamber, said wetting surface being provided by fluorination.

Description

[0066] The invention will be described in more detail in the following by means of embodiment examples and with reference to the enclosed drawings.

[0067] FIG. 1 shows an embodiment example of a nebulizer having a wetting surface on an air inlet pipe.

[0068] FIG. 2 shows a cross-section of a nebulizer without a wetting surface.

[0069] FIG. 3 shows a cross-section of the nebulizer shown in FIG. 1.

[0070] FIG. 4 shows a nebulizer, in which the entire nebulizing chamber is provided with the wetting surface.

[0071] FIG. 5 shows an embodiment example of a nebulizer having a wetting surface on a baffle.

[0072] FIG. 6 shows a nebulizer comprising a nebulizing chamber, a mouthpiece and a membrane aerosol generator.

[0073] FIG. 1 shows an embodiment example of a nebulizer 1 having a wetting surface 2 on an air inlet pipe 3. The nebulizer 1 shown in FIG. 1 comprises a delimiting wall 4, which encloses a nebulizing chamber 5. Disposed in the nebulizing chamber 5 is an aerosol generator 6, which is configured as a two-substance nozzle 7. The two-substance nozzle 7 comprises one gas channel 8 and three liquid channels 9, although only two of the three liquid channels 9 are shown in FIG. 1. The gas channel 8 has a connection for a compressed air source which is not shown. The liquid channels 9 are configured to cooperate with a medicament reservoir 10. The gas channel 8 and the liquid channels 9 adjacently open out into an atomization region 11 of the two-substance nozzle 7. Provided opposite a mouth 12 of the gas channel 8 is an airflow control 13.

[0074] An air inlet pipe 3 extends from an inlet opening 14 of the delimiting wall 4 in the direction of the two-substance nozzle 7. The outer side 15 of the air inlet pipe 3 is provided with a wetting surface 2. The wetting surface 2 extends over the entire length and half of the circumference of the air inlet pipe 3. The wetting surface 2 thereby extends over that half of the circumference of the air inlet pipe 3 which is facing an outlet 16 provided in the delimiting wall 4.

[0075] During operation of the nebulizer 1, a liquid medicament from the medicament reservoir 10 reaches the atomization region 11 through the liquid channels 9. Compressed air also reaches the atomization region 11 through the gas channel 8. Upon inhaling, a patient sucks ambient air through the air inlet pipe 3 into the atomization region 11. An aerosol is produced in the atomization region 11 with the aid of the airflow control 13. Upon inhaling, the patient sucks aerosol out of the nebulizer 1 through the outlet 16. As a result hereof, medicament liquid lands on the inner side of the delimiting wall 4 and on the air inlet pipe 3. This medicament liquid reduces the size of the passage 18 between the delimiting wall 4 and the air inlet pipe 3. As a result, less aerosol can reach the patient.

[0076] This effect is lower on the wetting surface 2, as will be described in the following by means of FIGS. 2 and 3.

[0077] FIG. 2 shows a cross-section of a nebulizer 1 without a wetting surface. Fat liquid droplets 17 are disposed on the delimiting wall 4 and on the air inlet pipe 3. The passage 18 between the delimiting wall 4 and the air inlet pipe 3 is greatly reduced in size by the fat liquid droplets 17. Many of the aerosol droplets that are guided through this passage 18 from the atomization region 11 in the direction of the outlet 16 collide with the fat liquid droplets 17 and cannot arrive at the outlet 16.

[0078] FIG. 3 shows a cross-section of the nebulizer 1 shown in FIG. 1. In this nebulizer 1, fat liquid droplets 17 are also disposed on the delimiting wall 4 and on the air inlet pipe 3. However, no fat liquid droplets 17 can be found in the region of the wetting surface 2, but rather flat liquid droplets 19. This is achieved owing to the good wettability of the wetting surface 2. Owing to the fact that there are no fat liquid droplets 17 on the wetting surface 2, the cross-section of the passage 18 is larger in this region. Fewer aerosol droplets collide with the flat liquid droplets 19. As a result, the output rate is greater than in a nebulizer 1 without a wetting surface 2.

[0079] FIG. 4 shows a nebulizer 1, in which the entire nebulizing chamber 5 has been provided with the wetting surface 2. The inner wall of the delimiting wall 4, the air inlet pipe 3, the inside of a connection 24, the two-substance nozzle 7 and the airflow control 13 are provided with the wetting surface 2.

[0080] FIG. 5 shows an embodiment example of a nebulizer 1 having a wetting surface 2 on a baffle 20. The nebulizer 1 shown in FIG. 5 essentially corresponds to the nebulizer 1 shown in FIG. 1. However, it is additionally equipped with a baffle 20, a baffle section 21 and a guide section 22.

[0081] The baffle 20 is arranged in the area of the atomization region 11. It essentially has the form of a hollow cylinder and is arranged such that the atomization region 11 is disposed approximately in the middle of the longitudinal axis of the baffle 20. The baffle 20 consequently extends around the atomization region 11. The baffle 20 is open at that end face 23 which faces in the direction of the medicament reservoir 10. The end face 23 of the baffle 20 which is disposed closer to the outlet 16 is covered by the baffle section 21.

[0082] The baffle section 21 extends up to the delimiting wall 4 in a region adjacent to the outlet 16. A passage 18 is provided between the opposite region of the delimiting wall 4 and the baffle 20.

[0083] The guide section 22 extends from the baffle section 21 in the direction of the inlet opening 14. A passage 18 thereby remains between the delimiting wall 4 with the inlet opening 14 and the guide section 22. The guide section 22 extends transversely between the outlet 16 and the region of the delimiting wall 4 opposite thereto.

[0084] Upon operation of the nebulizer 1 shown in FIG. 5, an aerosol is generated according to the same principle as for the operation of the nebulizer 1 shown in FIG. 1.

[0085] Upon inhalation, the patient also sucks aerosol out of the nebulizer 1 through the outlet 16. For this to happen, the aerosol must move from the atomization region 11 to the open end face 23 of the baffle 20. The aerosol then has to change direction and pass through the passage 18 between an outer side 15 of the baffle 20 and the delimiting wall 4. From the passage 18, it must flow in the direction of the inlet opening 14 and then around the guide section 22 to the outlet 16.

[0086] This predetermined path serves to filter out undesired aerosol droplets. Aerosol droplets that are too large to follow the predetermined aerosol flow collide with the baffle 20 or the guide section 22. Only a small region for the aerosol to pass through is provided between the baffle 20 and the two-substance nozzle 7. This region is restricted even further by the medicament depending on the level of liquid in the medicament reservoir 10. The precise geometry of the baffle 20 determines the filtered-out droplet spectrum. Owing to liquid disposed on the baffle 20, both the size of the region for the aerosol to pass through is reduced and the geometry is changed. As a result hereof, more droplets are filtered out such that the output rate is low. The filtered-out droplet spectrum is also changed.

[0087] In order to minimize these effects, the entire baffle 20 is provided with a wetting surface 2. In accordance with the principle described in FIG. 3, it is achieved owing to the provision of a wetting surface 2 that flat liquid droplets 19 are formed, which cause little change to the geometry of the baffle 20 and only slightly reduce the size of the region for the aerosol to pass through.

[0088] With reference to FIGS. 1, 4 and 5, the invention has been described in connection with a two-substance nozzle. However, it is not restricted to nebulizers having this type of aerosol generator.

[0089] FIG. 6 shows a nebulizer 1 comprising a nebulizing chamber 5, a mouthpiece 25 and a membrane aerosol generator 26. The oscillating membrane 27 can be caused to oscillate, for example, by annular piezo elements that are not shown in the figure. During operation of the nebulizer 1, a liquid is disposed on one side of the oscillating membrane 27, at the top in FIG. 6, which is transported through openings in the oscillating membrane 27 and is released on the other side of the oscillating membrane 27, at the bottom in FIG. 6, into the nebulizing chamber 5 as an aerosol.

[0090] The nebulizing chamber 5 is provided with a wetting surface 2.

[0091] The patient can inhale the aerosol disposed in the nebulizing chamber 5 at the mouthpiece 25. So as not to cause the patient to put down the therapy device after inhaling the aerosol, the mouthpiece 25 has an exhalation opening 28 which is sealed by a flexible valve element 29. If the patient exhales into the mouthpiece 25 and thus into the nebulizing chamber 5, the flexible valve element 29 opens such that the exhaled air can exit the interior of the nebulizer 1. Upon inhalation, ambient air flows through the membrane aerosol generator 26.

LIST OF REFERENCE NUMBERS

[0092] 1 Nebulizer [0093] 2 Wetting surface [0094] 3 Air inlet pipe [0095] 4 Delimiting wall [0096] 5 Nebulizing chamber [0097] 6 Aerosol generator [0098] 7 Two-substance nozzle [0099] 8 Gas channel [0100] 9 Liquid channels [0101] 10 Medicament reservoir [0102] 11 Atomization region [0103] 12 Mouth [0104] 13 Airflow control [0105] 14 Inlet opening [0106] 15 Outer side [0107] 16 Outlet [0108] 17 Fat liquid droplets [0109] 18 Passage [0110] 19 Flat liquid droplets [0111] 20 Baffle [0112] 21 Baffle section [0113] 22 Guide section [0114] 23 End face [0115] 24 Connection [0116] 25 Mouthpiece [0117] 26 Membrane aerosol generator [0118] 27 Oscillating membrane [0119] 28 Exhalation opening [0120] 29 Valve element