NEEDLE-FREE INJECTION DEVICE COMPRISING A MEMBRANE

Abstract

The invention relates to a needleless injection device, containing at least one membrane, or a corresponding device for needleless injection of a substance, having at least one membrane, with which a powdered, gel-like or liquid agent, in particular an active agent, can be injected in a needleless manner into a tissue or a body by means of high impact speed. The invention also relates to a method for such a needleless injection device containing a membrane, and use thereof.

Claims

1.-13. (canceled)

14. A needleless injection device comprising a skin-side membrane (15), wherein the membrane (15) is provided with a particle application (25), wherein one or more or at least some of the particles is/are larger than the rest of the particles.

15. The needleless injection device according to claim 14, wherein one or more or at least some of the particles is/are 2 times, 5 times, 10 times, or 20 times larger than the rest of the particles.

16. The needleless injection device according to claim 14, wherein the proportion of larger particles in the totality of the particle application (25) is 1%, 5%, 10% and more.

17. The needleless injection device according to claim 14, wherein at least the larger particles consist of a pharmaceutically compatible material.

18. The needleless injection device according to claim 14, wherein at least the smaller particles consist of an agent, in particular an active agent, or contain an agent, in particular an active agent, and the larger particles do not contain an active agent.

19. The needleless injection device according to claim 14, comprising a chamber (11) containing a pyrotechnic material, wherein the chamber (11) has at least one membrane (15) at a discharge opening and the membrane leads into the chamber (11) and the combustion chamber (24) thereof.

20. The needleless injection device according to claim 14, wherein the skin-side membrane (15) has a thickness of from 0.1 mm to 0.6 mm.

21. The needleless injection device according to claim 14, wherein the skin-side membrane (15) consists of steel, titanium, or sheet titanium.

22. The needleless injection device according to claim 14, containing an attachment (17) and/or support disc (16), characterised in that a distance of at least 5 mm is achieved between the skin (18) and the membrane (15).

23. The needleless injection device according to claim 14, wherein the membrane is formed as a multi-layered or double membrane, consisting of an inner membrane (13) and a skin-side membrane (15).

24. The needleless injection device according to claim 14, wherein at least one membrane (13) or (15) is curved.

25. The needleless injection device according to claim 14, wherein an activation unit (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) is provided in an axial direction relative to the membrane (15).

26. The needleless injection device according to claim 14 for use of an agent or of an active agent or drug for needle-free application.

Description

[0053] The following examples, and drawings are intended to explain the invention in greater detail, but without limiting the invention thereto.

[0054] FIG. 1 shows a cross-section of the injection device according to the invention with fixed membrane.

[0055] FIG. 2 shows more clearly the parts for producing the injection device according to the invention with fixed membrane.

[0056] FIG. 3:

[0057] Image sequence, left column:

[0058] Shooting of approximately 10 glass beads 250 μ in size, which are used as penetration bodies, at approximately 650 m/s into a skin-like gel. In the first image at the top, it is already possible to see the structure of the impact cone in the gel (slanted pressure shock), which can intensify or build further so as to then leave a relatively thin, air-filled strand/tube over the particular penetration body (bottom image).

[0059] Image sequence, right column:

[0060] Shooting of 5 glass beads (particles) 500 μ in size, which are used as penetration bodies, at approximately 650 m/s into a skin-like gel. The structure of the impact cone in the gel (slanted pressure shock) can already be seen in the first image at the top and can then intensify so as to then leave a relatively thin, air-filled strand/tube over the particular penetration body (bottom image, the strands are slightly inflated here).

[0061] FIG. 4:

[0062] Image sequence top left=2 images, approximately 50 glass beads (particles) having a diameter of 500 μm are shot into artificial skin, dusted on the membrane with sugar particles measuring 20 to 80 μm in size, which are coloured black.

[0063] Image sequence lower left=2 images, approximately 100 glass beads 250 μm in size, dusted on the membrane with sugar particles 20 to 80 μm in size, which are coloured black.

[0064] Image sequence right=4 images, ditto for glass beads/penetration bodies 500 μm in size.

[0065] Each of the above 3 image sequences shows the situation after triggering the needle-free injector or the pyrotechnic membrane device when, at the same time, small particles are also applied to/sputtered on the skin-side membrane of the penetration bodies. The penetration bodies here firstly penetrate at approximately 650 m/s, then an impact cone forms over each penetration body, which form a large inner surface for the somewhat slower particles flying in subsequently at approximately 620 m/s. Shortly thereafter, the impact cones “smack” together again (the speed of the penetration bodies is in the meantime below the speed of sound of the material of the penetrated body/the skin/the gel or has dropped to 0 m/s) and compact the previously introduced particles so to speak, which are hereby trapped as it were.

[0066] When sugar particles are used as penetration bodies, for example for medical purposes, they are broken down by the body/skin/tissue after their administration, and after this the particles compacted in the “tubes” created by the sugar particles remain.

[0067] Key: [0068] 1 trigger, button [0069] 2 trigger housing [0070] 3 battery [0071] 4 spring cap [0072] 5 contact pin [0073] 6 contact spring [0074] 7 grooved nut [0075] 8 holder for glass feedthrough [0076] 9 glass feedthrough with connections [0077] 10 mini detonator or ignition piece, EED [0078] 11 firing chamber or chamber [0079] 12 O-ring seal of the firing chamber (can also be omitted in some embodiments of the device) [0080] 13 inner membrane [0081] 14 spacer, also performs sealing functions [0082] 15 skin-side membrane, fixed to membrane (13) and spacer (14) [0083] 16 support disc [0084] 17 attachment [0085] 18 skin or the surface to be penetrated (bears against 17, not shown) [0086] 19 thread for ground connection screw (can also be omitted in some embodiments of the device) [0087] 20 firing chamber vent [0088] 21 cover, vent [0089] 22 housing for parts 7-21 [0090] 23 guide for contact pin [0091] 24 combustion chamber [0092] 25 particle application