Enzyme Formulation for Reducing Histamine Intolerance

Abstract

Disclosed is a formulation of the following enzymes: Alpha-galactosidase, Alpha amylase, Beta Glucanase, Lactase, BioCor DPP=IV (Proprietary blend) and Pectinase, which has been found to be effective in treating histamine intolerant people, and causing a significant improvement in a wide variety of pathologies and symptoms, including, but not limited to: inflammation, pruritus, urticaria, hypotension, tachycardia, fatigue, migraines, conjunctivitis, incontinence, nasal congestion, panic attacks, acid reflux, depression and angioedema.

Claims

1. A method comprising treating, preventing or ameliorating histamine intolerance by administering a subject a formulation including: Alpha-galactosidase, Alpha amylase, Beta Glucanase, Lactase, DPP-IV and Pectinase.

2. The method of claim 1 wherein the active ingredients in the formulation have the following doses: Alpha-galactosidase: 80 GaLU; Alpha amylase, 150 DU; Beta Glucanase, 70 BGU; Lactase, 1,000 ALU; DPP-IV, 80 mg, and Pectinase: 17 ENDO-PGU.

3. The method of claim 2 wherein the ingredients are administered to the subject at twice the doses therein with each meal consumed.

4. The method of claim 1 wherein the formulation is encapsulated in a capsule comprising cellulose and distilled water.

5. The method of claim 4 wherein the formulation does not contain any of the following: milk, casein gluten, dairy, egg, soy, corn, peanuts, tree nuts, fish shellfish, and, artificial colors, flavors or preservatives.

Description

DETAILED DESCRIPTIONS

[0008] The treatment and prevention regime with the formulation of the invention will now be described in greater detail with reference to the example below of an administration regime and testing with a number of patients.

EXAMPLE

Administering the Formulation to Screened Patients

[0009] A questionnaire shall be administered to twenty or more patients who are chronically reactive to the excessive accumulation of histamine in the body. These are patients who present a variety of symptoms, including, but not limited to one or more of: pruritus, urticaria, hypotension, tachycardia, fatigue, conjunctivitis, incontinence, nasal congestion, panic attacks, acid reflux, depression and angioedema. All the patients will have been mindfully eating a low histamine diet for three or more months, minimizing histamine producing bacteria and maximizing histamine degrading bacteria. They will have made dramatic improvements while managing their diets, but continue to have episodic symptoms because histamine intolerance is cumulative, i.e., it is not always immediate and is difficult to mitigate.

[0010] The formulation will then be administered to each patient. Over a three month period, patients symptoms will be monitored at monthly visits. After three months on the formulation, a follow-up questionnaire will be administered to determine if their episodic symptoms have improved and if their histamine intolerance has been reduced.

[0011] The preferred dosages and dosing regime for the formulation, as set forth in the Summary, are not the only dosages possible, and other more optimal dosages and dosing regimes may be discovered with routine experimentation, now that the preferred dosages are known. The routine experimentation would involve providing different dosages under different regimes, using behavioral kinesiology to determine the appropriate dosage and optimal regime for each individual child or adult in the case study, and determining which patients improved most in their monitored symptoms and conditions.

[0012] The starting point, for determining optimal dosing and an optimal regime, is the preferred dosages, administered at mealtimes, as above. Variations could be doubling, halving, or otherwise and reducing the quantities of one or more of the enzymes in a formulation. The dosing regime modifications could include increasing or reducing the number of administrations of the formulation each day for patients in a particular group. Such experimentation is routine in the pharmaceutical industry.

[0013] The terms and expressions that have been employed are used as terms of description and not of limitation, and there is no intent in the use of such terms and expressions to exclude any equivalent of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the invention as claimed. Thus, it will be understood that although the present invention has been specifically disclosed by preferred embodiments and optional features, modification and variation of the concepts herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the appended claims.