COMPOSITE POWDER, METHOD OF PRODUCING THEREOF AND COSMETIC COMPOSITION CONTAINING THE SAME

Abstract

The present invention relates to a method of producing a composite powder. A porous powder is physically covered by collagen and chitosan sequentially, thereby forming the composite powder. The composite powder has good dispersity, an ability of moisture retention and a low greasiness while being added in an oil-in-water emulsion base or a hydrogel base to form a cosmetic composition.

Claims

1. A method of producing a composite powder, comprising: performing a first mixing step on a porous powder and collagen in a first solution, so as to form a first mixture solution, wherein the collagen has a first weight-average molecular weight of 3 kDa to 30 kDa; performing a first filtering step on the first mixture solution, so as to form a semifinished powder; performing a second mixing step on chitosan and the semifinished powder in a second solution, so as to form a second mixture solution, wherein the chitosan has a second weight-average molecular weight of 3 kDa to 300 kDa; and performing a second filtering step on the second mixture solution, thereby forming the composite powder, and wherein based on an amount of the porous powder as 100 parts by weight, an amount of the collagen is 0.1 parts by weight to 20 parts by weight, and an amount of the chitosan is 0.1 parts by weight to 20 parts by weight.

2. The method of claim 1, wherein the porous powder comprises an organic powder, an inorganic powder or a combination thereof having a specific surface area of 0.5 m.sup.2/g to 200 m.sup.2/g and a first average particle size of 2 μm to 20 μm.

3. The method of claim 1, wherein the first solution has a pH of 5 to 9, and the second solution has a pH of 4 to 7.

4. The method of claim 1, wherein a weight ratio of the collagen and the first solution is 0.001 to 0.2, and a weight ratio of the chitosan and the second solution is 0.001 to 0.2.

5. The method of claim 1, wherein the first mixing step is performed at a first temperature of 4° C. to 40° C. for 5 minutes to 2 hours.

6. The method of claim 1, wherein the second mixing step is performed at a second temperature of 4° C. to 40° C. for 5 minutes to 2 hours.

7. The method of claim 1, wherein the first solution comprises water, an acetic acid solution or a hydrochloric acid solution, and the second solution comprises water, a lactic acid solution, an acetic acid solution, a citric acid solution, a mandelic acid solution or a hydrochloric acid solution.

8. A composite powder, obtained by a method of claim 1, wherein the composite powder comprises: a porous powder; a collagen layer, covering an outer surface of he porous powder; and a chitosan layer, covering the collagen layer.

9. The composite powder of claim 8, wherein a second average particle size of the composite powder is 3 μm to 25 μm.

10. An oil-in-water cosmetic composition comprising an oil-in-water emulsion base and the composite powder of claim 8 that is uniformly dispersed therein.

11. A hydrogel cosmetic composition comprising a hydrogel base and the composite powder of claim 8 that is uniformly dispersed therein.

Description

EXAMPLE 1

[0070] 100 parts by weight of porous sphere particles of polyrnethylmethacrylate (an average particle size of 8 μm; a specific surface area of 85 m.sup.2/g; a trade name of SUNPMMA-S; produced by Sunjin Chemical Co. Ltd) and 5 parts by weight of type 1 collagen (weight-average molecular weight of 3 kDa) dissolved in 0.01 M of an acetic acid solution were disposed in a stirrer (trade name: Rw28basic; produced by IKA company), and stirred at a rate of 100 rpm for 20 minutes under 25° C. to form the first mixing solution. Next, the first mixing solution was subjected to a filtering step in a centrifuge at rate of 3000 rpm, so as to precipitate and separate the semifinished powder. Then, 3 parts by weight of chitosan (weight-average molecular weight of 100 kDa) dissolved in 0.0001M of a dilute hydrochloric acid solution was added into the semifinished powder and stirred by the aforementioned stirrer to sufficiently ax the semifinished powder and chitosan to form the second mixture solution. Next, the second mixture solution was subjected to the precipitating and filtering step by centrifuge at a rate of 3000 rpm, thereby forming the composite powder. The compositions and evaluation results of Example 1 are shown as Table 1.

EXAMPLE 2 TO EXAMPLE 4

[0071] Example 2 to Example 4 were performed by the same method as Example 1, while the species or the amounts of the compositions were changed. The species and the amounts of the compositions, and evaluation results of Example 2 to Example 4 are shown as Table 1 rather than further described here.

Comparison Example 1 to Comparison Example 4

[0072] The porous powder of Comparison Example 1 to Comparison Example 4 were directly subjected to evaluation without wrapped by collagen and chitosan. The species of the porous powder and evaluation results of Comparison Example 1 to Comparison Example 4 are shown as Table 1.

Comparison Example 5 and Comparison Example 6

[0073] Comparison Example 5 and Comparison Example 6 were respectively wrapping the porous only by collagen or chitosan, and were subjected to the evaluation. The species of the porous powder and the evaluation results of Comparison Example 5 and Comparison Example 6 are shown as Table 1.

Evaluation

1. Dispersity

[0074] The dispersity of the composite powder produced by the method of the present invention is respectively evaluated in common bases such as water, the polar oil, the oil-in-water cream and the hydrogel. Situations such as lamination, aggregation are evaluated.

1-1 Dispersity in Water

[0075] The dispersity in water of the present invention refers to a degree of dispersion when the composite powder is added into deionized water. The dispersity in water is evaluated by uniformly mixing the composite powder and the deionized water with a weight ratio of 1:20 in a test tube and the mixture is left standing for a while. Time for the composite powder precipitating to the bottom of the test tube is then observed. The evaluation standards are shown as follows, in which the longer the time for the composite powder precipitating to the bottom of the test tube, the better the dispersity in water.

[0076] ◯: the time for the composite powder precipitating to the bottom of the test tube is more than 30 minutes.

[0077] Δ: the time for the composite powder precipitating to the bottom of the test tube is 5 minutes to 30 minutes.

[0078] X: the time for the composite powder precipitating to the bottom of the test tube is less than 5 minutes.

1-2 Dispersity in Polar Oil

[0079] The dispersity in a polar oil (i.e. caprylic/capric triglyceride) of the present invention refers to a degree of dispersion when the composite powder is added into the polar oil. The dispersity in the polar oil is evaluated by uniformly mixing the composite powder and the polar oil with a weight ratio of 1:20 in a test tube and the mixture is left standing for a while. Time for the composite powder precipitating to the bottom of the test tube is then observed. The evaluation standards are shown as follows, in which the longer the time for the composite powder precipitating to the bottom of the test tube, the better the dispersity in polar oil.

[0080] ◯: the composite powder precipitating to the bottom of the test tube is precipitated in a period of more than 30 minutes.

[0081] Δ: the composite powder precipitating to the bottom of the test tube is precipitated in a period of 5 minutes to 30 minutes.

[0082] X: the composite powder precipitating to the bottom of the test tube is precipitated in a period of less than 5 minutes.

1-3 Stability in Oil-in-Water Cream

[0083] The stability in oil-in-water cream refers to the dispersity of the composite powder after it is added into the oil-in-water cream (i.e. aggregation or lamination). The stability in oil-in-water cream oil is evaluated by uniformly mixing the composite powder and the oil-in-water cream with a weight ratio of 1:20 in a test tube and directly observing the lamination of the mixture. The evaluation standards are as follows, in which the less apparent the lamination, the better the stability in the oil-in-water cream.

[0084] ◯: The lamination is not apparent.

[0085] Δ: An emulsion layer exists.

[0086] X: The lamination is apparent.

1-4 Mixing Uniformity in Hydrogel

[0087] The mixing uniformity in the hydrogel of the present invention refers to observing whether aggregation occurs when the composite powder is mixed with the hydrogel. The mixing uniformity in the hydrogel is evaluated by mixing the composite powder and the hydrogel with a weight ratio of 1:20, and directly observing whether aggregates formed in the mixture. The less aggregation, the better the mixing uniformity, indicating that the composite powder is applicable to a hydrogel-based product. The evaluation standards are shown as follows:

[0088] ◯: The aggregation is not apparent.

[0089] Δ: Aggregated particles exist.

[0090] X: The aggregation is apparent.

Moisture Retention

[0091] The moisture retention of the present invention is evaluated by a sensory test which the composite powder is coated on a human skin. The evaluation standards are shown as follows.

[0092] ◯: good moisture retention.

[0093] Δ: proper moisture retention.

[0094] X: insufficient moisture, retention.

3. Greasiness

[0095] The greasiness of the present invention is directly evaluated by a sensory test which the composite powder is coated on the human skin to evaluate the composite powder is greasy or not. The evaluation standards are shown as follows:

[0096] ◯: not greasy.

[0097] Δ: a little greasy.

[0098] X: quite greasy.

[0099] According to Example to Example 4 of Table 1, the composite powder formed by the method of the present invention has good dispersity in various common bases (water, the polar oil, the oil-in-water cream and the hydrogel) used in makeups or skin care products, and has sufficient moisture retention and low greasiness. However, according to Comparison Example 1 to Comparison Example 4, if the porous powder was not physically adhered by the collagen and physically cross-linked by the chitosan, the desired dispersity, moisture retention and low greasiness could not be achieved. In addition, according to Comparison Example 5 and Comparison Example 6, if the porous powder was only wrapped by a single layer of the collagen layer or the chitosan layer, the desired dispersity, moisture retention and low greasiness could not be achieved, either.

[0100] The composite powder having an average particle size of 3 μm to 25 μm is produced by applying the composite powder and the method of producing the same of the present invention. The composite powder may have a double-layered wrap of the collagen layer and the chitosan layer, and thus the composite powder can have good dispersity, high moisture retention and low greasiness. In addition, the composite powder may be applied to makeups, skin care products or pharmaceutical products by adding additional additives.

TABLE-US-00001 TABLE 1 Example Comparison Example 1 2 3 4 1 2 3 4 5 6 Composite Porous A-1 100 — — — 100 — — — 100 — powder powder A-2 — 100 — — — 100 — — — 100 composition A-3 — — 100 — — — 100 — — — (part by A-4 — — — 100 — — — 100 — — weight) Collagen B-1  5 —  5 — — — — —  5 — B-2 —  3 —  3 — — — — — — Chitosan C-1  3 —  3 — — — — — —  5 C-2 —  5 —  5 — — — — — — First D-1 100 100 100 100 — — — — 100 — solution Second E-1 100 100 100 100 — — — — — 100 solution Composite Average particle size (μm)  8  5  3  8 — — — —  8  5 powder Evaluation Dispersity Dispersity in water Δ ◯ Δ ◯ X Δ X Δ X Δ method Dispersity in polar oil ◯ Δ ◯ Δ ◯ X Δ Δ ◯ X Stability in oil-in-water cream ◯ ◯ ◯ ◯ Δ Δ Δ Δ Δ Δ Mixing uniformity in hydrogel ◯ ◯ ◯ ◯ Δ Δ Δ Δ Δ Δ Moisture retention Δ ◯ Δ ◯ X Δ X Δ X Δ Greasiness ◯ ◯ ◯ ◯ Δ Δ Δ Δ Δ ◯ A-1 polymethylmethacrylate (average particle size: 8 μm, specific surface area: 85 m.sup.2/g: trade name; SUNPMMA-S; produced by Sunjin) A-2 silicon dioxide (trade name: SUNJIN, average particle size: 5 μm; produced by WWRC TAIWAN Co., Ltd.) A-3 carbon black (average particle size: 3 μm; produced by FuRui Chemical Industry Co., LTD.) A-4 titanium dioxide (reagent grade titanium oxide, 8 average particle size: 8 μm; produced by First Chemical Manufacture Co., Ltd.) B-1 collagen (weight-average molecular weight: 3 kDa) B-2 collagen (weight-average molecular weight: 30 kDa) C-1 chitosan (weight-average molecular weight: 100 kDa) C-2 chitosan (weight-average molecular weight: 10 kDa) D-1 0.01M acetic acid solution, about pH 5 E-1 0.0001M dilute hydrochloric acid solution, about pH 4