Composition and association of sunscreens for photostabilizing butyl methoxydibenzoylmethane (BMDBM)

Abstract

The present invention concerns a composition containing a photostabilized combination of Butyl Methoxydibenzoylmethane (BMDBM), Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (BEMT), and Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (MBBT) wherein: (i)—the BEMT/BMDBM mass ratio is greater than or equal to 1 and preferably greater than or equal to 1.5; (ii)—the content of BMDBM is comprised between 1% and 5% by weight with regard to the total weight of the composition; (iii)—the quantity of MBBT is comprised between 3% and 7% by weight with regard to the total weight of the composition, said combination containing no octocrylene, PABA or ethylhexyl methoxycinnamate, and a pharmaceutically or cosmetically acceptable excipient.

Claims

1. A composition comprising a pharmaceutically or cosmetically acceptable excipient, and a photostabilized combination of UVA and UVB filters consisting of (1) butyl methoxydibenzoylmethane (BMDBM), (2) bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), (3) methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT), and (4) a single additional UVB filter present in an amount of 1% to 10% by weight with regard to the weight of the composition, with the proviso that said single additional UVB filter is different from octocrylene, para-aminobenzoic acid (PABA), and ethylhexyl methoxycinnamate, wherein: i. the content of BEMT is comprised between 2% and 6% by weight with regard to the total weight of the composition, ii. the content of BMDBM is between 1% and 5% by weight with regard to the total weight of the composition, iii. the BEMT/BMDBM mass ratio is greater than or equal to 1.5 but less than or equal to 3, and iv. the quantity of MBBT is between 3% and 7% by weight with regard to the total weight of the composition.

2. The composition according to claim 1, wherein the single additional UVB filter is present in an amount of 1% to 5% by weight in all with regard to the weight of the composition.

3. The composition according to claim 1, wherein the single additional filter is a UVB filter that is selected from the group consisting of: ethylhexyl salicylate; phenylbenzimidazole sulfonic acid; ethylhexyl triazone; diethylhexyl butamido triazone; TiO.sub.2; and tris-biphenyl triazine.

4. The composition according to claim 2, wherein the single additional filter is a UVB filter that is selected from the group consisting of: ethylhexyl salicylate; phenylbenzimidazole sulfonic acid; ethylhexyl triazone; diethylhexyl butamido triazone; TiO.sub.2; and tris-biphenyl triazine.

5. A photoprotective system comprising the composition according to claim 1.

Description

COMPOSITION EXAMPLES

Composition 1

(1) TABLE-US-00001 Ingredients % Butyl 1-5 Methoxydibenzoylmethane Bis-Ethylhexyloxyphenol 2-6 Methoxyphenyl Triazine Methylene Bis- 3-7 Benzotriazolyl Tetramethylbutylphenol Glycerin 10.0 Demineralized water QSP 100 Na2EDTA 0.1 Xanthan gum 0.3 C12-C15 alkyl benzoate 25.0 Preservatives qs Stearyl alcohol 2.5 Glycerol monostearate 2.5 Potassium cetyl phosphate 1.8

Composition 2

(2) TABLE-US-00002 Ingredients % Butyl 1-5 Methoxydibenzoylmethane Bis-Ethylhexyloxyphenol 2-6 Methoxyphenyl Triazine Methylene Bis- 3-7 Benzotriazolyl Tetramethylbutylphenol UVB filter  1-10 Glycerin 10.0 Demineralized water QSP 100 Na2EDTA 0.1 Xanthan gum 0.3 C12-C15 alkyl benzoate 25.0 Preservatives qs Stearyl alcohol 2.5 Glycerol monostearate 2.5 Potassium cetyl phosphate 1.8
Photostability Results

(3) TABLE-US-00003 Composition Composition Photostability: 1 2 Total UV-5 MED 96% 93% UVA-5 MED 95% 92% Total UV-10 92% 90% MED UVA-10 MED 91% 89%