Formulations

Abstract

This invention relates to a formulation comprising a compound of formula (I) where R1 is hydrogen, methyl, ethyl, propyl or butyl; R2 is methyl or ethyl; R3 is hydrogen, methyl or ethyl; and n is 1, 2 or 3; to the use of a compound of formula (I) as a solvent; and to certain novel compounds of formula (I). ##STR00001##

Claims

1. A formulation comprising an agrochemical and a compound of formula (I) ##STR00003## where R.sup.1 is hydrogen, methyl, ethyl, propyl or butyl; R.sup.2 is methyl or ethyl; R.sup.3 is hydrogen, methyl or ethyl; n is 1 and wherein the agrochemical is azoxystrobin, difenoconazole or isopyrazam and the formulation is an emulsifiable concentrate or an emulsion.

2. A formulation as claimed in claim 1 where R.sup.1 is hydrogen.

3. A formulation as claimed in claim 1 where R.sup.3 is hydrogen.

4. A formulation as claimed in claim 2 where R.sup.3 is hydrogen.

Description

EXAMPLE 1

(1) This Example illustrates the high solubility of each of a number of agrochemical active ingredients in solvents of the present invention [compounds 1 and 2 of Table 1].

(2) A glass vial was approximately one eighth filled with an active ingredient [AI] and then solvent [in this example, propylene glycol benzoate or butylene glycol benzoate] was added until the vial was approximately one third full. The resultant sample was mixed with a Whirlimixer™ and was then stored at 25° C. The sample was checked every few days; if there was no solid active ingredient present then additional active ingredient was added; if there was no liquid remaining then additional solvent was added. This procedure was repeated until the sample had equilibrated for 4 weeks following the final addition of either active ingredient or solvent. The supernatant liquid layer was then analysed by gas chromotography for active ingredient concentration; the results are given in Table 2:

(3) TABLE-US-00002 TABLE 2 Solubility in Solubility in propylene glycol butylene glycol benzoate at 25° C. benzoate at 25° C. Active Ingredient (% w/w) (% w/w) Difenoconazole 50.5 — Chlorothalonil 1.32 — Cyprodinil 18.4 — 4-Hydroxy-3-[2-(2- 27.4 — methoxyethoxymethyl)-6- trifluoromethylpyridine- 3-carbonyl]- bicyclo[3.2.1]oct-3-en-2-one Azoxystrobin 5.5 8.1 Cyproconazole 4.5 6.9 Isopyrazam 12.7 12.4 

EXAMPLE 2

(4) This Example shows that the solvents of the present invention are particularly effective when solubilising pesticides belonging to the families: strobilurins, triazoles and succinate dehydrogenase inhibitors (SDHI) (particularly pyrazoles; suitably pyrazam chemistry). Tables 3a and 3b show the solubility of the pesticides azoxystrobin, difenoconazole, isopyrazam, cyprodinil, chlorothalonil and bicyclopyrone in the solvent propyle glycol benzoate [compound 1 of Table 1]. For comparison the solubilities in a series of commonly used solvents are also tabulated. The data show that in most cases the propylene glycol benzoate is a better solvent for the first three pesticides (respectively a triazole, an SDHI and a strobilurin,) than are the other common solvents. Solubilities are quoted as percentage w/w at 20° C.

(5) TABLE-US-00003 TABLE 3a Solvent Difenoconazole Isopyrazam Azoxystrobin Propylene glycol 50.5 12.7 5.5 benzoate n-Butylbenzoate 29.4 7.6 4.0 Solvesso ™ 37.8 0.0 1.7 100 ND/ULN Solvesso ™ 37.7 5.8 5.6 200 ND/ULN Dowanol ™ PnB 34.4 8.8 1.3 Isobornyl acetate 24.9 6.8 1.6 Benzoflex ™ 9-88 19.8 6.3 4.2 Butyl lactate 47.1 16.5 4.6 Dowanol ™ PGDA 34.1 6.9 9.4 Benzyl acetone 44.9 12.6 14.1 Benzyl acetate 46.0 8.9 13.8 Triacetin 22.3 4.3 6.4

(6) TABLE-US-00004 TABLE 3b Solvent Cyprodinil Bicyclopyrone Chlorothalonil Propylene glycol 18.4 27.4 1.3 benzoate n-Butylbenzoate 35.5 45.6 2.3 Solvesso ™ 31.1 52.3 7.1 100 ND/ULN Solvesso ™ 34.4 50.7 9.6 200 ND/ULN Dowanol ™ PnB 41.7 32.0 0.2 Isobornyl acetate 32.8 38.4 0.5 Benzoflex ™ 9-88 22.6 23.2 1.9 Butyl lactate 52.5 48.6 0.4 Dowanol ™ PGDA 31.3 38.3 0.6 Benzyl acetone 39.6 53.0 2.8 Benzyl acetate 36.8 55.5 2.0 Triacetin 18.9 33.3 0.4