Biocidal composition

Abstract

A biocidal composition comprising tributyl tetradecyl phosphonium chloride and tetrakis(hydroxymethyl)phosphonium sulfate at a weight ratio of 2:1 to 1:10, and its use for the control of microorganisms in aqueous and water-containing systems.

Claims

1. A biocidal composition comprising: tributyl tetradecyl phosphonium chloride and tetrakis(hydroxymethyl)phosphonium sulfate at a weight ratio of 1:1 to 1:10.

2. A method for controlling microorganism growth in an aqueous or water-containing system, the method comprising treating the aqueous or water-containing system with an effective amount of a composition according to claim 1.

3. A method according to claim 2 wherein the aqueous or water-containing system is paint, coating, aqueous emulsion, latex, adhesive, ink, pigment dispersion, household or industrial cleaner, detergent, dish detergent, mineral slurry polymer emulsion, caulk, adhesive, tape joint compound, disinfectant, sanitizer, metalworking fluid, construction product, personal care product, textile fluid, spin finish, industrial process water, oilfield functional fluid, fuel, air washer, wastewater, ballast water or filtration system.

Description

EXAMPLES

Example 1 Synergistic Effect of TTPC and THPS Against Microorganisms

(1) In this example, tributyl tetradecyl phosphonium chloride (TTPC), tetrakis(hydroxymethyl)phosphonium sulfate (THPS), and combinations of TTPC and THPS are tested at different concentrations for efficacy against bacteria isolated from a industrial cooling water sample. Water samples containing a final bacterial concentration of about 5×10.sup.7 CFU/ml are used. Biocide solutions are prepared and diluted in sterile deionized water and used within 2 hours.

(2) Time-kill tests are carried out to determine the threshold concentrations required for biocide activity in the cooling water samples. Tests are conducted in a 96-deep well block format using a total sample volume of 600 μl for all evaluations. In these samples, no more than 10% of the total volume consists of the biocide and organism solution and all non-matrix additions are normalized for all samples. Each experimental 96-well block contains biocide-treated samples and control samples which lack biocide. The biocides are added to the bacterial suspension at various concentrations and mixed well. The mixture samples are then incubated at 37° C. At several time intervals starting from 1 hour, viable bacteria left in the mixture are determined using the MPN method of serial dilution.

(3) Synergy Index (SI) is calculated as shown below. An SI value of less than 1 indicates synergy.
SI=Ca/CA+Cb/CB
Where: Ca: Concentration of biocide A required to achieve bacterial concentrations of 2×10.sup.3 CFU/ml or less when used in combination CA: Concentration of biocide A required to achieve bacterial concentrations of 2×10.sup.3 CFU/ml or less when used alone Cb: Concentration of biocide B required to achieve bacterial concentrations of 2×10.sup.3 CFU/ml or less when used in combination CB: Concentration of biocide B required to achieve bacterial concentrations of 2×10.sup.3 CFU/ml or less when used alone

(4) Table 1 summarizes the concentrations of TTPC, THPS, and combinations thereof needed to achieve bacterial concentrations of 2×10.sup.3 CFU/ml or less in the cooling water sample.

(5) TABLE-US-00001 TABLE 1 Concentration of active (ppm) 4 hr 24 hr 48 hr 3 day 5 day 7 day TTPC alone 30 40 40 40 40 40 THPS alone 100 75 75 75 75 75 TTPC in combo 5 5 5 5 5 5 THPS in combo 50 SI 0.79 TTPC:THPS  1:10 Ratio TTPC in combo 10 10 10 10 10 10 THPS in combo 20 20 40 40 40 40 SI 0.53 0.52 0.78 0.78 0.78 0.78 TTPC:THPS 1:2 1:2 1:4   1:4   1:4   1:4   Ratio TTPC in combo 20 20 20 20 20 20 THPS in combo 10 20 30 30 30 30 SI 0.77 0.77 0.90 0.90 0.90 0.90 TTPC:THPS 2:1 1:1 1:1.5 1:1.5 1:1.5 1:1.5 Ratio

(6) The data in Table 1 demonstrates that synergy is observed over a ratio range of TTPC to THPS of 2:1 to 1:10.

(7) While the invention has been described above according to its preferred embodiments, it can be modified within the spirit and scope of this disclosure. This application is therefore intended to cover any variations, uses, or adaptations of the invention using the general principles disclosed herein. Further, the application is intended to cover such departures from the present disclosure as come within the known or customary practice in the art to which this invention pertains and which fall within the limits of the following claims.