Keyless inking methods, apparatus, and systems with chamber blade system spanning anilox roll and form roll for digital offset printing
09809021 · 2017-11-07
Assignee
Inventors
Cpc classification
B41C1/1008
PERFORMING OPERATIONS; TRANSPORTING
B41F31/027
PERFORMING OPERATIONS; TRANSPORTING
B41P2227/70
PERFORMING OPERATIONS; TRANSPORTING
B41F31/02
PERFORMING OPERATIONS; TRANSPORTING
B41N3/08
PERFORMING OPERATIONS; TRANSPORTING
International classification
B41F31/02
PERFORMING OPERATIONS; TRANSPORTING
B41F31/20
PERFORMING OPERATIONS; TRANSPORTING
Abstract
A variable lithographic inking system includes a chamber blade system configured to supply ink to an anilox member of an inking system. The inking system includes a soft ink transfer roll and a hard form roll. Ink is transferred from the anilox roll to the form roll by way of the transfer roll, and from the form roll to a reimageable surface layer of an imaging member of a variable data lithographic system. An ink layer free of ink history is uniformly applied onto a surface of the form roll, and subsequently transferred to the reimageable surface layer while avoiding or substantially eliminating image ghosting related to inking non-uniformities.
Claims
1. A variable lithographic keyless inking method, comprising: metering a uniform layer of ink onto a hard form roll from a transfer roll, the transfer roll having a conformable surface, the metering including: transferring ink from an anilox roll to the transfer roll at a first transfer nip, the first transfer nip being defined by the anilox roll and the transfer roll, transferring ink from the transfer roll to the hard form roll at a second transfer nip, the second transfer nip being defined by the transfer roll and the hard form roll, urging the transfer roll against the anilox roll to apply pressure to the ink at the first transfer nip, and urging the transfer roll against the hard form roll to apply pressure to the ink at the second transfer nip; transferring the ink of the uniform layer directly from the hard form roll to a reimageable surface layer for variable data lithographic printing; cleaning a surface of the hard form roll, the cleaning comprising removing ink from the surface of the hard form roll; and removing dampening fluid from the surface of the hard form roll, the dampening fluid being transferred from the reimageable surface layer to the hard form roll, wherein the removing dampening fluid includes using an air knife to selectively evaporate dampening fluid from the surface of the hard form roll.
2. The method of claim 1, wherein the removing dampening fluid takes place before the removing ink from the surface of the hard form roll.
3. The method of claim 1, the removing ink further comprising contacting the surface of the hard form roll with a doctor blade whereby ink is removed from the hard form roll.
4. The method of claim 3, wherein the removing dampening fluid takes place before the removing ink from the surface of the hard form roll.
5. The method of claim 3, further comprising transferring ink from an anilox roll to the transfer roll at a first transfer nip, the first transfer nip being defined by the anilox roll and the transfer roll; and collecting the ink removed from the surface of the hard form roll by the doctor blade in a reservoir, the reservoir being in communication with an ink sump wherein collected ink may mix with ink for applying to the anilox roll.
6. The method of claim 5, wherein the removing dampening fluid takes place before the removing ink from the surface of the hard form roll.
7. The method of claim 6, further comprising actively driving a surface velocity of at least one of the anilox member, the intermediate transfer member, and the form member to vary the relative surface velocity of a first one of the anilox member, the intermediate transfer member, and the form member with a second of the anilox member, the intermediate transfer member, and the form member to slightly adjust the ink transfer efficiency and final optical saturation of ink delivered to the reimageable surface of a variable lithographic printing apparatus.
8. The method of claim 5, further comprising applying ink from the ink sump to a surface of the anilox roll.
9. A keyless variable lithographic inking apparatus, comprising: an anilox member, the anilox member being configured to carry ink; a transfer member, the transfer member having a conformable surface, and the transfer member being configured to define a first transfer nip with the anilox member; a form member, the form member having a hard surface, and the form member being configured to define a second transfer nip with the transfer member; an imaging member, the imaging member having a conformable reimageable surface layer, and the reimageable surface layer being configured to define a third transfer nip with the form member; and a chamber blade system, the chamber blade system having a form member doctor blade, the form member doctor blade being configured to contact a surface of the form member for removing ink from the surface of the form member, and an air knife to selectively evaporate dampening fluid from the surface of the form member.
10. The apparatus of claim 9, wherein the air knife is configured to remove the dampening fluid from the surface of the form member before the form member doctor blade removes the ink from the surface of the form member.
11. The apparatus of claim 10, the chamber blade system further comprising a removed ink reservoir, the removed ink reservoir being in communication with an ink sump, the ink sump being configured to accept removed ink from the removed ink reservoir.
12. The apparatus of claim 11, wherein the anilox member is configured to contact ink in the ink sump to uptake the ink.
13. The apparatus of claim 12, the anilox member being heated and temperature controlled, a temperature of the anilox member being adjustable to enhance metering for achieving a uniform ink layer on a surface of the transfer member.
14. The apparatus of claim 13, further comprising an anilox member doctor blade, the anilox member doctor blade being configured to doctor excess ink from a surface of the anilox member.
15. The apparatus of claim 9, the anilox member being heated and temperature controlled, a temperature of the anilox member being adjustable to enhance metering for achieving a uniform ink layer on a surface of the transfer member.
16. The apparatus of claim 9, further comprising an anilox member doctor blade, the anilox member doctor blade being configured to doctor excess ink from a surface of the anilox member.
17. A variable lithographic keyless inking system, comprising: an inking system for transferring a uniform layer of ink to a reimageable surface layer of an imaging member, the inking system having an anilox member, an intermediate transfer member, and a form member, the intermediate member having a soft surface, and the form member having a hard surface, the anilox member and the intermediate transfer member defining a first ink transfer nip, and the intermediate transfer member and the form member defining a second ink transfer nip, the form member being configured to transfer ink from the form member to the reimageable surface, the reimageable surface layer being a soft surface; and a chamber blade system, the chamber blade system having a form member doctor blade, the form member doctor blade being configured to contact a surface of the form member for removing ink from the surface of the form member, the chamber blade system having a reservoir for receiving the ink removed from the surface of the form member, and an air knife to selectively evaporate dampening fluid from the surface of the form member.
18. The system of claim 17, wherein the air knife is configured to evaporate the dampening fluid from the surface of the form member before the form member doctor blade removes the ink from the surface of the form member such that the ink received by the reservoir is substantially free of dampening fluid.
19. The system of claim 17, further comprising an ink sump in communication with the reservoir, wherein the ink sump is configured such that ink collected in the ink sump may mix with ink for applying to the anilox roll.
20. The system of claim 17, further comprising an anilox member doctor blade, the anilox member doctor blade being configured to doctor excess ink from a surface of the anilox member.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
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DETAILED DESCRIPTION
(6) Exemplary embodiments are intended to cover all alternatives, modifications, and equivalents as may be included within the spirit and scope of the apparatus and systems as described herein.
(7) Reference is made to the drawings to accommodate understanding of methods, apparatus, and systems for inking to a reimageable blanket surface for ghostless variable lithographic ink printing. In the drawings, like reference numerals are used throughout to designate similar or identical elements. The drawings depict various embodiments and data related to embodiments of illustrative methods, apparatus, and systems for inking from an inking member to the reimageable surface.
(8) Compact variable lithographic keyless inking systems that reduce ghosting issues are provided. Methods, apparatus, and systems accommodate reduced or substantially eliminated ghosting by cleaning a hard ink transfer form member with a doctor blade to remove ink leftover after ink transfer to a reimageable surface. The removed ink may be recycled for resupply to an anilox roll of the inking system, and subsequent transfer to the form roll. The ink transfer members of the inking system need not be large or of equal size.
(9) Inking systems or inker subsystems in accordance with embodiments may be incorporated into a variable lithographic architecture so that the inking system is arranged about a central drum holding an imaging member whose outer surface is a, conformable reimageable surface layer. A paper path architecture may be situated about the imaging member to form a media transfer nip.
(10) A uniform application of dampening fluid may be applied to the reimageable surface layer of the central imaging cylinder holding an imaging member using a dampening fluid subsystem. In the digital evaporation step, particular portions of the dampening fluid layer applied to the surface of the central imaging member may be evaporated by a digital evaporation system. For example, portions of the dampening fluid layer may be evaporated by laser patterning.
(11) In an inking step, ink may be transferred from an inking system to the reimageable surface layer of the imaging member. The transferred ink adheres to portions of this surface where dampening fluid has been evaporated. In a partial cure step, the transferred ink may be partially cured by irradiation. For example, UV cure source(s) may be arranged about the imaging member. In an image transfer step, the transferred ink may be transferred to media such as paper at a media transfer nip.
(12) A surface of the central imaging cylinder may be cleaned by a cleaning system. For example, tacky cleaning rollers may be used to clean the surface of the central imaging member. In a variable lithographic printing process, previously imaged ink must be removed from the imaging member to prevent ghosting. New ink applied to the imaging plate from an inking system should have no history of ink thickness depletion in the form roller due to prior ink transfer.
(13) The inking system may include an inking member such as an anilox roll. The anilox roll may have wells or cells in a surface thereof for carrying ink to the imaging member. The wells may be mechanically or laser engraved, and may be configured to contain a volume of ink. The anilox roll may be configured in an inking system so that a surface of the roll is submerged in an ink chamber or ink sump. An anilox doctor blade may be arranged to contact a surface of the anilox roll for leveling ink supplied to the roll by the ink sump as the anilox roll rotates in a process direction.
(14) The inking system may include an intermediate soft transfer roll. The transfer roll may have a soft, conformable surface made of, for example, a rubber such as EPDM or nitrile rubber that is compatible with the ink chemistry. The transfer roll may be configured to define a first ink transfer nip with the anilox roll. Ink may be metered onto the transfer roll at the first ink transfer nip. The transfer roll may be urged against the anilox roll to squeeze the ink at the first ink transfer nip to spread and smooth the ink as the ink is metered onto the transfer roll.
(15) An ink form member such as a roll having a hard surface may be arranged to define a second transfer nip with the soft intermediate transfer roll. The ink form roll may be a cylindrical drum or other suitable member. The ink form roll may comprise a hard surface. For example, the ink form member may be a roll having a surface comprising metal. The ink member may be an aluminum drum. The drum may have a diameter in the range of about 2 to about 3 inches diameter. Alternatively, the ink form roll may have a highly durable, hard outer surface comprising plated chrome or an alumina ceramic coating.
(16) The hard surface of the form member enables use of a doctor blade for cleaning ink from the form member. For example, a doctor blade may be applied to the surface of the form roll to wipe or scrape ink from the form member that is leftover after transferring ink to an imaging member. Ghostless variable data printing with offset ink requires that an inker subsystem form roll have substantially no prior ink history from a prior process of transferred ink onto an imaging plate. Because the surface of the form member is hard, the doctor blade can be applied without degrading the form member surface.
(17) The intermediate transfer member may apply a pressure at the second transfer nip to squeeze the ink as the ink is metered onto the form member. The soft surface of the transfer member mitigates the metering pattern of the ink and facilitates spreading and smoothing of the ink at both the first and second transfer nips. The soft intermediate transfer member may be configured for oscillation back and forth against the first and second nips in alternating succession. Additional members such as rolls may be used to enhance ink smoothing.
(18) A diameter of an intermediate transfer member such as a transfer roll and a form member such as a form roll may be different. Further, the anilox member, transfer member, and form member may have a diameter that is significantly smaller than related art anilox rolls, which are typically over 5 inches or more in diameter. Accordingly, an overall size of an inking systems having inking members in accordance with embodiments may have a reduced size, weight, and overall system cost in comparison with related art systems.
(19) The intermediate member may be a transfer roll that is configured to rotate at a first angular velocity. The form member may be a form roll that is configured to rotate at a second angular velocity. At least one of the first angular velocity and the second angular velocity may be slightly adjusted to enhance smoothing and spreading of ink at the second ink transfer nip for metering a uniform layer of ink onto the hard surface of the form roll. Further, the anilox member may be a temperature controlled anilox roll. The temperature of the anilox roll may be adjusted to bring the ink to a temperature that enhances spreading and smoothing of the ink at, for example, the first transfer nip. Further, a pressure applied at the ink transfer nips may be adjusted by adjusting, for example, the pressure applied by the intermediate transfer member, to accommodate inks of particular thicknesses. These parameters may be adjusted for varying a thickness and optical density of an ink layer on a reimageable surface layer of an imaging member used in variable data lithography.
(20) The form member may be configured to contact the outer reimageable surface layer and transfer ink without ink thickness variation or history of prior inking patterns onto the reimageable surface layer thereof. The imaging member and reimageable surface layer member may be configured as described by Stowe et al. in “Variable Data Lithography System” (U.S. patent application Ser. No. 13/095,714), as appropriate. For example the reimageable surface may be made from a soft silicone blanket material.
(21) A chamber blade system in accordance with embodiments may include a removed ink reservoir. Chamber blade system may be located adjacent to a form member so that ink cleaned from the form member may be captured at the removed ink reservoir. The chamber blade system may include an ink sump. The ink sump may be configured to communicate with the removed ink reservoir, so that the ink sump may receive ink from the ink reservoir. For example, the chamber blade system may be constructed to define a cavity having an upper portion and a lower portion. The upper portion of the cavity may be positioned beneath a form roll, and may include an ink reservoir. Ink removed from the form roll may fall into the reservoir of the upper portion of the cavity. The lower portion of the ink cavity may include an ink sump. The ink reservoir and the ink sump of the cavity may share a common bottom member that contains the ink in the chamber blade system. Ink received at the reservoir may fall down the common bottom portion from the reservoir and into the ink sump.
(22) A portion of the anilox member may be submerged in ink at the ink sump. For example, the anilox member may be an anilox roll that rotates through the ink contained in the ink sump whereby the ink sump supplies ink to a surface of the anilox roll. The ink may be contained in the cells of the anilox roll, and excess ink on a surface of the roll may be cleaned using an anilox doctor blade. The anilox doctor blade may be configured to doctor excess ink deposited in a cell of the inking member from the surface of the inking member. A chamber blade may be associated with the ink chamber. The chamber blade and the doctor blade may be configured to contain ink within the chamber. For example, the chamber blade and doctor blade, and bottom portion of the chamber blade system, in combination, may be configured to contain ink inside the ink chamber.
(23) The chamber blade system may also include a form member doctor blade that is configured to contact a surface of the form member. The form member doctor blade may be formed of a material comprising metal. The form member doctor blade may be formed of a hard material that is suitable for scraping ink from a surface of the hard form member. The form member doctor blade may be oleophobic, and may comprise, for example, fluorocarbon materials such as TEFLON®. In an inking system having a chamber blade system in accordance with an embodiment, the form member doctor blade may be arranged to contact a portion of the form member that is located directly above and facing the removed ink reservoir of the chamber blade system. As the form roll, for example, rotates in a process direction, the form member doctor blade may contact the surface of the form member to remove ink from the surface of the form member, causing the ink to fall into the ink reservoir.
(24) During transfer of the deposited ink from the form member to the imaging member, dampening fluid from the surface of the inking member may be transferred to the inking member. In an embodiment, a form member chamber blade may be made from a hydrophilic flexible material such as microporous nitrile butadiene rubber (NBR) which promotes the removal of water based dampening fluid from the surface of the ink coating the form member due to chemical diffusion away from the ink and into the chamber blade. Alternatively, if a hydrofluoroether based dampening fluid is used in digital variable lithographic, the form member chamber blade may be of a flexible fluorocarbon material such as viton which selectively promotes the removal of the hydrofluoroether dampening fluid from the ink by drawing it away from the surface. Thus, the form member chamber blade material may be made of a flexible oleophobic material which promotes selective absorption and removal of the dampening fluid based upon the dampening fluid chemistry.
(25) The form member chamber blade may be configured to contact a portion of the form member that includes ink and dampening fluid leftover form ink transfer at a third ink transfer nip defined by an imaging member and the form member. For example, with respect to a process direction, the form member chamber blade may be configured to contact a surface of the form member and remove dampening fluid therefrom before the form member doctor blade contacts a surface of the form member to remove leftover ink therefrom. Accordingly, ink removed from the surface of the form member may be substantially free of dampening fluid. The ink that is substantially free of dampening fluid may include a negligible amount of dampening fluid that is present in an amount that is low enough to be acceptable for resupply of the ink to the anilox member without degrading ink transfer or ink printing. As such, in an embodiment wherein the removed ink may be added to the ink sump for resupply to an anilox member, the ink supply may remain substantially free of dampening fluid. Accordingly, ink removed from the form member by cleaning the form member with the doctor blade may be recycled for resupply to the inking system.
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(27) The anilox roll 102 is a cylindrical rotatable roll having cells or wells defined in a surface thereof. The cells may be mechanically or laser engraved. The anilox roll 102 may be submerged in supply ink, and may be rotated through the ink for uptaking ink into the cells. The anilox roll may be heated, and may be temperature controlled. Depending on properties of the ink being used, such as a viscosity of the ink, a temperature of the anilox member may be adjusted improved smoothing and spreading of the ink at one or more ink transfer nips of the inking system.
(28) The intermediate transfer roll 105 may define a first ink transfer nip with the anilox roll 102. Ink carried by the anilox roll 102 may be carried to the first ink transfer nip, and metered onto the transfer roll 105 in a uniform layer. The intermediate roll 105 may have a diameter that is greater than or less than a diameter of the anilox roll 102. The transfer roll 105 may be driven passively through surface friction with the anilox roll in order to achieve a matching surface speed. The transfer roll surface thereby rotates in unison with surface of the anilox roll but the angular direction of rotation is opposite that of the anilox roll 102.
(29) The intermediate transfer roll 105 may have a soft surface. For example, the surface may comprise rubber, or elastomer such as EPDM. The intermediate transfer roll 105 may be a rotatable drum, or other member suitable for defining an ink transfer nip with an anilox roll 102 and a hard form roll such as form roll 108. The soft intermediate transfer roll 105 may define a second transfer nip with the hard form roll 108. The intermediate transfer roll 105 may transfer ink from the anilox roll 102 to the hard form roll 108 in a uniform layer.
(30) In an embodiment, the intermediate roll 105 may be configured to be urgable against the anilox roll 102 at the transfer nip for increasing a pressure applied to ink at the nip for squeezing the ink to spread and smooth the ink for metering the ink onto the intermediate transfer member in a uniform layer. In an embodiment, the transfer roll or member 105 may be urgable against the form roll or member 108 at the second ink transfer nip for increasing a pressure applied to ink at the nip for squeezing the ink to spread and smooth the ink for metering a uniform layer of ink onto the hard surface of the form roll 108. In an embodiment, the intermediate roll 105 may be configured to oscillate slowly back and forth in a direction perpendicular to the high speed rotation the anilox roll or member 102 and the form roll or member 108.
(31) In an embodiment, a transfer member such as transfer roll 105 may be rotatable and set to rotate at a velocity V1 set directly by a servo motor or indirectly through friction with the anilox roller 102. A form member such as form roll 108 may be rotatable and set to rotate at a velocity V2 set by an independent servo motor. In an embodiment, V2 may equal V1. Alternatively, V1 may differ from V2 slightly causing a small amount of controlled slippage. One or both of V1 and V2 may be adjusted to enhance uniformity of the ink layer transferred onto the hard form roll 108 from the soft intermediate transfer roll 105 at the second transfer nip. A diameter of the form roll 108 may be greater than or less than a diameter of the soft intermediate transfer roll 105.
(32) As shown in
(33) As the hard form roll 108 contacts the reimageable surface layer 112 at the third transfer nip to squeeze ink therebetween and transfer the ink onto the soft surface layer 112 of the imaging member 110, some ink may be left behind on the hard form roll 108. Further, as the hard form roll 108 contacts the digital imaging roll 110 at the third ink transfer nip to squeeze ink therebetween, dampening fluid deposited on the reimageable surface layer 112 prior to ink transfer may migrate from the digital imaging roll 110 to the hard form roll 108. Accordingly, the dampening fluid may be mixed with leftover ink on a surface of the form roll 108 that after ink transfer to the digital imaging roll 110 at the third transfer nip.
(34) As shown in
(35) Because the form roll 108 has a hard surface, the form roll doctor blade 127 may be configured to contact a surface of the form roll 108 for removing leftover ink from a surface of the form roll 108. The form roll doctor blade 127 may comprise a metal material, or other material suitable for removing ink from the hard surface of the form roll 108. The chamber blade system 120 may include a chamber blade 123. The chamber blade 123 may be configured to contact a surface of the form roll 108. The chamber blade 123 may comprise a flexible hydrophilic material if water based dampening solution is used, and thus the hydrophilic chamber blade 123 may wick away water-based dampening fluid 130 from the surface of the form roll 108. Alternatively if other dampening fluid chemistries are used, the chamber blade may be made of other materials designed to efficiently wick away the type of dampening fluid used. For example, if a hydrofluoroether based dampening fluid is used as the ink rejection layer in a variable data lithographic system, the chamber blade 123 may be chosen to me made from a fluoride rich fluorocarbon material such as viton or TEFLON.
(36) Accordingly, in an embodiment having a form roll doctor blade 127 and a chamber blade 123, removed ink 132 removed by the doctor blade 127 may be received by the ink reservoir. The ink of the ink reservoir may flow or be caused migrate to an ink sump for mixing with supply ink 135. The supply ink 135 may contain the recycled removed ink 132, and may be supplied to the anilox roll 102. The recycled removed ink 132 advantageously would include substantially no dampening fluid after mixing in the ink sump with supply ink 135 because the dampening fluid is substantially removed from the form roll 108 before leftover ink is removed from a surface of the form roll 108. A negligible amount of dampening fluid may be present in the collected ink, even if a chamber blade is implemented to wick away the dampening fluid as disclosed.
(37) As the anilox roll 102 rotates through the ink sump as shown in
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(39) Methods may include transferring ink from the transfer roll to an ink form member such as a form roll at S205. While the transfer roll has a soft surface comprising, for example, rubber, the form roll has a hard surface comprising, for example, metal. The form member and the transfer member define a second ink transfer nip at which ink is squeezed by the form roll and the transfer roll at S205.
(40) The pressure applied at the nip may be adjustable. For example, the intermediate transfer member or roll may be movable for urging against at least one of the anilox roll and the hard form roll.
(41) Methods may include transferring the ink from the transfer roll to a form roll having a hard surface at S305. Accordingly the ink may be squeezed at a second ink transfer nip defined by the transfer roll and the hard form roll. At S307, the transfer roll may be urged against the hard form roll and the ink at the second transfer nip to, e.g., apply or increase a pressure against ink at the nip during metering. S301-S307 may be implemented using a transfer roll that is configured to slowly oscillate back and forth in a direction perpendicular to the motion of the rollers shown in
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(43) At S405, the ink metered in a uniform layer onto a surface of the transfer roll may be transferred from the transfer roll to a hard form roll. The form roll may have a hard surface, and may comprise, for example, metal. The ink may be squeezed at a second transfer nip defined by the conformable transfer roll and the hard form roll to meter a uniform layer of ink onto the form roll.
(44) At S420, the ink may be transferred from the hard form roll to an imaging member such as a digital imaging plate or roll. The hard transfer roll and the imaging roll may define a third ink transfer nip. The imaging member includes a soft, conformable reimageable surface layer onto which the ink is transferred from the form roll. For example, the surface layer of the imaging member may comprise silicone or a fluorosilicone. As shown at S426, methods may include cleaning ink from a surface of the form roll that is left over after transfer of ink from the form roll to the imaging roll at S420. The ink may be cleaned from a surface of the hard form roll using a form roll doctor blade for scraping or wiping ink from the surface of the form roll. In another embodiment, methods may include removing dampening fluid from the leftover ink before removing the ink from the surface of the hard form roll at S420. For example, if a water-based dampening fluid is used, a hydrophilic chamber blade may be positioned near the form roll for contacting the left over ink on the form roll after image transfer to the imaging roll. The chamber blade may wick away the water-based dampening fluid from the leftover ink.
(45) As shown at S428, methods may include collecting the leftover ink cleaned from a surface of the hard form roll with the form roll doctor blade in a reservoir of a chamber blade system. In an embodiment wherein a chamber blade is used to remove dampening fluid from the leftover ink before the removing the ink from the form roll at S420, the collected ink may be substantially free of dampening fluid.
(46) As shown at S430, methods may include adding or supplying ink to the anilox roll from an ink sump of the chamber blade system. The ink sump may be in communication with the removed ink reservoir. Accordingly, the ink reservoir may collect removed ink from the hard form roll, and the collected ink may be transferred to the ink sump for resupply to the anilox roll. The ink sump may contain a mixture of new, unused ink and recycled ink that is supplied to the anilox roll at S430.
(47) It will be appreciated that various of the above-disclosed and other features and functions, or alternatives thereof, may be desirably combined into many other different systems or applications. Also, various presently unforeseen or unanticipated alternatives, modifications, variations or improvements therein may be subsequently made by those skilled in the art.