Composition For Enhancing Protein Strength

Abstract

A composition for enhancing protein strength according to the present invention contains an aminosilane compound capable of covalent binding with a protein of hair, scalp, skin, nails, leather, or textile, so that the protein and the amino silane compound form a covalent bond, and thus the composition can improve the protein strength enhancement effect and maximize the semi-permanent protein strength enhancement effect.

Claims

1. A method for enhancing protein strength, comprising: treating a protein with a composition comprising an aminosilane compound, a carbodiimide-based compound, and a solvent, wherein the protein is selected from the group consisting of hair, skin, finger nails, toe nails, leather and fiber, the aminosilane compound is selected from the group consisting of the compounds represented by Formulas 1 to 3 below: ##STR00007## wherein in Formulas 1 to 3, R.sub.1 is each independently hydrogen; or a linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring hydrocarbon, which includes one or more double bonds, or is optionally substituted with one or more atoms selected from the group consisting of O, N, S, P and Si, or substituted in an anionic, cationic or amphoteric form, or includes a structure to which a metal ion is bonded in a salt form; and R.sub.2 is each independently a linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring hydrocarbon, which includes one or more double bonds, or is optionally substituted with one or more atoms selected from the group consisting of O, N, S, P and Si, or substituted in an anionic, cationic or amphoteric form, or includes a structure to which a metal ion is bonded in a salt form, and in which at least one primary or secondary amine is included at an end of the molecular structure, and the carbodiimide-based compound is represented by Formula 4 below, or a salt form thereof formed by bonding with a metal ion: ##STR00008## wherein in Formula 4, A each independently represents a monomer selected from structures listed below, ##STR00009## wherein * denotes a connecting position, R each independently represents hydrogen; or C1 to C500 linear, branched or cyclic hydrocarbon; or an aromatic hydrocarbon, which includes one or more double bonds, or is optionally substituted with one or more atoms selected from the group consisting of O, N, S, P and Si, and m is an integer of 1 to 100, and when m is 2 or greater, each of ##STR00010## is the same or different from each other.

2. The method according to claim 1, wherein the aminosilane compound is one or more selected from the group consisting of 3-aminopropyltriethoxysilane, bis[(3-triethoxysilyl)propyl]amine, 3-aminopropyltrimethoxysilane, 4-aminobutyltriethoxysilane, bis[(3-trimethoxysilyl)propyl]amine, 3-aminopropylmethyldiethoxysilane, 3-aminopropyldimethylethoxysilane, 3-aminopropylmethyldimethoxysilane, aminoethylaminopropyltrimethoxysilane, aminoethylaminopropyltriethoxysilane, aminoethylaminopropylmethyldimethoxysilane, diethylenetriaminopropylmethyldimethoxysilane, piperazinylpropylmethyldimethoxysilane, (n-phenylamino)methyltrimethoxysilane, (n-phenylamino)methyltriethoxysilane, 3-(n-phenylamino)propyltrimethoxysilane, n-(n-butyl)-3-aminopropyltrimethoxysilane, 4-aminobutyltriethoxysilane, m-aminophenyltrimethoxysilane, p-aminophenyltrimethoxysilane, aminophenyltrimethoxysilane, m-aminophenyltriethoxysilane, p-aminophenyltriethoxysilane, aminophenyltriethoxysilane, 3-aminopropyltris(methoxyethoxy-ethoxy)silane, 11-aminoundecyltriethoxysilane, 3-(m-aminophenoxy(propyltrimethoxy-silane), aminopropylsilanetriol, 3-aminopropylmethyldiethoxysilane, 3-aminopropyldiisopropylethoxy-silane, 3-aminopropyldimethylethoxysilane, n-(2-aminoethyl)-3-aminopropyltrimethoxysilane, n-(2-aminoethyl)-3-aminopropyltri-ethoxysilane, n-(6-aminohexyl)aminomethyl-triethoxysilane, n-(6-aminohexyl)aminopropyl-trimethoxysilane, n-(2-aminoethyl)-11-aminoundecyl-trimethoxysilane, (aminoethylaminomethyl)phenethyl-trimethoxysilane, n-3-[amino(polypropylenoxy)]amino-propyltrimethoxysilane, n-(2-aminoethyl)-3-aminopropyl-silanetriol, n-(2-aminoethyl)-3-aminopropylmethyl-dimethoxysilane, n-(2-aminoethyl)-3-aminoisobutyl-methyldimethoxysilane, (aminoethylamino)-3-isobutyldi-methylmethoxysilane, (3-trimethoxysilylpropyl)diethylene-triamine, n-butylaminopropyltrimethoxy-silane, n-ethylaminoisobutyltrimethoxy-silane, n-methylaminopropyltrimethoxy-silane, n-phenylaminopropyltrimethoxy-silane, 3-(n-allylamino)propyltrimethoxy-silane, (cyclohexylaminomethyl)tri-ethoxysilane, n-cyclohexylaminopropyltrimeth-oxysilane, n-ethylaminoi sobutylmethyl-diethoxysilane, (phenylaminomethyl)methyl-dimethoxysilane, n-phenylaminomethyltriethoxysilane, n-methylaminopropylmethyl-dimethoxysilane, 3-(n-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane hydrochloride, n-(trimethoxysilylpropyl)isothio-uronium chloride, bis[(3-trimethoxysilyl)propyl]-ethylenediamine, bis[(3-trimethoxysilyl)propyl]-ethylenediamine, bis[3-(triethoxysilyl)propyl]urea, bis(trimethoxysilylpropyl)urea, bis(methyldi ethoxysilylpropyl)amine, ureidopropyltriethoxysilane, acetamidopropyltrimethoxysilane, n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam and ureidopropyltrimethoxysilane.

3. The method according to claim 1, wherein the carbodiimidie-based compound is a compound having at least one methane diimine (—N═C═N—) in the molecule.

4. The method according to claim 1, wherein the aminosilane compound is contained at 0.000001 to 30 parts by weight with respect to 100 parts by weight of the total composition.

5. The method according to claim 1, wherein the carbodiimide-based compound is contained at 0.001 to 20 parts by weight with respect to 100 parts by weight of the total composition.

6. The method according to claim 1, wherein the solvent consists of water.

Description

EXAMPLES 1 TO 12 AND COMPARATIVE EXAMPLES 1 TO 4

[0069] Shampoo compositions for enhancing the strength of a hair protein according to Examples 1 to 12 and Comparative Examples 1 to 4 were prepared with compositions and contents shown in Tables 1 and 2 below. Hair was thoroughly washed with each of the prepared shampoo compositions, and then about 3 g of a towel-dried hair tress was prepared, and therefrom, 50 strings of the hair were randomly extracted to measure a tensile strength using a hair tensile strength tester, and the result was determined to be hair tensile strength before use of the composition. Shampooing was performed 30 times on the specimens prepared from the same tress using 0.3 g of each composition, and then subjected to the measurement of tensile strength to evaluate strength variations. The results obtained from the all compositions were compared.

TABLE-US-00001 TABLE 1 Example Example Example Example Example Example (Parts by weight) 1 2 3 4 5 6 Water To To To To To To 100 100 100 100 100 100 Polyquaternium-10 0.5 0.5 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 Sodium Lauryl 35 35 35 35 35 35 Ether(2mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 3- 0.5 — — — 0.5 — aminopropyltriethoxysilane 3- — 0.5 — — — 0.5 aminopropylmethyldiethoxysilane 3- — — 0.5 — — — aminopropyldimethylethoxysilane p- — — — 0.5 — — aminophenyltriethoxysilane Benzene,1,3-bis(1- 1 1 1 1 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- — — — — 1 1 isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — — — yl)(dimethylamino)methylene]- N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — — yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100 Example Example Example Example Example Example (Parts by weight) 7 8 9 10 11 12 Water To To To To To To 100 100 100 100 100 100 Polyquaternium-10 0.5 0.5 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 Sodium Lauryl 35 35 35 35 35 35 Ether(2mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 3- — — 0.2 0.2 0.5 0.5 aminopropyltriethoxysilane 3- — — 0.2 0.2 — — aminopropylmethyldiethoxysilane 3- 0.5 — 0.2 0.2 — — aminopropyldimethylethoxysilane p- — 0.5 0.2 0.2 — — aminophenyltriethoxysilane Benzene,1,3-bis(1- — — — 0.5 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- 1 1 1 0.5 — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — 1 — yl)(dimethylamino)methylene]- N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — 1 yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100

TABLE-US-00002 TABLE 2 Comparative Comparative Comparative Comparative (Parts by weight) Example 1 Example 2 Example 3 Example 4 Water To 100 To 100 To 100 To 100 Polyquaternium-10 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 Sodium Lauryl Ether(2mole) Sulfate (30%) 35 35 35 35 Cocamidopropyl Betaine (30%) 15 15 15 15 Fragrance 0.9 0.9 0.9 0.9 3-aminopropyl triethoxysilane 0.5 — — — 3-aminopropylmethyldiethoxysilane — 0.5 — — 3-aminopropyldimethylethoxysilane — — 0.5 — p-aminophenyltriethoxysilane — — — 0.5 Benzene, 1,3-bis(1-isocyanato-1- — — — — methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- — — — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether- blocked N-[(1H-benzotriazole-1- — — — — yl)(dimethylamino)methylene]-N- methylmethaneaminium hexafluorophosphate N-oxide Benzotriazole-1-yloxytris(dimethylamino) — — — — phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100 100 100

TABLE-US-00003 TABLE 3 Example Example Example Example Example Example 1 2 3 4 5 6 Tensile 56.3 55.2 53.3 52.9 76.3 75.2 strength increase rate (%) Example Example Example Example Example Example 7 8 9 10 11 12 Tensile 73.4 73 75.8 76.9 55.2 53.1 strength increase rate (%)

TABLE-US-00004 TABLE 4 Comparative Comparative Comparative Comparative Example 1 Example 2 Example 3 Example 4 Tensile 31.6 28.3 25.6 20.3 strength Increase rate (%)

[0070] As shown in Tables 3 and 4, the experiments for the compositions of Examples 1 to 12 and Comparative Examples 1 to 4 showed that, compared to the compositions of Comparative Examples 1 to 4 including only an aminosilane component without a reaction mediator, the compositions including, as a reaction mediator, benzene, 1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 1 to 4 and 10) or 1,1′-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 5 to 10), N-[(1H-benzotriazole-1-yl)(dimethylamino)methylene]-N-methylmethaneaminium hexafluorophosphate N-oxide (Example 11) and benzotriazole-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (Example 12) exhibit a very excellent hair tensile strength enhancement effect after the use of the shampoos.

EXAMPLES 13 TO 24 AND COMPARATIVE EXAMPLES 5 to 8

[0071] Body wash compositions for enhancing elasticity through skin strengthening according to Examples 13 to 24 and Comparative Examples 5 to 8 were prepared with compositions and contents shown in Tables 5 and 6. The initial elasticity of artificial skin was measured, the elasticity of artificial skin after 30 times of use was assessed using each composition prepared previously, and the skin elasticity enhancement effect of the compositions were compared.

TABLE-US-00005 TABLE 5 Example Example Example Example Example Example (Parts by weight) 1 2 3 4 5 6 Water To To To To To To 100 100 100 100 100 100 Polyquaternium-7 0.5 0.5 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 Lauric Acid 3 3 3 3 3 3 Myristic acid 4 4 4 4 4 4 Sodium Lauryl Ether 20 20 20 20 20 20 (2mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 3- 0.5 — — — 0.5 — aminopropyltriethoxysilane 3- — 0.5 — — — 0.5 aminopropylmethyldiethoxysilane 3- — — 0.5 — — — aminopropyldimethylethoxysilane p- — — — 0.5 — — aminophenyltriethoxysilane Benzene, 1,3-bis(1- 1 1 1 1 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- — — — — 1 1 isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — — — yl)(dimethylamino)methylene]- N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — — yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100 Example Example Example Example Example Example (Parts by weight) 7 8 9 10 11 12 Water To To To To To To 100 100 100 100 100 100 Polyquaternium-7 0.5 0.5 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 Lauric Acid 3 3 3 3 3 3 Myristic acid 4 4 4 4 4 4 Sodium Lauryl Ether 20 20 20 20 20 20 (2mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 3- — — 0.2 0.2 0.5 0.5 aminopropyltriethoxysilane 3- — — 0.2 0.2 — — aminopropylmethyldiethoxysilane 3- 0.5 — 0.2 0.2 — — aminopropyldimethylethoxysilane p- — 0.5 0.2 0.2 — — aminophenyltriethoxysilane Benzene,1,3-bis(1- — — — 0.5 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- 1 1 1 0.5 — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — 1 — yl)(dimethylamino)methylene]- N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — 1 yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100

TABLE-US-00006 TABLE 6 Comparative Comparative Comparative Comparative (Parts by weight) Example 5 Example 6 Example 7 Example 8 Water To 100 To 100 To 100 To 100 Polyquaternium-7 0.5 0.5 0.5 0.5 EDTA 4Na 0.05 0.05 0.05 0.05 Lauric Acid 3 3 3 3 Myristic acid 4 4 4 4 Sodium Lauryl Ether (2mole) Sulfate 20 20 20 20 (30%) Cocamidopropyl Betaine (30%) 15 15 15 15 Fragrance 0.9 0.9 0.9 0.9 3-aminopropyltriethoxysilane 0.5 — — — 3-aminopropylmethyldiethoxysilane — 0.5 — — 3-aminopropyldimethylethoxysilane — — 0.5 — p-aminophenyltriethoxysilane — — — 0.5 Benzene, 1,3-bis(1-isocyanato-1- — — — — methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- — — — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether- blocked N-[(1H-benzotriazole-1- — — — — yl)(dimethylamino)methylene]-N- methylmethaneaminium hexafluorophosphate N-oxide Benzotriazole-1-yloxytris(dimethylamino) — — — — phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100 100 100

TABLE-US-00007 TABLE 7 Example Example Example Example Example Example 13 14 15 16 17 18 Skin 23.2 22.1 22 20.9 23.1 22.3 elasticity increase rate (%) Example Example Example Example Example Example 19 20 21 22 23 24 Skin 22.1 20 33.4 34.7 21.7 22.2 elasticity increase rate (%)

TABLE-US-00008 TABLE 8 Comparative Comparative Comparative Comparative Example 5 Example 6 Example 7 Example 8 Skin 10.2 9.8 9.7 8.5 elasticity increase rate (%)

[0072] As shown in Tables 7 and 8, the experiments for the compositions according to Examples 13 to 24 and Comparative Examples 5 to 8 showed that, compared to the compositions of Comparative Examples 5 to 8 including only an amino acid component without a reaction mediator, the compositions including, as a reaction mediator, benzene, 1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 13 to 16 and 22) or 1,1′-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 17 to 22), N-[(1H-benzotriazole-1-yl)(dimethylamino)methylene]-N-methylmethaneaminium hexafluorophosphate N-oxide (Example 23) and benzotriazole-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (Example 24) exhibit a very excellent skin elasticity improvement effect after the use of the body washes.

EXAMPLES 25 TO 36 AND COMPARATIVE EXAMPLES 9 TO 12

[0073] Compositions for strengthening nails according to Examples 25 to 36 and Comparative Examples 9 to 12 were prepared with compositions and contents shown in Tables 9 and 10 below. Each composition was used on 10 consumers for 20 days, and then conditions of nails such as splitting or cracking were compared to those of the initial conditions of the nails, and sensory evaluated on a 5-point scale (5: very good, 4: good, 3: no difference, 2: almost no effect, 1: no effect at all) for comparison.

TABLE-US-00009 TABLE 9 Example Example Example Example Example Example (Parts by weight) 25 26 27 28 29 30 Water To To To To To To 100 100 100 100 100 100 Amodimethicone 0.5 0.5 0.5 0.5 0.5 0.5 18-Methyl Eicosanoic 1 1 1 1 1 1 Acid Isostearylamine 1 1 1 1 1 1 Glycerin 2 2 2 2 2 2 Butylene glycol 2 2 2 2 2 2 Propylene glycol 2 2 2 2 2 2 Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 Carboxyvinyl polymer 0.1 0.1 0.1 0.1 0.1 0.1 Polysolvate 60 1.5 1.5 1.5 1.5 1.5 1.5 Liquid paraffin 5 5 5 5 5 5 Caprylic/capric 2.5 2.5 2.5 2.5 2.5 2.5 triglyceride Squalane 2.5 2.5 2.5 2.5 2.5 2.5 Cetearyl glucoside 2 2 2 2 2 2 Triethanolamine 0.1 0.1 0.1 0.1 0.1 0.1 3- 0.5 — — — 0.5 — aminopropyltriethoxysilane 3- — 0.5 — — — 0.5 aminopropylmethyldiethoxysilane 3- — — 0.5 — — — aminopropyldimethylethoxysilane p- — — — 0.5 — — aminophenyltriethoxysilane Benzene, 1,3-bis(1- 1 1 1 1 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′-methylene-bis-(4 — — — — 1 1 isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — — — yl)(dimethylamino) methylene]-N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — — yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100 Example Example Example Example Example Example (Parts by weight) 31 32 33 34 35 36 Water To To To To To To 100 100 100 100 100 100 Amodimethicone 0.5 0.5 0.5 0.5 0.5 0.5 18-Methyl Eicosanoic 1 1 1 1 1 1 Acid Isostearylamine 1 1 1 1 1 1 Glycerin 2 2 2 2 2 2 Butylene glycol 2 2 2 2 2 2 Propylene glycol 2 2 2 2 2 2 Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 Carboxyvinyl polymer 0.1 0.1 0.1 0.1 0.1 0.1 Polysolvate 60 1.5 1.5 1.5 1.5 1.5 1.5 Liquid paraffin 5 5 5 5 5 5 Caprylic/capric 2.5 2.5 2.5 2.5 2.5 2.5 triglyceride Squalane 2.5 2.5 2.5 2.5 2.5 2.5 Cetearyl glucoside 2 2 2 2 2 2 Triethanolamine 0.1 0.1 0.1 0.1 0.1 0.1 3- — — 0.2 0.2 0.5 0.5 aminopropyltriethoxysilane 3- — — 0.2 0.2 — — aminopropylmethyldiethoxysilane 3- 0.5 — 0.2 0.2 — — aminopropyldimethylethoxysilane p- — 0.5 0.2 0.2 — — aminophenyltriethoxysilane Benzene, 1,3-bis(1- — — — 0.5 — — isocyanato-1- methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′-methylene-bis-(4 1 1 1 0.5 — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- — — — — 1 — yl)(dimethylamino) methylene]-N- methylmethaneaminium hexafluorophosphate N- oxide Benzotriazole-1- — — — — — 1 yloxytris(dimethylamino) phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100

TABLE-US-00010 TABLE 10 Comparative Comparative Comparative Comparative (Parts by weight) Example 9 Example 10 Example 11 Example 12 Water To 100 To 100 To 100 To 100 Amodimethicone 0.5 0.5 0.5 0.5 18-Methyl Eicosanoic Acid 1 1 1 1 Isostearylamine 1 1 1 1 Glycerin 2 2 2 2 Butylene glycol 2 2 2 2 Propylene glycol 2 2 2 2 Fragrance 0.9 0.9 0.9 0.9 Carboxyvinyl polymer 0.1 0.1 0.1 0.1 Polysolvate 60 1.5 1.5 1.5 1.5 Liquid paraffin 5 5 5 5 Caprylic/caprictriglyceride 2.5 2.5 2.5 2.5 Squalane 2.5 2.5 2.5 2.5 Cetearyl glucoside 2 2 2 2 triethanolamine 0.1 0.1 0.1 0.1 3-aminopropyltriethoxysilane 0.5 — — — 3-aminopropylmethyldiethoxysilane — 0.5 — — 3-aminopropyldimethylethoxysilane — — 0.5 — p-aminophenyltriethoxysilane — — — 0.5 Benzene, 1,3-bis(1-isocyanato-1- — — — — methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked 1,1′- methylene-bis-(4- — — — — isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether- blocked N-[(1H-benzotriazole-1- — — — — yl)(dimethylamino)methylene]-N- methylmethaneaminium hexafluorophosphate N-oxide Benzotriazole-1-yloxytris(dimethylamino) — — — — phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100 100 100

TABLE-US-00011 TABLE 11 Example Example Example Example Example Example 25 26 27 28 29 30 Satisfaction 3.7 3.7 3.6 3.8 4.1 4 of nail strength improvement effect (5-point scale) Example Example Example Example Example Example 31 32 33 34 35 36 Satisfaction 4 3.9 4.2 4.4 3.6 3.6 of nail strength improvement effect (5-point scale)

TABLE-US-00012 TABLE 12 Comparative Comparative Comparative Comparative Example 9 Example 10 Example 11 Example 12 Satisfaction of 2.2 2.4 2.2 2.1 nail strength improvement effect (5-point scale)

[0074] As shown in Tables 11 and 12, experiments for the compositions according to Examples 25 to 36 and Comparative Examples 9 to 12 showed that, compared to the compositions of Comparative Examples 9 to 12 including only an amino acid component without a reaction mediator, the compositions including, as a reaction mediator, benzene, 1,3 -bi s(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 25 to 28 and 34) or 1,1′-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 29 to 34), N-[1H-benzotriazole-1-yl)(dimethylamino)methylene]-N-methylmethaneaminium hexafluorophosphate N-oxide (Example 35), and benzotriazole-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (Example 36) exhibit a very excellent nail strength enhancement effect.