NEW DELIVERY SYSTEM FOR FAT SOLUBLE VITAMINS
20220226254 · 2022-07-21
Inventors
Cpc classification
A61K9/5026
HUMAN NECESSITIES
A61K31/59
HUMAN NECESSITIES
A61K9/5036
HUMAN NECESSITIES
A61K31/122
HUMAN NECESSITIES
A61K9/5073
HUMAN NECESSITIES
A61K31/593
HUMAN NECESSITIES
International classification
A61K9/50
HUMAN NECESSITIES
A61K31/122
HUMAN NECESSITIES
A61K31/59
HUMAN NECESSITIES
Abstract
The present invention relates to a new delivery system for fat-soluble vitamins.
Claims
1. Delivery system consisting of (a) a solid core, which comprises at least one fat-soluble vitamin, and (b) an inner coating comprising at least one fermentable biopolymer, which is crosslinked, and (c) an outer coating which is resistant to stomach conditions and releasing in the small intestine.
2. Delivery system according to claim 1, wherein the solid core comprises at least one fat-soluble vitamin chosen from the group consisting of vitamin A, D, E and/or K (as well as derivatives thereof).
3. Delivery system according to claim 1, wherein the material of the inner coating is chosen from group consisting of alginate, chitosan, pectin, cyclodextrin as well as other gums.
4. Delivery system according to claim 1, wherein the inner coating layer is crosslinked with Zn, Mg and/or Ca ions.
5. Delivery system according to claim 1, wherein the outer coating is chosen from group consisting of shellac, methacrylate copolymers and fats.
6. Process of production delivery systems claim 1, wherein the process is carried out batchwise.
7. Process of production delivery systems according to claim 1, wherein the process is carried out continuously.
8. Process for the production of a premix, dietary supplement, food product, feed product, personal care product or pharmaceutical product using at least one delivery systems according to claim 1.
9. Premix, dietary supplement, food product, feed product, personal care product or pharmaceutical product comprising at least one delivery systems according claim 1.
Description
EXAMPLES
Example 1
[0062] 15 g Na-alginate (grinsted sodium alginate) was dissolved in 485 g water at 60° C. with stirring. 31.5 g Ca chloride dihydrate was dissolved in 98.5 g water. 100 g Vitamin E beadlets (containing 44% Vitamin E in a matrix of modified food starch) was filled in a fluid-bed processor (WFP mini, DMR, Wurster configuration). All coating steps were performed at a product temperature between 50 and 60° C. The alginate solution was sprayed on the fluidized Vitamin E powder first. After spraying of the alginate solution, the feeding tube was briefly rinsed with water. The Ca chloride solution was sprayed on the inner coating at 53° C. product temperature for hardening. After the hardening solution, 154 g aqueous shellac preparation with a solids content of 25% (SSB Aquagold, Stroever) was sprayed as outer coating. After spraying of the shellac, the product was dried in the fluid bed. 102 g coated granules were obtained.
[0063] Composition of the final coated granulate was 65% Core material (=29% Vitamin E), 9% alginate, 1% Ca chloride and 25% shellac.