Anti-Aging Formula

Abstract

An anti-aging formula is provided. The anti-aging formula comprises a first microbial blend, a second microbial blend, chondroitin sulfate, vitamin D.sub.3, vitamin E, astragalus, and resveratrol. The first microbial blend comprises one or more lactobacillus bacteria, one or more streptococcus bacteria, one or more bifidobacterium bacteria, and kefir microflora. The second microbial blend comprises one or more lactobacillus bacterium, one or more lactococcus bacteria, and one or more bifidobacterium bacteria. The anti-aging formula is provided as a dietary supplement or drug for human use and is aimed at reversing aging. The formula targets particular genes and proteins that influence the process of aging, including Klotho, telomerase, and sirtuins. In addition, the anti-aging formula induces DNA time dilation, time reversal and quantum entanglement.

Claims

1. An anti-aging formula, comprising: a first microbial blend; a second microbial blend; chondroitin sulfate; vitamin D.sub.3; vitamin E; astragalus; and resveratrol.

2. The anti-aging formula of claim 1, wherein the first microbial blend comprises one or more lactobacillus bacteria; one or more streptococcus bacteria; one or more bifidobacterium bacteria; and kefir microflora.

3. The anti-aging formula of claim 2, wherein the one or more lactobacillus bacteria comprise lactobacillus acidophilus; lactobacillus casei; lactobacillus rhamnosus; lactobacillus reuteri; lactobacillus plantarum; lactobacillus delbruekii; the one or more streptococcus bacteria comprise streptococcus thermophilus; the one or more bifidobacterium bacteria comprise bifidobacterium bifidum; bifidobacterium lactis; and bifidobacterium breve.

4. The anti-aging formula of claim 3, further comprising up to 14.8% wt. lactobacillus acidophilus up to 14.8% wt. lactobacillus casei; up to 14.8% wt. lactobacillus rhamnosus; up to 14.8% wt. lactobacillus reuteri; up to 23.8% wt. lactobacillus plantarum; up to 5.9% wt. lactobacillus delbruekii; up to 5.9% wt. streptococcus thermophilus; up to 1.5% wt. bifidobacterium bifidum; up to 1.5% wt. bifidobacterium lactis; up to 1.5% wt. bifidobacterium breve; and up to 0.75% wt. kefir microflora.

5. The anti-aging formula of claim 1, wherein the second microbial blend comprises one or more lactobacillus bacterium; one or more lactococcus bacteria; and one or more bifidobacterium bacteria.

6. The anti-aging formula of claim 5, wherein the one or more lactobacillus bacteria comprise lactobacillus salivarius; lactobacillus acidophilus; lactobacillus casei; lactobacillus rhamnosus; the one or more lactococcus bacteria comprise lactococcus lactis; the one or more bifidobacterium bacteria comprise bifidobacterium infantis; bifidobacterium bifidum; and bifidobacterium lactis.

7. The anti-aging formula of claim 6, further comprising up to 12.5% wt. lactobacillus salivarius; up to 12.5% wt. lactobacillus acidophilus; up to 12.5% wt. lactobacillus casei; up to 12.5% wt. lactobacillus rhamnosus; up to 12.5% wt. lactococcus lactis; up to 12.5% wt. bifidobacterium infantis; up to 12.5% wt. bifidobacterium bifidum; and up to 12.5% wt. bifidobacterium lactis.

8. The anti-aging formula of claim 1, wherein the formula is formed as one or more vegetarian capsules.

9. An anti-aging formula, comprising a first microbial blend comprising one or more lactobacillus bacteria , one or more streptococcus bacteria, one or more bifidobacterium bacteria, and kefir microflora; a second microbial blend comprising one or more lactobacillus bacteria , one or more lactococcus bacteria, one or more bifidobacterium bacteria; chondroitin sulfate; vitamin D.sub.3; vitamin E; astragalus; and resveratrol.

10. The anti-aging formula of claim 9, further comprising up to 13.1% wt. first microbial blend; up to 13.1% wt. second microbial blend; up to 26.1% wt. chondroitin sulfate; up to 2.6% wt. vitamin D.sub.3; up to 4.9% wt. vitamin E; up to 37.8% wt. astragalus; and up to 2.6% wt. resveratrol.

11. The anti-aging formula of claim 9, wherein the formula is formed as one or more vegetarian capsules.

12. An anti-aging formula, comprising lactobacillus acidophilus; lactobacillus casei; lactobacillus rhamnosus; lactobacillus reuteri; lactobacillus plantarum; lactobacillus delbruekii; lactobacillus salivarius; streptococcus thermophilus; bifidobacterium bifidum; bifidobacterium lactis; bifidobacterium breve; bifidobacterium infantis; lactococcus lactis; kefir microflora; chondroitin sulfate; vitamin D.sub.3; vitamin E; astragalus; and resveratrol.

13. The anti-aging formula of claim 12, further comprising up to 3.66% wt. lactobacillus acidophilus; up to 3.66% wt. lactobacillus casei; up to 3.66% wt. lactobacillus rhamnosus; up to 2.62% wt. lactobacillus reuteri; up to 4.19% wt. lactobacillus plantarum; up to 1.05% wt. lactobacillus delbruekii; up to 1.05% wt. lactobacillus salivarius; up to 1.05% wt. streptococcus thermophilus; up to 1.31% wt. bifidobacterium bifidum; up to 1.31% wt. bifidobacterium lactis; up to 0.26% wt. bifidobacterium breve; up to 1.05% wt. bifidobacterium infantis; up to 1.05% wt. lactococcus lactis; up to 0.13% wt. kefir microflora; up to 26.10% wt. chondroitin sulfate; up to 2.60% wt. vitamin D.sub.3; up to 4.90% wt. vitamin E; up to 37.80% wt. astragalus; and up to 2.60% wt. resveratrol.

14. The anti-aging formula of claim 15, wherein the formula is formed as one or more vegetarian capsules.

Description

DETAILED DESCRIPTION

[0039] Having summarized various aspects of the present disclosure, reference will now be made in detail to certain exemplary embodiments. While the disclosure will be described in connection with these embodiments, there is no intent to limit it to the embodiment or embodiments disclosed herein. Rather, the intent is to cover all alternatives, modifications and equivalents included within the spirit and scope of the disclosure as defined by the appended claims.

[0040] An anti-aging formula is provided that, in some embodiments, may reverse the effects of aging. Specifically, the formula may target specific genes and proteins, including Klotho, telomerase, and sirtuins, which may provide anti-aging benefits. Upregulation of Klotho, telomerase, and sirtuins may enhance healthy aging by, for example, allowing cells to divide without senescence and prolonging apoptosis, or programmed cell death. Moreover, the anti-aging formula may induce DNA time dilation, time reversal, and quantum entanglement, further slowing the progression of aging in cells.

[0041] In certain embodiments, the anti-aging formula may comprise a first microbial blend, a second microbial blend, chondroitin sulfate, vitamin D.sub.3, vitamin E, astragalus, and resveratrol. The first microbial blend and the second microbial blend may synthesize proteins with similar structures and functions to human Klotho, thereby providing an exogenous source of Klotho. The first and second microbial blends may therefore provide anti-aging effects. The first microbial blend may comprise one or more lactobacillus bacteria, one or more streptococcus bacteria, one or more bifidobacterium bacteria, and kefir microflora. The second microbial blend may comprise one or more lactobacillus bacteria, one or more lactococcus bacteria, and one or more bifidobacterium bacteria.

[0042] In some embodiments, the one or more lactobacillus bacteria of the first microbial blend may comprise lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, and lactobacillus delbruekii. One or more of the one or more lactobacillus bacteria may enhance telomerase stimulation, thereby causing anti-aging effects. For example, lactobacillus plantarum may synthesize Foldase protein PrsA 2, which may help post-translocational extracellular folding of secreted proteins and interacts with human Src, a non-receptor protein tyrosine kinase.

[0043] The percentage weight of the one or more lactobacillus bacteria of the first microbial blend may vary. According to certain embodiments, the one or more lactobacillus bacteria may comprise up to 90.0% weight of the first blend. Moreover, each of the lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, and lactobacillus delbruekii may be provided in amounts varying between 5.0% weight to 24.0% weight of the first microbial blend. One of ordinary skill in the art will recognize that each of the one or more lactobacillus bacteria may be provided in other amounts as well. Further, the one or more lactobacillus bacteria may comprise other lactobacillus bacteria not mentioned herein.

[0044] The one or more bifidobacterium bacteria may comprise any bifidobacterium bacteria known in the art. In accordance with some embodiments, the one or more bifidobacterium bacteria of the first microbial blend may comprise bifidobacterium bifidum, bifidobacterium lactis, and bifidobacterium breve. In such embodiments, the one or more bifidobacterium bacteria may comprise up to 5.0% weight of the first microbial blend. In addition, each of the bifidobacterium bifidum, bifidobacterium lactis, and bifidobacterium breve may be provided in amounts varying between 1.0% weight to 2.0% weight of the first microbial blend. Of course, the one or more bifidobacterium may be present in other amounts in following this invention.

[0045] As mentioned previously, the first microbial blend may further comprise one or more streptococcus bacteria and kefir microflora. The one or more streptococcus bacteria may comprise streptococcus thermophilus. The streptococcus thermophilus may secrete signal peptidase 1, a protein that truncates c-Jun, which may, in turn, enhance the effects of resveratrol. The kefir microflora may be cultured from kefir grains in a lactose-free medium. In certain embodiments, the kefir microflora may comprise up to 1.0% and the one or more streptococcus bacteria may comprise up to 6.0% of the first microbial blend.

[0046] According to certain embodiments, each of the bacterium of the one or more lactobacillus bacteria , one or more lactococcus bacteria, and one or more bifidobacterium bacteria may comprise equal percentage weight of the second microbial blend. For instance, each of the bacterium may comprise up to 12.5% weight of the second microbial blend. In other embodiments, the amounts of each of the bacterium may vary and some of the bacterium may be present in quantities proportionately larger than other bacterium.

[0047] The one or more lactobacillus bacteria of the second microbial blend may comprise lactobacillus salivarius, lactobacillus acidophilus, lactobacillus casei, and lactobacillus rhamnosus. In alternate embodiments, the one or more lactobacillus bacteria may comprise other types of lactobacillus bacteria . In embodiments where each of the bacterium of the second microbial blend may be present in equal amounts, the aggregate amount of the one or more lactobacillus bacteria may comprise up to 50% weight of the second microbial blend.

[0048] The second microbial blend may also comprise one or more lactococcus bacteria. In some embodiments, the one or more lactococcus bacteria may comprise lactococcus lactis. In even further embodiments, the lactococcus lactis may further comprise cremoris as a subspecies. In embodiments where each of the bacterium of the second microbial blend may be present in equal amounts and the one or more lactococcus bacteria may comprise lactococcus lactis, the lactococcus lactis may comprise up to 12.5% weight of the second microbial blend.

[0049] The one or more bifidobacterium bacteria of the second microbial blend may comprise bifidobacterium infantis, bifidobacterium bifidum, and bifidobacterium lactis. In alternate embodiments, the second microbial blend may comprise other types of bifidobacterium bacteria. In embodiments where each of the bacterium of the second microbial blend may be present in equal amounts, the one or more bifidobacterium bacteria may comprise up to 37.5% weight of the second microbial blend. The one or more bifidobacterium bacteria may be present in other quantities as well.

[0050] Each of the one or more lactobacillus bacteria, bifidobacterium bacteria, streptococcus bacteria, lactococcus bacteria, and kefir microflora of the first microbial blend and the second microbial blend may provide anti-aging benefits. In addition, each of the aforementioned bacteria may provide health benefits known to be associated with probiotics. As an example, the bacteria of the first microbial blend and the second microbial blend may balance bacteria in the digestive system, boost the immune system, enhance cardiovascular health, and improve mental health.

[0051] Chondroitin sulfate may have a low molecular weight and may be microbially-derived. In such embodiments where chondroitin sulfate may not be derived from animals, chondroitin sulfate may not contain non-negligible amounts of contaminants found in animal-derived chondroitin sulfate. Indeed, in certain embodiments, chondroitin sulfate may be up to 99% pure and also, may be compatible with vegetarian or vegan diets. Moreover, because microbial-derived chondroitin sulfate may be the result of microbial fermentation, the chondroitin sulfate of this anti-aging formula may be more akin to human chondroitin sulfate.

[0052] Chondroitin sulfate may also upregulate Klotho, telomerase, and sirtuins. In some embodiments, chondroitin sulfate may serve as a carrier, favoring bioavailability and targeting of anti-aging proteins. Chondroitin sulfate may form disaccharides through microbial metabolism, which may bind to and enhance biological efficacy of vitamin D.sub.3, vitamin E, astragalus, and resveratrol. In this manner, chondroitin sulfate may enhance the effects of vitamin D.sub.3, vitamin E, astragalus, and resveratrol in upregulating and increasing the activity of Klotho, telomerase, and sirtuins.

[0053] According to some embodiments, chondroitin sulfate may be further involved in relativistic DNA time dilation and DNA/tubulin quantum entanglement. As mentioned before, chondroitin sulfate may form disaccharides which may bind DNA and because of the slowing of time, DNA repair mechanism is provided extra time to repair both genetic and epigenetic mutations. As a result, aging may be slowed at the level of DNA. Moreover, chondroitin sulfate may modify quantum properties of DNA which may result in optimizing the ability for DNA to retain, process, and emit information entangled at quantum level.

[0054] Vitamin D.sub.3, also known as 1,25-dihydroxyvitamin D or cholecalciferol, may be orally available. Vitamin D.sub.3 may upregulate the expression of Klotho, telomerase, and sirtuins. In certain embodiments, vitamin D.sub.3 may associate with a vitamin D receptor. The ability of vitamin D.sub.3 to interact with the vitamin D receptor may be enhanced by Klotho-like proteins synthesized by the first microbial blend and the second microbial blend. Klotho-like proteins bind the vitamin D.sub.3 carrier, thereby displacing vitamin D.sub.3. Once displaced, vitamin D.sub.3 may bind disaccharides formed through microbial metabolism of chondroitin sulfate. In this way, vitamin D.sub.3 may upregulate Klotho and telomerase expression. Additionally, vitamin D.sub.3 may upregulate sirtuins expression via interaction with FoxO proteins.

[0055] Vitamin E may also be orally available and may interact with nuclear receptors in a manner similar to vitamin D.sub.3. In particular, vitamin E may be transported into plasma by a carrier protein, alpha tocopherol transfer protein. The ability of vitamin E to interact with a nuclear receptor may be enhanced by Klotho-like proteins synthesized by the first microbial blend and the second microbial blend. Klotho-like proteins bind the alpha tocopherol transfer protein, thereby displacing vitamin E. Once displaced, vitamin E may bind disaccharides formed through microbial metabolism of chondroitin sulfate.

[0056] In some embodiments, astragalus may activate telomerase which may, in turn, elongate telomeres. Astragalus may be orally available and may upregulate expression of Klotho, telomerase, and sirtuins. Astragalus may also upregulate Klotho, thereby further stimulating telomerase activity. In certain embodiments, astragalus may further comprise cycloastragenol. Cycloastragenol may upregulate telomerase by activating signaling pathways. Cycloastragenol may be further enhanced by interaction with chondroitin sulfate and one or more proteins secreted by the one or more bacteria of the first microbial blend and the second microbial blend.

[0057] Finally, resveratrol may be provided in the anti-aging formula. Resveratrol is a natural polyphenol. Resveratrol may also be orally available and may cause anti-aging effects relating to sirtuins. In particular, resveratrol may upregulate Klotho, telomerase, and sirtuins expression. More specifically, resveratrol may upregulate expression of Klotho through a c-Jun signaling pathway. In this manner, resveratrol may provide an alternative, yet complimentary pathway to activate endogenous Klotho production. Indeed, resveratrol-mediated transcriptional activation of Klotho may act independently of vitamin D.sub.3, vitamin E, and astragalus.

[0058] The anti-aging formula may be formed into any convenient means for human delivery. As one example, the anti-aging formula may be formed as one or more vegetarian capsules. In such embodiments, the one or more vegetarian capsules may comprise hypromellose and gellan gym. The anti-aging formula may be formed into other drug forms, such as tablets. The anti-aging formula may also be formed as a beverage or packaged into a food item. Moreover, the anti-aging formula may be delivered intravenously or via other known means.

[0059] It should be emphasized that the above-described embodiments are merely examples of possible implementations. Many variations and modifications may be made to the above-described embodiments without departing from the principles of the present disclosure. All such modifications and variations are intended to be included herein within the scope of this disclosure and protected by the following claims.

[0060] Moreover, embodiments and limitations disclosed herein are not dedicated to the public under the doctrine of dedication if the embodiments and/or limitations: (1) are not expressly claimed in the claims; and (2) are or are potentially equivalents of express elements and/or limitations in the claims under the doctrine of equivalents.

EXAMPLES OF THE PREFERED EMBODIMENTS

[0061] In order to more fully teach what the Applicants regards as their invention, the following examples of the certain embodiments of this invention are given. It should be understood that the formulations set forth in these Examples are not to be construed as limiting the scope of the invention, except so far as they comprise an anti-aging formula having the desired properties and characteristics. The following ingredients are an example of embodiments of Applicant's invention with the percentages being given by weight of the composition:

Example 1: Anti-Aging Formula

[0062]

TABLE-US-00001 Ingredient Percentage Vitamin D.sub.3 2.60 Vitamin E 4.89 Chondroitin sulfate 26.06 First microbial blend 13.03 Second microbial blend 13.03 Astragalus 37.78 Resveratrol 2.60

Example 2: First Microbial Blend

[0063]

TABLE-US-00002 Ingredient Percentage Lactobacillus acidophilus 14.81 Lactobacillus casei 14.81 Lactobacillus rhamnosus 14.81 Lactobacillus reuteri 14.81 Lactobacillus plantarum 23.70 Lactobacillus delbruekii 5.93 Streptococcus thermophilus 5.93 Bifidobacterium bifidum 1.48 Bifidobacterium lactis 1.48 Bifidobacterium breve 1.48 Kefir 0.74

Example 3: Second Microbial Blend

[0064]

TABLE-US-00003 Ingredient Percentage Lactobacillus salivarius 12.5 Lactobacillus acidophilus 12.5 Lactobacillus casei 12.5 Lactobacillus rhamnosus 12.5 Lactococcus lactis 12.5 Bifidobacterium infantis 12.5 Bifidobacterium bifidum 12.5 Bifidobacterium lactis 12.5

CONCLUSIONS, RAMIFICATIONS, AND SCOPE

[0065] While certain embodiments of the invention have been illustrated and described, various modifications are contemplated and can be made without departing from the spirit and scope of the invention. For example, various types of lactobacillus bacteria, bifidobacterium bacteria, streptococcus bacteria, and lactococcus bacteria may be used in accordance with this invention. As another example, while the anti-aging formula has been described as being formed into a vegetarian capsule, the anti-aging formula may take virtually any consumable form. Accordingly, it is intended that the invention not be limited, except as by the appended claims.

[0066] The teachings disclosed herein may be applied to other systems, and may not necessarily be limited to any described herein. The elements and acts of the various embodiments described above can be combined to provide further embodiments. All of the above patents and applications and other references, including any that may be listed in accompanying filing papers, are incorporated herein by reference. Aspects of the invention can be modified, if necessary, to employ the systems, functions and concepts of the various references described above to provide yet further embodiments of the invention.

[0067] Particular terminology used when describing certain features or aspects of the invention should not be taken to imply that the terminology is being refined herein to be restricted to any specific characteristics, features, or aspects of the anti-aging formula with which that terminology is associated. In general, the terms used in the following claims should not be constructed to limit the anti-aging formula to the specific embodiments disclosed in the specification unless the above description section explicitly define such terms. Accordingly, the actual scope encompasses not only the disclosed embodiments, but also all equivalent ways of practicing or implementing the disclosed formula. The above description of embodiments of the anti-aging formula is not intended to be exhaustive or limited to the precise form disclosed above or to a particular field of usage.

[0068] While specific embodiments of, and examples for, the formula are described above for illustrative purposes, various equivalent modifications are possible for which those skilled in the relevant art will recognize.

[0069] While certain aspects of the formula disclosed are presented below in particular claim forms, various aspects of the formula are contemplated in any number of claim forms. Thus, the inventor reserves the right to add additional claims after filing the application to pursue such additional claim forms for other aspects of the anti-aging formula.