ACCOMMODATION CASE, ACCOMMODATION CASE STACK, AND METHOD OF OPERATING MICROFLUIDIC DEVICE
20210395673 · 2021-12-23
Inventors
- Hidetoshi TAKAYAMA (Kanagawa, JP)
- Koju Ito (Kanagawa, JP)
- Takahiro Oba (Kanagawa, JP)
- Keisuke OKU (Kanagawa, JP)
Cpc classification
H02J50/502
ELECTRICITY
B01L2200/025
PERFORMING OPERATIONS; TRANSPORTING
B01L7/00
PERFORMING OPERATIONS; TRANSPORTING
B01L2200/147
PERFORMING OPERATIONS; TRANSPORTING
B01L2200/141
PERFORMING OPERATIONS; TRANSPORTING
B01L2300/046
PERFORMING OPERATIONS; TRANSPORTING
C12M43/08
CHEMISTRY; METALLURGY
H02J50/005
ELECTRICITY
B01L2300/023
PERFORMING OPERATIONS; TRANSPORTING
H02J50/70
ELECTRICITY
B01L9/527
PERFORMING OPERATIONS; TRANSPORTING
B01L3/502715
PERFORMING OPERATIONS; TRANSPORTING
International classification
C12M3/06
CHEMISTRY; METALLURGY
H02J50/00
ELECTRICITY
Abstract
There is provided an accommodation case (1) having a first wall part (33) in which a power supply unit (40) that transmits electric power to a power supply destination in a noncontact state is provided, a second wall part (34) in which a power reception unit (50) that receives electric power that is supplied from a power supply source in a noncontact state is provided, where the second wall part (34) faces the first wall part (33), and an accommodation space (35) that is surrounded by a plurality of wall parts including the first wall part (33) and the second wall part (34).
Claims
1. An accommodation case comprising: a first wall part in which a power supply unit that transmits electric power to a power supply destination in a noncontact state is provided; a second wall part in which a power reception unit that receives electric power that is supplied from a power supply source in a noncontact state is provided, the second wall part facing the first wall part; and an accommodation space that is surrounded by a plurality of wall parts including the first wall part and the second wall part.
2. The accommodation case according to claim 1, further comprising: a moisture-proof mechanism for preventing infiltration of aqueous moisture into the accommodation space.
3. The accommodation case according to claim 1, wherein the first wall part is arranged in an upper part of the accommodation space, and the second wall part is arranged in a lower part of the accommodation space.
4. The accommodation case according to claim 1, wherein the power supply unit is arranged at a position spaced apart from an outer edge of the first wall part, and the power reception unit is arranged at a position spaced apart from an outer edge of the second wall part.
5. The accommodation case according to claim 1, wherein at least one of the plurality of wall parts has a shielding part that shields electromagnetic waves radiated from the power supply unit and the power reception unit.
6. The accommodation case according to claim 1, further comprising: an access port for accessing an accommodated object that is accommodated in the accommodation space.
7. An accommodation case stack in which a first accommodation case and a second accommodation case are stacked, in which each of the first accommodation case and the second accommodation case has; a first wall part in which a power supply unit that transmits electric power to a power supply destination in a noncontact state is provided, a second wall part in which a power reception unit that receives electric power that is supplied from a power supply source in a noncontact state is provided, the second wall part facing the first wall part, and an accommodation space that is surrounded by a plurality of wall parts including the first wall part and the second wall part, wherein the first wall part of the first accommodation case and the second wall part of the second accommodation case are adjacent to each other.
8. A method of operating a microfluidic device, which uses the accommodation case according to claim 1, the method comprising: accommodating an electric device that is operated by receiving electric power that is supplied from the power reception unit, in the accommodation space of the accommodation case; connecting the microfluidic device to the electric device; and arranging the accommodation case in which the electric device is accommodated and the microfluidic device in an incubator to operate the microfluidic device.
9. A method of operating a microfluidic device, which uses the accommodation case stack according to claim 7, the method comprising: accommodating a first electric device that is operated by receiving electric power that is supplied from the power reception unit that is provided on the second wall part of the first accommodation case, in the accommodation space of the first accommodation case; accommodating a second electric device that is operated by receiving electric power that is supplied from the power reception unit that is provided on the second wall part of the second accommodation case, in the accommodation space of the second accommodation case; connecting a first microfluidic device to the first electric device; connecting a second microfluidic device to the second electric device; and arranging the first accommodation case in which the first electric device is accommodated, the second accommodation case in which the second electric device is accommodated, the first microfluidic device, and the second microfluidic device in an incubator to operate the first microfluidic device and the second microfluidic device.
10. The method of operating a microfluidic device according to claim 9, wherein the first electric device communicates with the second electric device.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Exemplary embodiments according to the technique of the present disclosure will be described in detail based on the following figures, wherein:
[0024]
[0025]
[0026]
[0027]
[0028]
[0029]
[0030]
[0031]
DETAILED DESCRIPTION
[0032] Hereinafter, embodiments of the present invention will be described with reference to the drawings. In each of the drawings, substantially the same or equivalent configuration elements or parts are designated by the same reference numeral.
First Embodiment
[0033]
[0034] The accommodation case 30 includes a lid 31 having a first wall part 33, and a main body 32 having a second wall part 34 facing the first wall part 33. Further, the accommodation case 30 has an accommodation space 35 that is surrounded by a plurality of wall parts including the first wall part 33 and the second wall part 34. The first wall part 33 is arranged at the upper part of the accommodation space 35, and the second wall part 34 is arranged at the lower part of the accommodation space 35. The lid 31 is provided attachably and detachably with respect to the main body 32. The lid 31 and the main body 32 are made of, for example, an insulator such as plastic. The shape of the accommodation case 30 is not particularly limited; however, it is typically a rectangular parallelepiped shape.
[0035] The accommodation case 30 has a moisture-proof mechanism that suppresses the infiltration of aqueous moisture into the accommodation space 35. Specifically, the lid 31 has a groove 31A provided along the outer edge part thereof, and the upper end portion of the main body 32 is fitted into the groove 31A to seal the accommodation space 35, whereby it is suppressed that aqueous moisture infiltrates the inside of the accommodation space 35. A sealing member such as an O-ring, packing, or gasket may be provided at a portion where the lid 31 comes into contact with the main body 32 to enhance the moisture-proof function.
[0036] Further, the accommodation case 30 includes a power supply unit 40 that is provided on the first wall part 33 and a power reception unit 50 that is provided on the second wall part 34. More specifically, the power supply unit 40 is attached on the surface of the first wall part 33 on the side of the accommodation space 35, and the power reception unit 50 is attached on the surface of the second wall part 34 on the side of the accommodation space 35.
[0037] The power supply unit 40 is a wireless power supply unit that transmits electric power to a power supply destination in a noncontact state. As the electric power transmission method in the power supply unit 40, a magnetic field coupling method such as an electromagnetic coupling method or a magnetic field resonance method is applied. Accordingly, the power supply unit 40 has a configuration in which a power transmission coil (not illustrated in the drawing) is included. The wireless power supply by a magnetic field coupling method is a method of contactlessly transmitting electric power in which a power reception coil receives a magnetic field generated by a power transmission coil. As the power supply unit 40, for example, a power supply unit having an output of about 100 kHz to several hundred kHz and 5 W to 15 W according to the Qi standard is used. As the power supply destination of the power supply unit 40, as will be described later, a power reception unit that is provided in another accommodation case stacked on the accommodation case 30 is considered.
[0038] The power reception unit 50 is a wireless power reception unit that receives electric power that is supplied from a power supply source in a noncontact state. The electric power transmission method in the power reception unit 50 is the same as that in the power supply unit 40. The power reception unit 50 has a configuration in which a power reception coil (not illustrated in the drawing) that receives a magnetic field generated by a power transmission coil of a power supply source is included. As the power supply source that receives electric power supplied by the power reception unit 50, as will described later, a power supply unit that is provided in another accommodation case arranged under the accommodation case 30 or a power supply unit that is provided on a stage of an incubator, on which the accommodation case 30 is placed is considered.
[0039] The power supply unit 40 is arranged at a position spaced apart from the outer edge of the first wall part 33 by a predetermined distance X1. Similarly, the power reception unit 50 is arranged at a position spaced apart from the outer edge of the second wall part 34 by a predetermined distance X2. The distance X1 and the distance X2 are each preferably 10 mm or more.
[0040] The accommodation case 30 has a power supply port 36 for supplying electric power to the power supply unit 40. In a case where the power supply unit 40 receives electric power through the power supply port 36 and a power supply line 41, a current flows through a power transmission coil (not illustrated in the drawing), whereby a magnetic field is generated. In addition, the accommodation case 30 has an access port 37 for accessing an accommodated object that is accommodated in the inside of the accommodation space 35.
[0041]
[0042]
[0043] An accommodation case 30B is stacked on an accommodation case 30A, and an accommodation case 30C is stacked on the accommodation case 30B. That is, the first wall part 33 of the accommodation case 30A and the second wall part 34 of the accommodation case 30B are adjacent to each other, and the first wall part 33 of the accommodation case 30B and the second wall part 34 of the accommodation case 30C are adjacent to each other.
[0044] Since the first wall part 33 of the accommodation case 30A and the second wall part 34 of the accommodation case 30B are adjacent to each other, the power supply unit 40 that is provided in the accommodation case 30A and the power reception unit 50 that is provided in the accommodation case 30B are adjacent to each other, and electric power can be transmitted between the power supply unit 40 that is provided in the accommodation case 30A and the power reception unit 50 that is provided in the accommodation case 30B with relatively high transmission efficiency. The electric device 60 that is accommodated in the accommodation case 30B is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30B.
[0045] Since the first wall part 33 of the accommodation case 30B and the second wall part 34 of the accommodation case 30C are adjacent to each other, the power supply unit 40 that is provided in the accommodation case 30B and the power reception unit 50 that is provided in the accommodation case 30C are adjacent to each other, and electric power can be transmitted between the power supply unit 40 that is provided in the accommodation case 30B and the power reception unit 50 that is provided in the accommodation case 30C with relatively high transmission efficiency. The electric device 60 that is accommodated in the accommodation case 30C is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30C.
[0046] The power reception unit 50 that is provided in the accommodation case 30A receives electric power that is supplied from, for example, a power supply unit that is provided on the stage of the incubator in which the accommodation case stack 300 is placed. The electric device 60 that is accommodated in the accommodation case 30A is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30A.
[0047] In the accommodation case 30A that is arranged at the lowermost part, the power reception unit 50 may not be provided. In this case, an operation without accommodating the electric device 60 in the accommodation case 30A is considered. Further, in the accommodation case 30C that is arranged at the uppermost part, the power supply unit 40 may not be provided.
[0048]
[0049] The microfluidic device 110 has a micro flow channel 111 that is formed by using a microfabrication technology such as MEMS technology, an inflow port 112 that is provided at one end of the micro flow channel 111, and an outflow port 113 that is provided at the other end of the micro flow channel 111. Further, the microfluidic device 110 has an electrode 114 that is provided in the middle of the micro flow channel 111. In cell culture using the cell culture system 100, cells are arranged inside the micro flow channel 111, and then the cells are cultured.
[0050] The storage container 120 is connected to the inflow port 112 through the pipe 130. The pump 121 and the flow rate sensor 122 are provided in the middle of the pipe 130. The storage container 120 stores a liquid such as a medium, additives, and reagents, which is used for culturing cells accommodated in the microfluidic device 110. The cell culture system 100 may have a plurality of storage containers respectively storing a plurality of different kinds of liquids or may have a configuration such that liquids accommodated inside a plurality of storage containers can be selectively supplied to the microfluidic device 110.
[0051] The pump 121 carries out feeding of a liquid such as a medium stored in the storage container 120. In a case where the pump 121 is driven, the liquid accommodated in the storage container 120 is supplied to the micro flow channel 111 through the inflow port 112. The flow rate sensor 122 detects the flow rate of the liquid supplied to the microfluidic device 110 per unit time and outputs a detection signal indicating the detected flow rate. The liquid supplied to the micro flow channel 111 flows out from the outflow port 113 and is collected in the waste liquid container 123 through the pipe 130.
[0052] The impedance measuring instrument 124 is connected to the electrode 114 that is provided in the middle of the micro flow channel 111 and outputs an impedance value depending on the state of cells that are cultured on the micro flow channel 111 based on an electric signal supplied from the electrode 114. The above impedance value may correspond to, for example, a transepithelial electrical resistance value.
[0053] The system control unit 125 controls the drive of the pump 121 based on the detection signal output from the flow rate sensor 122. That is, the system control unit 125 controls the feeding amount of liquid in the pump 121 so that the flow rate of the liquid per unit time, which is indicated by the detection signal output from the flow rate sensor 122, becomes a predetermined value. Further, the system control unit 125 carries out control for recording the impedance value measured by the impedance measuring instrument 124 and transmitting it to the external system.
[0054] The electric device including the pump 121, the flow rate sensor 122, the impedance measuring instrument 124, and the system control unit 125 is operated by receiving electric power that is supplied from the power reception unit 50.
[0055]
[0056] The incubator 1 has the accommodation space 2 shielded from the external environment. The incubator 1 has a controller 10, a humidifying unit 11, a heater 12, a CO.sub.2 controller 13, a temperature sensor 14, and a CO.sub.2 sensor 15 as environmental control units for controlling the environment of the accommodation space 2.
[0057] The temperature sensor 14 is provided inside the accommodation space 2, detects the temperature in the accommodation space 2, and supplies a detection signal indicating the detected temperature to the controller 10. The CO.sub.2 sensor 15 is provided inside the accommodation space 2, detects the CO.sub.2 concentration in the accommodation space 2, and supplies a detection signal indicating the detected CO.sub.2 concentration to the controller 10.
[0058] The controller 10 controls the heater 12 so that the temperature in the accommodation space 2 becomes the temperature specified by a user, based on the temperature detected by the temperature sensor 14. Further, the controller 10 controls the CO.sub.2 controller 13 so that the CO.sub.2 concentration in the accommodation space 2 becomes the concentration specified by a user, based on the CO.sub.2 concentration detected by the CO.sub.2 sensor 15. The CO.sub.2 controller 13 is connected to a CO.sub.2 cylinder 16, which is installed outside the incubator 1, through a pipe 17, and adjusts the amount of CO.sub.2 gas that is released into the inside of the accommodation space 2 based on the control by the controller 10, where the CO.sub.2 gas is supplied from the CO.sub.2 cylinder 16.
[0059] The humidifying unit 11 has a configuration in which a vat in which water is stored is included, and the humidity in the accommodation space 2 is maintained above a predetermined value due to the spontaneous vaporization of the water in the vat.
[0060] A stage 20 is provided in the accommodation space 2. A plurality of power supply units 45 are provided on the stage 20. As each of the power supply units 45, the power supply unit the same as the power supply unit 40 that is provided in the accommodation case 30 is used.
[0061] On the stage 20, the accommodation case stacks 300 are arranged at positions matching with the respective power supply units 45. In the example illustrated in
[0062] Each of the power supply units 40 accommodated in the accommodation case 30 and each of the power supply units 45 provided on the stage 20 are connected to the power source unit 70 through the power supply line 41, and electric power is supplied from the power source unit 70, whereby a current flows to the power transmission coil (not illustrated in the drawing) to generate a magnetic field. In the example illustrated in
[0063] The power source unit 70 is arranged in a shielded space 4 that is shielded from the accommodation space 2. The humidity in the shielded space 4 is set to be the same level as that of the humidity outside the incubator 1 and is lower than the humidity in the accommodation space 2 that is maintained at a relatively high humidity. Since the power source unit 70 is arranged in the shielded space 4, the power source unit 70 is prevented from being exposed to a high humidity environment, and the occurrence of problems such as electric leakage is suppressed. The power supply line 42 for supplying electric power to the power source unit 70 is led out to the outside of the incubator 1 through the power supply port 3 that is provided on the wall surface of the incubator 1. Here, in a case where the number of power supply lines that are led out to the outside of the incubator 1 is increased, the risk of foreign matters such as dust and bacteria being mixed into the inside of the accommodation space 2 of the incubator 1 increases. In a case where electric power is distributed from the power source unit 70 accommodated inside the incubator 1 to a plurality of power supply units 40 and power supply units 41 through the power supply line 41, the number of power supply lines that are led out to the outside of the incubator 1 can be reduced to one, and thus the risk of the inside of the accommodation space 2 being contaminated can be suppressed.
[0064] The power reception unit 50 that is provided in the accommodation case 30A arranged at the lowermost part of the accommodation case stack 300 receives electric power that is supplied from the power supply unit 45 that is provided on the stage 20. In a case where the electric device 60 that is accommodated in the accommodation case 30A arranged at the lowermost part of the accommodation case stack 300 is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30A, whereby the above electric device 60 connected to the microfluidic device 110 is operated.
[0065] The power reception unit 50 that is provided in the accommodation case 30B stacked on the accommodation case 30A receives electric power that is supplied from the power supply unit 40 that is provided in the accommodation case 30A. In a case where the electric device 60 that is accommodated in the accommodation case 30B is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30B, whereby the above electric device 60 connected to the microfluidic device 110 is operated.
[0066] The power reception unit 50 that is provided in the accommodation case 30C stacked on the accommodation case 30B receives electric power that is supplied from the power supply unit 40 that is provided in the accommodation case 30B. In a case where the electric device 60 that is accommodated in the accommodation case 30C is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the accommodation case 30C, whereby the above electric device 60 connected to the microfluidic device 110 is operated.
[0067] As described above, the first aspect of the method of operating the microfluidic device 110 according to the embodiment of the disclosed technology is realized by using the accommodation case 30. That is, the method of operating the microfluidic device 110 include accommodating the electric device 60 that is operated by receiving electric power that is supplied from the power reception unit 50, in the accommodation space 35 of the accommodation case 30, connecting the microfluidic device 110 to the electric device 60, and arranging the accommodation case in which the electric device 60 is accommodated and the microfluidic device 110 inside the incubator 1, to operate the microfluidic device 110.
[0068] In addition, the second aspect of the method of operating the microfluidic device 110 according to the embodiment of the disclosed technology is realized by using the accommodation case stack 300. That is, the method of operating the microfluidic device 110 includes accommodating a first electric device 60 that is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in a first accommodation case 30, in the accommodation space 35 of the first accommodation case 30, accommodating a second electric device 60 that is operated by receiving electric power that is supplied from the power reception unit 50 that is provided in the second accommodation case 30, in the accommodation space 35 of the second accommodation case that is stacked on the first accommodation case 30, connecting the first microfluidic device 110 to the first electric device 60, connecting the second microfluidic device 110 to the second electric device 60, and arranging the first accommodation case 30 in which the first electric device 60 is accommodated, the second accommodation case 30 in which the second electric device 60 is accommodated, the first microfluidic device 110, and the second microfluidic device 110 inside the incubator 1, to operate the first microfluidic device 110 and the second microfluidic device 110.
[0069] According to the method of operating the accommodation case 30, the accommodation case stack 300, and the microfluidic device 110, according to the embodiment of the disclosed technology, electric power can be transmitted between the upper and lower accommodation cases adjacent to each other since a plurality of accommodation cases 30 are stacked. As a result, the degree of freedom in arranging the power reception unit 50 in the incubator 1 can be increased as compared with the case where the power supply unit is provided only in the stage 20 of the incubator 1. Therefore, it is possible to ensure a degree of freedom in arranging the electric devices 60 such as the sensor and the pump that are operated by receiving electric power that is supplied from the power reception unit 50.
[0070] Further, since the electric device 60 such as the sensor and the pump is accommodated in the accommodation case 30, the electric device 60 is not exposed to a high humidity environment in the incubator 1, and thus it is possible to suppress the risk of damaging electric devices due to moisture. In a case where the accommodation case 30 has a moisture-proof mechanism for preventing infiltration of aqueous moisture into the inside of the accommodation space 35, it is possible to enhance the effect of suppressing the risk of damage.
[0071] In addition, the power supply unit 40 is arranged at a position spaced apart from the outer edge of the first wall part 33, and the power reception unit 50 is arranged at a position spaced apart from the outer edge of the second wall part 34. As a result, as illustrated in
[0072] In the above embodiment, the case where each of the cell culture systems 100 is provided to correspond to each of the accommodation cases 30 is illustrated; however, the present invention is not limited to this aspect. That is, a plurality of electric devices constituting one cell culture system 100 may be dispersedly accommodated in a plurality of accommodation cases 30. In this case, in a case where a part or all of the plurality of electric devices dispersedly accommodated in the plurality of accommodation cases 30 are connected to the microfluidic device 110, the microfluidic device 110 is operated.
[0073] Further, in the above embodiment, a case where the power reception unit 50 is provided in the accommodation case 30A that is arranged at the lowermost part of the accommodation case stack 300, and the electric power supply to the power reception unit 50 is carried out by the power supply unit 45 that is provided on the stage 20; however, the present invention is not limited to this aspect. For example, the power supply unit 45 may not be provided on the stage 20. In this case, the power reception unit 50 may not be provided in the accommodation case 30A that is arranged at the lowermost part of the accommodation case stack 300, or the electric device 60 may not be accommodated in the accommodation case 30A. Further, in the accommodation case 30C that is arranged at the uppermost part of the accommodation case stack 300, the power supply unit 40 may not be provided.
[0074] Further, as illustrated in
Second Embodiment
[0075]
[0076] As described above, since the accommodation case 30A has the shielding part 90, it is possible to suppress the leakage of electromagnetic waves radiated from the power supply unit 40 and the power reception unit 50 to the outside of the accommodation case 30A. This makes it possible to suppress a risk that the electric device that is provided outside the accommodation case 30A malfunctions due to the electromagnetic waves radiated from the power supply unit 40 and the power reception unit 50.
[0077] The accommodation case stack 300 may have a configuration in which the accommodation case 30A according to the present embodiment is included. In addition, the electric device 60 that is operated by receiving electric power that is supplied from the power reception unit 50 may be accommodated in the accommodation space 35 of the accommodation case 30A according to the present embodiment, the microfluidic device 110 may be connected to the electric device 60, and the accommodation case 30A in which the electric device 60 is accommodated and the microfluidic device 110 may be arranged inside the incubator 1, to operate the microfluidic device 110.
[0078] The disclosure of JP2019-044497 filed on Mar. 12, 2019, is incorporated in the present specification in its entirety by reference. In addition, all documents, patent applications, and technical standards described in the present specification are incorporated in the present specification by reference, to the same extent as in the case where each of the documents, patent applications, and technical standards is specifically and individually described.