NEW POLYOL POLYRHAMNOSIDES, PROCESS FOR THE PREPARATION THEREOF, AND COSMETIC AND/OR PHARMACEUTICAL COMPOSITION COMPRISING SAME

Abstract

Disclosed is a composition based on a polyol of formula: HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—OH and on alkyl polyrhamnosides of formula: HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—O-(Rham).sub.x-H; process for preparing same, and cosmetic or pharmaceutical composition including same.

Claims

1. A composition (C.sub.1) comprising, per 100% of mass: (1)—an amount of greater than 0% by mass and less than or equal to 25% by mass of a polyol of formula (I):
HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—OH  (I); in which formula (I) m represents an integer equal to 2, 3 or 4; (2)—an amount of greater than 0% by mass and less than or equal to 30% by mass of one or more anhydrides of said polyol of formula (I); (3)—from 60% by mass to 95% by mass of a composition (C.sub.R) represented by formula (II):
HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—O-(Rham).sub.x-H  (II), in which formula (II) Rham represents the rhamnose residue, m is as defined previously in formula (I) and x, which indicates the average degree of polymerization of said Rham residue, represents a decimal number greater than 1.0 and less than or equal to 2.5; and (4)—an amount of greater than 0% by mass and less than or equal to 5% by mass of rhamnose.

2. The composition (C.sub.1) as defined in claim 1, for which, in formulae (I) and (II), m represents the number 2.

3. The composition (C.sub.1) as defined in claim 1, for which, in formulae (I) and (II), m represents the number 3.

4. The composition (C.sub.1) as defined in claim 3, comprising, per 100% of mass: (1)—up to 25% by mass of the compound of formula:
HO—CH.sub.2—(CHOH).sub.3—CH.sub.2—OH (2)—up to 5% by mass of the compound of formula (B.sub.12): ##STR00003## and (3)—from 70% by mass to 95% by mass of a composition (C.sub.R3) represented by the formula
HO—CH.sub.2—(CHOH).sub.3—CH.sub.2—O-(Rham).sub.x-H; and (4)—up to 2% by mass of rhamnose.

5. The composition (C.sub.1) as defined in claim 1, for which, in formulae (I) and (II), m represents the number 4.

6. The composition (C.sub.1) as defined in claim 5, comprising, per 100% of mass: (1)—up to 25% by mass of the compound of formula:
HO—CH.sub.2—(CHOH).sub.4—CH.sub.2—OH; (2)—up to 30% by mass of the compound of formula (B.sub.13): ##STR00004## alone or in combination with the compound of formula (B.sub.14), ##STR00005## (3)—from 70% by mass to 95% by mass of a composition (C.sub.R4) represented by the formula:
HO—CH.sub.2—(CHOH).sub.4—CH.sub.2—O-(Rham).sub.x-H; and (4)—up to 4% by mass of rhamnose.

7. The composition (C.sub.1) as defined in claim 6, comprising, per 100% of mass: (1)—up to 25% by mass of the compound of formula:
HO—CH.sub.2—(CHOH).sub.4—CH.sub.2—OH; (2)—up to 25% by mass of the compound of formula (B.sub.13) as defined previously; (2′)—up to 5% by mass of the compound of formula (B.sub.14) as defined previously; (3)—from 70% by mass to 95% by mass of a composition (C.sub.R4) represented by the formula:
HO—CH.sub.2—(CHOH).sub.4—CH.sub.2—O-(Rham).sub.x-H; and (4)—up to 2% by mass of rhamnose.

8. A process for preparing the composition (C.sub.1) as defined in claim 1, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

9. A topical cosmetic or dermocosmetic composition (C), comprising an effective amount of composition (C.sub.1) as defined in claim 1.

10. A topical pharmaceutical or dermopharmaceutical composition (C′), comprising an effective amount of composition (C.sub.1) as defined in claim 1.

11. A process for preparing the composition (C.sub.1) as defined in claim 1, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; and a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed.

12. A process for preparing the composition (C.sub.1) as defined in claim 2, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

13. A process for preparing the composition (C.sub.1) as defined in claim 3, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

14. A process for preparing the composition (C.sub.1) as defined in claim 4, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

15. A process for preparing the composition (C.sub.1) as defined in claim 5, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

16. A process for preparing the composition (C.sub.1) as defined in claim 6, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

17. A process for preparing the composition (C.sub.1) as defined in claim 7, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed; and a step d) of neutralizing the solution obtained on conclusion of step d), to obtain said composition (C.sub.1).

18. A process for preparing the composition (C.sub.1) as defined in claim 2, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; and a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed.

19. A process for preparing the composition (C.sub.1) as defined in claim 3, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; and a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed.

20. A process for preparing the composition (C.sub.1) as defined in claim 4, comprising: a step a) of heating, with gentle stirring, the polyol of formula (I) as defined previously, until the polyol is brought to a higher temperature (T.sub.1) of at least 5° C. above a melting point of the polyol; a step b) of dispersing, with stirring, rhamnose monohydrate in the previously molten medium in the desired stoichiometric ratio; and a step c) of acetalization by adding, with stirring, to the liquid medium obtained from step b), a catalytic amount of strong acid, while maintaining all the reaction mixture under partial vacuum and distilling off the water formed.

Description

[0108] The examples that follow illustrate the invention without, however, limiting it.

A)—Preparation of Compositions C.SUB.1 .According to the Invention

[0109] The general procedure for the glycosylation reaction performed for preparing the compositions according to the invention is as follows: [0110] loading the polyol into a reactor equipped with a mechanical stirrer and a vacuum distillation assembly, [0111] loading rhamnose monohydrate in powder form in the stoichiometric proportions indicated in tables 1 and 2 below, [0112] stirring and heating until the rhamnose has totally melted, [0113] placing under partial vacuum to remove the water contained in the rhamnose, [0114] adding the catalytic system 1.0% of H.sub.3PO.sub.2 at 50% (relative to the rhamnose), [0115] heating until the rhamnose has disappeared. [0116] If necessary, neutralizing the medium with sodium hydroxide/sodium borohydride mixture, depending on the viscosity of the reaction medium.

TABLE-US-00001 Operating conditions Initial proportion of xylitol 1 molar eq. 1 molar eq. Initial proportion of rhamnose 1.25 molar eq. 3.33 molar eq. Catalyst H.sub.3PO.sub.2 H.sub.3PO.sub.2 Acylation temperature 135° C. 135° C. Characteristic of the composition obtained (mass %) Composition (C.sub.1A) Composition (C.sub.1B) Xylityl polyrhamnoside 74.2% 89.2% Mean degree of polymerization (*) 1.64 2.06 Xylitan 2.2% 0.2% Xylitol 22.7% 7.6% Residual rhamnose 0.6% 3.0% Water 0.3% n.d.

TABLE-US-00002 Operating conditions Initial proportion of sorbitol 1 molar eq. 1 molar eq. Initial proportion of sorbitan 0 0 Initial proportion of rhamnose 1.25 molar eq. 3.00 molar eq. Catalyst H.sub.3PO.sub.2 H.sub.3PO.sub.2 Acylation temperature 135° C. 135° C. Characteristic of the composition obtained (mass %) Composition (C.sub.1C) Composition (C.sub.1D) Sorbityl/sorbitan/isosorbide 74.4%  87.7% polyrhamnoside Mean degree of polymerization* 1.62 2.01 Sorbitan 1.1% nd Isosorbide .sup. 0% nd Sorbitol 23.6%  9.8% Residual rhamnose 0.7% 2.2% Water 0.2% 0.3% Operating conditions Initial proportion of sorbitol 0.20 molar eq. 0.20 molar eq. Initial proportion of sorbitan 0.60 molar eq. 0.60 molar eq. Initial proportion of isosorbide 0.20 molar eq. 0.20 molar eq. Initial proportion of rhamnose 1.25 molar eq. 0.6 molar eq. Catalyst H.sub.3PO.sub.2 H.sub.3PO.sub.2 Acylation temperature 135° C. 105° C. Characteristic of the composition obtained (mass %) Composition (C.sub.1E) Composition (C.sub.1F) Sorbityl/sorbitan/isosorbide 73.8% 49.7% polyrhamnoside Mean degree of polymerization* 1.64 1.30 Sorbitan 20.5% 35.2% Isosorbide 2.5% 2.8% Sorbitol 2.8% 1.3% Residual rhamnose 0.4% 3.7% *the mean degree of polymerization of the polyol rhamnosides is obtained from a gas chromatography, followed by: i) determining the mass percentages of each oligomer, ii) normalizing the mass proportions obtained to 100%, iii) converting into molar percentages the normalized mass percentages obtained, and iv) calculating the mean degree of polymerization on the basis of each molar percentage obtained, weighted by the number of rhamnose units in the oligomer under consideration.

B)—Evaluation of the Moisturizing Effect of the Compositions According to the Invention—Measurement of the Production of Hyaluronic Acid on Human Fibroblast Cultures:

[0117] Normal human fibroblasts are seeded and cultured in 96-well plates in 10% FCS (fetal calf serum) culture medium, at 37° C. in a humid atmosphere containing 5% CO.sub.2. When the cells reach 80% of confluence, they are or are not (control) treated with 10 ng/ml of EGF (epidermal growth factor), the positive reference for the model, the two batches of sorbityl rhamnoside at 0.1% in medium containing 2% FCS. Each condition is performed in n=4. At the end of a 72-hour incubation, the amount of hyaluronic acid excreted into the culture supernatant is measured using a specific assay kit (Hyaluronan Duo Set Assay Development Kit—Biotechne); and the amount of protein present in the cell lawns is measured using the BC Assay kit (Interchim). The amount of hyaluronic acid assayed is then expressed relative to the amount of protein per well. Means and standard deviations are calculated per condition and the level of hyaluronic acid production is evaluated by comparing the test conditions with the control condition (untreated cells). The results are collated in the following table:

TABLE-US-00003 Amount of hyaluronic acid produced Mean (ng/μg Standard deviation Difference relative to the protein) (ng/μg protein) control (in %) Control 16.8 1.29  0% EGF (10 ng/ml) 32.29 3.74 95% Composition (C.sub.1F) 21.92 0.93 32% Control 9.57 1.90 — EGF (10 ng/ml) 25.28 2.30 164%  Composition (C.sub.1E) 22.91 1.73 139% 

C) Formulations

[0118] In the following formulas, the percentages are expressed by weight of the formulation.

C.1 Makeup-Removing Fluid for the Face

Formula

[0119]

TABLE-US-00004 Composition (C.sub.1A) 10.00% Methyl paraben 0.15% Phenoxyethanol 0.80% Sepicalm ™ S 1.00% Perfume/Fragrance 0.10% Water qs 100.00%

[0120] Procedure: Mix the various ingredients in the water with magnetic stirring, in the order indicated, and adjust the pH to about 7.

C.2 Infant Hair and Body Shampoo

Formula

[0121]

TABLE-US-00005 A Composition (C.sub.1B) 15.00% Proteol ™ APL 5.00% Sepicide ™ HB 0.50% Perfume/Fragrance 0.10% B Water 20.00% Capigel ™ 98 3.50% C Water qs 100.00% Sepicide ™ CI 0.30% Colorant qs Sodium hydroxide qs pH = 7.2

[0122] Procedure: Mix composition (E.sub.4) with the Proteol™ APL and the Sepicide™ HB (Phase A). Dilute the Capigel™ 98 in a portion of the water and add it to phase A obtained previously (Phase B). Add the rest of the water to phase B, followed by the Sepicide™ CI and the colorant. Adjust the pH of the mixture to about 7.2 with sodium hydroxide.

C.3 Makeup-Removing Wipes for the Eyes

Formula

[0123]

TABLE-US-00006 A Composition (C.sub.1C) 3.00% B Sepicide ™ HB2 0.50% C Sepicalm ™ VG 0.50% Perfume/Fragrance 0.05% D Water qs 100.00%

[0124] Procedure: Mix the ingredients of phase B and those of phase C in phase A until the solution is clear. Add phase D.

C.4 Mild Foaming Gel

Formula

[0125]

TABLE-US-00007 A Composition (C.sub.1D) 8.50% Proteol ™ APL 3.00% Euxyl ™ PE9010 1.00% Perfume/Fragrance 0.10% B Water qs 100.00% Lactic acid qs pH = 6.0

[0126] Procedure: Dissolve the fragrance and the preserving agent Euxyl™ PE9010 in the mixture composed of composition E.sub.4 and the Proteol™ APL (phase A). Add the water and adjust the pH to about 6.0 with lactic acid.

C.5 Regular-Use Shampoo

Formula

[0127]

TABLE-US-00008 A Composition (C.sub.1E) 12.80%  Proteol ™ OAT 5.00% Euxyl ™ PE9010 1.00% Perfume/Fragrance 0.30% Water qs 100.00% B Montaline ™ C40 8.50% Lactic acid qs pH = 6.0

[0128] Procedure: Mix all the ingredients of phase A and, after homogenization, add the Montaline™ C40 and adjust the pH to about 6.0 with lactic acid.

C.6 Ultra-Mild Baby Shampoo

Formula

[0129]

TABLE-US-00009 A Composition (C.sub.1F) 10.00% Amisoft ™ CS-11 4.00% Perfume/Fragrance 0.10% Sepicide ™ HB 0.30% Sepicide ™ CI 0.20% Water qs 100.00% B Water 20.00% Capigel ™ 98 3.50% Tromethamine qs pH = 7.2

[0130] Procedure: Mix all the ingredients of phase A, in the order indicated, until a clear phase A is obtained. Separately, add the Capigel™ 98 to the water and then add this phase B thus prepared to phase A and adjust the pH to 7.2 using tromethamine.

C.7 Baby Cleansing Milk

Formula

[0131]

TABLE-US-00010 A Simulsol ™ 165 2.00% Montanov ™ 202 1.00% Lanol ™ 99 3.00% Dimethicone 1.00% Isohexadecane 3.00% B Water qs 100.00% C Sepiplus ™ 400 0.30% D Composition (C.sub.1E) 6.35% E Sepicide ™ HB 0.30% DMDM Hydantoin 0.20% Perfume/Fragrance 0.10%

[0132] Procedure: Heat, separately, phases A and B constituted by mixing the various constituents. Add phase C to the hot fatty phase and make the emulsion by pouring in the aqueous phase; homogenize for a few minutes with vigorous stirring (by means of a rotor/stator turbomixer). Next, add phase D to the hot emulsion and cool the emulsion with moderate stirring down to room temperature. Add phase E at 40° C.

C.8 Cleansing Powder Lotion for Sensitive Skin

Formula

[0133]

TABLE-US-00011 A Lipacide ™ C8G 0.95% Methyl paraben 0.10% Ethyl paraben 0.024% Propyl paraben 0.0119% Butyl paraben 0.024% Isobutyl paraben 0.0119% Water 20.00% Disodium EDTA 0.10% Triethanolamine 1.38% B Composition (C.sub.1D) 1.80% Perfume/Fragrance 0.10% C Sepicalm ™ S 0.28% Water qs 100.00% Lactic acid qs pH = 5.2 D Micropearl ™ M310 5.00%

[0134] Procedure: Dissolve the ingredients of phase A in the water at 80° C. Separately, dissolve the fragrance in composition (E.sub.4) to prepare phase B. Add the cooled phase A to phase B, then introduce the Sepicalm™ S and the remaining water. Check the final pH and adjust to about 5.2 if necessary. Next, add the Micropearl™ M310.

C.9 Infant Shower Gel

Formula

[0135]

TABLE-US-00012 A Water 56.06% Sepimax ™ Zen 3.00% Sepiplus ™ S 0.80% B Proteol ™ OAT 20.80% Oramix ™ NS 10 9.30% Amonyl ™ 265 BA 5.10% C Composition (C.sub.1C) 2.00% Glyceryl glucoside 1.00% Phenoxyethanol & ethylhexyl glycerol 1.00% Perfume/Fragrance 0.90% Colorant 0.04%

[0136] Procedure: Disperse the Sepimax™ ZEN in the water and stir using a magnetic stirrer equipped with a deflocculator, a counter-rotating impeller and an anchor paddle, until a perfectly smooth gel is obtained. Add the Sepiplus™ S and then stir until the mixture is homogeneous. Next, add the ingredients of phase B, homogenize and individually add the additives of phase C. Adjust the pH to 6.0-6.5.

C.10 BB Cream

Formula

[0137]

TABLE-US-00013 A Easynov ™ 2.30% Lanol ™ 99 1.00% Sepimat ™ H10W 1.00% Ethylhexyl methoxycinnamate 5.00% B Cyclomethicone 6.00% Triethoxycaprylsilane & alumina-silane & titanium oxide 8.00% Red iron oxide & triethoxycaprylsilane 0.24% Yellow iron oxide & triethoxycaprylsilane 0.66% Black iron oxide & triethoxycaprylsilane 0.09% Perfume/Fragrance 0.10% C Water qs 100% Sepinov ™ EMT10 1.20% D Composition (C.sub.1D) 2.00% Sepitonic ™ M3 1.00% Phenoxyethanol & ethylhexyl glycerol 1.00%

[0138] Procedure: Prepare phase B by mixing the various ingredients and homogenize using a mixer equipped with a rotor-stator system at a spin speed of 4500 rpm, for a time of 6 minutes. Prepare phase C by adding the Sepinov™ EMT10 to the mixture of water and glycerol, and homogenize using a mixer equipped with a rotor-stator system at a spin speed of 4000 rpm for 4 minutes. Add phases A and B to phase C, and stir the resulting mixture using a mechanical stirrer equipped with an anchor paddle, at a speed of 30 rpm for 2 minutes, and then at a speed of 50 rpm for 20 minutes. Add the components of phase 5 one by one and stir at a speed of 50 rpm for 25 minutes.

C.11 High-Protection Antisun Spray with an SPF of Greater than 30

Formula

[0139]

TABLE-US-00014 A Montanov ™L 1.00% Montanov ™ 82 1.00% C12-15 Alkyl benzoate 17.00% Dimethicone 3.00% Octocrylene 6.00% Ethylhexyl methoxycinnamate 6.00% Bis(ethylhexyloxyphenol)methoxyphenyltriazine 3.00% Tocopherol 0.05% B Water qs 100% C Simulgel ™ INS 100 0.50% Cyclodimethicone 5.00% D Composition (C.sub.1F) 3.00% Phenoxyethanol & ethylhexyl glycerol 1.00% Perfume/Fragrance 0.20% E Methylenebis(benzotriazolyl) Tetramethylbutylphenol 10.00% 25% Citric acid qs pH = 5

[0140] Sepicalm™ S: Mixture of N-cocoyl amino acids, sarcosine, potassium aspartate and magnesium aspartate;

[0141] Proteol™ APL: Mixture of sodium salts of N-cocoyl amino acids, obtained by acylation of amino acids characteristic of apple juice;

[0142] Sepicide™ HB: Mixture of phenoxyethanol, methyl paraben, ethyl paraben, propyl paraben and butyl paraben, which is a preserving agent;

[0143] Capigel™ 98: Acrylate copolymer;

[0144] Sepicide™ CI: Imidazoline urea, which is a preserving agent;

[0145] Sepicide™ HB: Mixture of phenoxyethanol, methyl paraben, ethyl paraben, propyl paraben, butyl paraben and isobutyl paraben, which is a preserving agent;

[0146] Sepicalm™ VG: Mixture of N-palmitoyl proline in sodium salt form and of extract of Nymphea alba blossom;

[0147] Euxyl™ PE9010: Mixture of phenoxyethanol and ethylhexyl glycerol;

[0148] Proteol™ OAT: Mixture of N-lauryl amino acids obtained by total hydrolysis of oat protein as described in WO 94/26694;

[0149] Montaline™ C40: Chloride salt of monoethanolamine cocamidopropyl betainamide;

Amisoft™ CS-11: Sodium salt of N-cocoyl glutamate;
Simulsol™ 165: Mixture of PEG-100 stearate and glyceryl stearate;
Montanov™ 202 (arachidyl alcohol, behenyl alcohol and arachidyl glucoside), is a self-emulsifying composition such as those described in EP 0 977 626;
Lanol™ 99: Isononyl isononanoate;
Sepiplus™ 400: Self-invertible inverse latex of polyacrylates in polyisobutene and including polysorbate 20, as described in WO 2005/040230;
Lipacide™ C8G: Capryloylglycine sold by the company SEPPIC;
Micropearl™ M310: Crosslinked polymethyl methacrylate polymer in powder form, used as a texture modifier;
Sepimax™ Zen (INCI name: Polyacrylate Crosspolymer-6): Thickening polymer in the form of a powder;
Sepiplus™ S (INCI name: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer & Polyisobutene & PEG-7 Trimethylolpropane Coconut Ether): Self-invertible inverse latex;
Amonyl™ 265 BA (INCI name: cocoyl betaine): foaming amphoteric surfactant;
Sepinov™ EMT10 (INCI name: Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer): Thickening polymer in the form of a powder;
Easynov™ (INCI name: Octyldodecanol and Octyldodecyl Xyloside and PEG-30 Dipolyhydroxystearate): Emulsifying agent of lipophilic tendency;
Sepimat™ H10 FW (INCI name: Methyl Methacrylate Crosspolymer and Squalane): Polymer used as texture agent;
Sepitonic™ M3 (INCI name: Magnesium Aspartate and Zinc Gluconate and Copper Gluconate): Mixture used as free-radical scavenger and energizing agent for cells;
Montanov™ L (INCI name: C14-22 Alcohols and C12-20 Alkylglucoside): Emulsifying agent;
Montanov™ 82 (INCI name: Cetearyl Alcohol and Coco-glucoside): Emulsifying agent;
Simulgel™ INS100 (INCI name: Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer and isohexadecane and Polysorbate 60): Polymeric thickener.