OPHTHALMIC IMPLANT SYSTEM FOR DRUG DELIVERY

Abstract

An ophthalmic implant configured for peri-operative, intra-operative, or post-operative assembly and disassembly. Drug delivery devices may be implanted with an intraocular lens, and later removed and replaced with new drug delivery devices.

Claims

1-24. (canceled)

25. An ophthalmic implant (20) comprising: an IOL assembly (22) and a drug delivery device (30); said IOL assembly (22) comprising a lens (24), a tab (26), and a haptic (28), said IOL assembly (22) characterized by an anterior surface and a posterior surface, said IOL assembly (22) configured for implantation into an eye of a patient with said anterior surface disposed anterior to said posterior surface; said tab (26) extending radially outwardly from the circumference of the lens (24), said tab (26) configured to engage the drug delivery device (30), said haptic (28) extending in a plane of the lens (24), radially outwardly from the lens (24), such that said haptic (28) is configured to hold the IOL assembly (22) in place within a capsular bag of a patient's eye; wherein said drug delivery device (30) comprises a fixation portion (64) having a first compartment, said first compartment having a first aperture sized and dimensioned to receive the tab and secure the drug delivery device (30) to the IOL assembly (22); said first aperture is disposed on a radially inward facing portion of the drug delivery device, such that the drug delivery device, when fixed on the tab, is disposed radially outwardly of the lens and radially outwardly of a portion of the tab; and the drug delivery device (30) further comprises a drug pad comprising a matrix with a therapeutic agent embedded or dispersed within the matrix.

26. The ophthalmic implant (20) of claim 25 wherein: the drug delivery device (30) has an arcuate form, characterized by an inner curve and an outer curve, wherein the first aperture is disposed on inner curve.

27. An ophthalmic implant (20) comprising: an IOL assembly (22) and a drug delivery device (71) and a drug pad (73); said IOL assembly (22) comprising a lens (24), a tab (26), and a haptic (28), said IOL assembly characterized by an anterior surface and a posterior surface, said IOL assembly (22) configured for implantation into an eye of a patient with said anterior surface disposed anterior to said posterior surface; said tab (26) extending from the IOL (24), said tab (26) configured to engage the drug delivery device (71), said haptic (28) extending in a plane of the lens, radially outwardly from the lens, such that said haptic (28) is configured to hold the IOL assembly in place with a capsular bag of a patient's eye; and said drug delivery device (71) comprises fixation portion (64) having a first compartment, and said drug delivery device (30) having a second compartment (72), said first compartment having an aperture sized and dimensioned to receive the tab (26) and secure the drug delivery device (71) to the IOL assembly, said second compartment sized and dimensioned to receive the drug pad (73); wherein the second compartment opens on a radially inward surface of the drug delivery device.

28. The ophthalmic implant (20) of claim 27 wherein: the drug delivery device (71) has an arcuate form, characterized by an inner curve and an outer curve, wherein the first aperture is disposed on the inner curve.

29. The ophthalmic implant (20) of claim 27 wherein: the second compartment (72) is sized relative to the drug pad (73) such that the drug pad (73) may be pulled from the second compartment (72) while the ophthalmic implant (20) is disposed within the eye of the patient .

30. The ophthalmic implant (20) of claim 25 wherein: the tab (26) extends from the lens (24) in the radially outward direction to a distance that is less than the distance that the haptic (28) extends from the lens; and the tab (26) comprises a first radial portion (60), extending radially outwardly from a radially inward location proximate a circumferential edge of the lens, said first radial portion (60) spanning a first arc (61) along the circumferential edge of the IOL and also comprises a second radial portion (62), extending from the first radial portion further radially outwardly and spanning a second arc (63) relative to the circumferential edge of the IOL lens (22L) which is larger than the first arc (61) of the first radial portion.

31. The ophthalmic implant (20) of claim 27 wherein: the tab (26) extends from the lens (24) in the radially outward direction to a distance that is less than the distance that the haptic (28) extends from the lens; and the tab (26) comprises a first radial portion (60), extending radially outwardly from a radially inward location proximate a circumferential edge of the lens, said first radial portion (60) spanning a first arc (61) along the circumferential edge of the IOL and also comprises a second radial portion (62), extending from the first radial portion further radially outwardly and spanning a second arc (63) relative to the circumferential edge of the IOL lens (22L) which is larger than the first arc (61) of the first radial portion.

32. The ophthalmic implant (20) of claim 30 or 31 wherein: the second radial portion (62) of the tab (26) is configured for resilient compression to a first configuration to pass through the slot of the drug delivery device (30, 71) and extend radially outwardly from the slot and resilient expansion to return to a second configuration which is wider than the slot.

33. The ophthalmic implant (20) of claim 30 or 31 wherein: the fixation portion (64) of the drug delivery device (30, 71) is configured for resilient expansion to a first configuration to stretch over the second radial portion (62) of the tab (26) and for the resilient return to a second configuration which is narrower than the second radial portion (62) of the tab (26).

34. The ophthalmic implant (20) of claim 27 wherein: the drug pad (73) has an inner edge (74) subtending a first arc (75) and an outer edge (76) subtending a second arc (77) smaller than the first arc, and the second compartment (72) has a corresponding opening approximating the first arc which narrows to the spacing approximating the second arc, to provide a friction fit for the drug pad (73).

35. The ophthalmic implant (20) of claim 10 wherein: the drug pad (73) is provided with a pin-hole (76) proximate its inner edge (74), which is sized to accommodate a tool suitable for engagement with the pinhole (76), with which the drug pad (73) can be manipulated for extraction of a drug pad (73) from the compartment and insertion of a drug pad (73) into the compartment.

36. A method of implanting an ophthalmic implant (20), the method comprising: providing an ophthalmic implant (20) comprising an IOL assembly (22) and a drug delivery device (30); said IOL assembly (22) comprising a lens (24), a tab (26), and a haptic (28), said IOL assembly (22) characterized by an anterior surface and a posterior surface, said IOL assembly (22) configured for implantation into an eye of a patient with said anterior surface disposed anterior to said posterior surface; said tab (26) extending from the IOL, said tab (26) configured for engage the drug delivery device (30), said haptic (28) extending in a plane of the lens (24), radially outwardly from the lens (24), such that said haptic (28) is configured to hold the IOL assembly (22) in place with a capsular bag of a patient's eye; said drug delivery device (30) comprises a first compartment, said first compartment having a first aperture sized and dimensioned to receive the tab and secure the drug delivery device (30) to the IOL assembly (22); said drug delivery device (30) having an arcuate form, characterized by an inner curve and an outer curve, wherein the first aperture is disposed on the inner curve; the drug delivery device (30) further comprises a drug pad (73) comprising a matrix with a therapeutic agent embedded or dispersed within the matrix; injecting the IOL and drug delivery device (30) into the patient's eye; joining the drug delivery device (30) to the IOL by fitting a fixation portion (64) of the drug delivery device (30) onto the tab of the IOL assembly (23); and positioning the joined drug delivery device (30) and IOL assembly (22) in the patient's eye with the IOL assembly (22) held in place by a capsular bag of the patient's eye.

37. The method claim 36, wherein the step of joining the drug delivery device (30) to the IOL is performed before the step of injecting the IOL and drug delivery device (30) into the patient's eye.

38. The method claim 36, wherein the step of joining the drug delivery device (30) to the IOL is performed after the step of injecting the IOL and drug delivery device (30) into the patient's eye.

39. The method claim 36, further comprising the step of: after injecting the IOL and drug delivery device (30) into the patient's eye, removing the drug delivery device (30) from the patient's eye without removing the IOL assembly (22) from the patient's eye, and inserting a new drug delivery device (30) into the patient's eye, and joining the new drug delivery device (30) to the IOL by fitting a fixation portion (64) of the new drug delivery device (30) onto the tab of the IOL assembly (22)).

40. The method claim 36, wherein: the step of injecting the IOL and drug delivery device (30) into the patient's eye is accomplished by creating a first incision in the patient's eye proximate an edge of a cornea of the patient's eye; and the method further comprises the step of: after injecting the IOL and drug delivery device (30) into the patient's eye, and after the first incision has healed, creating a new incision in the patient's eye for removing the drug delivery device (30) from the patient's eye through the new incision without removing the IOL assembly (22)) from the patient's eye, and inserting a new drug delivery device (30) into the patient's eye through the new incision, and joining the new drug delivery device (30) to the IOL by fitting a fixation portion (64) of the new drug delivery device (30) onto the tab of the IOL assembly (22).

41. The method claim 36, wherein: the step of injecting the IOL and drug delivery device (30) into the patient's eye is accomplished by creating a first incision in the patient's eye proximate an edge of a cornea of the patient's eye; and the method further comprises the step of: after injecting the IOL and drug delivery device (30) into the patient's eye, and after drugs in the drug delivery device (30) are depleted, creating a new incision in the patient's eye for removing the drug delivery device (30) from the patient's eye through the new incision without removing the IOL assembly (22) from the patient's eye, and inserting a new drug delivery device (30) into the patient's eye through the new incision, and joining the new drug delivery device (30) to the IOL by fitting a fixation portion (64) of the new drug delivery device (30) onto the tab of the IOL assembly (22).

42. A method of implanting an ophthalmic implant (20), the method comprising: providing an ophthalmic implant (20) comprising an IOL assembly (22) and a drug delivery device (71) and a drug pad (73); said IOL assembly (22) comprising a lens (24), a tab (26), and a haptic (28), said IOL assembly (22) characterized by an anterior surface and a posterior surface; said tab (26) extending from the lens (24), said tab (26) configured for engaging the drug delivery device (71), said haptic (28) extending in a plane of the lens (24), radially outwardly from the lens (24), such that said haptic (28) is configured to hold the IOL assembly (22) in place with a capsular bag of a patient's eye; said drug delivery device (71) comprises a fixation portion (64) having a first compartment, and said drug delivery device (71) having a second compartment, said first compartment having a first aperture sized and dimensioned to receive the tab and secure the drug delivery device (71) to the IOL assembly (22), said second compartment having a second aperture sized and dimensioned to receive the drug pad (73); said drug delivery device (71) having an arcuate form, characterized by an inner curve and an outer curve, wherein the first aperture and second aperture are disposed on the inner curve; injecting the IOL, drug delivery device (71) and drug pad (73) into the patient's eye; joining the drug delivery device (71) to the IOL by fitting the fixation portion (64) of the drug delivery device (71) onto the tab of the IOL assembly (22); and inserting the drug pad (73) into the second compartment; and positioning the joined drug pad (73), drug delivery device (71) and IOL assembly (22) in the patient's eye with the IOL assembly (22)) held in place by a capsular bag of the patient's eye.

43. The method claim 42, wherein the step of joining the drug delivery device (71) to the IOL is performed before the step of injecting the IOL and drug delivery device (71) into the patient's eye.

44. The method claim 42, wherein the step of joining the drug delivery device (71) to the IOL is performed after the step of injecting the IOL and drug delivery device (71) into the patient's eye.

45. The method claim 42, wherein the step of inserting the drug pad (73) into the second compartment of the drug delivery device (71) is performed before the step of injecting the IOL and drug delivery device (71) into the patient's eye.

46. The method claim 42, wherein the step of inserting the drug pad (73) into the second compartment of the drug delivery device (71) is performed after the step of injecting the IOL and drug delivery device (71) into the patient's eye.

47. The method claim 42, further comprising the step of: after injecting the IOL and drug delivery device (71) and drug pad (73) into the patient's eye, removing the drug pad (73) from the patient's eye without removing the IOL assembly (22) and drug delivery device (71) from the patient's eye, and inserting a new drug pad (73) into the patient's eye, and inserting the new drug pad (73) into the second compartment of the drug delivery device (71).

48. The method claim 42, wherein: the step of injecting the IOL and drug delivery device (71) and drug pad (73) into the patient's eye is accomplished by creating a first incision in the patient's eye proximate an edge of a cornea of the patient's eye; and the method further comprises the step of: after injecting the IOL and drug delivery device (71) and drug pad (73) into the patient's eye, and after the first incision has healed, creating a new incision in the patient's eye the removing the drug pad (73) from the patient's eye through the new incision without removing the IOL assembly (22) and drug delivery device (71) from the patient's eye, and inserting a new drug pad (73) into the patient's eye through the new incision, and inserting the new drug pad (73) into the second compartment of the drug delivery device (71).

49. The method claim 42, wherein: the step of injecting the IOL and drug delivery device (71) and drug pad (73) into the patient's eye is accomplished by creating a first incision in the patient's eye proximate an edge of a cornea of the patient's eye; and the method further comprises the step of: after injecting the IOL and drug delivery device (71) and drug pad (73) into the patient's eye, and after the drug pad (73) is depleted, creating a new incision in the patient's eye the removing the drug pad (73) from the patient's eye through the new incision without removing the IOL assembly and drug delivery device (71) from the patient's eye, and inserting a new drug pad (73) into the patient's eye through the new incision, and inserting the new drug pad (73) into the second compartment of the drug delivery device (71).

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0004] FIGS. 1 and 2 illustrate the environment of use of an ophthalmic implant system for drug delivery.

[0005] FIGS. 3A through 3D illustrate an ophthalmic implant system including an IOL assembly and a drug delivery device.

[0006] FIGS. 4A through 4E illustrate an ophthalmic implant system including an IOL assembly, a first drug delivery device and a second drug delivery device.

DETAILED DESCRIPTION OF THE INVENTIONS

[0007] FIGS. 1 and 2 illustrate placement and use of an ophthalmic implant system in the eye of a patient. The eye 1 includes a lens 2 (the natural lens of the eye) and lens capsular bag 3, and the anterior chamber 4 which includes the cornea 5 and iris 6 and aqueous humour filling the space between the cornea and the iris, and a posterior chamber 7 between the iris and the capsular bag. The posterior cavity/vitreous body 8 is the large space between the lens and the retina 9. The natural lens 2 of the eye is characterized by an optical axis 10. (In the following description of the ophthalmic implant and or intraocular lens system, the terms posterior and anterior will be used in relation to the anatomy of the eye, in which the cornea is anterior and the retina is posterior.)

[0008] FIG. 2 illustrates a placement of the ophthalmic implant system or intraocular lens system 11 in the eye including the intraocular lens assembly 12 and drug delivery device 30 which is implanted in the capsular bag in conjunction with an intraocular lens assembly 12. As shown in FIG. 2, the drug delivery device is disposed anteriorly to the intraocular lens assembly 12, and is fitted over the intraocular lens assembly. The drug delivery device may also be placed below the iris and above the capsular bag. The capsular bag may contain the native lens, an artificial lens or no lens at all.

[0009] As shown in FIGS. 3A through 3D, a primary device is an ophthalmic implant system 20 which may include the IOL assembly 22, which includes a lens 24, one or more tabs 26 and one or more haptics 28, and one or more secondary devices 30. The ophthalmic implant 20 is characterized by an anterior surface 20A and a posterior surface 20P. In other embodiments the ophthalmic implant 20 may comprise other devices such as a capsular tension ring, or a capsular scaffold for holding the secondary device in place.

[0010] The secondary device 30 is a drug delivery device configured for attachment (preferably releasable attachment) to a tab 26 which is part of the IOL assembly 22 and extends radially outwardly from the circumference of the lens portion 24 of the IOL 22. The tab 26 extends outwardly along a plane of the IOL lens 24, or a parallel plane, and preferably also extends in the radially outward direction to a distance that is less that the distance that the haptic 28 extends in its plane, which is also preferably in a plane of the IOL lens, or a parallel plane. The outward extent of the haptic 28 is long enough to impinge on the capsular bag when the system is implanted, while the radially outward extent of the drug delivery device 30, when installed on the implanted IOL, is preferably shorter than that of the haptic, so as to avoid impingement of the drug delivery device on the capsular bag in the equatorial region of the capsular bag. The tab 26 shown in FIG. 3A includes a first radial portion 60, extending radially outwardly from a radially inward location (in this case, the circumferential edge of the IOL) which spans a first, small arc 61 along the circumferential edge of the IOL and also includes a second radial portion 62, extending from the first radial portion further radially outwardly and spanning a second arc 63 relative to the circumferential edge of the IOL lens 22L which is larger than the first, small arc 61 of the first radial portion.

[0011] The corresponding drug delivery device shown in FIG. 3B includes a fixation portion 64 with a slot 65, extending from its radially inner surface 66, radially outwardly into the device and trough to the radially outer surface 67 (opposite the inner surface 66). The slot is configured relative to the tab to receive the tab, such that the second radial portion 62 may be resiliently compressed to a first configuration for passage through the slot, until the second radial portion 62 of the tab extends outwardly from the slot, and resiliently returns toward the second configuration which is wider than the slot, so that the tab, in conjunction with the slot, functions to secure the drug delivery device to the IOL assembly. (Conversely, the fixation portion (64) of the drug delivery device (30) may configured for resilient expansion to a first configuration to stretch over the second radial portion (62) of the tab (26) resilient return to return to a second configuration which is narrower than the second radial portion (62) of the tab (26).) The fixation portion may be configured as shown, or as a retaining ring extending posteriorly from drug delivery device, or as another form of anchor, fastener, or catch configured relative to the tab, to permit releasable attachment and detachment of the drug delivery device from the tab, without use of additional fastening elements or use of tools other than commonly used graspers and/or manipulating hooks. The system with a drug delivery device secured to the IOL assembly is shown FIG. 3C. FIG. 3D illustrates the system with first drug delivery devices disposed on each of two tabs.

[0012] The drug delivery device also comprises a therapeutic agent, which may comprise the entirety of the drug delivery device, or an anterior portion 68 of the drug delivery device (such as a pad) anterior to the fixation portion 64, or may be embedded within a drug eluting matrix which may also comprise the entirety of the drug delivery device, or an anterior portion of the drug delivery device (such as a pad).

[0013] The ocular implant system may be introduced into the eye of a patient, through a small incision at the edge of the cornea, and into the capsular bag of the patient. For initial installation of the drug delivery device, the drug delivery device may be fixed to the IOL assembly prior to insertion of both into the eye, and the assembled system may be folded and passed through the incision and then released in the capsular bag. For initial installation of the drug delivery device, the drug delivery device may be fixed to the IOL assembly after insertion of the IOL into the eye, by first inserting the IOL through the incision and releasing it in the capsular bag, and then inserting the drug delivery device through the incision and manipulating the drug delivery device to slip the fixation portion over the tab and thereby fix the drug delivery device to the tab and IOL assembly. When an originally implanted first drug delivery device is depleted, either by elution or bio-erosion, a subsequent surgical procedure may be performed in which a surgeon removes the original first drug delivery device, making another incision at the border of the cornea to insert and fix a new first drug delivery device to the tab and IOL assembly using a grasping tool. The removal of the original first drug delivery device and replacement with a new first drug delivery device may be performed, for example, after the original first drug delivery device is exhausted or depleted, or whenever it is desired to replace the original first drug delivery device with a new first drug delivery device which contains a different therapeutic agent, and may be performed after the incision made to implant the first drug delivery device has healed, and thus requires making a new incision. During the surgical procedure, if necessary, the surgeon may insert a grasping tool to remove the first drug delivery device from the tab and IOL assembly, and remove it from the eye, and insert a new drug delivery device and use the grasping tool to manipulate the new drug delivery device to slip it over the tab and thereby secure it to the IOL assembly.

[0014] In the embodiment shown in the FIGS. 4A through 4E, the ophthalmic implant 20 includes the IOL assembly, which includes a lens 24, a tab 26 and a haptic 28, and a secondary device 30. The ophthalmic implant 20 is characterized by an anterior surface 20A and a posterior surface 20P. In other embodiments the ophthalmic implant 20 may comprise other devices such as a capsular tension ring, or a capsular scaffold for holding the secondary device in place.

[0015] The secondary device 30 is a drug delivery device configured, as in FIGS. 3A through 3D, for attachment (preferably releasable attachment) to a tab 26 which is part of the IOL assembly 22 extends radially outwardly from the circumference of the lens portion 24 of the IOL 22. The tab extends outwardly along a plane of the IOL lens 24, or a parallel plane, and preferably also extends in the anterior direction to a distance that is less that the distance that the haptic 28 extends in it plane, which is also preferably in a plane of the IOL lens 24, or a parallel plane. The outward extent of the haptic is long enough to impinge on the capsular bag when the system is implanted, while the radially outward extent of the drug delivery device, when installed on the implanted IOL, is shorter than that of the haptic, so as to avoid impingement of the drug delivery device on the capsular bag in the equatorial region of the capsular bag. The tab 26 shown in FIG. 4B includes a first radial portion 60, extending radially outwardly from a radially inward location (in this case, the circumferential edge of the IOL) which spans a first, small arc 61 along the circumferential edge of the IOL and also includes a second radial portion 62, extending from the first radial portion further radially outwardly and spanning a second arc 63 relative to the circumferential edge of the IOL which is larger than the first, small arc 61 of the first radial portion.

[0016] The corresponding drug delivery device shown in FIG. 4B includes a fixation portion 64 with a slot 65, extending from its radially inner surface 66, radially outwardly into the device, and, preferably, through to the radially outer surface 67. The slot is configured relative to the tab to receive the tab, such that the second radial portion 62 may be compressed to a first configuration for passage through the slot, until the second radial portion 62 of the tab extends outwardly from the slot, and resiliently returns toward the second configuration which is wider than the slot, so that the tab, in conjunction with the slot, functions to secure the drug delivery device to the IOL assembly. (Conversely, the fixation portion (64) of the drug delivery device (30) may configured for resilient expansion to a first configuration to stretch over the second radial portion (62) of the tab (26) and resiliently return to return to a second configuration which is narrower than the second radial portion (62) of the tab (26).) The fixation portion may be configured as shown, or as a retaining ring extending posteriorly from drug delivery device, or as another form of anchor, fastener, or catch configured relative to the tab, to permit releasable attachment and detachment of the drug delivery device from the tab, without use of additional fastening elements or use of tools other than commonly used graspers and/or manipulating hooks. The system with a drug delivery device secured to the IOL assembly is shown FIG. 4D. FIG. 4E illustrates the system with first drug delivery devices disposed on each of two tabs.

[0017] The drug delivery device 71 of FIG. 4B also comprises a compartment 72, with an opening on the radial inner surface (preferably), configured to fit a third device 73 shown in FIG. 4C. The third device is a second drug delivery device, and comprises a therapeutic agent, which may comprise the entirety of the second drug delivery device. The second drug delivery device may also comprise a drug eluting matrix with the therapeutic agent embedded within a drug eluting matrix which may also comprise the entirety of the second drug delivery device.

[0018] FIG. 4C illustrates a second drug delivery device 73 suitable for use with the first drug delivery device shown in FIG. 4B. As shown, the second drug delivery device may be formed as a drug pad configured, relative to the compartment 72 of the first drug delivery device, for a friction fit in the compartment, or other releasable attachment means (slight detents on one component and detent recesses on the other, for example) suitable for intraocular use. In the example shown in FIGS. 4A through 4E, the second drug delivery device may have an inner edge 74 subtending a first arc 75 and an outer edge 76 subtending a second arc 77 smaller than the first arc, and the compartment 72 has a corresponding opening approximating the first arc which narrows to the spacing approximating the second arc, to provide a friction fit for the second drug delivery device while allowing easy insertion of the second drug delivery device into the compartment. The second drug delivery device is provide with a pin-hole 78 proximate its inner edge, which is sized to accommodate a tool suitable for engagement with the pinhole (an ophthalmic hook may be used), with which the second drug delivery device can be manipulated for extraction of a second drug delivery device from the compartment, and insertion of a second drug delivery device into the compartment. With this arrangement, the second drug delivery device may be inserted into the compartment before implantation of the IOL, immediately after insertion of the IOL in an intra-operative time frame (that is, during the course of a same surgical operation in which the IOL is inserted), inserting the second drug delivery device into the eye after the IOL and first drug delivery device are implanted and then inserting the second drug delivery device into the compartment. Also, long after the surgical operation in which the IOL is inserted, the second drug delivery device may be removed in a second surgical operation and, optionally, replaced with a new second drug delivery device, for example, when a drug eluting second drug delivery device has eluted much of the therapeutic agent which was initially embedded in the second drug delivery device. The assembled ophthalmic implant, including the IOL assembly, first drug delivery device and second drug delivery device, is illustrated in FIG. 4D. FIG. 4E illustrates the system with first and second drug delivery devices disposed on each of two tabs.

[0019] The ocular implant system of FIGS. 4A through 4E may be introduced into the eye of a patient, through a small incision at the edge of the cornea, and into the capsular bag of the patient. For initial installation of the drug delivery device, the drug delivery device may be fixed to the IOL assembly prior to insertion of both into the eye, and the assembled system may be folded and passed through the incision and then released in the capsular bag. Likewise, the second drug delivery device (the drug pad) can be secured within the first drug delivery device before or after prior to insertion of both into the eye. For initial installation of the drug delivery device, the second drug delivery device may be fixed to the first drug delivery device after insertion of the first drug delivery device into the eye, by first inserting the first drug delivery device through the incision and releasing it in the capsular bag, and then inserting the second drug delivery device through the incision and manipulating the second drug delivery device to insert it into the compartment 72 of the first drug delivery device. When a second drug delivery device is depleted, either by elution or bio-erosion, a subsequent surgical procedure may be performed in which a surgeon removed the original second drug delivery device, making another incision at the border of the cornea to insert and fix a new second drug delivery device within the compartment 72 using a grasping tool. If necessary, the surgeon may insert a grasping tool to remove the original second drug delivery device from the compartment of the first drug delivery device, and remove it from the eye, and insert a new second drug delivery device and use the grasping tool to manipulate the new second drug delivery device to slip it into the compartment and thereby secure it to the first drug delivery device.

[0020] In each embodiment described above, the drug delivery device of FIGS. 3A through 3D or the second drug delivery device (the drug pad) of FIGS. 4A through 4E can be configured to deliver various therapeutic agents to treat various conditions. Brimonidine, latanoprost, timolol, pilocarpine, brinzolamide and other drugs in the general categories of beta blockers, alpha agonists, ROCK Inhibitors, adenosine receptor agonists, carbonic anhydrase inhibitors, adrenergic and cholinergic receptor activating agents, and prostaglandin analogues may be incorporated into the drug delivery devices to treat glaucoma. Aflibercept, bevacizumab, pegaptanib, ranibizumab, steroids, and aptamers may be incorporated into the drug delivery devices to treat wet macular degeneration. Complement factors, anti-oxidants and anti-inflammatory agents may be incorporated into the drug delivery devices to treat dry macular degeneration. Methotrexate, antibodies, dexamethasone, triamcinolone, and other steroid agents may be incorporated into the drug delivery devices to treat uveitis. Anti-proliferative agents, anti-mitotic agents, anti-inflammatory agents, and other medications that would inhibit the spread of lens epithelial cells may be incorporated into the drug delivery devices to treat posterior capsular opacification. Antibiotics such as fluoroquinolones, non-steroidal agents such as ketorolacs, and steroids such as prednisolones may be incorporated into the drug delivery devices for post-op management after cataract surgery include.

[0021] While the preferred embodiments of the devices and methods have been described in reference to the environment in which they were developed, they are merely illustrative of the principles of the inventions. The elements of the various embodiments may be incorporated into each of the other species to obtain the benefits of those elements in combination with such other species, and the various beneficial features may be employed in embodiments alone or in combination with each other. Other embodiments and configurations may be devised without departing from the spirit of the inventions and the scope of the appended claims.