Bone density measurement device, bone density measurement system, and imaging assisting tool
11191507 · 2021-12-07
Assignee
Inventors
- Shinji Shimoda (Kanagawa, JP)
- Kaoru Kobayashi (Kanagawa, JP)
- Akitoshi Katsumata (Gifu, JP)
- Hironobu Tsuji (Tokyo, JP)
- YOSUKE TSUJI (TOKYO, JP)
- TATSURO HAYASHI (TOKYO, JP)
Cpc classification
A61B6/5217
HUMAN NECESSITIES
International classification
Abstract
Provided are: a device (1) and a system (100) for quantitatively calculating bone density by using an X-ray image of a bone pail, in particular, an alveolar bone; and an imaging assisting tool (4) for accurately and easily performing X-ray imaging of an alveolar bone. This bone density measurement device (1) comprises: an image display unit (101) for displaying X-ray images for an imaged bone part and a reference body on the same screen; a reference body density measurement unit (103) for measuring the density of the displayed X-ray image for the reference body; a bone part density measurement unit (105) for measuring the density of the displayed X-ray image for the bone part; and a bone density calculation unit (106) for calculating the hone density of the bone part by comparing the density of the X-ray image for the bone part with the density of the X-ray image for the reference body.
Claims
1. A bone density measurement device, comprising: an image display unit for displaying an X-ray image relating to a photographed bone portion and a plurality of reference bodies, whose equivalent values of bone density each are given, on identical screen; a reference body density measurement unit configured to measure density of said X-ray image of the displayed plurality of reference bodies; a bone portion density measurement unit configured to measure density of said X-ray image of the displayed bone portion; a reference body region of interest setting unit configured to set a region of interest of the plurality of reference bodies; and a bone density calculation unit configured to calculate bone density of the bone portion by gaining a relation between the plurality of X-ray image density of the plurality of reference bodies and each corresponding bone density, by making an amendment to the relation to obtain an amended relation expressed by a linear regression line between the plurality of X-ray image density of the plurality of reference bodies and each corresponding bone density, and by referring to the amended relation expressed by the linear regression line and the X-ray image density of the bone portion, wherein a case in which the reference bodies are accommodated is provided with a marker, wherein, in said reference body region of interest setting unit, a center coordinate of said marker is extracted, center coordinates of the farthest of said reference bodies are determined by using said center coordinate of said marker, center coordinates of the rest of said reference bodies are determined by using said center coordinate of said marker and said center coordinates of the farthest of said reference bodies, wherein areas of a predetermined number of pixels in vertical and horizontal directions are set from said center coordinates of said reference bodies to set said region of interest of the reference bodies, and wherein said reference body density measurement unit measures the density of said X-ray image of said region of interest of the reference body set by said reference body region of interest setting unit.
2. The bone density measurement device according to claim 1, wherein each of the plurality of reference bodies has a composition close to that of a tooth.
3. The bone density measurement device according to claim 2, wherein each of the plurality of reference bodies is characterized in that a hydroxyapatite or a hydroxyapatite homolog in which hydroxyl group of the apatite is substituted with another element is mixed with carbon at different mixing ratios.
4. The bone density measurement device according to claim 1, wherein each of the plurality of reference bodies includes a sample from which three levels of image density can be obtained, and wherein the bone density calculation unit calculates bone density using the three levels of image density.
5. A bone density measurement system, comprising: a plurality of reference bodies for bone density measurement; a photographing device for simultaneously photographing an X-ray image of a bone portion and an X-ray image of the plurality of reference bodies; and a bone density measurement device, wherein the bone density measurement device comprises: an image display unit configured to display the photographed X-ray image of the bone portion and the photographed X-ray image of the plurality of reference bodies, whose equivalent values of bone density each are given, on identical screen; a reference body concentration measurement unit configured to measure a density of the displayed X-ray image of the plurality of reference bodies; a bone density measurement unit configured to measure a density of the displayed X-ray image of the bone portion; a reference body region of interest setting unit configured to set a region of interest of the plurality of reference bodies; and a bone density calculation unit configured to calculate bone density of the bone portion by gaining a relation between the plurality of X-ray image density of the plurality of reference bodies and each corresponding bone density, by making an amendment to the relation to obtain an amended relation expressed by a linear regression line between the plurality of X-ray image density of the plurality of reference bodies and each corresponding bone density, and by referring to the amended relation expressed by the linear regression line and the X-ray image density of the bone portion, wherein a case in which the reference bodies are accommodated is provided with a marker, wherein, in said reference body region of interest setting unit, a center coordinate of said marker is extracted, center coordinates of the farthest of said reference bodies are determined by using said center coordinate of said marker, center coordinates of the rest of said reference bodies are determined by using said center coordinate of said marker and said center coordinates of the farthest of said reference bodies, wherein areas of a predetermined number of pixels in vertical and horizontal directions are set from said center coordinates of said reference bodies to set said region of interest of the reference bodies, and wherein said reference body concentration measurement unit measures the density of said X-ray image of said region of interest of the reference body set by said reference body region of interest setting unit.
6. The bone density measurement system according to claim 5, wherein each of the plurality of reference bodies has a composition close to that of a tooth.
7. The bone density measurement system according to claim 6, wherein each of the plurality of reference bodies is characterized in that a hydroxyapatite or a hydroxyapatite homolog in which hydroxyl group of the apatite is substituted with another element is mixed with carbon at different mixing ratios.
8. The bone density measurement system according to claim 5, wherein each of the plurality of reference bodies comprises a sample capable of obtaining three levels of image density.
9. The bone density measurement system according to claim 5, further comprising: a case for housing the plurality of reference bodies; and an auto-readable marker provided on the case.
10. The bone density measurement system according to claim 5, further comprising a photographing aid device configured to hold the plurality of reference bodies to simultaneously photograph the plurality of reference bodies and the bone portion.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
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EMBODIMENTS OF THE INVENTION
(20) Hereinafter, a bone density measuring system and a bone density measurement apparatus according to a first embodiment of the present invention are described with references to the drawings. In the following, the part necessary for the description to achieve the object of the present invention is schematically shown, the part necessary to describe the corresponding part of the present invention is mainly described, and omitted part is regard to be based on well-known technologies.
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(22) Here, the bone density measurement apparatus I may be one or plurality of personal computer, server, or dedicated device comprising a display unit 11 for displaying character and image information, an input unit 12 such as a keyboard for inputting information, an output unit 13 such as a printer for outputting information, storage unit 14 such as hard disk drives for storing information and programs, an interface unit 15 connected to the outside by wire and/or wireless, and a control unit 16 such as a CPU for controlling the whole system. These components may be integrally configured, or distributed as in cloud computing.
(23) The imaging device 2 is a device for imaging a dental alveolar hone portion radiographically and the like. Although a dental X-ray imaging apparatus is suitable, it is not limited thereto, and a dental panoramic X-ray imaging apparatus, an X-ray imaging apparatus not limited to dental use, an imaging apparatus by MRI, CT, etc., an imaging apparatus by ultrasonic waves or a combination thereof may be applied. Depending on the images obtained, it may be possible to make an appropriate bone density measurement.
(24) The imaging apparatus 2 includes an image information detection device provided apart from the apparatus main body. As the image information detection device, for example, an imaging plate 21 such as a plate where a photostimulable phosphor powder is coated on one side of an organic film is suitable, but it is not limited thereto. A film (X-ray film) or a solid semiconductor detector such as a flat panel detector (FPD) may be used as the image information detection device.
(25) The reference 3 is disposed so as to be captured on the same screen when imaging a bone portion of the subject, in particular, an alveolar bone portion (outside of the configuration of the present invention). Here, it is preferable that the reference 3 has a composition close to that of the tooth, and more specifically, hydroxyapatite or a homolog of hydroxyapatite obtained by replacing the group of the apatite with another element, and carbon. More preferably, they are mixed at different mixing ratios.
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(27) reference 3a: mixing ratio 20% bone density, which corresponds to an equivalent value of 0.50 g/square cm,
(28) reference 3b: mixing ratio 60% bone density, which corresponds to an equivalent value of 0.75 g/square cm, and
(29) reference 3c: mixing ratio 100% bone density, which corresponds to an equivalent value of 1.00 g/square cm.
(30) Here, the mixing ratio is the ratio of homologues of hydroxyapatite to the whole, which is also referred to as apatite equivalent. Practical accuracy is obtained with references of three-steps of densities. Of course, more detailed steps, four to five steps, for example, may be used, which makes handling more complicated, but can be expected to improve the accuracy.
(31) Although the equivalent bone density value of the reference may be determined by a theoretical value calculated from the composition of the reference, it may be determined by imaging the reference along with a sample called “bone mineral determination phantom” or “bone density standard chart”.
(32) Although the approximate dimensions of the reference 3 are, for example, squares having an edge of 5 mm on a side facing to the imaging device 2 and a depth of about 10 mm, dimensions are not limited to these, and the thickness may be similar to that of a hard tissue such as a bone to be measured, because expression in g/square cm is commonly used. For example, it may be 8 mm for the lower front teeth, 10 mm for the premolars, and 12 mm for the molars.
(33) Further, the reference 3 is inserted into and accommodated in the hole provided in the case 31, and the case 31 is provided with an automatic readable marker 32 formed in the form of a short cross in the direction perpendicular to the reference 3 in the direction of the reference 3 with a copper metal wire for example. Further, the position, shape of the marker are not limited to those shown in the figure as long as automatic reading is easy, and the insertion direction of the reference 3 is not limited to the side from the marker 32, and they can be from the opposite side, the top, or the bottom.
(34) Furthermore, two protrusions 33 are provided on the top surface of the case 31. This is for positioning and fixing at the time of assembly.
(35) The approximate dimensions of the case 31 are preferably, but not limited to for example, about 7 mm×24 mm on the side facing to the imaging device 2 with a depth of about 10 mm. It is not always necessary for the reference to be accommodated in the case 31. Automatic reading may be realized using the position of the image, the shape of the reference, etc. without the marker 32, or it can be realized by the operator of the apparatus using an input unit such as a mouse.
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(37) The imaging aid 4 comprises a holding portion 41 for holding the planar imaging plate 21 for capturing an X-ray image so as to be substantially orthogonal to the imaging main axis Z of the main body of the imaging device 2, an elongated rod-like support portion 42 provided at one end of the holding portion 41 so as to be substantially orthogonal to the holding portion 41 and for supporting the holding portion 41 in an appropriate position by engaging the upper and lower teeth with each other, and an annular direction indication guide 43 provided on the opposite side of the holding portion 41 of the support portion 42 for facilitating imaging, wherein in particular, in
(38) Note that
(39) Furthermore, the case 31 accommodating the reference 3 is installed at the end of the support portion 42 on the holding portion 41 side so as to be detected by the imaging plate 21 together with the alveolar bone portion.
(40) Specifically, the case 31 containing the reference 3 is inserted into a substantially U-shaped space formed at the end of the support unit 42 on the side of the holding unit 41, and the two projections 33 provided on the case 31 side are fixed by fitting it into the groove on the side of the support portion 42, which is not shown.
(41) Here, the installation position and the fixing method of the case 31 accommodating the reference 3 are not limited to the above description, and may be installed in the holding unit 41, and the known method such as screwing may be used as the fixing method or alternatively, the reference 3 and the marker 32 may be fixed to the support unit 42 or the holding unit 41 without using the case 31.
(42) The imaging aid 4 may be used for imaging bone portions other than alveolar bone portions. In that case, the shapes of the holder 4 for holding the imaging plate 21 and the case 31 containing the reference 3 or the reference 3 itself and the support 42 for properly supporting the holder 41 is designed according to the imaging portion, and in short, it may be able enough to capture the bone portion and the reference 3 on the same screen.
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(44) The operations of the bone density measurement system and the bone density measurement unit of these configurations are described.
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(46) In case for the lower teeth, the holding portion 41 is placed upside-down.
(47) Next, the imaging device 2 is fixed with its leading portion abutting on the direction indication guide 43, a picture is taken by the intraoral method so that the reference 3 and the alveolar bone part enter the same screen, and an image is captured on the imaging plate 21 (step S02).
(48) Next, the bone density measurement device 1 receives the photographed image information via the main body of the imaging device 2 from imaging plate, or alternatively by reading the imaging plate 21 directly by the input unit 12 of the bone density measurement device 1, and the photographed image is displayed on the screen by bone density measuring the image display unit 101 (step 503).
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(50) In the drawing, the marker 32 and the reference 3 are not aligned in the horizontal direction, and are photographed slightly inclined. There are various situations in taking photographs, and a method that can accurately grasp the reference 3 is required even in a situation where they shift from the horizontal direction, which often occurs.
(51) For that purpose, the region of interest reference setting unit 102 for the reference sets a region of interest for the reference.
(52) First, center coordinates of the marker 32 are extracted on the image (step S11). Specifically, using the fact that the image of the marker 32 is a relatively thin line and having high luminance, only the image of the marker 32 is determined by a method such as gray scale OPENING processing, image difference processing, etc., and its center coordinates (Position) is extracted. In addition, extraction of the center coordinates of the marker 32 is not limited to the method, and may be searched by pattern matching, for example.
(53) Next, the center coordinates of the farthest reference sample 3a are determined by using the center coordinates of the marker 32 (step S12). Specifically, the center coordinates is determined by the position of the distance on the screen corresponding to the furthest distance to the reference 3c on the screen, which was previously set, by extending edge of marker 32 in the substantially horizontal direction.
(54) Next, the region of interest of the reference is determined using the center coordinates of the marker 32 and the center coordinates of the farthest reference sample 3a (step S13). Specifically, as shown in
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(56) Thereafter, areas of a predetermined number of pixels in the vertical and horizontal directions are set from the center coordinates of the reference samples 3a, 3b, and 3c. These are the reference regions of interest 3ar, 3br, and 3cr. Here, the sizes of each of the reference regions of interest 3ar, 3br, and 3cr are squares with one edge length of 30 pixels.
(57) By the before-mentioned methods, the region of interest of the reference can be automatically and accurately determined without human intervention, giving a large effect.
(58) Of course, reference in the image shown in
(59) Next, the reference density measurement unit 103 measures the image density of the reference samples 3a, 3b, and 3c from the image of the region of interest of the reference 3 by a known method (Step S04 in
(60) For example, since it is preferable to use the central value as the representative value of the density as for the concentrations of the reference bodies 3a, 3b and 3c, it is desirable to use an average value or median value, and especially the average value is the most desirable when the density distribution is stable. On the other hand, in the case of a density distribution in which only a portion is peaked as shown in the marker 32, it is preferable to use the mode as the representative value of the density.
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(62) density=96 for the reference 3a, density=135 for the reference 3b,
(63) density=152 for the reference 3c.
(64) Here, since the densities at the reference 3b and the reference 3c become excessively high because of the overlapping with the holding portion 41 or the support portion 42 of the imaging aid 4, they are corrected as follows:
(65) density=96 for the reference 3a (no correction),
(66) reference density=135×0.93=126 for the reference 3b,
(67) density=152×0.97=148 for the reference 3c. As a result, the relationship between image densities and bone densities mentioned above is as follows:
(68) bone density equivalent value=0.50 g/square cm for reference density 96 of the reference 3a,
(69) bone density equivalent value=0.75 g/square cm for density 126 of the reference 3b,
(70) bone density equivalent value−1.00 g/square cm for density 148 of the reference 3c.
(71) These are illustrated in
(72) This relation is expressed by an linear regression line of y=0.0095x−0.427, where x and y are image density and bone density, respectively.
(73) Next, the bone portion region of interest setting unit 104 sets a bone portion, in particular, a region of interest Br of the alveolar bone portion (step S05 in
(74) Here, different hone region of interest may be set as a region of interest.
(75) Here,
(76) As for the region of interest of the bone portion, the region may not necessarily be set, and a specific portion may be designated to measure the density at that portion.
(77) Next, the bone portion density measurement unit 105 measures the density of the bone portion, in particular, the region of interest in the alveolar bone portion (step S06 in
(78) Although it is preferable to obtain the density as a representative value for the region of interest from the viewpoint of guaranteeing the accuracy, the density may be obtained by other methods such as the density of only a specific part. In some cases, it can be measured simply.
(79) Next, the bone density calculation unit 106 calculates the bone density of the alveolar bone from the correlation between the density of the reference and the bone density and the density of the region of interest in the alveolar hone (step S07 in
(80) Note that the relationship between the reference density and the bone density described above is different for each photographed image. While
INDUSTRIAL APPLICABILITY
(81) The present application has a broad industrial applicability in that it can measure bone density using dental x-ray images, and can be used to support the diagnosis of osteoporosis and the like.
DESCRIPTION OF THE CODE
(82) 1 Bone density measurement device
(83) 2 Shooting device
(84) 3 Reference
(85) 4 imaging aids
(86) 100 Bone density measurement system