ADENOSINE PHOSPHATE-CONTAINING O/W TYPE EMULSION COMPOSITION HAVING LOW VISCOSITY

Abstract

The present disclosure provides an O/W emulsion composition, comprising an adenosine phosphate and/or a salt thereof; an acrylic acid-alkyl methacrylate copolymer; an oil content; and water; and comprising a water-soluble polymer selected from a swelling thickener, an associative thickener, a polysaccharide and a derivative thereof and a mixture thereof, and/or a pH adjuster which is an organic alkali compound; wherein the composition has a viscosity of less than 10,000 mPa.Math.s.

Claims

1. An O/W emulsion composition, comprising Ingredient (A), Ingredient (B), Ingredient (E), and Ingredient (F); and comprising Ingredient (C) and/or Ingredient (D); wherein Ingredient (A): an adenosine phosphate and/or a salt thereof; Ingredient (B): an acrylic acid-alkyl methacrylate copolymer; Ingredient (C): a water-soluble polymer selected from a swelling thickener, an associative thickener, a polysaccharide and a derivative thereof, and a mixture thereof; Ingredient (D): a pH adjuster which is an organic alkali compound; Ingredient (E): an oil content; Ingredient (F): water, and wherein the composition has a viscosity of less than 10,000 mPa.Math.s.

2. The composition according to claim 1, wherein Ingredient (B) is an acrylic acid-alkyl methacrylate copolymer having a molecular weight of 100,000 to 5,000,000.

3. The composition according to claim 1, wherein Ingredient (C) is a water-soluble polymer selected from: a swelling thickener selected from sodium polyacrylate, ammonium polyacrylate, ammonium polyacrylate, acrylamide/sodium acrylate copolymer, vinylpyrrolidone/2-acrylamide-2-methylpropanesulfonic acid copolymer, a mixture of polyacrylamide and sodium polyacrylate, sodium acrylate/2-acrylamide-2-methylpropanesulfonic acid copolymer, hydroxyethyl acrylate/2-acrylamide-2-methylpropanesulfonic acid copolymer, and a mixture thereof; a urethane associative thickener selected from PEG-240/HDI copolymer bis-decyltetradeceth-20 ether, PEG-150/stearyl alcohol/SMDI copolymer, PEG-150/decyl alcohol/SMDI copolymer, polyurethane-59 and a mixture thereof; and a mixture thereof.

4. The composition according to claim 1, wherein Ingredient (D) is a pH adjuster which is an organic alkali compound selected from tromethamine, aminomethyl propanediol, aminomethyl propanol, arginine and a mixture thereof.

5. The composition according to claim 1, wherein the composition comprises Ingredient (C), and Ingredient (C)/Ingredient (A) (weight ratio) is 0.01 to 30.

6. The composition according to claim 1, wherein the composition comprises Ingredient (C), and Ingredient (C)/(Ingredient (A)+Ingredient (B)) (weight ratio) is 0.005 to 20.

7. The composition according to claim 1, wherein the composition comprises Ingredient (C), and Ingredient (C)/Ingredient (B) (weight ratio) is 0.05 to 60.

8. The composition according to claim 1, wherein the composition has a pH of 5.5 to 7.5.

9. The composition according to claim 1 comprising Ingredient (A): an adenosine phosphate and/or a salt thereof; Ingredient (B): acrylates/C10-30 alkyl acrylate crosspolymer; Ingredient (C): cross-linked sodium polyacrylate and/or PEG-240/HDI copolymer bis-decyltetradeceth-20 ether; Ingredient (E): an oil content; and Ingredient (F): water, wherein the composition has a viscosity of 1,500 to 10,000 mPa.Math.s.

10. The composition according to claim 1 comprising Ingredient (A): an adenosine phosphate and/or a salt thereof; Ingredient (B): acrylates/C10-30 alkyl acrylate crosspolymer; Ingredient (D): tromethamine and/or arginine; Ingredient (E): an oil content; and Ingredient (F): water, wherein the composition has a viscosity of 1,500 to 10,000 mPa.Math.s, and a pH of 6 to 7.

11. The composition according to claim 1, wherein the composition comprises 0.001 to 10% by weight of Ingredient (A), 0.05 to 2% by weight of Ingredient (B), and 0.1 to 50% by weight of Ingredient (E).

12. The composition according to claim 1, wherein the composition comprises 0.01 to 10% by weight of Ingredient (C).

13. The composition according to claim 1 comprising Ingredient (A): an adenosine phosphate and/or a salt thereof 0.4 to 3.5% by weight; Ingredient (B): acrylates/C10-30 alkyl acrylate crosspolymer 0.2 to 0.4% by weight; Ingredient (C): cross-linked sodium polyacrylate and/or PEG-240/HDI copolymer bis-decyltetradeceth-20 ether 0.04 to 0.8% by weight; Ingredient (E): an oil content 5 to 8% by weight; and Ingredient (F): water, wherein the composition has a viscosity of 1,500 to 10,000 mPa.Math.s.

14. The composition according to claim 1 comprising Ingredient (A): an adenosine phosphate and/or a salt thereof 0.4 to 3.5% by weight; Ingredient (B): acrylates/C10-30 alkyl acrylate crosspolymer 0.2 to 0.4% by weight; Ingredient (D): tromethamine, aminomethyl propanediol, and/or arginine; Ingredient (E): an oil content 5 to 8% by weight; and Ingredient (F): water, wherein the composition has a viscosity of 1,500 to 10,000 mPa.Math.s, and a pH of 6 to 7.

15. The composition according to claim 1, wherein the composition does not comprise a pH adjuster which is an inorganic alkali compound, or, the composition comprises a pH adjuster which is an inorganic alkali compound, and the pH adjuster which is an inorganic alkali compound/Ingredient (D) (weight ratio) is 0.1 or less.

16. The composition according to claim 1, wherein Ingredient (E) comprises Ingredient (G) selected from: an uncrystallized high melting point oil having a melting point of 30° C. or higher selected from an uncrystallized triglyceride having a melting point of 30° C. or higher; an uncrystallized sterol fatty acid ester having a melting point of 30° C. or higher; petrolatum; and a mixture thereof; an oil-based gelling agent selected from an inulin fatty acid ester, a dextrin fatty acid ester, polyglycerol, dibutyl ethylhexanoyl glutamide, dibutyl lauroyl glutamide, sodium dilauramidoglutamide lysine, vinyl dimethicone/methicone silsesquioxane crosspolymer, PEG/PPG-19/19 dimethicone, and a mixture thereof; a silicone agent for improving feel selected from an amino-modified silicone, a silicone wax, polyether-modified silicone, highly polymerized dimethicone, a silicone wax, a silicone emulsion, a silicone powder, and a mixture thereof; and a mixture thereof, and wherein the amount of Ingredient (G) is 0.1 to 50% by weight based on Ingredient (E).

17. The composition according to any one claim 1 wherein the composition comprises 0.1 to 5% by weight of Ingredient (G).

18. The composition according to claim 1, wherein the composition further comprises Ingredient (H): a water-soluble humectant.

Description

EXAMPLE

[0269] The present invention is explained in further detail with reference to Formulation Examples and Test Examples. However, the scope of the invention is not limited to these Examples.

Test Example 1

[0270] Each of the ingredients were combined together and mixed according to the compositions shown in Table 1 to give skin emulsion compositions of Examples 1 to 6 and Comparative examples 1 to 3. Specifically, the pH was adjusted by ingredient 7 while mixing ingredients 1 to 6, 8 and 9 shown in the table, and the mixture was uniformly mixed to give a gel. The resulting gel was uniformly mixed with ingredient 10 and emulsified.

[0271] The viscosity and pH of the resulting emulsion composition was measured, and a centrifugation method and an accelerated test at 60° C. were performed to evaluate the stability of the composition.

[0272] The pH was measured at a room temperature of 25° C. using a pH meter F-52 (manufactured by HORIBA, Ltd.).

[0273] The viscosity was measured by B-type viscometer. Specifically, the viscosity was measured at a room temperature of 25° C. using BM type viscometer (manufactured by Tokyo Keiki) (rotor No. 3, 12 rpm, 60 seconds). The unit is mPa.Math.s.

[0274] The stability was examined using a centrifuge. Specifically, t centrifugation was perfomed at 2000 rpm for 60 seconds in a centrifuge, himac SCT5BA (manufactured by Hitachi), and the degree of separation was visually evaluated (X: Completely separated, ⊚: No change).

TABLE-US-00001 TABLE 1 (Wt %) Comp. Comp. Comp. Ingredient Ex. 1 Ex. 1 Ex. 2 Ex. 3 Ex. 2 Ex. 4 Ex. 3 Ex. 5 Ex. 6 1 Purified Balance Balance Balance Balance Balance Balance Balance Balance Balance water 2 Acrylates/ 0.2 0.2 0.2 0.2 0.25 0.25 0.4 0.4 0.2 C10-30 alkyl acrylate crosspolymer 3 Carboxyvinyl 0.2 — — — 0.1 — 0.1 — — polymer 4 Cross-linked — 0.5 0.8 — — 0.2 — — 0.2 sodium polyacrylate 5 PEG-240/HDI — — — 0.5 — — — 0.2 — copolymer bis- decyltetradeceth-20 ether 6 Adenosine 1 1 1 1 1 1 5 5 1 phosphate 7 Potassium q.s q.s q.s q.s q.s q.s q.s q.s q.s hydroxide 8 1,3-BG 7 7 7 7 3 3 3 3 3 9 Methylparaben 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 10 Liquid 5 5 5 5 5 5 5 5 5 paraffin Total 100 100 100 100 100 100 100 100 100 Viscosity 1312.5 1872.5 7750 6750 950 6500 1162.5 2180 2400 pH 6.5 to 6.5 to 6.5 to 6.5 to 6.5 to 6.5 to 6.5 to 6.5 to 6.5 to 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 Emulsification X ⊚ ⊚ ⊚ X ⊚ X ⊚ ⊚ stability (Centrifugation 2000 rpm × 1 min) Comp. Ex.: Comparative example Ex.: Example q.s: quantum sufficit

[0275] As shown in Table 1, the emulsification stability of Comparative example 1 to 3 comprising carboxyvinylpolyme was poor. On the other hand, Examples 1 to 6 comprising cross-linked sodium polyacrylate or PEG-240/HDI copolymer bis-decyltetradeceth-20 ether, both of which are water-soluble polymers, showed a good emulsification stability.

Test Example 2

[0276] According to the compositions shown in Table 2, each of the ingredients were combined together mixed to give the skin emulsion compositions of Examples 7 to 9 and Comparative example 4. Specifically, while ingredients 1 to 3 and 8 shown in the table were mixed, the pH of the mixture was adjusted by an addition of one of ingredients 4 to 7, and the mixture was uniformly mixed to give a gel. The resulting gel was uniformly mixed with Ingredient 9 and emulsified. The pH and emulsification stability were determined in the same manner as in Test Example 1. In addition, the resulting emulsion compositions were placed in a constant temperature chamber at 60° C. and allowed to stand for 2 weeks, and then the color and odor were evaluated by a sensory evaluation.

TABLE-US-00002 TABLE 2 Comp. Ingredient (% by weight) Ex. 4 Ex. 7 Ex. 8 Ex. 9 1 Purified water Balance Balance Balance Balance 2 Acrylates/C10-30 alkyl 0.5 0.5 0.5 0.5 acrylate crosspolymer 3 Adenosine phosphate 3 3 3 3 4 Potassium hydroxide q.s — — — 5 Tromethamine — q.s — — 6 Aminomethyl — — q.s — propanediol 7 Arginine — — — q.s 8 BG 3 3 3 3 9 Liquid paraffin 5 5 5 5 Total 100 100 100 100 Viscosity 4500 5600 5100 5900 pH 6.5 6.5 6.5 6.5 Emulsification stability X ⊚ ⊚ ⊚ (Centrifugation 2000 rpm × 1 min) Discoloration Δ ⊚ ⊚ Δ Odor change X ⊚ Δ ⊚ Comp. Ex.: Comparative example Ex.: Example q.s: quantum sufficit

[0277] As shown in Table 2, the emulsion stability of Comparative example 4 comprising potassium hydroxide, which is an inorganic alkali compound, was poor. In addition, Comparative example 4 was slightly discolored and markedly changed in odor.

[0278] On the other hand, Examples 7 to 9 comprising tromethamine, aminomethyl propanediol or arginine, all of which are organic alkali compounds, showed a good emulsification stability, and the results of discoloration were equivalent to or better than that of Comparative example 4, and the results of odor change were better than that of Comparative example 4.

Test Example 3-1

[0279] Each of the ingredients were combined together and mixed according to the compositions shown in Table 3-1 to give the skin emulsion compositions of Example 10 to 13 and Comparative examples 5 to 6. Specifically, while ingredients 1 to 3 and 5 to 7 shown in the table were mixed, the pH of the mixture was adjusted by an addition of the ingredients 4, and the mixture was uniformly mixed to give a gel. The resulting gel was uniformly mixed with ingredient 8 to 12 and emulsified.

[0280] A sensory evaluation of Examples 10 to 13 and Comparative examples 5 to 6 was performed by 4 panelists.

[0281] As for the feel during use,

the more thickness feeling is, the better result is;
the more richness feeling is, the better result is;
the less stickiness feeling is, the better result is;
the more fresh feeling is, the better result is.

<Sensory Evaluation Score>

[0282] The same amount of the test composition (0.1 g) was spread on the inner side of the forearm with a constant force, and the thickness feeling, the richness feeling, the less stickiness feeling, the fresh feeling were scored as below, using point 3 of Comparative example 5 as a reference point. The average points based on 4 panelists were calculated.

5 points: markedly improved
4 points: improved
3 points: no difference
2 points: worsened
1 point: markedly worsened

[0283] The total sum of each of the average points of the thickness feeling, the richness feeling, the less stickiness feeling, and the fresh feeling was used as an overall score for each sample. A comprehensive evaluation of the feeling during use was rated based on this overall score as follows.

<Comprehensive Evaluation>

[0284] “⊚” represents that overall score was 17 or more, which shows that the feel during use was improved.
“◯” represents that overall score was 13 or more but less than 17, which shows that the feel during use was slightly improved.
“Δ” represents that overall score was 10 or more but less than 13, which shows that no improvement in the feel during use was perceived.
“X” represents that overall score was less than 10, which shows that the feel during use was worsened.

TABLE-US-00003 TABLE 3-1 Ingredient Comp. Comp. Ex. Ex. Ex. Ex. (% by weight) Ex. 5 Ex. 6 10 11 12 13 1 Purified water Balance Balance Balance Balance Balance Balance 2 Acrylates/C10-30 0.5 0.5 0.5 0.5 0.5 0.5 alkyl acrylate crosspolymer 3 Adenosine phosphate 3 3 3 3 3 3 4 Tromethamine q.s q.s q.s q.s q. s q.s 5 Glycerin 3 3 3 3 3 3 6 Diglycerin 1.5 1.5 1.5 1.5 1.5 1.5 7 Pentylene glycol 3 3 3 3 3 3 8 Liquid paraffin 8 6 6 7.5 6 7 9 Cetyl alcohol — 2 — — — — 10 Caprylic/capric/ — — 2 0.5 — — myristic/stearic triglyceride 11 Theobroma — — — — 2 — grandiflorum seed butter 12 Phytosteryl/behenyl/ — — — — — 1 octyldodecyl lauroyl glutamate pH 6.5 6.5 6.5 6.5 6.5 6.5 Viscosity 8500 N/A 8250 8750 8750 9050 Thickness feeling 3 N/A 4.75 4.25 4.75 5 Richness feeling 3 N/A 5 4.25 4.75 4.5 Less stickiness feeling 3 N/A 4.5 3.25 4.5 3.75 Fresh feeling 3 N/A 4.75 3.75 4.75 4 Overall score 12 N/A 19 15.5 18.75 17.25 Comprehensive evaluation — X ⊚ ◯ ⊚ ⊚ Comp. Ex.: Comparative example Ex.: Example q.s: quantum sufficit N/A in Thickness, Richnes, Less stickiness, Fresh feelings: Preparation not available N/A in Overall score: Calculation Not available

[0285] As shown in Table 3-1, Examples 10 to 13 comprises caprylic/capric/myristic/stearic triglyceride, theobroma grandiflorum seed butter, or phytosteryl/behenyl/octyldodecyl lauroyl glutamate, all of which are uncrystallized high melting point oils. As shown in Table 3-1, Examples 10 to 13 comprising an uncrystallized high melting point oil each showed an improvement in the feel during use compared with Comparative example 5, which does not comprise an uncrystallized high melting point oil. Comparative Example 6 in which cetyl alcohol, an uncrystallized high melting point oil, was blended, did not form a uniform composition.

Test Example 3-2

[0286] Each of the ingredients were combined together and mixed according to the compositions shown in Table 3-2 to give the skin emulsion compositions of Comparative example 7, Examples 14 to 15. The pH and viscosity of the resulting emulsion composition for skin were determined in the same manner as in Test Example 1, and the feeling during use was evaluated in the same manner as in Test Example 3-1.

TABLE-US-00004 TABLE 3-2 Comp. Ingredient (% by weight) Ex. 7 Ex. 14 Ex. 15  1 Purified water Balance Balance Balance  2 Acrylates/C10-30 alkyl 0.5 0.5 0.5 acrylate crosspolymer  3 Adenosine phosphate 3 3 3  4 Tromethamine q.s q.s q.s  5 Glycerin 3 3 3  6 Diglycerin 1.5 1.5 1.5  7 Pentylene glycol 3 3 3  8 Liquid paraffin 8 7.8 7.5  9 Stearoyl inulin — 0.2 — 10 Dextrin myristate — — 0.5 pH 6.5 6.5 6.5 Viscosity 8500 9150 9100 Thickness feeling 3 3.5 4.25 Richness feeling 3 4 4.5 Less stickiness feeling 3 4.25 4.25 Fresh feeling 3 5 5 Overall score 12 16.75 18 Comprehensive evaluation — ◯ ⊚ Comp. Ex.: Comparative example Ex.: Example q.s: quantum sufficit

[0287] As shown in Table 3-2, Examples 14 to 15 comprise stearoyl inulin or dextrin myristate, both of which an oil-based gelling agent. Examples 14 to 15 comprising an oil-based gelling agent each showed an improvement in the feel during use compared with Comparative Example 7, which does not comprise an oil-based gelling agent.

Test Example 3-3

[0288] Each of the ingredients were combined together and mixed according to the compositions shown in Table 3-3 to give the skin emulsion compositions of Comparative example 8, Examples 16 to 17.

[0289] The pH and viscosity of the resulting emulsion compositions for skin were determined in the same manner as in Test Example 1, and the feeling during use was evaluated in the same manner as in Test Example 3-1.

TABLE-US-00005 TABLE 3-3 Comp. Ingredient (% by weight) Ex. 8 Ex. 16 Ex. 17 1 Purified water Balance Balance Balance 2 Acrylates/C10-30 alkyl 0.4 0.4 0.4 acrylate crosspolymer 3 Cross-linked 0.2 0.2 0.2 sodium polyacrylate 4 Adenosine phosphate 2 2 2 5 Potassium hydroxide q.s q.s q.s 6 Cyclopentasiloxane 5.5 5 5 7 Aminopropyl dimethicone — 0.5 — 8 Stearyl dimethicone — — 0.5 pH 6.5 to 7.0 6.5 to 7.0 6.5 to 7.0 Viscosity 4550 4700 4750 Thickness feeling 3 5 4 Richness feeling 3 5 4.5 Less stickiness feeling 3 4 4.75 Fresh feeling 3 4 4 Overall score 12 18 17.25 Comprehensive evaluation X ⊚ ⊚ Comp. Ex.: Comparative example Ex.: Example q.s: quantum sufficit

[0290] As shown in Table 3-3, Examples 16 to 17 comprise aminopropyl dimethicone or stearyl dimethicone, both of which are silicone agents for improving feel. Examples 16 to 17 comprising a silicone agent for improving feel each showed an improvement in the feel during use compared with Comparative example 8, which does not comprise a silicone agent for improving feel.

[0291] Formulation Examples of Oil-in-Water Emulsified Cosmetics

All amounts are expressed in % by weight based on the total weight of the product.

TABLE-US-00006 <1. Emollient emulsion>  1 Adenosine phosphate 0.5  2 Acrylates/C10-30 alkyl acrylate crosspolymer 0.3  3 Sodium polyacrylate 0.2  4 BG 4  5 Glycerin 4  6 PEG/PPG/polybutylene glycol-8/5/3 glycerin 2  7 Cetyl ethylhexanoate 3  8 Cyclopentasiloxane 2 10 Isostearic acid 0.5 11 Hydrogenated polyisobutene 3 12 Aminopropyl dimethicone 0.5 13 Potassium hydroxide 0.2 14 Phenoxyethanol 0.4 15 Purified water Balance TOTAL 100

TABLE-US-00007 <2. Gel emulsion>  1 Adenosine phosphate 3.0  2 Acrylates/C10-30 alkyl acrylate crosspolymer 0.5  3 Carboxyvinylpolymer 0.1  4 Sorbitol culture polysaccharide solution 1  5 POE methylglucoside 2  6 BG 4  7 Glycerin 4  8 Cyclopentasiloxane 5  9 Highly polymerized dimethicone 0.5 10 Tromethamine q.s 11 Paraben 0.25 12 Purified water Balance TOTAL 100

TABLE-US-00008 <3. Sunscreen emulsion>  1 Adenosine phosphate 1  2 Cyclomethicone 4  3 Phytosteryl macadamiate 0.4  4 C12-15 alkyl benzoate 2  5 2-ethylhexyl p-methoxycinnamate 7  6 Octocrylene 2  7 Diethylamino hydroxybenzoyl hexyl benzoate 3  8 Acrylates/C10-30 alkyl acrylate crosspolymer 0.2  9 PEG-240/HDI copolymer 0.5 bis-decyltetradeceth-20 ether 10 Concentrated glycerin 4 11 1,3-Butylene glycol 3 12 Ethanol 5 13 Potassium hydroxide q.s 14 Phenoxyethanol 0.3 15 Purified water Balance TOTAL 100

TABLE-US-00009 <4. Cleansing milk>  1 Adenosine phosphate 3  2 Cyclomethicone 10  3 PEG-7 glyceryl cocoate 5  4 Stearoyl inulin 0.4  5 Acrylates/C10-30 alkyl acrylate crosspolymer 0.4  6 Sodium polyacrylate 0.2  7 1,3-Butylene glycol 15  8 Potassium hydroxide q.s  9 Paraben 0.3 10 Purified water Balance TOTAL 100