NEW DELIVERY SYSTEM FOR POLYUNSATURATED FATTY ACIDS
20220192998 · 2022-06-23
Inventors
Cpc classification
A61K31/202
HUMAN NECESSITIES
A61K9/5063
HUMAN NECESSITIES
A61K9/5036
HUMAN NECESSITIES
International classification
A61K9/50
HUMAN NECESSITIES
A61K31/202
HUMAN NECESSITIES
Abstract
The present invention relates to a new delivery system for PUFAs.
Claims
1. Delivery system consisting of (a) a solid core, which comprises at least one PUFA, and (b) an inner coating comprising at least one fermentable biopolymer, which is crosslinked, and (c) an outer coating which is resistant to stomach conditions and releasing in the small intestine.
2. Delivery system according to claim 1, wherein the PUFA is chosen from the group consisting of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (ARA).
3. Delivery system according to claim 1, wherein the material of the inner coating is chosen from group consisting of alginate, chitosan, pectin, cyclodextrin as well as other gums.
4. Delivery system according to claim 1, wherein the inner coating layer is crosslinked with Zn, Mg and/or Ca ions.
5. Delivery system according to claim 1, wherein the outer coating is chosen from group consisting of shellac, methacrylate copolymers and fats.
6. Process of production delivery systems according to claim 1, wherein the process is carried out batchwise.
7. Process of production delivery systems according to claim 1, wherein the process is carried out continuously.
8. Process for the production of a premix, dietary supplement, food product, feed product, personal care product or pharmaceutical product using at least one delivery systems according to claim 1.
9. Premix, dietary supplement, food product, feed product, personal care product orpharmaceutical product comprising at least one delivery systems according to claim 1.
Description
EXAMPLES
Example 1
[0064] 15 g Na-alginate (grinsted sodium alginate) is dissolved in 485 g water at 60° C. with stirring. 31.5 g Ca chloride dihydrate is dissolved in 98.5 g water. 100 g PUFA powder (MEG-3 30% Powder, containing 180 mg/g of powder as triglyceride in a matrix of gelatine) is filled in a fluid-bed processor (WFP mini, DMR, Wurster configuration). All coating steps are performed at a product temperature between 50 and 60° C. The alginate solution is sprayed on the fluidized PUFA powder first. After spraying of the alginate solution, the feeding tube is briefly rinsed with water. The Ca chloride solution is sprayed on the inner coating at 53° C. product temperature for hardening. After the hardening solution, 154 g aqueous shellac preparation with a solids content of 25% (SSB Aquagold, Stroever) is sprayed as outer coating. After spraying of the shellac, the product is dried in the fluid bed.
[0065] Composition of the final coated granulate is 65% Core material (=ca 12% PUFA), 9% alginate, 1% Ca chloride and 25% shellac.