Thioether precursors for fragrant ketones and aldehydes

Abstract

Disclosed is a use of a compound of formula (I), a composition of matter comprising a compound of formula (I) and a consumer product comprising a compound of formula (I). ##STR00001##

Claims

1. A method of generating a compound selected from the group consisting of a compound of formula (II) and a compound of formula (III) by decomposition of a compound of formula (I) ##STR00028## wherein R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-5-alkyl; R.sub.3 is H or C.sub.1-5-alkyl; and R.sub.4 is C.sub.1-6-alkyl; or R.sub.1 and R.sub.4 together with the carbon atoms to which they and R.sub.2 are attached form a 5, 6 or 7 membered ring; R.sub.2 is H or C.sub.1-4-alkyl; and R.sub.3 is H or C.sub.1-4-alkyl; and wherein R.sub.5 is H or a residue comprising 1 to 20 carbon atoms; and R.sub.6 is a residue comprising 3 to 20 carbon atoms.

2. The method according to claim 1, wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 6.

3. The method according to claim 2, wherein R.sub.6 is a residue comprising 7 to 16 carbon atoms.

4. The method according to claim 3, wherein R.sub.6 is a residue comprising 8 to 14 carbon atoms.

5. The method according to claim 2, wherein R.sub.6 is an alkyl, alkenyl or aromatic residue.

6. The method according to claim 2, wherein the compound of formula (I) is selected from the group consisting of 3-(octylthio)butanal, 4-methyl-4-(octylthio)pentan-2-one, 3-(decylthio)butanal, 4-(decylthio)-4-methylpentan-2-one, 4-(dodecylthio)pentan-2-one, 4-(dodecylthio)-4-methylpentan-2-one, 4-(dodecylthio)-3-methylpentan-2-one, 3-(dodecylthio) -3-methylbutanal, 3-(dodecylthio)butanal, 3-(dodecylthio)-3-methylcyclohexan-1-one, 3-(dodecylthio)-3-methylcyclopentan-1-one, 3-(tetradecylthio)butanal and 4-methyl-4-(tetradecylthio)pentan-2-one, 4-methyl-4-((6-methyloctyl)thio) pentan-2-one, 3-((3-(4-isobutyl-2-methylphenyl)propyl)thio)butanal and 4-((3-(4-isobutyl-2-methylphenyl)propyl)thio)-4-methylpentan-2-one.

7. The method according to claim 2, wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 5.

8. The method according to claim 7, wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 4.

9. The method according to claim 8, wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 3.

10. The method according to claim 1, wherein R.sub.1 is H; R.sub.2 is H; R.sub.3 is H; and R.sub.4 is methyl.

11. The method according to claim 1, wherein R.sub.1 is H; R.sub.2 is H; R.sub.3 is methyl; and R.sub.4 is methyl.

12. The method according to claim 1, wherein R.sub.1 is methyl; R.sub.2 is H; R.sub.3 is H; and R.sub.4 is methyl.

13. The method according to claim 1, wherein R.sub.1 is methyl; R.sub.2 is H; R.sub.3 is methyl; and R.sub.4 is methyl.

14. The method according to claim 1, wherein the decomposition of the compound of formula (I) comprises cleavage of the bond between the sulfur atom and the carbon atom in the δ-position to the carbonyl group which results in the compound selected from the group consisting of a compound of formula (II) and a compound of formula (III).

15. The method according to claim 1, wherein the compound of formula (II) which exhibits fragrance notes with a fruity, blackcurrant or passionfruit character.

16. A composition of matter comprising a compound of formula (I) and a compound of formula (A) ##STR00029## wherein R.sub.1 is H or C.sub.1-3alkyl; R.sub.2 is H or C.sub.1-5-alkyl; R.sub.3 is H or C.sub.1-5-alkyl; and R.sub.4 is C.sub.1-6-alkyl; or R.sub.1 and R.sub.4 together with the carbon atoms to which they and R.sub.2 are attached form a 5, 6 or 7 membered ring; R.sub.2 is H or C.sub.1-4-alkyl; R.sub.3 is H or C.sub.1-4-alkyl; R.sub.5 is H or a residue comprising 1 to 20 carbon atoms; R.sub.6 is a residue comprising 3 to 20 carbon atoms, wherein the amount of the compound of formula (A) in relation to the total amount of the compound of formula (I) and the compound of formula (A) is 0.1 to 3.0 wt.-%.

17. A consumer product comprising a composition of matter according to claim 16.

18. The composition of matter according to claim 16, wherein the amount of the compound of formula (A) in relation to the total amount of the compound of formula (I) and the compound of formula (A) is 0.3 to 1.2 wt.-%.

19. The composition of matter according to claim 18, wherein the amount of the compound of formula (A) in relation to the total amount of the compound of formula (I) and the compound of formula (A) is 0.6 to 1.0 wt.-%.

20. The composition of matter according to claim 16, wherein the composition exhibits lesser thiol off-odors as compared to a like composition wherein the compound of formula (A) is excluded.

21. A consumer product comprising a compound of formula (I) ##STR00030## wherein R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-4-alkyl; R.sub.3 is H or C.sub.1-4-alkyl; and R.sub.4 is C.sub.1-4-alkyl; or R.sub.1 and R.sub.4 together with the carbon atoms to which they and R.sub.2 are attached form a 5, 6 or 7 membered ring; R.sub.2 is H or C.sub.1-4-alkyl; R.sub.3 is H or C.sub.1-4-alkyl; R.sub.5 is H or a residue comprising 1 to 20 carbon atoms; R.sub.6 is a residue comprising 6 to 20 carbon atoms; and wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 4, preferably 1 to 3.

22. A consumer product according to claim 21, wherein the concentration of the compound of formula (I) is 0.1% to 10%.

23. The consumer product according to claim 21, wherein the total combined number of carbon atoms of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is 1 to 3.

Description

Example 1: 4-(Dodecylthio)-4-methylpentan-2-one

(1) ##STR00010##

(2) 1-Dodecanethiol (30.0 g, 148 mmol, 1 equiv.), 4-methylpent-3-en-2-one (29.1 g, 2 equiv.) and DBU (22.6 g, 1 equiv.) were dissolved in THF (200 mL) and the solution was stirred for 24 h at room temperature, after which it was diluted with hexane (200 mL) and poured on 2M aqueous HCl-solution (400 mL). The organic layer was separated, washed with water and brine (pH 6), dried over MgSO.sub.4, filtered by suction and evaporated in a rotatory evaporator. The resulting liquid was further dried under high vacuum at 60° C./0.08 mbar to yield 4-(dodecylthio)-4-methylpentan-2-one as a clear, yellow liquid (44.5 g, 100%).

(3) Odor (1% wt/vol in EtOH on blotter after 24 h): cassis, mango, passionfruit, juicy, lindenblossom

(4) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.69 (s, 2H), 2.54 (t, J=7.3 Hz, 2H), 2.20 (s, 3H), 1.51-1.62 (m, 2H), 1.42 (s, 6H), 1.34-1.23 (m, 18H), 0.88 (t, J=6.6 Hz, 3H).

(5) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 54.7 (t), 43.3 (s), 32.3 (q), 31.9 (t), 29.6 (3 t), 29.5 (2 t), 29.4 (t), 29.3 (2 t), 28.5 (2 q), 28.1 (t), 22.7 (t), 14.1 (q).

(6) MS (EI, 70 eV): 300 (2, M.sup.+), 98 (15), 83 (34), 69 (16), 57 (15), 56 (15), 55 (41), 43 (100), 41 (36), 39 (16), 29 (23).

Example 2: 4-Methyl-4-((2-methylundecyl)thio)pentan-2-one

(7) ##STR00011##

(8) The procedure described in Example 1 was repeated with 2-methylundecane-1-thiol (preparation see B. Hache, Y. Gareau, Tetrahedron Lett. 1994, 35(12), 1837), (8.0 g, 39.5 mmol, 1 equiv.), 4-methylpent-3-en-2-one (7.76 g, 2 equiv.) and DBU (6.0 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-methyl-4-((2-methylundecyl)thio)pentan-2-one as a colorless liquid (5.95 g, 50%).

(9) Odor (1% wt/vol in EtOH on blotter after 24 h): green, tomato leaves, cassis

(10) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.69 (s, 2H), 2.53 (dd, J=11.4, 5.7 Hz, 1H), 2.38 (dd, J=11.2, 7.3 Hz, 1H), 2.20 (br s, 3H), 1.56-1.71 (m, 1H), 1.42 (br s, 6H), 1.24-1.30 (m, 16H), 0.98 (d, J=6.6 Hz, 3H), 0.89 (t, J=6.6 Hz, 3H). .sup.13C-NMR (CDCl.sub.3, 101 MHz): 207.0 (s), 54.7 (t), 43.1 (s), 36.5 (t), 35.4 (t), 33.5 (d), 32.4 (q), 31.9 (t), 29.8 (t), 29.6 (t), 29.6 (t), 29.3 (t), 28.5 (2q), 27.0 (t), 22.7 (t), 19.7 (q), 14.1 (q).

(11) MS (EI, 70 eV): 300 (2, M.sup.+), 201(16), 99 (22), 83 (29), 69 (15), 57 (26), 56 (15), 55 (31), 43 (100), 41 (33), 29 (19).

Example 3: 3-((3-(4-(tert-Butyl)phenyl)propyl)thio)butanal

(12) ##STR00012##

3a) Preparation of 3-(4-(tert-butyl)phenyl)propane-1-thiol

(13) This thiol was prepared by tosylation of the corresponding alcohol, nucleophilic substitution with potassium thioacetate and reduction of the thioester to the free thiol as described in the following:

(14) 3-(4-(tert-Butyl)phenyl)propan-1-ol (32.7 g, 170 mmol, 1 equiv.) was dissolved in MTBE (100 mL) and tosyl chloride (33.5 g, 1 equiv.) was added. The solution was cooled to 5° C., then pyridine (29.0 g, 2.1 equiv.) was added dropwise over 15 min. The cooling bath was removed and the solution was heated to 60° C. for 6 h under stirring. The solution was diluted with water and extracted with MTBE. The combined organic layers were washed with 0.5 M HCl, then with water and brine and dried over MgSO.sub.4. The solvents were removed by rotary evaporation, and the residue was dried at room temperature at 0.08 mbar. The tosylate, a slightly yellow, viscous oil, was dissolved in DMF (170 mL) and potassium thioacetate (39.2 g, 2.0 equiv.) was added and the resulting brown suspension was heated to 80° C. for 2 h, cooled to room temperature and left stirring for 16 h. The suspension was then diluted with MTBE/hexane 1:1 and washed with brine/water 1:1, then with brine. The organic layer was separated and dried over MgSO.sub.4. After evaporation of the solvent, a dark red-brown oil was obtained (36 g) with intense sulfury smell. This product was dissolved in diethyl ether (200 mL) and added dropwise to a cooled (−10° C.) suspension of LiAlH.sub.4 (5.46 g, 144 mmol) in diethyl ether (100 mL) during 20 min. The temperature rose to 5° C. The resulting suspension was further stirred for 2 h at 5° C., then cooled to −5° C. Saturated aqueous NH.sub.4Cl solution (50 mL) was added dropwise, which caused a strong hydrogen evolution. Upon the addition of 2 M aqueous HCl solution (80 mL), a voluminous precipitate was formed. The slurry was diluted with MTBE and water and the aqueous layer was further extracted with MTBE. The combined organic layers were washed with brine and dried over MgSO.sub.4. The crude light brown oil (25.3 g) with strong sulfury smell obtained after removal of the solvent was used directly for the preparation of the subsequent 1,4-addition reactions.

3b) Preparation of 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal

(15) 3-(4-(tert-Butyl)phenyl)propane-1-thiol (2.14 g, 10.2 mmol, 1 equiv.) was dissolved in EtOH (5 mL) and the solution of (E)-but-2-enal (0.9 g, 1.2 equiv.) in EtOH (3 mL) was added dropwise. The resulting solution was stirred for 3 days at room temperature, then concentrated in a rotatory evaporator under reduced pressure and the residue was purified by FC using hexane/MTBE 9:1 to yield 3-((3-(4-(tert-butyl)phenyl) propyl)thio)butanal (2.15 g, 75%) as a colorless oil.

(16) Odor (1% wt/vol in EtOH on blotter after 24 h): aldehydic, fruity, cassis

(17) .sup.1H-NMR (CDC.sub.3, 400 MHz): 9.79 (t, J=1.9 Hz, 1H), 7.33-7.39 (m, 2H), 7.14-7.19 (m, 2H), 3.31 (sxt, J=6.9 Hz, 1H), 2.57-2.77 (m, 6H), 1.95 (quin, J=7.5 Hz, 2H), 1.38 (d, J=6.8 Hz, 3H), 1.36 (s, 9H).

(18) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 201.0 (s), 149.2 (s), 138.7 (s), 128.5 (2d), 125.7 (2d), 50.9 (t), 34.8 (s), 34.7 (t), 34.5 (d), 31.9 (3q), 31.6 (t), 30.5 (t), 22.2 (q).

(19) MS (EI, 70 eV): 278 (2, M.sup.+), 208 (27), 193 (100), 159 (62), 131 (43), 117 (49), 115 (25), 91 (31), 57 (18), 41 (30), 39 (17).

Example 4: 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one

(20) ##STR00013##

(21) The procedure described in Example 1 was repeated with 3-(4-(tert-butyl)phenyl)propane-1-thiol (prepared in example 3a) (2.12 g, 10.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (1.0 g, 1 equiv.) and DBU (1.54 g, 1 equiv.) in ethanol (5 mL). The crude product was purified by FC with hexane/MTBE 19:1 to yield 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one as a colorless liquid (2.22 g, 71%).

(22) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis

(23) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 7.31-7.37 (m, 2H), 7.13-7.19 (m, 2H), 2.69-2.76 (m, 4H), 2.60 (t, J=7.3 Hz, 2H), 2.20 (s, 3H), 1.92 (quin, J=7.3 Hz, 2H), 1.44 (s, 6H), 1.34 (s, 9H).

(24) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 207.3 (s), 149.1 (s), 138.8 (s), 128.5 (2d), 125.7 (2d), 55.1 (t), 43.9 (s), 35.0 (t), 34.8 (s), 32.8 (q), 31.8 (3q), 31.5 (t), 28.9 (2q), 28.0 (t).

(25) MS (EI, 70 eV): 306 (3, M.sup.+), 208 (30), 193 (100), 159 (81), 131 (42), 117 (68), 91 (39), 83 (32), 57 (42), 55 (34), 43 (75).

Example 5: 4-Methyl-4-(phenethylthio)pentan-2-one

(26) ##STR00014##

(27) The procedure described in Example 1 was repeated with 2-phenylethane-1-thiol (5.0 g, 36.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (5.5 g, 1 equiv.) and DBU (7.1 g, 2 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-methyl-4-(phenethylthio)pentan-2-one as a colorless liquid (6.33 g, 74%).

(28) Odor (1% wt/vol in EtOH on blotter after 24 h): bee's wax, fruity, cassis

(29) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 7.31-7.36 (m, 2H), 7.22-7.28 (m, 3H), 2.79-2.92 (m, 4H), 2.71 (s, 2H), 2.19 (s, 3H), 1.46 (s, 6H).

(30) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.8 (s), 140.7 (s), 128.5 (2d), 128.5 (2d), 126.4 (d), 54.6 (t), 43.7 (s), 36.0 (t), 32.3 (q), 29.9 (t), 28.5 (2q).

(31) MS (EI, 70 eV): 236 (4, M.sup.+), 145 (18), 138 (16), 105 (31), 104 (47), 103 (12), 99 (30), 91 (65), 83 (11), 77 (14), 43 (100).

Example 6: 4-((1-(3,3-Dimethylcyclohexyl)ethyl)thio)-4-methylpentan-2-one

(32) ##STR00015##

6a) 1-(3,3-Dimethylcyclohexyl)ethane-1-thiol

(33) This thiol was prepared according to the procedure described in example 3a) from 1-(3,3-dimethylcyclo-hexyl)ethanol and used without purification for the subsequent reaction described in Example 6b) below.

6b) 4-((1-(3,3-Dimethylcyclohexyl)ethyl)thio)-4-methylpentan-2-one

(34) The procedure described in Example 1 was repeated with 1-(3,3-dimethylcyclohexyl)ethane-1-thiol (6.9 g, 40 mmol, 1 equiv.), 4-methylpent-3-en-2-one (7.86 g, 2 equiv.) and DBU (6.1 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-((1-(3,3-dimethylcyclohexyl)ethyl)thio)-4-methylpentan-2-one as a colorless liquid (6.06 g, 56%, mixture of 2 diastereomers 96:4).

(35) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, passionfruit

(36) .sup.1H-NMR (CDCl.sub.3, 400 MHz): (major diastereomer) 2.71 (s, 2H), 2.57-2.65 (m, 1H), 2.18 (s, 3H), 1.54-1.81 (m, 3H), 1.43 (2s, together 6H), 1.31-1.40 (m, 3H), 1.29 (d, J=7.1 Hz, 3H), 0.93-1.13 (m, 3H), 0.90 (d, J=12.2 Hz, 6H).

(37) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 55.4 (t), 44.3 (s), 43.2 (d), 42.4 (t), 40.2 (d), 39.2 (t), 33.5 (q), 32.4 (q), 30.8 (s), 29.8 (t), 28.9 (2q), 24.8 (q), 22.4 (t), 21.5 (q).

(38) MS (EI, 70 eV): 270 (3, M.sup.+), 171 (18), 138 (17), 123 (18), 99 (50), 95 (20), 83 (36), 69 (44), 55 (31), 43 (100), 41 (27).

Example 7: (Z)-4-Methyl-4-(non-6-en-1-ylthio)pentan-2-one

(39) ##STR00016##

7a) (Z)-Non-6-ene-1-thiol

(40) This thiol was prepared according to the procedure described in example 3a) from (Z)-non-6-en-1-ol and used without purification for the subsequent reaction described in Example 7b) below.

7b) (Z)-4-Methyl-4-(non-6-en-1-ylthio)pentan-2-one

(41) The procedure described in Example 1 was repeated with (Z)-non-6-ene-1-thiol (6.2 g, 39.2 mmol, 1 equiv.), 4-methylpent-3-en-2-one (7.69 g, 2 equiv.) and DBU (5.96 g, 1 equiv.) in THF (80 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-((1-(3,3-dimethylcyclohexyl)ethyl) thio)-4-methylpentan-2-one as a colorless liquid (6.12 g, 61%).

(42) Odor (1% wt/vol in EtOH on blotter after 24 h): green, fruity, cassis

(43) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 5.25-5.45 (m, 2H), 2.69 (s, 2H), 2.54 (t, J=7.6 Hz, 2H), 2.20 (s, 3H), 1.97-2.10 (m, 4H), 1.52-1.64 (m, 2H), 1.42 (s, 6H), 1.34-1.45 (m, 4H), 0.96 (t, J=7.5 Hz, 3H).

(44) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 131.8 (d), 128.9 (d), 54.7 (t), 43.3 (s), 32.3 (q), 29.4 (t), 29.4 (t), 28.9 (t), 28.5 (2q), 28.1 (t), 26.9 (t), 20.5 (t), 14.4 (q).

(45) MS (EI, 70 eV): 157 (31), 101 (16), 99 (22), 87 (20), 83 (17), 67 (16), 55 (27), 43 (100), 41 (30), 39 (15).

Example 8: (Z)-4-(Hex-3-en-1-ylthio)-4-methylpentan-2-one

(46) ##STR00017##

8a) (Z)-Hex-3-ene-1-thiol

(47) This thiol was prepared according to the procedure described in example 3a) from (Z)-hex-3-en-1-ol and used without purification for the subsequent reaction described in Example 8b) below.

8b) (Z)-4-(Hex-3-en-1-ylthio)-4-methylpentan-2-one

(48) The procedure described in Example 1 was repeated with (Z)-Hex-3-ene-1-thiol (2.8 g, 24.1 mmol, 1 equiv.), 4-methylpent-3-en-2-one (4.73 g, 2 equiv.) and DBU (3.67 g, 1 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield (Z)-4-(hex-3-en-1-ylthio)-4-methylpentan-2-one as a slightly yellow liquid (2.23 g, 43%).

(49) Odor (1% wt/vol in EtOH on blotter after 24 h): fresh green, fruity, cassis

(50) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 5.31-5.50 (m, 2H), 2.70 (s, 2H), 2.55-2.59 (m, 2H), 2.26-2.34 (m, 2H), 2.19 (s, 3H), 2.00-2.10 (m, 2H), 1.43 (s, 6H), 0.97 (t, J=7.5 Hz, 3H).

(51) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.8 (s), 133.2 (d), 126.9 (d), 54.6 (t), 43.4 (s), 32.3 (q), 28.5 (2q), 28.2 (t), 27.2 (t), 20.6 (t), 14.2 (q).

(52) MS (EI, 70 eV): 115 (48), 99 (31), 87 (10), 83 (8), 82 (9), 67 (11), 55 (14), 43 (100), 41 (22), 39 (12).

Example 9: 4-(Dodecylthio)-3-methylpentan-2-one

(53) ##STR00018##

(54) The procedure described in Example 1 was repeated with 1-dodecanethiol (7.0 g, 34.6 mmol, 1 equiv.), (E)-3-methylpent-3-en-2-one (6.79 g, 2 equiv.) and DBU (5.27 g, 1 equiv.) in THF (60 mL). The crude product was purified by FC with hexane/MTBE 95:5 to yield 4-(dodecylthio)-3-methylpentan-2-one as a colorless liquid (9.4 g, 90%).

(55) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis

(56) .sup.1H-NMR (CDCl.sub.3, 400 MHz): (mixture of 2 diastereomers 48:52) 2.96-3.13 (m, 1H), 2.57-2.73 (m, 1H), 2.53 (t, J=7.5 Hz, 2H), 2.22 (s, 1.5H), 2.21 (s, 1.5H), 1.53-1.63 (m, 2H), 1.30 (d, J=6.8 Hz, 1.5H), 1.25-1.40 (m, 18H), 1.23 (d, J=7.0, 1.5H), 1.22 (d, J=7.0, 1.5H), 1.13 (d, J=6.8 Hz, 1.5H), 0.87-0.92 (m, 3H).

(57) .sup.13C-NMR (CDCl.sub.3, 101 MHz): (mixture of 2 diastereomers 48:52) 211.1 (s), 210.7 (s), 52.5 (d), 51.9 (d), 42.6 (d), 41.1 (d), 31.9 (t), 31.4 (t), 31.0 (t), 29.8 (t), 29.7 (t), 29.7 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.2 (t), 29.0 (t), 22.7 (t), 20.5 (q), 18.0 (q), 14.4 (q), 14.1 (q), 12.8 (q).

(58) MS (EI, 70 eV): 300 (5, M.sup.+), 229 (20), 99 (40), 98 (24), 83 (29), 69 (25), 57 (19), 55 (51), 43 (100), 41 (40), 29 (24).

Example 10: 3-(Dodecylthio)-3-methylbutanal

(59) ##STR00019##

(60) The procedure described in Example 1 was repeated with 1-dodecanethiol (24.1 g, 119 mmol, 1 equiv.), 3-methylbut-2-enal (10.0 g, 1 equiv.) and DBU (18.1 g, 1 equiv.) without solvent. The crude product was purified by FC with hexane/MTBE 95:5 to yield 3-(dodecylthio)-3-methylbutanal as a colorless liquid (7.0 g, 21%).

(61) Odor (1% wt/vol in EtOH on blotter after 24 h): cassis, sulfury

(62) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 9.87 (t, J=2.9 Hz, 1H), 2.53-2.58 (m, 4H), 1.52-1.63 (m, 2H), 1.45 (s, 6H), 1.28-1.41 (m, 18H), 0.90 (t, J=6.8 Hz, 3H).

(63) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 202.0 (d), 54.6 (t), 42.7 (s), 32.3 (t), 30.0 (t), 30.0 (t), 30.0 (t), 29.9 (t), 29.8 (t), 29.7 (2q), 29.6 (2t), 29.6 (s), 28.4 (t), 23.1 (t), 14.5 (q).

(64) MS (EI, 70 eV): 286 (2, M.sup.+), 97 (35), 84 (50), 83 (54), 70 (32), 69 (47), 57 (89), 56 (73), 55 (100), 43 (53), 41 (77).

Example 11: 3-(Dodecylthio)-3-methylcyclohexan-1-one

(65) ##STR00020##

(66) The procedure described in Example 1 was repeated with 1-dodecanethiol (7.7 g, 38.0 mmol, 1 equiv.), 3-methyl-2-cyclohexen-1-one (5.03 g, 1.2 equiv.) and DBU (5.79 g, 1 equiv.) in THF (60 mL) during 4 days at room temperature. The crude product was purified by FC with hexane to hexane/MTBE 9:1 to yield 3-(dodecylthio)-3-methylcyclohexan-1-one as a colorless liquid (3.09 g, 26%).

(67) Odor (1% wt/vol in EtOH on blotter after 24 h): aldehydic, floral, green, slightly sulfury

(68) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.53-2.58 (m, 1H), 2.44-2.52 (m, 2H), 2.34-2.43 (m, 2H), 2.08-2.30 (m, 2H), 1.77-2.01 (m, 3H), 1.51-1.61 (m, 2H), 1.40 (s, 3H), 1.27-1.42 (m, 18H), 0.89 (t, J=6.8 Hz, 3H).

(69) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 208.9 (s), 53.5 (t), 48.3 (s), 40.3 (t), 36.8 (t), 31.9 (t), 29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.4 (t), 29.3 (t), 29.2 (t), 29.2 (t), 28.8 (q), 27.4 (t), 22.7 (t), 22.1 (t), 14.1 (q).

(70) MS (EI, 70 eV): 312 (1, M.sup.+), 112 (21), 111 (100), 110 (36), 83 (30), 82 (56), 69 (29), 55 (78), 43 (32), 41 (42), 39 (22).

Example 12: 3-(Dodecylthio)-3-methylcyclopentan-1-one

(71) ##STR00021##

(72) The procedure described in Example 1 was repeated with 1-dodecanethiol (8.7 g, 43.0 mmol, 1 equiv.), 3-methylcyclopent-2-enone (4.96 g, 1.2 equiv.) and DBU (6.54 g, 1 equiv.) in THF (60 mL) during 4 days at room temperature. The crude product was purified by FC with hexane to hexane/MTBE 9:1 to yield 3-(dodecylthio)-3-methylcyclopentan-1-one as a colourless liquid (0.68 g, 5%).

(73) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury

(74) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.44-2.63 (m, 4H), 2.16-2.37 (m, 3H), 1.93-2.05 (m, 1H), 1.56 (s, 3H), 1.54-1.63 (m, 2H), 1.28-1.38 (m, 18H), 0.90 (t, J=6.6 Hz, 3H).

(75) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 216.9 (s), 52.7 (t), 49.1 (s), 36.9 (t), 36.1 (t), 31.9 (t), 29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.2 (t), 29.2 (t), 28.8 (t), 28.3 (q), 22.7 (t), 14.1 (q).

(76) MS (EI, 70 eV): 298 (4, M.sup.+), 201 (19), 97 (100), 96 (41), 83 (19), 69 (52), 67 (19), 55 (35), 43 (32), 41 (48), 39 (18).

Example 13: 5-(Dodecylthio)-5-methylhexan-3-one

(77) ##STR00022##

(78) The procedure described in Example 1 was repeated with 1-dodecanethiol (4.9 g, 24.2 mmol, 1 equiv.), 5-methylhex-4-en-3-one (5.43 g, 2 equiv.) and DBU (3.69 g, 1 equiv.) in THF (80 mL) during 20 h at room temperature. The crude product was purified by FC with hexane/MTBE 96:4 to yield 5-(dodecylthio)-5-methylhexan-3-one as a colourless liquid (3.45 g, 46%).

(79) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic

(80) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.68 (s, 2H), 2.54 (t, J=7.3 Hz, 2H), 2.50 (q, J=7.3 Hz, 2H), 1.52-1.62 (m, 2H), 1.43 (s, 6H), 1.27 (1.42-1.20, m, 18H), 1.05 (t, J=7.2 Hz, 3H), 0.89 (t, J=6.6 Hz, 3H).

(81) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 209.5 (s), 53.6 (t), 43.5 (s), 38.2 (t), 31.9 (t), 29.7 (t), 29.6 (t), 29.6 (t), 29.6 (t), 29.5 (t), 29.3 (t), 29.3 (2t), 28.6 (2q), 28.2 (t), 22.7 (t), 14.1 (q), 7.6 (q).

(82) MS (EI, 70 eV): 314 (3, M.sup.+), 257 (3), 243 (7), 201 (8), 113 (11), 97 (13), 83 (57), 69 (17), 57 (100), 43 (31), 29 (29).

Example 14: 4-(Decylthio)-4-methylpentan-2-one

(83) ##STR00023##

(84) The procedure described in Example 1 was repeated with 1-decanethiol (10.0 g, 57.4 mmol, 1 equiv.), 4-methylpent-3-en-2-one (11.26 g, 2 equiv.) and DBU (8.73 g, 1 equiv.) in THF (80 mL) during 24 h at room temperature. The crude product was purified by FC with hexane/MTBE 95:5 to yield 4-(decylthio)-4-methylpentan-2-one as a colourless liquid (14.12 g, 90%).

(85) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic.

(86) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.70 (s, 2H), 2.54 (t, J=7.8 Hz, 2H), 2.20 (s, 3H), 1.52-1.62 (m, 2H), 1.43 (s, 6H), 1.27 (1.43-1.23, m, 14H), 0.89 (t, J=6.6 Hz, 3H).

(87) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 54.7 (t), 43.3 (s), 32.4 (q), 31.9 (t), 29.5 (t), 29.5 (t), 29.5 (t), 29.3 (t), 29.3 (t), 29.3 (t), 28.5 (2q), 28.1 (t), 22.7 (t), 14.1 (q).

(88) MS (EI, 70 eV): 272 (6, M.sup.+), 173 (17), 140 (4), 99 (26), 83 (24), 69 (9), 55 (23), 43 (100), 29 (11).

Example 15: 4-Methyl-4-(tetradecylthio)pentan-2-one

(89) ##STR00024##

(90) The procedure described in Example 1 was repeated with 1-tetradecanethiol (4.16 g, 18.1 mmol, 1 equiv.), 4-methylpent-3-en-2-one (3.54 g, 2 equiv.) and DBU (2.75 g, 1 equiv.) in THF (50 mL) during 24 h at room temperature. The crude product was purified by FC with hexane/MTBE 95:5 to yield 4-methyl-4-(tetradecylthio)pentan-2-one as a colourless liquid (3.21 g, 54%).

(91) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, sulfury, slightly aldehydic

(92) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.70 (s, 2H), 2.54 (t, J=7.6 Hz, 2H), 2.21 (s, 3H), 1.53-1.62 (m, 2H), 1.43 (s, 6H), 1.25-1.42 (m, 22H), 0.89 (t, J=6.8 Hz, 3H).

(93) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 54.7 (t), 43.3 (s), 32.4 (q), 31.9 (t), 29.7 (t), 29.7 (t), 29.7 (2t), 29.6 (t), 29.5 (t), 29.5 (t), 29.4 (t), 29.3 (2t), 28.5 (2q), 28.1 (t), 22.7 (t), 14.1 (q).

(94) MS (EI, 70 eV): 328 (3, M.sup.+), 285 (4), 271 (3), 229 (11), 168 (2), 111 (8), 99 (27), 83 (46), 69 (21), 55 (39), 43 (100), 29 (15).

Example 16: 4-Methyl-4-((6-methyloctyl)thio)pentan-2-one

(95) ##STR00025##

(96) The procedure described in Example 1 was repeated with 6-methyloctane-1-thiol (prepared according to Example 3a) from 6-methyl octanol; 8.5 g, 53 mmol, 1 equiv.), 4-methylpent-3-en-2-one (10.4 g, 2 equiv.) and DBU (8.07 g, 1 equiv.) in THF (120 mL). The crude product was purified by FC with hexane/MTBE 96:4 to yield 4-methyl-4-((6-methyloctyl)thio)pentan-2-one as a clear, colorless liquid (9.3 g, 68%).

(97) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, slightly aldehydic

(98) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 2.69 (s, 2H), 2.59 (br. t, J=7.5 Hz, 2H), 2.19 (s, 3H), 1.52-1.63 (m, 2H), 1.42 (s, 6H), 1.22-1.41 (m, 7H), 1.06-1.19 (m, 2H), 0.85 (t, J=7.2 Hz, 3H), 0.84 (d, J=6.0 Hz, 3H).

(99) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 54.7 (t), 43.3 (s), 36.4 (t), 34.3 (d), 32.3 (q), 29.6 (t), 29.6 (t), 29.4 (t), 28.5 (2q), 28.1 (t), 26.7 (t), 19.2 (q), 11.4 (q).

(100) MS (EI, 70 eV): 258 (3, M.sup.+), 159 (12), 99 (22), 97 (15), 83 (22), 69 (11), 57 (16), 55 (28), 43 (100), 41 (25), 29 (19).

Example 17: 3-((3-(4-Isobutyl-2-methylphenyl)propyl)thio)butanal

(101) ##STR00026##

(102) The procedure described in Example 3b) was repeated with 3-(4-isobutyl-2-methylphenyl)propane-1-thiol (prepared according to Example 3a) from 3-(4-isobutyl-2-methylphenyl)propan-1-ol {prepared as described in WO 2014/180945 A1}; 5.1 g, 22.9 mmol, 1 equiv.) and (E)-but-2-enal (3.21 g, 2 equiv.). The crude product was purified by FC with hexane/MTBE 94:6 to yield 3-((3-(4-isobutyl-2-methylphenyl) propyl)thio)butanal as a clear, colorless liquid (0.39 g, 6%).

(103) Odor (1% wt/vol in EtOH on blotter after 24 h): aldehydic, sulfury

(104) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 9.80 (t, J=2.0 Hz, 1H), 7.06 (d, J=7.6 Hz, 1H), 6.92-6.98 (m, 2H), 3.32 (sxt, J=6.8 Hz, 1H), 2.58-2.74 (m, 6H), 2.44 (d, J=7.1 Hz, 2H), 2.32 (s, 3H), 1.83-1.94 (m, 3H), 1.38 (d, J=6.6 Hz, 3H), 0.93 (d, J=6.6 Hz, 6H).

(105) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 200.6 (d), 139.4 (s), 136.7 (s), 135.4 (s), 131.1 (d), 128.6 (d), 126.7 (d), 50.5 (t), 45.0 (t), 34.1 (d), 32.0 (t), 30.4 (t), 30.2 (d), 30.1 (t), 21.7 (2q), 22.5 (q), 19.4 (q).

(106) MS (EI, 70 eV): 292 (5, M.sup.+), 222 (35), 188 (17), 179 (47), 161 (36), 145 (100), 131 (43), 119 (41), 105 (19), 91 (15), 61 (9), 41 (24).

Example 18: 4-((3-(4-Isobutyl-2-methylphenyl)propyl)thio)-4-methylpentan-2-one

(107) ##STR00027##

(108) The procedure described in Example 1 was repeated with 3-(4-isobutyl-2-methylphenyl)propane-1-thiol (prepared according to Example 3a) from 3-(4-isobutyl-2-methylphenyl)propan-1-ol {prepared as described in WO 2014/180945 A1}; 5.1 g, 22.9 mmol, 1 equiv.), 4-methylpent-3-en-2-one (4.5 g, 2 equiv.) and DBU (3.49 g, 1 equiv.) in THF (50 mL). The crude product was purified by Kugelrohr distillation (140-165° C., 0.02 mbar) to yield 4-((3-(4-isobutyl-2-methylphenyl)propyl) thio)-4-methylpentan-2-one as a clear, colorless liquid (3.6 g, 49%).

(109) Odor (1% wt/vol in EtOH on blotter after 24 h): fruity, cassis, sulfury

(110) .sup.1H-NMR (CDCl.sub.3, 400 MHz): 7.06 (d, J=7.6 Hz, 1H), 6.91-6.97 (m, 2H), 2.68-2.74 (m, 4H), 2.62 (t, J=7.3 Hz, 2H), 2.43 (d, J=7.3 Hz, 2H), 2.31 (s, 3H), 2.21 (s, 3H), 1.82-1.92 (m, 3H), 1.45 (s, 6H), 0.92 (d, J=6.6 Hz, 6H).

(111) .sup.13C-NMR (CDCl.sub.3, 101 MHz): 206.9 (s), 139.4 (s), 136.8 (s), 135.4 (s), 131.1 (d), 128.6 (d), 126.6 (d), 54.7 (t), 45.0 (t), 43.5 (s), 32.3 (d), 32.3 (t), 30.2 (q), 30.1 (t), 28.5 (2q), 27.9 (t), 22.4 (2q), 19.3 (q).

(112) MS (EI, 70 eV): 320 (6, M.sup.+), 222 (27), 188 (44), 179 (37), 161 (50), 145 (100), 131 (60), 119 (43), 105 (20), 83 (24), 57 (14), 55 (23), 41 (79).

Example 19: Release of Odoriferous Volatiles from 4-(dodecylthio)-4-methylpentan-2-one

(113) A 10% wt/wt solution of 4-(dodecylthio)-4-methylpentan-2-one (prepared according to Example 1) in MTBE (200 μl, 16.3 mg) was applied on a paper blotter (4×1.2 cm.sup.2, conditioned by rinsing with MeOH and vacuum drying). After 5 min evaporation of the solvent in open air, the blotter was placed at the bottom of a 2 L glass jar closed with a lid containing two openings which were sealed with Parafilm. The glass jar was left for 48 h at 25° C. in a cabinet lit with a fluorescent UV A/B-light source (ca. 0.8 mW/cm.sup.2).

(114) Then a stainless steel tube (length 25 cm, i.d. 0.8 mm) with a Porapak Q filter (cf. R. Kaiser, “Meaningful Scents around the World”, Helvetica Chimica Acta, Zürich 2006, chapter 1.3.) attached to its tip with shrinking tube and secured with Parafilm, was introduced into the jar through one of the openings, to which it was attached by an air-tight Teflon joint. The tube was attached to a peristaltic pump with a thin rubber hose and the other opening of the jar (the air inlet) was equipped with a charcoal filter. An air volume of 2 L was drawn through the filter with a flow of 10 mL/min. The trapped volatiles were desorbed with 100 μL of MTBE and the liquid sample was analysed by GC/MS and GC-sniff. As shown in FIG. 1, the presence of the odorants 4-mercapto-4-methylpentan-2-one and dodecanal was detected among the volatiles released from 4-(dodecylthio)-4-methylpentan-2-one.

Example 20: Release of Odoriferous Volatiles from 3-((3-(4-(tert-butyl)phenyl)propyl) thio)butanal

(115) Example 19 was repeated with 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal. The presence of the odorant 3-(4-(tert-butyl)phenyl)propanal was detected among the volatiles released from 3-((3-(4-(tert-butyl)phenyl)propyl)thio)butanal (FIG. 2).

Example 21: Release of Odoriferous Volatiles from 4-((3-(4-(tert-butyl)phenyl)propyl) thio)-4-methylpentan-2-one

(116) Example 19 was repeated with 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one. The presence of the odorants 4-mercapto-4-methylpentan-2-one and 3-(4-(tert-butyl)phenyl)propanal was detected among the volatiles released from 4-((3-(4-(tert-butyl)phenyl)propyl)thio)-4-methylpentan-2-one (FIG. 3).

Example 22: A Fresh Clean Citrus Fragrance for an All-Purpose Cleaner

(117) The following fragrance accord has been created for an all-purpose cleaner and is to be assessed at 0.3% in the unperfumed product base.

(118) TABLE-US-00001 Amount parts CAS number Ingredient name wt/wt 140-11-4 Benzyl acetate 15 80-26-2 Terpenyl Acetate 60 101-86-0 alpha Hexyl Cinnamic 30 Aldehyde 112-31-2 Decanal 18 67634-00-8 Allyl amyl glycolate 3 1092785-58-4 Cassyrane ™ (Givaudan) 0.5 106-22-9 Citronellol 20 68039-49-6 Cyclal C 5 57378-68-4 delta Damascone 1 65405-70-1 4-E-Decenal 0.2 18479-58-8 Dihydro Myrcenol 60 8000-48-4 Eucalyptus Essence 10 67634-14-4 Floralozone 3 125109-85-5 Florhydral 2 14765-30-1 Freskomenthe 5 54464-57-2 Iso E Super 20 20665-85-4 Isobutavan 0.2 1335-46-2 Isoraldeine 70 10 198404-98-7 Javanol 1 81783-01-9 Labienoxime 1% in 3 TEC/IPM 61792-11-8 Lemonile 35 73018-51-6 Lime Oxide 20 78-70-6 Linalool 90 39255-32-8 Manzanate 2 37677-14-8 Myraldene 10 1637294-12-2 Nympheal 8 68647-72-3 Orange Terpenes 300 916887-53-1 Petalia ™ (Givaudan) 7 313973-37-4 Pharaone ™ (Givaudan) 4 10% in DPG 82461-14-1 Rhubafuran 0.5 1655500-83-6 Rosyfolia ™ (Givaudan) 3 16510-27-3 Toscanol ™ (Givaudan) 1 Reference Accord Accord Accord A B 4-(dodecylthio)-4- 0 2 10 methylpentan-2-one (Example 1) 25265-71-8 Dipropylene Glycol 252.6 250.6 242.6 Total parts wt/wt 1000 1000 1000

(119) The olfactory character imparted to the product by the reference accord is citrus and fresh floral aldehydic, with a watery facette.

(120) Addition of 0.2% of 4-(dodecylthio)-4-methylpentan-2-one (Example 1) enhances the citrus odor aspect, while addition of 1% renders the accord more intense citrus and enhances the juicy aspect. After 24 hours application on a floor tile, the perfume is slightly more intense with the addition of 0.2% 4-(dodecylthio)-4-methylpentan-2-one and clearly more intense, fresher and juicier than the reference with 1%.

Example 23: Olfacive Evaluation of Compound According to Example 1 and Mixtures Thereof with Mesityl Oxide

(121) Mixtures of the compound according to Example 1 (4-(dodecylthio)-4-methylpentan-2-one) with mesityl oxide were prepared in different ratios and subjected to olfactive evaluation. All samples were assessed as 10% solutions in ethanol on a fresh blotter.

(122) TABLE-US-00002 Sample Olfacive evaluation 4-(dodecylthio)-4-methylpentan-2-one cassis, sulphur, eucalyptus bud, overall sulphurous impression is dominant, polarizing 4-(dodecylthio)-4-methylpentan-2-one, effect is minor, and olfactive spiked with 0.01 wt.-% or 0.03 wt.-% profile still very close to pure mesityl oxide material 4-(dodecylthio)-4-methylpentan-2-one, combination starts to bring a spiked with 0.1 wt.-% mesityl oxide positive olfactive benefit 4-(dodecylthio)-4-methylpentan-2-one, combination brings a positive spiked with 0.3 wt.-% mesityl oxide olfactive benefit, more juicy, more pleasant 4-(dodecylthio)-4-methylpentan-2-one, fruity juicy cassis, juicy, containing 0.8% mesityl oxide pleasant 4-(dodecylthio)-4-methylpentan-2-one, combination brings a positive spiked with 1.0 wt.-% mesityl oxide olfactive benefit, more juicy 4-(dodecylthio)-4-methylpentan-2-one, mesityl oxide starts to spiked with 3.0 wt.-% mesityl oxide dominate, and brings an additional green and technical facet mesityl oxide green, solvent, plastic like, then fruity, almondy, cherry

(123) The above results show that there is an optimum ratio between 4-(dodecylthio)-4-methylpentan-2-one and mesityl oxide, in which the mixture shows superior olfactive properties.

Example 24: Application in Liquid Detergent 1

(124) Three samples of liquid detergent samples (34 g each) were prepared by adding 0.2 wt.-% of the following precursors according to the present invention to a non fragranced heavy duty liquid detergent base (pH 8.4): 4-(decylthio)-4-methylpentan-2-one (Example 14), 4-(dodecylthio)-4-methylpentan-2-one (Example 1) and 4-methyl-4-(tetradecylthio)pentan-2-one (Example 15). The samples were used to wash a load of 5 cotton terry towels (ca. 200 g dry weight each, 1.1 kg total load) in a standard frontloading washing machine. The wash cycle was carried out at 40° C., followed by two cold rinse cycles and spinning at 1000 rpm. The washed towels were assessed blind by a panel of 6 experienced evaluators for fragrance intensity on wet towel and after 24 h line dry at room temperature. The intensity was indicated on a scale from 0 (odorless) to 5 (very strong).

(125) TABLE-US-00003 Fragrance intensity Fragrance intensity on dry towel Ingredient on wet towel (24 h line dry) 4-(decylthio)-4-methyl- 1.5 0.8 pentan-2-one 4-(dodecylthio)-4- 1.2 2.1 methylpentan-2-one 4-methyl-4-(tetra- 1.0 1.3 decylthio)pentan-2-one

(126) As can be seen from the results provided in the table above, the comparative study of three precursors according to the present invention with R.sub.1=R.sub.3=R.sub.4=methyl, R.sub.2=R5=H and R.sub.6=nonyl, undecyl or tridecyl, the strongest precursor effect was observed with R.sub.6=undecyl. The observed differencies between R.sub.6=undecyl and R.sub.6=nonyl or R.sub.6=tridecyl were significant at confidence levels of 99.8% and 96%, respectively.

(127) Due to the high volatility and water solubility of the released odorant 4-mercapto-4-methyl-2-pentanone (clogP=1.0, as compared to clogP=7.2 for 4-(dodecylthio)-4-methylpentan-2-one), it would not have been technically possible to deposit a sufficient amount of the material on fabric to trigger a fragrance impact.

Example 25: Application in Liquid Detergent 2

(128) a) General

(129) As series of experiments was conducted in order to determine whether fragrance ingredients according to the present invention show intensity benefits in fabric detergents. The compound of Example 1 (4-(dodecylthio)-4-methylpentan-2-one) was tested with two fragrances A and B, which had different olfactive profiles. The products were assessed on wet cloth and on 1 day, 3 days and 7 days dried cloth.

(130) The members of a sensory analysis panel were selected on a basis of their olfactory sensory acuity and then trained for several months. Their training enabled them to identify individual odor characteristics and score their perceived intensity against given standards in a consistent manner.

(131) The fabrics were washed in European washing machines (40° C.-1,000 spin/min) with one unit dose per wash load. For the wet stage, after washing, the cloths were placed into 500 mL wide necked glass jars ready for assessment. For the dry cloth assessment, the cloth was lined-dried and left overnight in a perfume free room at 25° C. Cloths washed with fragrance A were used as the control.

(132) For all stages the overall perceived intensity was assessed by the trained sensory panel using a 0-100 linear scale. All overall perceived intensities were scaled against a reference sample A, for which the overall perceived intensity was set at 35 for wet cloth assessment and 10 for the dry cloth assessments where the reference sample was a 1 day dry cloth. The reference sample A was presented in the same format as the test samples for the wet cloth and dry cloth assessment.

(133) For the wet cloth assessment, each sample was assessed twice by 20 panellists, thus giving 40 assessments per product. For the 1 day, 3 days and 7 days dry cloth assessments, each sample was assessed twice by 14 panellists, thus giving 28 assessments per product.

(134) The estimated product means are reported on the next pages, together with any statistically significant differences between products.

(135) b) Wet Cloth

(136) TABLE-US-00004 Overall Perceived Significance of Product Intensity Differences Fragrance A 35.7 A Fragrance A + 2% Precursor 35.8 A Fragrance B 44.6 B Fragrance B + 2% Precursor 45.2 B

(137) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(138) When assessed from wet cloth, cloth washed with Fragrance B or Fragrance B+2% precursor were not perceived to be significantly different, but were perceived to be significantly stronger than cloth washed with Fragrance A or Fragrance A+2% precursor, which were also not perceived to be significantly different to each other.

(139) c) Dry Cloth 1 Day

(140) TABLE-US-00005 Overall Perceived Significance of Product Intensity Differences Fragrance A 10.9 A Fragrance A + 2% Precursor 23.4 B Fragrance B 12.3 A Fragrance B + 2% Precursor 27.3 C

(141) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(142) When assessed from 1 day dry cloth, cloth washed with Fragrance A+precursor was perceived to be significantly stronger than cloth washed with Fragrance A. Cloth washed with Fragrance B was perceived to be significantly weaker than cloth washed with Fragrance B+precursor.

(143) d) Dry Cloth 3 Days

(144) TABLE-US-00006 Overall Perceived Significance of Product Intensity Differences Fragrance A 11.1 A Fragrance A + 2% Precursor 22.9 C Fragrance B 16.0 B Fragrance B + 2% Precursor 26.1 D

(145) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(146) When assessed from 3 day dry cloth, cloth washed with Fragrance B+2% precursor was perceived to be significantly stronger than cloth washed with any of the other products. Whereas, cloth washed with Fragrance A was perceived to be significantly weaker than cloth washed with any of the other products.

(147) e) Dry Cloth 7 Days

(148) TABLE-US-00007 Overall Perceived Significance of Product Intensity Differences Fragrance A 14.1 A Fragrance A + 2% Precursor 23.1 B Fragrance B 15.6 A Fragrance B + 2% Precursor 25.2 B

(149) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(150) When assessed from 7 day dry cloth, cloth washed with Fragrance A+2% precursor or Fragrance B+2% precursor were not perceived to be significantly different, but were perceived to be significantly stronger than cloth washed Fragrance A or Fragrance B which were also not perceived to be significantly different to each other.

(151) f) Conclusion

(152) When assessed from wet cloth, for both Fragrance A and Fragrance B, the cloth washed with product containing the precursor was comparable in terms of strength to cloth washed with product not containing the precursor. When assessed from 1 day, 3 day and 7 day dry cloth, for both Fragrance A and Fragrance B, the cloth washed with product containing the precursor was perceived to be significantly stronger than the same fragrance without the precursor.

Example 26: Application in All-Purpose Cleaner

(153) a) General

(154) As series of experiments was conducted in order to determine whether fragrance ingredients according to the present invention show intensity benefits in all purpose cleaners (APCs). The compound of Example 1 (4-(dodecylthio)-4-methylpentan-2-one) was tested with two fragrances A and B, which had different olfactive profiles. The products were assessed in booths on the floor at fresh (time=0) and after 1 hour, 2 hours and 4 hours application.

(155) The members of a sensory analysis panel were selected on a basis of their olfactory sensory acuity and then trained for several months. Their training enabled them to identify individual odor characteristics and score their perceived intensity against given standards in a consistent manner.

(156) The testing was carried out in small booths (10 m.sup.3 booths, 21° C., 50% RH) specifically designed. The booths were closed during testing, with the doors sealed. The APC products were diluted at 1.2% in warm water (45° C.+/−2° C.). 60 mL of the diluted product was applied directly to the booth floor. It was evenly spread using a gloved hand, over an area of 65 cm×65 cm.

(157) The system was assessed through a porthole in the door of the booth. The overall perceived intensity was assessed by the trained sensory panel using a 0-100 line scale. The dilution assessment was conducted over four sessions. The Fresh (time=0), 1 hour and 4 hour stages were assessed by 16 panelists, thus giving 32 assessments per product. The 2 hour stage was assessed by 17 panelists, thus giving 34 assessments per product.

(158) The estimated product means are reported on the next pages, together with any statistically significant differences between products.

(159) b) Fresh (time=0) bloom from floor assessment

(160) TABLE-US-00008 Overall Perceived Significance of Product Intensity Differences Fragrance A 33.8 A Fragrance A + 5% Precursor 33.7 A Fragrance B 36.5 A Fragrance B + 4% Precursor 37.8 A Fragrance B + 8% Precursor 36.5 A

(161) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(162) When the products were assessed fresh (time=0), there was no perceived significant difference between the booths containing any of the five products tested.

(163) c) One hour bloom from floor assessment

(164) TABLE-US-00009 Overall Perceived Significance of Product Intensity Differences Fragrance A 28.8 A Fragrance A + 5% Precursor 37.9 C Fragrance B 33.1 B Fragrance B + 4% Precursor 35.4 BC Fragrance B + 8% Precursor 37.0 C

(165) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(166) When the products were assessed after 1 hour application, booths containing Fragrance B+8% precursor or Fragrance A+5% precursor were not perceived to be significantly different to booths containing Fragrance B+4% precursor, but were perceived to be significantly stronger than booths containing Fragrance A or Fragrance B.

(167) d) Two Hour Bloom from Floor Assessment

(168) TABLE-US-00010 Overall Perceived Significance of Product Intensity Differences Fragrance A 21.6 A Fragrance A + 5% Precursor 29.2 B Fragrance B 18.2 A Fragrance B + 4% Precursor 19.5 A Fragrance B + 8% Precursor 31.1 B

(169) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(170) When the products were assessed after 2 hours application, the booths containing Fragrance A+5% precursor or Fragrance B+8% precursor, which were not perceived to be significantly different, were perceived to be significantly stronger than the booths containing Fragrance A, Fragrance B or Fragrance B+4% precursor, which were also not perceived to be significantly different to each other.

(171) e) Four Hour Bloom from Floor Assessment

(172) TABLE-US-00011 Overall Perceived Significance of Product Intensity Differences Fragrance A 20.4 B Fragrance A + 5% Precursor 28.6 C Fragrance B 10.8 A Fragrance B + 4% Precursor 20.8 B Fragrance B + 8% Precursor 27.2 C

(173) Where the same letter is shown in the “significance of differences” column there are no statistically significant differences between the relevant figures.

(174) When the products were assessed after 4 hours application, the booths containing Fragrance B+8% precursor or Fragrance A+5% precursor, which were not perceived to be significantly different, were perceived to be significantly stronger than booths containing Fragrance A or Fragrance B+4% precursor, which were also not perceived to be significantly different to each other. Furthermore, booths containing Fragrance B were perceived to be significantly weaker than the booths containing any of the other four products tested.

(175) f) Conclusion

(176) Fragrance A+5% precursor was comparable in terms of strength to Fragrance A at fresh (time=0), but was perceived to be significantly stronger than Fragrance A when assessed 1 hour, 2 hours and 4 hours after application.

(177) The Fragrance B+8% precursor was comparable in terms of strength to Fragrance B at fresh (time=0) but was perceived to be significantly stronger than Fragrance B when assessed 1 hour, 2 hours and 4 hours after application. Whereas Fragrance B+4% precursor was comparable in terms of strength to Fragrance B at the fresh, 1 hour and 2 hour assessments, but was perceived to be significantly stronger than Fragrance B when assessed 4 hours after application.

(178) Furthermore, Fragrance A+5% precursor and Fragrance B+8% precursor were comparable in terms of strength when assessed at all time points (0, 1, 2 and 4 hours).