SIGNAL TRANSMISSION FOR MAGNETIC-PARTICLE-IMAGE SIGNAL DETECTION

Abstract

The invention relates to a method for carrying out signal detection by means of magnetic particle imaging, in which method magnetic/magnetisable particles (4), arranged in the field-free region of a location-dependent magnetic field, in particular a gradient magnetic field, are magnetised by means of an excitation magnetic field that changes over time, and the harmonics (9, 15), generated by the particles (4), of the frequency of the excitation magnetic field are detected as a signal from the magnetic particles (4) by means of a receiver coil arrangement (1) which in particular surrounds the particles (4), wherein a signal-transmitting arrangement, which has an outer coil (10) and at least one inner coil (11; 16, 17) connected in series to said outer coil, is positioned within the receiver coil arrangement (1) around the particles (4), wherein the signal received from the particles (4) by the at least one inner coil (11; 16, 17) is transmitted to the outer coil (10) by current flow and is re-emitted by said outer coil, in particular as a result of which the signal (S) received directly from the particles (4) and the signal (S) received from the particles (4) indirectly by the outer coil (10) are superimposed at the receiver coil arrangement (1). The invention also relates to a signal-transmitting arrangement for a magnetic-particle-imaging scanner/spectrometer, comprising an outer coil (10) which in particular has a smaller diameter than the sample-receiving channel (2) of the scanner/spectrometer, and comprising at least one inner coil (11; 16, 17) which is arranged in the outer coil (10), preferably arranged coaxially therein, and in particular has greater diameter than a sample to be examined, wherein the outer coil (10) and the inner coil (11; 16, 17) are electrically connected in series. The invention also relates to a system comprising a magnetic-particle-imaging scanner and a signal-transmitting arrangement.

Claims

1. A method of detecting a signal with magnetic-particle imaging, the method comprising the steps of: magnetizing magnetic/magnetizable in a field-free region of a location-dependent magnetic field by a gradient and temporally changing excitation magnetic field; receiving harmonics of the frequency of the excitation magnet as signals from the magnetized particles by a receiving coil assembly surrounding the particles; and providing the coil assembly with a signal-transmission assembly having an outer coil and at least one inner coil connected in series therewith; relatively oriented such that a signal received from the particles by the inner coil is transmitted by current flow to the outer coil and is emitted again thereby and in particular the signal directly received by the receiving-coil assembly from the particles are superimposed on the signal received indirectly from by the particles by the receiving-coil assembly.

2. The method according to claim 1, further comprising the step of: resonantly tuning the signal-transmission assembly by a capacitor assembly that is adjustable with respect to capacitance and that is connected in series with the outer coil and the inner coil to the frequency range of the harmonic while damping reception of the base frequency of the excitation magnetic field such that the capacitor is outside the excitation magnetic field.

3. The method according to claim 1, further comprising the step of: moving the inner coil relative to the outer coil and relative to the particles during a signal-detection sequence.

4. The method according to claim 1, further comprising the step of: selectively connecting one of at least two subcoils of the inner coil that are spaced from one another on the same axis in series with the outer coil by a switch assembly.

5. The method according to claim 4, further comprising the step of: differently tuning the inner subcoils that simultaneously receive signals from the particles.

6. A signal-transmission assembly for a magnetic particle imaging scanner/spectrometer, the assembly comprising: an outer coil that is smaller in diameter than a sample-receiving passage of the scanner/spectrometer, and an inner coil that is in the outer coil coaxially therein and larger in diameter than a sample to be examined, the outer coil and the inner coil being electrically connected in series.

7. The signal-transmission assembly according to claim 6, further comprising: a capacitor adjustable with respect to capacitance and connected in series to the outer coil and to the inner coil, the capacitor being spaced from the coils; a cable connecting the capacitor to the outer coil, and a separate shielding housing holding the capacitor.

8. The signal-transmission assembly according to claim 6, further comprising: a common coil support carrying the outer coil and the inner coil.

9. The signal-transmission assembly according to claim 8, wherein the inner coil is movable relative to the outer coil or to the coil support part thereof.

10. The signal-transmission assembly according to claim 6, wherein each inner coil is formed by two inner subcoils spaced apart on the same axis and alternately connectable in series with the outer coil by a switch assembly.

11. The signal-transmission assembly according to claim 10, wherein the inner subcoils are both connected in series with the same outer coil and in series with a respective capacitor to form a respective subassembly therewith, the subassemblies being connected in parallel with each other and in series with the outer coil.

12. The signal-transmission assembly according to claim 6, further comprising: a coil support for the outer coil and a coil support for the inner coil that are mechanically and electrically detachable and connectable, the inner coil support being connected to the inner coil and selected from a set of a plurality of inner coil supports having inner coils that are different in diameter.

13. The signal-transmission assembly according to that claim 6, wherein electrical conductors of the coils are coolable by a coolant flowed in the conductors for dissipating lost heat and/or for cooling into a superconducting range.

14. The signal-transmission assembly according to that claim 6, wherein the inner and outer coils are each wound around a longitudinal axis of a coil conductor winding with a pitch of the winding in the direction of the longitudinal axis as a solenoid coil.

15. The signal-transmission assembly according to claim 6, wherein the inner and/or the outer coil is formed by two coil parts that are connected to one another in series and are opposite one another opposite one another by 180° around a longitudinal axis.

16. The signal-transmission assembly according to claim 15, wherein each of the two coil parts is a conductor shaped as a helical winding formed in a partially circular manner in a plane perpendicular to the longitudinal axis and formed around a cylindrical surface or lies on a cylindrical surface.

17. A system comprising a magnetic-particle imaging scanner and a signal-transmission assembly according to claim 6.

Description

[0061] The prior art and preferred embodiments are shown in the following figures.

[0062] FIG. 1A is a structural view of a prior-art MPI scanner;

[0063] FIG. 1B: shows the electrical equivalent circuit diagram for FIG. 1B;

[0064] FIG. 1C shows a prior-art signal spectrum according to FIGS. 1A and 1B as a signal amplitude against the frequency;

[0065] FIG. 2A is a structural view according to the invention in section perpendicular to the coil axes;

[0066] FIG. 2B shows the electrical equivalent circuit diagram of the embodiment of FIG. 2A;

[0067] FIG. 2C shows a signal spectrum compared to the prior art according to the invention of FIG. 2A/2B with signal amplitude mapped against frequency;

[0068] FIG. 3A is a structural view of second embodiment according to the invention in section parallel to the coil axis;

[0069] FIG. 3B: shows the electrical equivalent circuit diagram of the embodiment of FIG. 3A;

[0070] FIG. 3C shows the magnetic field strength and thus the detection sensitivity of both coils of the embodiment of FIGS. 3A-3B against the Z-axis, i.e. the coil axis [; and

[0071] FIGS. 4A-4F show possible embodiments of the inner and outer coils of the signal-transmitting apparatus.]

[0072] An embodiment according to the prior art is shown in FIGS. 1[A-C] and 2[A-C]. In this embodiment, an exciting coil 1 driven by a driving voltage 5 generates the time-varying excitation magnetic field as well and also acts as a receiving coil to detect signals of the particles 4. The coil assembly 1 is radially outwardly surrounded by a cover 2 internally defining the sample-receiving passage. The field-free region is located in a test space 3 and in this passage can be varied locally.

[0073] The location-dependent magnetic field, in particular the gradient magnetic field, forming a field-free region is assumed here as given. The means for generating this magnetic field are not further shown or, in one possible embodiment, could also be simultaneously provided by the coil assembly 1.

[0074] As a result of the magnetic alternating field of the exciting coil 1, particles 4 in the field-free region of the test space 3 are nonlinearly remagnetized. The magnetization of the particles 4 thus changes with the base frequency of excitation and higher harmonics of this frequency. FIG. 1C shows a frequency spectrum of the measured frequencies of the alternating magnetic field generated by the particles 4. Signal components S of a base frequency/excitation frequency 8 and of the harmonics 9 that can be unambiguously assigned only to the particles 4 as the source of the signal are here plotted against frequency f.

[0075] FIGS. 2[A-C] show a first possible embodiment of the invention. In the same way, the exciting/receiving coil 1 of a commercial MPI scanner, for example, can be seen radially behind the housing/sample-receiving passage 2.

[0076] In addition, FIGS. 2[A-C] show a signal-transmission assembly inserted into the sample-receiving passage and also the particles 4 in the test space 3.

[0077] The signal-transmission assembly comprises an outer coil 10 that is smaller in diameter than the sample-receiving passage 2 and an inner coil 11 that is smaller in diameter than the outer coil 10, but in particular larger than a sample to be surrounded with the particles 4. Both coils 10 and 11 are electrically connected in series to one another and to a capacitor 13. In this case, the capacitor 13 that serves for resonance tuning is connected with a twisted-pair line 14 extending out of the sample-receiving passage 2 and is in a shielding housing 12. The capacitor 13 can be of fixed capacitance, but can also be adjustable, for example in that it comprises at least one rotary capacitor.

[0078] FIGS. 2[A-C] show that the inner coil 11 is closer to the particles 4 than the excitation/receiving coil assembly 1 and also closer than the outer coil 10. The magnetic field generated by the particles 4 thus induces a voltage in the inner coil 11, in particular a higher voltage than directly in the coil assembly 1. This induced voltage current to flow through the inner coil 11 and the outer coil 10, so that the latter in turn generates a magnetic field that also generates an induction voltage in the coil assembly 1. The induction voltages generated on directly and indirectly via the coils 10 and 11 in the coil assembly 1 overlap and have the same frequency components as in FIG. 1C. In contrast, FIG. 2C shows that the signal amplitude S in the harmonics 9 is increased by the signal components 15 using the invention compared to the prior art on account of the better coupling of the magnetic field generated by the particles 4 via the signal transmission device. Here, the signal components 15 increased by the invention are shown by dotted lines.

[0079] FIGS. 3[A-C] show a further embodiment in which two inner subcoils 16 and 17 are used in the signal transmission device according to the invention. Each of the two inner subcoils 16 and 17 may alternatively be connected by a switch 19 in series with the outer coil 10 and capacitor 13.

[0080] According to FIG. 3C, two inner subcoils 16 and 17 have magnetic field strength distributions B along the coil axis Z that preferably overlap in some regions—as shown here—and that likewise form the receiving sensitivity distributions for magnetic fields generated by the particles 4 as a function of the coil axis position Z represent. On the basis of these distributions known for the coils 16 and 17, the position of the particles 4 on the coil axis Z can be inferred from the signal spectra detected on the one hand with the coil 16 and, on the other hand, with the coil 17, and thus the spatial resolution can be improved.

[0081] Instead of switching, the use of one capacitor in each case for each of the coils 16 and 17 is also possible, so that different resonance frequencies are obtained that thus make possible a simultaneous measurement.

[0082] FIGS. 4[A-F] show possible embodiments of the signal transmission device with regard to formation of the inner and outer coils.

[0083] FIG. 4A shows a view of the Z-axis that is the longitudinal axis of the sample-receiving passage. The view shows the last winding position of the inner coil 11 and the outer coil 10 that are each a solenoid coil, as shown in FIG. 4E, i.e. the windings of the coil conductor extend helically about the Z-axis.

[0084] In contrast, FIGS. 4B and 4C show inner and outer coils 10 and 11. The series connection of both coil parts is not shown here.

[0085] FIG. 4F shows each coil part of the two coils 10, 11 in a coplanar representation. In this illustration, the coil part is a spiral winding of the conductor. An application of this type is such however, that the spiral winding is bent, in particular bent around an imaginary or even actual cylindrical surface, for example the cylindrical surface of the inner or outer coil support that are not shown here.

[0086] The two coil parts lie diametrically opposite each other relative to the Z-axis. Thus, in the opposite position of FIG. 4C, a passage of signal detection extends in the X direction and in FIG. 4C a passage extending in the Y direction.

[0087] FIG. 4D shows a signal transmission apparatus where the coil assemblies of FIGS. 4A, B and C are jointly combined about the Z axis is shown. Signal contributions in all three directions can be detected in this arrangement.