SWAB FOR COLLECTING SAMPLE AND MANUFACTURING METHOD THEREOF

Abstract

A swab for collecting a sample includes a swab support, and a swab pile formed at one side of the swab support. The swab pile has a thickness of 0.5 to 2.5 deniers and a length of 0.8 to 1.0 mm. A method for manufacturing the swab includes: manufacturing a flocking jig by coating an adhesive on the swab support, performing electric charge to the swab pile, and planting a swab pile into one side of the swab support.

Claims

1. A swab for collecting a sample comprising: a swab support; and a swab pile formed at one side of the swab support.

2. The swab according to claim 1, wherein the swab pile has a thickness of 0.5 to 2.5 deniers and a length of 0.8 to 1.0 mm.

3. A manufacturing method of a swab for collecting a sample comprising the steps of: (S1) manufacturing a flocking jig by coating an adhesive on the swab support; (S2) performing electric charge to the swab pile; and (S3) planting a swab pile into one side of the swab support.

4. The manufacturing method according to claim 3, wherein the step (S1) comprises the steps of: (S1A) coating an adhesive on one side of the swab support; and (S1B) fixing the swab support, on which the adhesive is coated, to the flocking jig.

5. The manufacturing method according to claim 3, wherein the step (S3) comprises the steps of: (S3A) positioning the flocking jig and the swab pile between a first high-pressure plate and a second high-pressure plate; (S3B) applying voltage of 15 to 45 kV and current of 1 to 5 mA to the first high-pressure plate, and applying voltage of 15 to 45 kV to the second high-pressure plate; and (S3C) planting the swab pile into one side of the swab support using a potential difference between the first high-pressure plate and the second high-pressure plate.

6. The manufacturing method according to claim 3, further comprising the step of: (S4) drying the swab support in which the swab pile is planted.

7. The manufacturing method according to claim 6, wherein the step (S4) is a step of drying the swab support, in which the swab pile is planted, at temperature of 55 to 65° C. and in a humidity condition of 20 to 80%.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The above and other objects, features and advantages of the present invention will be apparent from the following detailed description of the preferred embodiments of the invention in conjunction with the accompanying drawings, in which:

[0038] FIG. 1 is a schematic front view illustrating a swab for collecting a sample according to the present invention;

[0039] FIG. 2 is a schematic view illustrating a step of coating an adhesive on one side of a swab support in a manufacturing method of a swab for collecting a sample according to the present invention;

[0040] FIG. 3 is a schematic view illustrating a step of fixing the swab support coated with the adhesive to a flocking jig in the manufacturing method of a swab for collecting a sample according to the present invention;

[0041] FIG. 4 is a schematic view illustrating a step of planting a swab pile into one side of the swab support through high pressure treatment in the manufacturing method of a swab for collecting a sample according to the present invention;

[0042] FIG. 5 illustrates measurement of the swab pile of the swab for collecting a sample through a scanning electron microscope (SEM); and

[0043] FIG. 6 illustrates a swab (embodiment 1) for collecting a sample, which is manufactured according to the present invention, and a comparative swab (comparative example 2) for collecting a sample.

DETAILED DESCRIPTION

[0044] Terms including descriptive or technical terms which are used herein should be construed as having meanings that are obvious to one of ordinary skill in the art. However, the terms may have different meanings according to an intention of one of ordinary skill in the art, precedent cases, or the appearance of new technologies. Also, some terms may be arbitrarily selected by the applicant, and in this case, the meaning of the selected terms will be described in detail in the detailed description of the invention. Thus, the terms used herein have to be defined based on the meaning of the terms together with the description throughout the specification.

[0045] Unless otherwise defined, all terms, including technical and scientific terms, used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this inventive concept belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and/or the present application, and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

[0046] The numerical range includes the numerinal values defined the range. All maximum numerical limits given throughout this specification include all lower numerical limits as if the lower numerical limits were clearly written. All minimum numerical limits given throughout this specification include all higher numerical limitations as if the higher numerical limit were clearly written. All numerical limits given throughout this specification will include all better numerical ranges within the broader numerical ranges, as if narrower numerical limits are clear written.

[0047] Hereinafter, embodiments of the present invention will be described in detail, but the protection scope of the present invention is not limited to the following embodiments.

[0048] Swab for Collecting Sample

[0049] The present invention provides a swab 1 for collecting a sample, comprising: a swab support 100; and a swab pile part 200 formed on one side of the swab support 100.

[0050] The swab support 100 is made of a resin material, and is at least one selected from the group consisting of polyoxymethylene (POM), polystyrene (PS), polypropylene (PP), polyethylene (PE), polyurethane (PU), polyamide (PA), polycarbonate (PC), high density polyethylene (HDPE), low density polyethylene (LDPE), polymethyl methacrylate (PMMA), polyvinyl chloride (PVC), and acrylonitrile butadiene styrene copolymer resin (ABS resin).

[0051] The swab pile part 200 may be one or more swab piles 210 selected from the group consisting of nylon, rayon, polypropylene, polyester, polyamide, and acrylic.

[0052] The swab pile part 200 can be formed on one side of the swab support 100, and is preferably located on the upper portion of the swab support 100.

[0053] The swab pile part 200 can have a thickness of 0.5 to 2.5 deniers. The swab pile part 200 of the swab according to the present invention shows higher sample extraction efficiency when collecting a sample since having the thickness of 0.5 to 2.5 deniers.

[0054] The term “denier” used in the present invention is a measure of a thickness of a yarn, and the denier applied to the present invention means a thickness of the swab pile of the present invention.

[0055] The swab pile part 200 can have a length of 0.8 to 1.0 mm. If the length of the swab pile part 200 is less than 0.8 mm, the swab pile part 200 holds together on the swab support 100 due to a warp phenomenon when the swab 1 for collecting a sample is manufactured. If the length of the swab pile part 200 exceeds 1.0 mm, lumpishness may occur during drying when the swab 1 for collecting a sample is manufactured. Therefore, it is preferable that the swab pile part 200 be 0.8 to 1.0 mm.

[0056] In the swap 1 for collecting a sample, the swab support 100 and the swab pile part 200 can be formed at a length ratio of 3:1 to 12:1 (swab support to swab pile part), and the swab support 100 and the swab pile part 200 are formed at a thickness ratio of 0.1:1 to 0.6:1 (swab support to swab pile part), thereby improving structural stability.

[0057] In addition, the swab 1 for collecting a sample according to the present invention can be a swab for the nasal cavity or the oral cavity.

[0058] The swap 1 for collecting a sample according to the present invention has the swab pile of 0.5 to 2.5 deniers planted into a swab support, thereby providing a remarkably improved sample extraction efficiency without agglomeration of cilia.

[0059] Manufacturing Method of Swab for Collecting Sample

[0060] The present invention provides a manufacturing method of a swap 1 for collecting a sample, comprising the following steps:

[0061] (S1) manufacturing a flocking jig 110 by coating an adhesive 300 on the swab support 100; (S2) performing electric charge to the swab pile 210; and

[0062] (S3) planting a swab pile 210 into one side of the swab support 100.

[0063] The swap 1 for collecting a sample is as described above.

[0064] The step (S1) is a step of coating an adhesive 300 on the swab support 100 to manufacture a flocking jig 110, and includes the steps:

[0065] (S1A) coating an adhesive 300 on one side of the swab support 100; and

[0066] (S1B) fixing the swab support 100, on which the adhesive 300 is coated, to the flocking jig 110.

[0067] In more detail, the step (S1A) is a step of coating an adhesive 300 on one side of the swab support 100. The swab support 100 can be coated with the adhesive 300 when being dipped in a mold containing the adhesive 300 therein.

[0068] The adhesive 300 is a mixed adhesive of an acrylic monomer and urethane, and the acrylic monomer may be methyl methacrylate and methacrylic acid.

[0069] Furthermore, the adhesive 300 may have a viscosity of 18,000 to 25,000 cps at 25° C., and preferably, has a viscosity of 18,000 to 22,000 cps at 25° C.

[0070] In addition, the adhesive 300 may be a neutral range of 7 pH to 8.5 pH or may be weakly basic.

[0071] The adhesive 300 may be coated to have a thickness ranging from 0.20 mm to 1.00 mm from the surface of the swab support 100. More specifically, if the adhesive 300 is coated on the surface of the swab support 100 to be less than 0.20 mm, the swab pile 210 may not be fixed. If the adhesive 300 is coated on the surface of the swab support 100 to exceed 1.00 mm, the swab pile 210 is injected into the adhesive 300 so deeply that the swab pile 210 gets too shorter in the swab 1 for collecting a sample according to the present invention. Therefore, it is most preferred that the adhesive 300 be coated to have a thickness of 0.20 to 1.00 mm from the surface of the swab support 100.

[0072] The step (S2) is a step of performing electric charge to the swab pile 210. Silica, a metallic material, or tannin is coated on the surface of the swab pile 210. In more detail, since silica, a metallic material, or tannin is coated on the surface of the swab pile 210, the swab pile 210 can be fixed to the swab support by being charged during high-pressure treatment, which will be described later, it can prevent the swab pile 210 from yellowing through the charging process.

[0073] In the step (S3), a swab pile 210 is planted into one side of the swab support 100 to manufacture a swap 1 for collecting a sample, and includes the following steps of:

[0074] (S3A) positioning the flocking jig 110 and the swab pile 210 between a first high-pressure plate and a second high-pressure plate;

[0075] (S3B) applying voltage of 15 to 45 kV and current of 1 to 5 mA to the first high-pressure plate, and applying voltage of 15 to 45 kV to the second high-pressure plate; and (S3C) planting the swab pile 210 into one side of the swab support 100 using a potential difference between the first high-pressure plate and the second high-pressure plate.

[0076] In the step (S3), high pressure is applied to the first high-pressure plate and the second high-pressure plate, and the swab pile 210 can be more strongly planted into one side of the swab support 100 by the potential difference generated at the same time.

[0077] The step (S3) may be performed at temperature of 15 to 40° C. and in a humidity condition of 20 to 80%.

[0078] Moreover, the manufacturing method of the swap 1 for collecting a sample may further include a step of: (S4) drying the swab support 100 in which the swab pile 210 is planted to form a swab pile part 200.

[0079] In more detail, the step (S4) may be the step of: (S4) drying the swab support 100, in which the swab pile 210 is planted to form the swab pile part 200, at temperature of 55 to 65° C. and in a humidity condition of 20 to 80%.

[0080] The manufacturing method of the swap 1 for collecting a sample according to the present invention is capable of mass-producing the swabs efficiently and sanitarily without agglomeration of cilia since the swab pile of 0.5 to 2.5 deniers is charged with electricity and the cilia are flocked to the swab support 100 coated with the adhesive 300.

[0081] Advantages and features of the present disclosure and methods accomplishing the advantages and features will become apparent from the following detailed description of exemplary embodiments with reference to the accompanying drawings. However, the present invention is not limited to exemplary embodiment disclosed herein but will be implemented in various forms. The exemplary embodiments are provided so that the present invention is completely disclosed, and a person of ordinary skilled in the art can fully understand the scope of the present invention. Therefore, the present invention will be defined only by the scope of the appended claims.

Embodiment 1. Manufacturing of Swab for Collecting Sample

[0082] A swab support made of polyoxymethylene (POM) was dipped in a mixed adhesive of acrylic monomer (methylmethacrylate and methacrylic acid) and urethane (21,000 cps, 7 pH, and 25° C.) to be coated by a thickness of 0.57 mm, and a swab support was fixed to the flocking jig. Next, a swab pile which was made of a nylon material and had a thickness of 1.1 denier and a length of 0.9 mm was coated with tannin to be charged with electricity. In addition, the swab support fixed to the flocking jig and the swab pile were located between a first high-pressure plate, in which voltage of 20 kV and current of 2 mA flows, and a second high-pressure plate, in which voltage of 20 kV flows, and the swab pile was planted into one side of the swab support by a potential difference between the first high-pressure plate and the second high-pressure plate. Through high-pressure treatment, the swab support in which the swab pile was planted was dried at temperature of 60° C. and under humidity condition of 45%, thereby manufacturing a swab for collecting a sample according to the present invention.

Comparative Example 1. Manufacturing of Comparative Swab 1 for Collecting Sample

[0083] All conditions were the same as in the Embodiment 1, except that a comparative swab 1 for collecting a sample was manufactured such that a swap pile of the comparative swab had a thickness of 3.0 deniers.

Comparative Example 2. Manufacturing of Comparative Swab 2 for Collecting Sample

[0084] All conditions were the same as in the Embodiment 1, except that a comparative swab 2 for collecting a sample was manufactured such that an adhesive coated on a swap support had a thickness of 1.5 mm.

Comparative Example 3. Manufacturing of Comparative Swab 3 for Collecting Sample

[0085] All conditions were the same as in the Embodiment 1, except that a comparative swab 3 for collecting a sample was manufactured such that a swap pile was planted in a state where only a first high-pressure plate existed without a second high-pressure plate.

Experimental Example 1

[0086] In order to confirm manufacturing of the swab for collecting a sample with 1.1 deniers, the swab manufactured in the Embodiment 1 was measured with a scanning electron microscope (SEM), and the measured result is illustrated in FIG. 5.

[0087] Referring to FIG. 5, it is confirmed that the swab for collecting a sample with 1.1 deniers was manufactured.

Experimental Example 2

[0088] In the swab with 1.1 deniers, in order to confirm a swap manufacturing result according to the thickness of the coated adhesive, the swabs manufactured by the Embodiment 1 and the Comparative example 2 were checked, and the check results are illustrated in FIG. 6.

[0089] Referring to FIG. 6, FIG. 6(A) shows that the swab with 1.1 deniers according to the present invention was manufactured in the form that the swab pile was dispersed evenly, but FIG. 6(B) shows that the comparative swab 2 having the adhesive coated thick caused lumpishness of the swab pile.

[0090] Through the results, it was confirmed that the thickness of the adhesive coated on one side of the swab support according to the present invention was optimized in planting the swab pile evenly.

Experimental Example 3. Extraction Efficiency

[0091] In order to confirm sample extraction efficiency of the swab for collecting a sample according to the present invention, as shown in the following [Table 1], a sample solution and an extracting solution were prepared. The swab pile of the swab manufactured in the Embodiment 1 was soaked in the sample solution for ten seconds, and then, the swab (Embodiment 1) absorbing the sample solution was soaked in the extracting solution. Then, the sample solution absorbed into the swab was dissociated in the extracting solution, and light with the wavelength of 595 nm was irradiated to the dissociated extracting solution three times in order to investigate absorbance. After that, sample extraction efficiency of the swab (Embodiment 1) according to the present invention was confirmed through the following [Mathematical Equation 1]. In order to compare the sample extraction efficiency, the same test was performed using the existing swab (Comparative example 1) having the swab pile of 3.0 deniers, and the test result is shown in the following [Table 2].

[0092] ※ Positive Control: Extracting Solution

[0093] ※ Negative Control: Buffer Solution

TABLE-US-00001 TABLE 1 Solution Composition Sample Mixture of artificial saliva (A.S.) and trypan solution blue of 0.4% (dye solution) (which were mixed at a volume ratio of 3:1) Extracting Mixture of sample solution and buffer solution solution (Tris buffer of 10 mM (8.0 pH) (which were mixed at a volume ratio of 1:5)

[00001]$\begin{array}{cc}\frac{\begin{array}{c}\mathrm{Absorbance}\mathrm{of}\mathrm{dissociated}\\ \mathrm{extracting}\mathrm{solution}-\\ \mathrm{Absorbance}\mathrm{of}\mathrm{negative}\mathrm{control}\end{array}}{\begin{array}{c}\mathrm{Absorbance}\mathrm{of}\mathrm{positive}\mathrm{control}-\\ \mathrm{Absorbance}\mathrm{of}\mathrm{negative}\mathrm{control}\end{array}}\times 100=\begin{array}{c}\mathrm{Extraction}\mathrm{efficiency}\\ \mathrm{of}\mathrm{swab}\end{array}& \left[\mathrm{Mathematical}\mathrm{Equation}1\right]\end{array}$

TABLE-US-00002 TABLE 2 Comparative Embodiment 1 example 1 No. (Swab of 1.1 deniers) (Swab of 3.0 deniers) 1 97.5 85.9 2 96.4 85.7 3 96.3 85.1 Average 96.73 85.57

[0094] As confirmed in [Table 2], it is confirmed that the swab for collecting a sample according to the present invention has high sample extraction efficiency of 96.73%. Compared with the sample extraction efficiency of the existing swab having the swab pile of 3.0 deniers, the sample extraction efficiency of the swab according to the present invention is improved by 13% or more.

[0095] Through the above results, it shows that the swab for collecting a sample according to the present invention can provide a superior test result through high sample extraction efficiency when collecting bacteria, viruses, etc.

[0096] Those skilled in the art will understand that the present invention can be implemented as other concrete forms without changing the inventive concept or essential features. Therefore, it should be understood that the embodiments as described above are only proposed for illustrative purposes and do not limit the present invention.