STRENGTHENING AND TUMOR ELIMINATING TRADITIONAL CHINESE MEDICINE COMPOSITION, ITS PREPARATION METHOD AND APPLICATION

Abstract

This invention provides a strengthening and tumor eliminating traditional Chinese medicine composition, its preparation method and application, which specifically relate to the technical field of the treatment of intermediate and advanced stage and postoperative malignant tumor, wherein the strengthening and tumor eliminating traditional Chinese medicine composition comprises: 8-30 parts of Radix Codonopsis, 5-30 parts of Rhizoma Atractylodis Macrocephalae, 5-30 parts of Poria cocos, 5-30 parts of Pseudobulb of Appendiculate Cremastra, 5-30 parts of Scutellaria barbata, 5-30 parts of Sarcandra glabra, 3-30 parts of peach kernel, 2-30 parts of Ligustrum lucidum, 5-30 parts of Eclipta and 1-20 parts of licorice. This invention also provides a preparation method of the described strengthening and tumor eliminating traditional Chinese medicine composition.

Claims

1. A strengthening and tumor eliminating traditional Chinese medicine composition, which is characterized in that the raw materials include components of the following pbw: 8-30 parts of Radix Codonopsis, 5-30 parts of Rhizoma Atractylodis Macrocephalae, 5-30 parts of Poria cocos, 5-30 parts of Pseudobulb of Appendiculate Cremastra, 5-30 parts of Scutellaria barbata, 5-30 parts of Sarcandra glabra, 3-30 parts of peach kernel, 2-30 parts of Ligustrum lucidum, 5-30 parts of Eclipta and 1-20 parts of licorice.

2. The strengthening and tumor eliminating traditional Chinese medicine composition according to claim 1, which is characterized in that it comprises components of the following pbw: 8-12 parts of Radix Codonopsis, 12-18 parts of Rhizoma Atractylodis Macrocephalae, 8-12 parts of Poria cocos, 7-11 parts of Pseudobulb of Appendiculate Cremastra, 8-12 parts of Scutellaria barbata, 8-12 parts of Sarcandra glabra, 4-7 parts of peach kernel, 8-12 parts of Ligustrum lucidum, 8-12 parts of Eclipta and 2-5 parts of licorice.

3. The strengthening and tumor eliminating traditional Chinese medicine composition according to claim 1, which is characterized in that it comprises components of the following pbw: 10 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 9 parts of Pseudobulb of Appendiculate Cremastra, 10 parts of Scutellaria barbata, 10 parts of Sarcandra glabra, 5 parts of peach kernel, 10 parts of Ligustrum lucidum, 10 parts of Eclipta and 3 parts of licorice.

4. A method for preparing the strengthening and tumor eliminating traditional Chinese medicine composition according to claim 1, which is characterized in that it comprises the following steps: (1) Weigh raw materials; (2) Mix the raw materials weighed in step (1), decoct them with water to obtain the decoction, and filter the decoction to obtain the filtrate; (3) Concentrate the filtrate obtained in step (2) under vacuum to make the extract with relative density of 1.20-1.25, dry the extract in vacuum, crush and sieve it to make the dry extract powder, and obtain the strengthening and tumor eliminating traditional Chinese medicine composition.

5. The preparation method according to claim 4, which is characterized in that the described step (2) is to mix the raw materials weighed in step (1) and decoct them one or more times. Add water 10 times the amount of the raw materials and decoct them for 1.5 h each time. After each decocting, filter it through a 200 mesh sieve to get the filtrate and dregs, and merge the filtrate.

6. The preparation method according to claim 4, which is characterized in that the vacuum drying conditions in the described step (3) are as follows: the thickness of the paving material is controlled to be 0.7-1.0 cm, the drying temperature is 60-80° C., and the vacuum degree is −0.08 Mpa to −0.10 Mpa.

7. The application of the strengthening and tumor eliminating traditional Chinese medicine composition in preparing cancer drug according to any one of claims 1 to 3.

8. An application according to claim 7, which is characterized in that the described cancer drug comprises the strengthening and tumor eliminating traditional Chinese medicine composition, and also comprises pharmaceutically acceptable excipients or auxiliary components, which can be processed into any dosage form suitable for pharmaceutical use.

9. The application according to claim 8, which is characterized in that the dosage forms of the described cancer drug are decoction, pill, capsule, tablet or granule.

10. The application according to claim 7, which is characterized in that the described cancer is a kind of spleen deficiency and phlegm-stasis type intermediate and advanced stage and postoperative malignant tumor.

Description

DESCRIPTION OF THE INVENTION

[0034] Various exemplary embodiments of this invention will be described in detail, which should not be considered as a limitation of this invention, but as a more detailed description of certain aspects, characteristics and embodiments of this invention.

[0035] It should be understood that the terms used in this invention are only for describing particular embodiments and are not intended to limit this invention. In addition, for the numerical range in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each smaller range between any stated value or the intermediate value within the stated range and any other stated value or the intermediate value within the described range is also included in this invention. The upper and lower limits of these smaller ranges can be included or excluded from the range independently.

[0036] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning commonly understood by those of ordinary skill in the art of this invention. Although this invention only describes preferred methods and materials, any methods and materials similar to or equivalent to those described herein may also be used in the embodiments or tests of this invention. All documents in these instructions are incorporated by reference to disclose and describe the methods and/or materials related to the described documents. In case of conflict with any incorporated document, the content of these instructions shall prevail.

[0037] Without deviating from the scope or spirit of this invention, various improvements and changes can be made to the specific embodiments of the instructions of this invention, which is obvious to those skilled in the art. Other embodiments obtained from the instructions of this invention are obvious to the technicians. The instructions and embodiments of this application are exemplary only.

[0038] The words “contain”, “include”, “possess”, “have” and so on used in this paper are all open terms, that is, they mean to include but not limited to.

Embodiment 1

[0039] (1) Weigh 10 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 9 parts of Pseudobulb of Appendiculate Cremastra, 10 parts of Scutellaria barbata, 10 parts of Sarcandra glabra, 5 parts of peach kernel, 10 parts of Ligustrum lucidum, 10 parts of Eclipta and 3 parts of licorice.

[0040] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0041] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.20 (60° C.). Take the extract. The thickness of the paving material is controlled to be 1.0 cm, the drying temperature is 60° C., and the vacuum degree is −0.09 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0042] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 70° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Embodiment 2

[0043] (1) Weigh 8 parts of Radix Codonopsis, 18 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 7 parts of Pseudobulb of Appendiculate Cremastra, 10 parts of Scutellaria barbata, 12 parts of Sarcandra glabra, 4 parts of peach kernel, 8 parts of Ligustrum lucidum, 10 parts of Eclipta and 5 parts of licorice.

[0044] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0045] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.23 (60° C.). Take the extract. The thickness of the paving material is controlled to be 0.8 cm, the drying temperature is 70° C., and the vacuum degree is −0.10 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0046] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 60° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Embodiment 3

[0047] (1) Weigh 12 parts of Radix Codonopsis, 18 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Poria cocos, 10 parts of Pseudobulb of Appendiculate Cremastra, 12 parts of Scutellaria barbata, 8 parts of Sarcandra glabra, 6 parts of peach kernel, 12 parts of Ligustrum lucidum, 8 parts of Eclipta and 2 parts of licorice.

[0048] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0049] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.25 (60° C.). Take the extract. The thickness of the paving material is controlled to be 0.7 cm, the drying temperature is 70° C., and the vacuum degree is −0.09 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0050] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 65° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Embodiment 4

[0051] (1) Weigh 10 parts of Radix Codonopsis, 12 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Poria cocos, 11 parts of Pseudobulb of Appendiculate Cremastra, 8 parts of Scutellaria barbata, 11 parts of Sarcandra glabra, 7 parts of peach kernel, 12 parts of Ligustrum lucidum, 12 parts of Eclipta and 4 parts of licorice.

[0052] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0053] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.20 (60° C.). Take the extract. The thickness of the paving material is controlled to be 0.9 cm, the drying temperature is 80° C., and the vacuum degree is −0.08 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0054] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 65° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Embodiment 5

[0055] (1) Weigh 8 parts of Radix Codonopsis, 5 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Poria cocos, 5 parts of Pseudobulb of Appendiculate Cremastra, 5 parts of Scutellaria barbata, 5 parts of Sarcandra glabra, 3 parts of peach kernel, 2 parts of Ligustrum lucidum, 5 parts of Eclipta and 1 part of licorice.

[0056] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0057] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.20 (60° C.). Take the extract. The thickness of the paving material is controlled to be 1.0 cm, the drying temperature is 60° C., and the vacuum degree is −0.09 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0058] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 70° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Embodiment 6

[0059] (1) Weigh 30 parts of Radix Codonopsis, 28 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of Poria cocos, 30 parts of Pseudobulb of Appendiculate Cremastra, 25 parts of Scutellaria barbata, 26 parts of Sarcandra glabra, 30 parts of peach kernel, 30 parts of Ligustrum lucidum, 28 parts of Eclipta and 19 parts of licorice.

[0060] (2) Mix the weighed medicinal materials, add 10 times of water, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Again, add 10 times of water to the dregs, decoct for 1.5 h, and filter it with a 200 mesh sieve while it is hot to get the filtrate and dregs. Merge the above two filtrate.

[0061] (3) Concentrate the filtrate obtained in step (2) to an extract with a relative density of 1.20 (60° C.). Take the extract. The thickness of the paving material is controlled to be 1.0 cm, the drying temperature is 60° C., and the vacuum degree is −0.09 Mpa. Vacuum dry and crush it, and filter it with an 80 mesh sieve to the dry extract powder.

[0062] (4) Take appropriate amount of dry extract powder and dextrin, mix well, and granulate by wet method. Add 90% medicinal softwood made with ethanol, filter it with a 14 mesh sieve and granulate, dry it at 70° C. until the moisture content of the granules ≤6%, and filter the whole granules with a 12 mesh sieve, Check the appearance, granularity and solubility of the semi-finished granules to obtain the granules of the strengthening and tumor eliminating traditional Chinese medicine composition. The content of dry extract powder is 45%.

Experimental Example 1

[0063] (1) Select 100 postoperative patients with lung cancer, each of whom took the granules of the strengthening and tumor eliminating traditional Chinese medicine composition prepared in Embodiments 1-6 every day. Take the granules with boiled water by 3 times a day and 2 bags at a time. After a long time of continuous follow-up observation of 100 patients, it was found that the strengthening and tumor eliminating therapy can delay the recurrence time after operation. The research results showed that the application of the strengthening and tumor eliminating therapy after operation could reduce the risk in disease progress by 80%. If adjuvant chemotherapy is completed <4 cycles, the long-term treatment (>6 months) of the strengthening and tumor eliminating composition can extend the disease-free survival for about 3 years. If the adjuvant chemotherapy is completed >4 cycles, benefit from the strengthening and tumor eliminating traditional Chinese medicine composition can last a longer period.

[0064] (2) Select 100 spleen deficiency and phlegm-stasis type intermediate and advanced stage patients with lung cancer, each of whom took the granules of the strengthening and tumor eliminating traditional Chinese medicine composition prepared in Embodiments 1-6 every day. Take the granules with boiled water by 3 times a day and 2 bags at a time. The strengthening and tumor eliminating traditional Chinese medicine composition was used on the basis of and in combination with chemotherapy for treatment. Through observation, it was found that it could reduce 40% of the risk of death and extend 5 months of the overall survival.

[0065] (3) The symptoms of spleen deficiency and phlegm-stasis type intermediate and advanced stage patients with liver cancer, and intestinal cancer include fatigue, anorexia and emaciation, cough, expectoration, and pain in chest, rib and back. Select 100 spleen deficiency and phlegm-stasis type intermediate and advanced stage patients with liver cancer or intestinal cancer respectively, each of whom took the granules of the strengthening and tumor eliminating traditional Chinese medicine composition prepared in Embodiments 1-6 every day. Take the granules with boiled water by 3 times a day and 2 bags at a time. The treatment with the strengthening and tumor eliminating traditional Chinese medicine composition can relieve cancer-related fatigue, increase weight, and relieve cough and expectoration and other symptoms of patients.

[0066] The embodiments described above describe the preferred modes of this invention only, not limit the scope of this invention. Without deviating from the design spirit of this invention, all modifications and improvements made by ordinary technicians in the art to the technical scheme of this invention shall fall into the protection scope determined by the claims of this invention.