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FATTY ACID ESTERS AS ANTI-MALASSEZIA AGENTS

20220142885 · 2022-05-12

    Inventors

    Cpc classification

    International classification

    Abstract

    The present invention primarily relates to a fatty acid ester or mixture of two or more fatty acid esters or mixture comprising one or more fatty acid esters, wherein the fatty acid ester or one, two, three or more, preferably all, of the fatty acid ester(s) is/are selected from the group consisting of 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate and glyceryl monoundecylenate, for use in the treatment of an excess of Malassezia on the skin surface of mammals, preferably of humans. The present invention further relates to particular mixtures or products, and to the cosmetic, non-therapeutic use of fatty acid esters or of mixtures or products comprising fatty acid esters as defined herein to reduce the amount of Malassezia on the skin surface of mammals, preferably of humans.

    Claims

    1-15. (canceled)

    16. A method for treating excess Malassezia on skin comprising application of a mixture of one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate to the skin.

    17. The method of claim 16, wherein the mixture comprises 3-hydroxypropyl caprylate, glyceryl monocaprylate and/or 3-hydroxypropyl undecylenate.

    18. The method of claim 16, wherein the mixture comprises 3-hydroxypropyl caprylate and/or 3-hydroxypropyl undecylenate.

    19. The method according to claim 16, wherein the skin is the skin of a mammal.

    20. The method according to claim 19, wherein the mammal is a human.

    21. The method according to claim 16, wherein the mixture further comprises one or more 1,2-alkane diol(s).

    22. The method according to claim 21, wherein the one or more 1,2-alkane diol(s) are chosen from 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and 1,2-decanediol, more preferably one 1,2-alkane diol selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol.

    23. The method according to claim 16, wherein the Malassezia is/are chosen from M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. restricta, M. slooffiae, M. dermatis, M. japonica, M. nana, M. yamatoensis, M. caprae, M. equina, M. cuniculi, M. brasiliensis, M. psitaci and M. arunalokei, preferably is/are selected from the group consisting of M. restricta, M. globosa, M. furfur, M. sympodialis, and M. dermatis.

    24. The method according to claim 16, wherein the mixture is a skin or hair care product.

    25. The method according to claim 16, wherein the mixture comprises: 1,2-pentanediol and 3-hydroxypropyl caprylate, 1,2-pentanediol and 3-hydroxypropyl undecylenate, 1,2-hexanediol and 3-hydroxypropyl caprylate, 1,2-hexanediol and 3-hydroxypropyl undecylenate, 1,2-octanediol and 3-hydroxypropyl caprylate, 1,2-octanediol and 3-hydroxypropyl undecylenate, 1,2-decanediol and 3-hydroxypropyl caprylate, 1,2-decanediol and 3-hydroxypropyl undecylenate, 1,2-pentanediol and glyceryl monocaprylate, 1,2-pentanediol and glyceryl monoundecylenate, 1,2-hexanediol and glyceryl monocaprylate, 1,2-hexanediol and glyceryl monoundecylenate, 1,2-octanediol and glyceryl monocaprylate, 1,2-octanediol and glyceryl monoundecylenate, 1,2-decanediol and glyceryl monocaprylate, or 1,2-decanediol and glyceryl monoundecylenate.

    26. The method of claim 16, wherein the mixture comprises: 3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate, glyceryl monocaprylate and 3-hydroxypropyl undecylenate, 3-hydroxypropyl caprylate and glyceryl monoundecylenate, glyceryl monocaprylate and glyceryl monoundecylenate, or 3-hydroxypropyl caprylate and glyceryl monocaprylate.

    27. A skin or hair care product comprising one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate.

    28. The product of claim 27 comprising: 1,2-pentanediol and 3-hydroxypropyl caprylate, 1,2-pentanediol and 3-hydroxypropyl undecylenate, 1,2-hexanediol and 3-hydroxypropyl caprylate, 1,2-hexanediol and 3-hydroxypropyl undecylenate, 1,2-octanediol and 3-hydroxypropyl caprylate, 1,2-octanediol and 3-hydroxypropyl undecylenate, 1,2-decanediol and 3-hydroxypropyl caprylate, 1,2-decanediol and 3-hydroxypropyl undecylenate, 1,2-pentanediol and glyceryl monocaprylate, 1,2-pentanediol and glyceryl monoundecylenate, 1,2-hexanediol and glyceryl monocaprylate, 1,2-hexanediol and glyceryl monoundecylenate, 1,2-octanediol and glyceryl monocaprylate, 1,2-octanediol and glyceryl monoundecylenate, 1,2-decanediol and glyceryl monocaprylate, or 1,2-decanediol and glyceryl monoundecylenate.

    29. The product of claim 27 comprising: 3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate, glyceryl monocaprylate and 3-hydroxypropyl undecylenate, 3-hydroxypropyl caprylate and glyceryl monoundecylenate, glyceryl monocaprylate and glyceryl monoundecylenate, or 3-hydroxypropyl caprylate and glyceryl monocaprylate.

    30. The product according to claim 27 being a leave-on product or a rinse-off product.

    31. The product according to claim 27 in the form of an oil-in-water emulsion or a water-in-oil emulsion.

    32. The product according to claim 27 being a shampoo.

    33. The shampoo according to claim 32 being an anti-dandruff shampoo.

    34. The product according to claim 27, further comprising one or more 1,2-alkane diol(s).

    35. The product according to claim 34, wherein the one or more 1,2-alkane diol(s) are chosen from 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol.

    Description

    EXAMPLES

    1. Microbial Test Strains

    [0093] The fatty acid esters and their mixtures were tested for growth inhibition against Malassezia. The following reference strains were included:

    TABLE-US-00001 TABLE 1 CBS = Centraalbureau voor Schimmelcultures, Utrecht, NI; The M. globosa wildtype strain PM1 was isolated and maintained by Prof. P. Mayser, JLU Giessen. M. furfur CBS 1878, CBS 7019 M. sympodialis CBS 7222, CBS 7979, ATCC 42132, DSM 6171 M. globosa CBS 7966, PM1, CBS 7705 M. restricta CBS 7877 M. pachydermatis CBS 1879, 1892

    2. Preparation of Test Plates

    [0094] Tests were performed on solid media using agar dilution tests. Stock solutions of test substances were prepared in mDixon-Agar (cf. Table 2). Lower test concentrations were obtained by diluting stock solutions with fresh agar.

    [0095] Preparation of liquid agar was carried out in temperated water bath. Required amounts of test substances were weighed in 130 ml of Dixon Agar and mixed with fresh Dixon-Agar to reach desired concentrations of test substances. Agar solutions with test substances were then poured into 24 well-plates. The pH value in all assays was maintained at 5.5. Preparation of test substances was done on weight per volume base. All results are expressed in parts per million (1 ppm=0.0001%).

    TABLE-US-00002 TABLE 2 Composition of mDixon-Agar (for 350 ml) Malt extract-bouillon 12.6 g Peptone (Casein) 3.5 g Ox gall 7.0 g Agar 7.0 g Cycloheximide 175 mg Chloramphenicol 175 mg Tween 40 3.5 ml Olive oil 0.7 ml Glycerol 0.7 ml

    3. Inoculation of Test Strains

    [0096] Microbial test strains were prepared according to the procedure described by Mayser (Mayser P., Medium chain fatty acid ethyl esters—activation of antimicrobial effects by Malassezia enzymes. Mycoses 2015; 58:215-9). Briefly, Malassezia strains were cultivated on selective agar for pathogenic fungi (Merck) and overlaid with a thin layer of cold-sterilized olive oil. Cell counts were determined in a Neubauer chamber and 1.75×10.sup.6 cells suspended in 20 μl olive oil transferred to the test plates (corresponds to 10.sup.6 cells per cm.sup.2). Incubation was carried out at 32° C. over a maximal duration of 14 days with regular inspection and documentation of growth status. Minimal inhibitory concentrations (MICs) were determined as the lowest concentrations of test compound without visible growth. Each experiment was repeated to confirm results.

    4. Results

    4.1. Antifungal Activity

    [0097] Minimal inhibitory concentrations for test substances were determined for the different test strains (Table 3, 4, 5). As reference substances, the pure acids caprylic acid and undecylenic acid were used.

    TABLE-US-00003 TABLE 3 Minimal inhibitory concentrations (MICs) against Malassezia test strains (the term “test substance” relates to the compounds listed in the column underneath; the numbers in the row to the right of the term “test substance” relate to the respective Malassezia test strains) Strain M. M. M. furfur M. sympodialis M. globosa restricta pachydermatis Test substance 1878 7019 7222 7979 42132 6171 7966 PM1 7705 7877 1879 1892 Caprylic acid 1000 2000 330 1000 330 500 1000 500 n.d. 200 100 200 Ethyl >20000 10000 1000 1000 1000 1000 1000 1000 n.d. 4000 <500 1000 caprylate 3-Hydroxypropyl 2000 2000 1000 2000 1000 2000 1000 500 1000 1000 330 500 caprylate Glyceryl 4000 4000 1000 1000 1000 2000 1000 500- 1000 330 330 500 monocaprylate 1000 Undecylenic 2000 >2000 100 200 100 100 2000 677 330 500 1000 500 acid Ethyl 20000 >20000 200 200 200 200 10000 8000 4000 1000 2000 500 undecylenoate 3-Hydroxypropyl 8000 8000 4000 1000 2000 2000 2000 2000 1000 1000 2000 1000 undecylenoate Glyceryl 8000 8000 500 500 500 200 2000 2000 1000 1000 8000 4000 monounde cylenoate

    [0098] The results in Table 3 demonstrate that monoesters of caprylic and undecylenic acid with either 1,3-propanediol or glycerol are highly active against a broad spectrum of Malassezia strains inhabiting human and animal skin.

    TABLE-US-00004 TABLE 4 Minimal inhibitory concentrations (MICs) against Malassezia test strains (the term “test substance” relates to the compounds listed in the column underneath; the numbers in the row to the right of the term “test substance” relate to the respective Malassezia test strains) Strain M. M. M. furfur M. sympodialis M. globosa restricta pachydermatis Test substance 1878 7019 7222 7979 42132 6171 7966 PM1 7705 7877 1879 1892 3-Hydroxypropyl >20000 20000 20000 20000 4000 20000 8000 8000 n.d. n.d. n.d. n.d. dicaprylate PEG9-caprylate 20000 10000 10000 8000 10000 8000 2000 2000 n.d. 2000 2000 4000

    [0099] The results in Table 4 show that diesters or ethoxylated variants of caprylic acid are not or only partially active against Malassezia strains.

    TABLE-US-00005 TABLE 5 Minimal inhibitory concentrations (MICs) against Malassezia test strains (the term “test substance” relates to the compounds listed in the column underneath; the numbers in the row to the right of the term “test substance” relate to the respective Malassezia test strains) Strain M. furfur M. globosa M. restricta M. pachydermatis Test substance 1878 7019 7966 PM1 7705 7877 1879 1892 3-Hydroxypropyl >20000 >20000 10000 10000 n.d. n.d. n.d. n.d. diundecylenoate Glyceryl 10000 >20000 >20000 8000 8000 4000 4000 4000 triundecylenoate PEG-9-undecylenoate 20000 >20000 10000 8000 n.d. 4000 8000 8000

    [0100] The results in Table 5 show that diesters, triesters or ethoxylated variants of undecylenic acid are not or only partially active against Malassezia strains.

    [0101] Additionally, MIC-values for various alkane diols were determined (Table 6).

    TABLE-US-00006 TABLE 6 Minimal inhibitory concentrations (MICs) for alkane diols against Malassezia test strains (the term “test substance” relates to the compounds listed in the column underneath; the numbers in the row to the right of the term “test substance” relate to the respective Malassezia test strains) Strain M. sympodialis M. globosa M. restricta Test substance 7222 7979 42132 6171 7966 PM1 7705 7877 1,3-Propandiol 33000 80000 40000 80000 40000 33000 80000 33000 1,2-Pentandiol 20000 20000 20000 20000 10000 10000 20000 10000 1,2-Hexandiol 10000 10000 10000 10000 5000 5000 10000 5000 1,2-Octandiol 2000 2000 2000 2000 2000 2000 4000 1000 1,2-Decandiol 1000 2000 1000 4000 8000 8000 8000 1000 1,2-Dodecandiol 4000 4000 2000 4000 40000 40000 40000 8000

    [0102] Subsequently, binary mixtures of caprylic acid and undecylenic acid esters were prepared (Table 7) and MIC-values determined as described above (Table 8).

    [0103] Synergistic antimicrobial effects were determined by calculation of Synergy Indices (SI) according to Kull's equation (I) (Kull, F. C., Eismann, P. C., Sylvestrowicz, H. D., and R. L. Mayer (1961). Mixtures of Quaternary Ammonium Compounds and Long-chain Fatty Acids as Antifungal Agents. Applied Microbiology 9, 538-541. Steinberg, D. C. (2000). Measuring Synergy. Cosmetics & Toiletries 115 (11), 59-62).


    SI=(C.sub.mixture×P.sub.A)/C.sub.A+(C.sub.mixture×P.sub.B)/C.sub.B  (I)

    where
    SI is the Synergy Index according to Kull
    C.sub.A is the cell count for substance A
    C.sub.B is the cell count for substance B
    C.sub.mixture is the cell count for the mixture of substances A and B
    P.sub.A is the proportion of the substance A in the mixture
    P.sub.B is the proportion of the substance B in the mixture.

    [0104] SI-values below 1 indicate synergistic activity of test substances.

    TABLE-US-00007 TABLE 7 Binary mixtures of caprylic acid and undecylenic acid esters including ratios tested Designation Ratio of test of mixture substances Test substance 1a 1:1 3-Hydroxypropyl caprylate/ 1b 1:2 glyceryl monoundecylenate 1c 2:1 2a 1:1 3-Hydroxypropyl caprylate/ethyl 2b 1:2 undecylenate 2c 2:1 3a 1:1 3-Hydroxypropyl undecylenate/ 3b 1:2 glyceryl monocaprylate 3c 2:1 4a 1:1 3-Hydroxypropyl caprylate/3- 4b 1:2 hydroxypropyl undecylenate 4c 2:1

    TABLE-US-00008 TABLE 8 Minimal inhibitory concentrations (MICs) for binary mixtures of caprylic acid and undecylenic acid esters against Malassezia test strains and calculated SI-indices (the term “test mixture” relates to the mixtures listed in the column underneath; the numbers in the row to the right of the term “test mixture” relate to the respective Malassezia test strains) Strain M. M. M. furfur M. sympodialis M. globosa restricta pachydermatis Test mixture 1878 7019 7222 7979 42132 6171 7966 PM1 7705 7877 1879 1892 1a 20000 4000 1000 1000  500 330 1000 1000 1000 330 500 500 SI 6.25 1.20 1.50 1.25    .sup. 0.75 0.91 0.75 1.25 1.00 0.33 0.79 0.56 1b n.d. n.d. 200 200  <100.sup.1) 200 500 1000 1000 200 n.d. n.d. SI n.d. n.d. 0.33 0.30     0.08 0.70 0.33 1.00 1.00 0.20 n.d. n.d. 1c n.d. n.d. 200 500  <100.sup.1) 330 500 330 500 200 n.d. n.d. SI n.d. n.d. 0.26 0.50    .sup. 0.07 0.65 0.41 0.49 0.50 0.20 n.d. n.d. 2a 4000 4000 330 1000  500 500 500 1000 500 500 330 500 SI 1.10 1.10 1.000 2.75   .sup. 1.5 2.75 0.28 1.06 0.31 0.33 0.58 1.00 2b n.d. n.d. 200 330  200 330 500 1000 500 330 n.d. n.d. SI n.d. n.d. 0.73 1.14    .sup. 0.73 1.14 0.20 0.74 0.20 0.32 n.d. n.d. 2c n.d. n.d. 330 1000  330 500 330 330 330 200 n.d. n.d. SI n.d. n.d. 0.76 1.90    .sup. 0.76 1.00 0.23 0.58 0.25 0.20 n.d. n.d. 3a 4000 4000 330 1000 1000 500 1000 1000 1000 330 500 500 SI 0.75 0.75 0.21 1.00   .sup.  0.75 0.50 0.75 0.75 1.00 0.67 0.89 0.75 3b n.d. n.d. 330 1000  330 1000 500 500 1000 330 n.d. n.d. SI n.d. n.d. 0.11 1.00   .sup.  0.27 0.50 0.41 0.41 1.00 0.77 n.d. n.d. 3c n.d. n.d. 330 500  330 500 500 1000 500 330 n.d. n.d. SI n.d. n.d. 0.22 0.50   .sup.  0.22 0.25 0.33 0.66 0.50 0.55 n.d. n.d. 4a 2000 4000 500 1000  500 500 1000 1000 1000 330 1000 500 SI 0.63 1.25 0.31 0.75   .sup.  0.38 0.50 0.75 1.25 1.00 0.33 1.76 0.75 4b n.d. n.d. 200 500  200 330 500 1000 1000 330 n.d. n.d. SI n.d. n.d. 0.10 0.41   .sup.  0.13 0.16 0.21 0.66 1.00 0.33 n.d. n.d. 4c n.d. n.d. 330 1000  200 500 330 500 500 330 n.d. n.d. SI n.d. n.d. 0.14 0.66   .sup.  0.20 0.25 0.22 0.75 0.50 0.33 n.d. n.d. .sup.1)MIC-values <100 were set to 50 for SI-calculation

    [0105] In a further experiment, binary mixtures of caprylic acid esters and undecylenic acid esters, respectively, with alkane diols were prepared (Table 9) and MIC-values determined as described above (Table 10). Synergistic antimicrobial effects were determined by calculation of Synergy Indices (SI) according to Kull's equation as described above.

    TABLE-US-00009 TABLE 9 Binary mixtures of caprylic acid esters and undecylenic acid esters, respectively, with alkane diols including ratios tested. Designation Ratio of test of mixture substances Test substance 5a 3:1 1,2-Pentanediol/3-Hydroxypropyl caprylate 5b 3:1 1,2-Pentanediol/3-Hydroxypropyl undecylenate 6a 3:1 1,2-Hexanediol/3-Hydroxypropyl caprylate 6b 3:1 1,2-Hexanediol/3-Hydroxypropyl undecylenate 7a 2:1 1,2-Octanediol/3-Hydroxypropyl caprylate 7b 2:1 1,2-Octanediol/3-Hydroxypropyl undecylenate 8a 1:2 1,2-Decanediol/3-Hydroxypropyl caprylate 8b 1:2 1,2-Decanediol/3-Hydroxypropyl undecylenate

    TABLE-US-00010 TABLE 10 Minimal inhibitory concentrations (MICs) for binary mixtures of caprylic acid esters and undecylenic acid esters, respectively, with alkane diols against Malassezia test strains and calculated SI-indices (the term “test mixture” relates to the mixtures listed in the column underneath; the numbers in the row to the right of the term “test mixture” relate to the respective Malassezia test strains) Strain M. sympodialis M. globosa M. restricta Test mixture 7222 7979 42132 6171 7966 PM1 7705 7877 5a 4000 4000 4000 4000 4000 4000 4000 2000 SI   .sup.  1.15   .sup.  0.65    .sup. 1.15 0.65 1.30 2.30 1.15 0.65 5b  330  330  330 330 4000 1000 4000 2000 SI   .sup.  0.03   .sup.  0.10   .sup.  0.05 0.05 0.80 0.20 0.65 0.65 6a 2000 4000 2000 4000 4000 2000 4000 2000 SI   .sup.  0.65   .sup.  0.80   .sup.  0.65 0.80 1.60 1.30 1.30 0.80 6b  330  330  500 500 2000 2000 4000 1000 SI   .sup.  0.05   .sup.  0.11   .sup.  0.10 0.10 0.55 0.55 1.30 0.40 7a 1000 2000 2000 2000 2000 2000 4000 1000 SI   .sup.  0.67   .sup.  1.00   .sup.  1.33 1.00 1.33 1.00 2.00 1.00 7b  330  330  330 330 2000 1000 4000 1000 SI   .sup.  0.14   .sup.  0.22   .sup.  0.17 0.17 1.00 0.50 2.00 1.00 8a 1000 2000 1000 1000 1000 1000 2000 1000 SI   .sup.  1.00   .sup.  1.00   .sup.  1.00 0.42 0.71 1.37 1.42 1.00 8b  <100.sup.1)  200  <100.sup.1) 330 2000 2000 4000 1000 SI   .sup.  0.03   .sup.  0.17   .sup.  0.03 0.14 0.75 0.75 2.80 1.00 .sup.1)MIC-values <100 were set to 50 for SI-calculation

    4.2. Ester Cleavage

    [0106] The two substances 3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate have shown outstanding activity against different Malassezia species and strains. For these two substances ester cleavage by M. globose and M. restricta lipases and hydrolases and subsequent liberation of free fatty acids was demonstrated.

    [0107] It is well known in the art that free short- and mid-chain saturated fatty acids, for example capric acid (C10:0), caprylic acid (C8:0), and capronic acid (C6:0) show antimicrobial activity. Use of these free fatty acids for treating Malassezia-associated conditions and diseases in cosmetic or medical products are hampered by their intense, negatively perceived odour and their irritating potential at higher concentrations.

    [0108] Surprisingly it was found that a similar antimicrobial effect can be obtained against Malassezia spp., but not Candida spp., when monoesters of these fatty acids are used. This highly specific effect is facilitated by Malassezia lipases and hydrolases, which cleave the esters and thereby liberate the active principle of the fatty acid. This results in a targeted activation of the antimicrobial molecules only in local areas of the skin, where Malassezia density is high.

    [0109] For esters of monohydric alcohols, cleavage by Malassezia spp. has been demonstrated before. Esters of monohydric alcohols (e.g. methanol, ethanol, propanol, isopropanol etc.), however, are less active against different Malassezia species and also have the severe disadvantage of strong odour, which limits their use to low concentrations.

    [0110] During the studies underlying the present invention, experimental proof of ester cleavage for 3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate was demonstrated for the two species M. globosa and M. restricta (cf. Table 11). These two species are the most frequently detected ones on human scalp and skin and their hydrolytic/lipolytic activities on fatty acid esters has not yet been investigated before.

    TABLE-US-00011 TABLE 11 Malassezia strains used for the experiments on ester cleavage M. restricta CBS* 7877 M. globosa CBS* 7705 *Reference strains of the Centraalbureau voor Schimmelcultures, Utrecht, NL

    4.2.1. Method

    [0111] Malassezia strains were cultivated on selective agar for pathogenic fungi (Merck) and overlaid with a thin layer of cold-sterilized olive oil. After 3 to 5 days, fungal cells were harvested and resuspended in the respective test substance. Cell numbers were determined using a Neubauer counting chamber (cf. Table 12). Sterile Petri dishes (diameter: 3 cm) were prepared containing selective agar for pathogenic fungi, overlaid with 100 μl of the test suspensions and incubated at 32° C.

    TABLE-US-00012 TABLE 12 Determined Malassezia cell numbers per μl for each assay 3-Hydroxypropyl 3-Hydroxypropyl caprylate undecylenate M. globosa CBS 20500 26500 7705 M. restricta CBS 12500 5550 7877

    [0112] After defined incubation times (0, 3, 6, 12, 24, 48, and 72 h), test suspensions were removed from the agar surface by rinsing with 1 ml chloroform and stored under cool conditions in gastight tubes until analysis. Chloroform was removed by evaporation at 30° C. in the fume hood and the remaining liquid mixed with 1 ml isopropanol, transferred in Eppendorf tubes and centrifuged. The supernatant was transferred to new Eppendorf tubes.

    [0113] In order to analytically quantify esters and free fatty acid resulting from cleavage by Malassezia enzymes, gas chromatography was used.

    [0114] For quantification (range 0.1-10 wt %) a multilevel calibration method with internal standard (ISTD, docosane [C22]; 500 mg in MtBE) was used. An equal amount of corresponding acid, ester and possible side products [0.2-50 mg/10 mL] were mixed with ISTD, diluted to an appropriate concentration and 1 μL [split1:50] was directly used for GC-analysis with the following conditions: GC Agilent 6890 with a 20 m ZB-Wax column [0.20 mm×0.20 μm], injector temperature of 250° C., detector temperature of 275° C., flow gas of 1.3 mL/min hydrogen [constant]. For temperature profile 60° C. to 240° C. with a heating rate of 9° C./min was used.

    4.2.2. Results

    [0115] 3-Hydroxypropyl caprylate was rapidly cleaved to caprylic acid and 1,3-propanediol by the two Malassezia strains. With M. globosa CBS 7705, 75% of the ester was cleaved after 6 hours and 90% was cleaved after 12 hours (FIG. 1). On the other hand, M. restricta CBS 7877 was capable of cleaving 21% of the ester after 6 hours and 65% after 12 hours (FIG. 2). In assays without Malassezia cells, no caprylic acid was detected until the end of the experiment after 72 hours.

    [0116] 3-Hydroxypropyl undecylenate was accepted as a preferred substrate by Malassezia enzymes, as well, leading to fast generation of undecylenic acid. Incubating M. globosa CBS 7705 together with this substance resulted in 95% cleavage after 6 hours and 99.5% cleavage after 12 hours (FIG. 3). When M. restricta CBS 7877 was used, 56% cleavage was observed after 6 hours and 96% after 12 hours (FIG. 4). In assays without Malassezia cells, no undecylenic acid was detected until the end of the experiment after 72 hours.

    5. Formulation Examples

    [0117]

    TABLE-US-00013 TABLE 13 Composition of perfume oil 1 (PO1, Amounts in ‰ b.w.) Ingredients Amount ALDEHYDE C14 SO-CALLED 2 ALLYL AMYL GLYCOLATE 10% DPG 5 ANISIC ALDEHYDE PURE 5 APPLE OLIFFAC TYPE 10 Benzylacetat 50 BERGAMOT IDENTOIL ® COLOURLESS 15 CANTHOXAL 5 CETALOX 10% IPM 3 CITRONELLOL 950 40 DAMASCENONE TOTAL 1% DPG 5 DAMASCONE ALPHA 10% DPG 5 DAMASCONE DELTA 10% DPG 2 DIMETHYL BENZYL CARBINYL BUTYRATE 2 DIPROPYLENE GLYCOL 178 EBANOL 2 ETHYL DECADIENOATE TRANS 2 CIS-2, 4 10% IPM FLOROSA 5 FRAMBINON ® 10% DPG 7 GALAXOLIDE 50% IN IPM 100 GALBEX TYPE BASE 1 GERANYL ACETATE PURE 2 HEDIONE 30 HELIOTROPIN 10 HEXENYL ACETATE CIS-3 10% DPG 1 HEXENYL SALICYLATE CIS-3 5 HEXYL CINNAMIC ALDEHYDE ALPHA 70 HEXYL SALICYLATE 50 HYDROXY CITRONELLAL 10 ISO E SUPER 15 ISORALDEINE 70 20 LEAFOVERT ® 1 LILIAL 60 LINALOOL 60 LINALYL ACETATE 20 LYRAL 7 MANZANATE 2 PHENOXANOL 7 PHENYLETHYL ALCOHOL 120 SANDAL MYSORE CORE 2 SANDRANOL ® 7 STYRALYL ACETATE 3 TAGETES RCO 10% TEC 2 TERPINEOL PURE 20 TETRAHYDROGERANIOL 10% DPG 5 TONALIDE 7 VERTOCITRAL 10% DPG 5 VERTOFIX 15 Total 1000

    TABLE-US-00014 TABLE 14 Composition of perfume oil 2 (PO2, Amounts in ‰ b.w.) Ingredients Amount Acetophenone, 10% in DPG 10 n-Undecanal 5 Aldehyde C14, so-called (peach aldehyde) 15 Allylamyl glycolate, 10% in DPG 20 Amyl salicylate 25 Benzyl acetate 60 Citronellol 80 d-Limonene 50 Decenol trans-9 15 Dihydromyrcenol 50 Dimethylbenzylcarbinyl acetate 30 Diphenyloxide 5 Eucalyptol 10 Geraniol 40 Nerol 20 Geranium oil 15 Hexenol cis-3, 10% in DPG 5 Hexenyl salicylate cis-3 20 Indole, 10% in DPG 10 Alpha-ionone 15 Beta-ionone 5 Lilial ® (2-methyl-3-(4-tert-butyl-phenyl)propanal) 60 Linalool 40 Methylphenyl acetate 10 Phenylethyl alcohol 275 Styrolyl acetate 20 Terpineol 30 Tetrahydrolinalool 50 Cinnamyl alcohol 10 Total: 1000

    TABLE-US-00015 TABLE 15 Composition of perfume oil 3 (PO3, Amounts in ‰ b.w.) Ingredients Amount Benzyl acetate 60 Citronellyl acetate 60 Cyclamenaldehyde (2-methyl-3-(4-isopropylphenyl)propanal 20 Dipropylene glycol (DPG) 60 Ethyllinalool 40 Florol (2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol) 30 Globanone ® [(E/Z)-8-cyclohexadecen-1-one] 180 Hedione ® (methyldihydrojasmonate) 140 Hexenyl salicylate, cis-3 10 Vertocitral (2,4-dimethyl-3-cyclohexenecarboxaldehyde) 5 Hydratropaldehyde, 10% in DPG 5 Isodamascone (1-(2,4,4-trimethyl-2-cyclohexen-1-yl)-2-buten-1- 5 one, 10% in DPG Isomuscone (cyclohexadecanone) 40 Jacinthaflor (2-methyl-4-phenyl-1,3-dioxolane) 10 Cis-jasmone, 10% in DPG 20 Linalool 50 Linalyl acetate 30 Methyl benzoate, 10% in DPG 25 para-Methyl cresol, 10% in DPG 10 Nerol 20 Phenylpropylaldehyde 5 2-Phenylethyl alcohol 82 Tetrahydrogeraniol 13 2,2-Dimethyl-3-cyclohexyl-1-propanol 80 Total: 1000

    TABLE-US-00016 TABLE 16 Composition of perfume oil 4 (PO4, Amounts in ‰ b.w.) Ingredients Amount AMBRETTOLIDE (MACRO) 10 AMBROXIDE 10% in IPM 10 BENZYL ACETATE 20 BENZYL SALICYLATE 15 BERGAMOT OIL. bergapten-free 60 CALONE ® 1951 10% in DPG 15 COUMARIN 5 CYCLOGALBANATE ® 10% in DPG 10 ALPHA-DAMASCONE 1% in DPG 20 DIHYDROMYRCENOL 10 ETHYL LINALOOL 75 ETHYL LINALYLACETATE 50 ETHYL MALTOL 1% in DEP 10 ETHYLENE BRASSYLATE (MACRO) 80 FLOROSA 40 GERANYLACETATE 10 HEDIONE ® HC/30 35 HEDIONE ® 210 HELIONAL ® 15 HELVETOLIDE ® (ALICYC) 30 HEXENYLSALICYLATE CIS-3 20 ISO E SUPER ® 40 LEAFOVERT ® 10% in DEP 10 LILIAL ® 80 LYRAL ® 20 MANDARIN OIL 10 STYRALYL ACETATE 5 SYMROSE ® 15 VANILLIN 10% in DEP 20 DIPROPYLENE GLYCOL (DPG) 50 TOTAL 1000

    TABLE-US-00017 TABLE 17 Composition of perfume oil 5 (PO5, Amounts in ‰ b.w.) Ingredients Amount AMAROCITE ® 10 AMBROCENIDE ® 10% in DPG 5 AMBROXIDE 15 AURELIONE ® (7/8-Cyclohexadecenone) (MACRO) 70 BERGAMOT OIL. bergapten-free 90 CALONE ® 1951 10% in DPG 20 CARAWAY OIL 10 CITRAL 20 COUMARIN 10 ALPHA-DAMASCONE 1% in DPG 15 DIHYDROMYRCENOL 70 ESTRAGON OIL 10 ETHYL LINALOOL 100 ETHYL LINALYLACETATE 90 EUGENOL 10 EVERNYL ® 5 FRUCTATE ® 5 GERANIUM OIL 5 HEDIONE ® HC/30 100 HELIONAL ® 10 INDOLE 10% in DPG 5 ISO E SUPER ® 100 KEPHALIS ® 5 LAVENDER OIL 40 CITRUS OIL 80 LILIAL ® 30 MANDARIN OIL 20 MUSCENONE (MACRO) 5 SANDRANOL ® 10 VANILLIN 10% in DPG 5 DIPROPYLENE GLYCOL 30 TOTAL 1000

    [0118] The perfume oils P01, P02, P03, PO4, or P05 from the above examples were worked separately in each case into the formulations presented below.

    [0119] Cosmetic formulations (compositions)—amounts are indicated as % by weight for all formulations.

    TABLE-US-00018 TABLE 18 Cream o/w Ingredients INCI Amount Dracorin ® CE Glyceryl Stearate Citrate 1.0 Lanette ® O Cetearyl Alcohol 2.0 Cutina ® GMS-V Glyceryl Stearate 1.0 Tegosoft ® MM Myristyl Myristate 1.0 Xiameter ® PMX-0246, Cyclohexasiloxane (and) 0.5 Cyclosiloxane Cyclopentasiloxane Dragoxat ® 89 Ethylhexyl Isononanoate 2.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate 0.2 Crosspolymer Keltrol ® CG-T Xanthan Gum 0.1 Water Water (Aqua) ad 100 Glycerol 99, 5 P. Glycerol 3.0 1,2-Propylene Glycol 99 P GC Propylene Glycol 2.0 Sodium Benzoate Sodium Benzoate 0.1 Sodium Hydroxide 10% Sodium Hydroxide 0.5 solution Perfume oil PO1, PO2, PO3, Perfume 0.3 PO4, or PO5 Euxyl ® K702 Dehydroacetic Acid, Benzoic Acid, 0.3 Phenoxyethanol, Polyaminopropyl Biguanide, Ethylhexylglycerin 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.3 3-Hydroxypropyl undecylenate Hydroxypropyl undecylenate 0.1

    TABLE-US-00019 TABLE 19 Hand and body cream Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride PCL-Solid Stearyl Heptanoate, Stearyl Caprylate 2.5 Lanette ® O Cetearyl Alcohol 1.5 Cutina ® GMS-V Glyceryl Stearate 1.0 Dragoxat ® 89 Ethylhexyl Isononanoate 3.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 7.0 Isodragol ® Triisononanoin 4.0 Xiameter ® PMX-0345 Cyclopentasiloxane (and) 0.5 Cyclosiloxane Cyclohexasiloxane Water Water (Aqua) ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate 0.2 Crosspolymer Keltrol ® CG-RD Xanthan Gum 0.1 Glycerol 85 P. Glycerol 3.0 DragoBetaGlucan Water (Aqua), Butylene Glycol, Glycerol, Avena Sativa (Oat) Kernel 1.5 Extract Potassium Sorbat Potassium Sorbate 0.1 Sodium Hydroxide 10% Sodium Hydroxide 0.5 solution Perfume oil PO1, PO2, PO3, Fragrance 0.2 PO4, or PO5 Euxyl ® K300 Methyl-, Butyl-, Ethyl-, Propyl, 0.3 Isobutylparaben, Phenoxyethanol 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 Glyceryl monocaprylate Glyceryl caprylate 0.05

    TABLE-US-00020 TABLE 20 Daily face cream SPF 20 Ingredients Amount SymOcide PH 1 Phenoxyethanol, Hydroxyacetophenone, Caprylyl Glycol, Water (Aqua) Ascorbyl Palmitate 0.1 Ascorbyl Palmitate Biotive L-Arginine 0.2 Arginine Buriti oil 1 Mauritia Flexuosa Fruit Oil Cocoa butter 2 Theobroma Cacao (Cocoa) Seed Butter Dimethicone 0.5 Dimethicone Disodium EDTA 0.1 Disodium EDTA Dragosantol 100 0.1 Bisabolol Dragoxat 89 5 Ethylhexyl Isononanoate Emulsiphos 2 Potassium Cetyl Phosphate, Hydrogenated Palm Glycerides Extrapone Corail 1 Glycerin, Aqua, Hydrolyzed Corallina Officinalis Glycerin 3 Glycerin Isoadipate 5 Diisopropyl Adipate Jojoba Wax Flakes 1 Hydrogenated Jojoba Oil Keltrol CG-T 0.1 Xanthan Gum Lanette O 5 Cetearyl Alcohol Lanette 16 1 Cetyl Alcohol Lanette 22 1 Behenyl Alcohol Neo Heliopan 357 3 Butyl Methoxydibenzoylmethane Neo Heliopan HMS 10 Homosalate Neo Heliopan Hydro used as a 25% aq. Solution neutralized by 8 arginine Phenylbenzimidazole Sulfonic Acid Neo Heliopan OS 5 Ethylhexyl Salicylate Orgasol Caresse 1 Polyamide-5 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.1 Shea butter 3 Butyrospermum Parkii (Shea) Butter Simugel EG 1 Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80 SymFinity 1298 0.1 Echinacea Purpurea Extract SymMatrix 0.1 Maltodextrin, Rubus Fructicosus (Blackberry) Leaf Extract SymSitive 1609 1 Pentylene Glycol, 4-t-Butylcyclohexanol Tegosoft TN 4 C12-15 Alkyl Benzoate 3-Hydroxypropyl caprylate 0.3 Glyceryl monoundecylenate 0.1 Water ad 100 Aqua

    TABLE-US-00021 TABLE 21 w/o night cream Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Aloe Vera Gel Concentrate Water (Aqua), Aloe Barbadensis Leaf 3.0 10/1 * Juice Alugel 34 TH Aluminium Stearate 1.0 Dragosan W/O P* Sorbitan Isostearate, Hydrogenated 6.0 Castor Oil, Ceresin, Beeswax (Cera Alba) Dragosantol ® 100* Bisabolol 0.2 Extrapone ® Witch Hazel Propylene Glycol, Hamamelis 1.0 Distillate colourless Virginiana (Witch Hazel) Water, Water (Aqua), Hamamelis Virginiana (Witch Hazel) Extract Perfume oil PO1, PO2, PO3, Fragrance 0.4 PO4, or PO5 Glycerol 85 % Glycerin 2.0 Karion F Sorbitol 2.0 Magnesium Chloride Magnesium Chloride 0.7 PCL Liquid 100 Cetearyl Ethylhexoate 12.0 Retinyl Palmitate in Oil Retinyl Palmitate 0.2 Sun Flower Oil Helianthus Amuus (Sunflower) Seed 5.0 Oil Sweet Almond Oil Prunus dulcis 5.0 SymMatrix ® Maltodextrin, Rubus Fruticosus 1.0 (Blackberry) Leaf Extract SymOcide PS Phenoxyethanol, Decylene glycol, 1,2- 1.0 Hexanediol SymVital ® AgeRepair Zingiber Officinale (Ginger) Root 0.1 Extract Tocopherol Acetate Tocopheryl Acetate 3.0 Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00022 TABLE 22 Body lotion Ingredients Amount Cetearyl Alcohol 2.0 Ethylhexyl Isononanoate 5.0 Cetearyl Ethylhexanoate, Isopropyl Myristate 3.0 Glyceryl Oleate Citrate, Caprylic/Capric Triglyceride 4.0 Water (Aqua) ad 100 Carbomer 0.3 Sodium Benzoate 0.1 Propylene Glycol 5.0 Sodium Hydroxide 30% solution 0.3 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 Triethylene Glycol, Imidazolidinyl Urea, Methylparaben, 0.3 Propylparaben, Dehydroacetic Acid 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.2

    TABLE-US-00023 TABLE 23 Antibacterial body lotion, sprayable Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 2,4-Hexadienoic acid, Sorbic acid, potassium salt 0.2 potassium salt Dow Corning 345 Fluid Cyclomethicone 0.5 Dracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride Drago-Calm Water, Glycerin, Avena Sativa (Oat) 1.0 Kernel Extract Dragosantol ® 100* Bisabolol 0.1 Perfume oil PO1, PO2, PO3, Fragrance 0.3 PO4, or PO5 Hydrolite ®-5 Pentylene Glycol 5.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 Paraffin Oil Mineral Oil 4.0 PCL Liquid 100 Cetearyl Ethylhexoate 7.0 Pemulen TR-2 Acrylates/C10-30 Alkyl Acrylate 0.2 Crosspolymer Sodium Hydroxide (10% Sodium Hydroxide 0.4 sol.) SymDeo ® MPP Dimethyl Phenylbutanol 0.5 SymRelief ® 100 Bisabolol, Zingiber Officinale (Ginger) 0.1 Root Extract Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00024 TABLE 24 Aseptic wound cream Ingredients Amount Sorbitan Isostearate, Hydrogenated Castor 6.0 Oil, Ceresin, Beeswax (Cera Alba) Petrolatum 21.0 Cera Alba 5.0 Cetearyl Alcohol 7.0 Prunus Dulcis 7.0 Lanolin 5.0 Paraffinum Liquidum 12.0 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 Water (Aqua) ad 100 Panthenol 7.0 Magnesium Sulfate 0.7 Pentylene Glycol 1.0 Tocopheryl Acetate 1.0 Octenidine dihydrochloride 0.1 Phenoxyethanol 0.5 3-Hydroxypropyl caprylate 0.4 Glyceryl monocaprylate 0.2

    TABLE-US-00025 TABLE 25 Anti acne balm Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.2 undecylenate Abil 350 Dimethicone 1.0 Allantoin Allantoin 0.1 Aloe Vera Gel Water (Aqua), Aloe 3.0 Concentrate 10/1 * Barbadensis Leaf Juice Azelaic Acid Azelaic Acid 5.0 Cetiol OE Dicaprylyl Ether 4.0 Cetiol SB 45 Butyrospermum Parkii 1.0 (Shea Butter) D-Panthenol Panthenol 1.0 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 Frescolat ® ML cryst. Menthyl Lactate 0.8 Glycerol 85% Glycerin 4.0 Hydroviton ® PLUS Water, Pentylene Glycol, 1.0 Glycerin, Fructose, Urea, Citric Acid, Sodium Hydroxide, Maltose, Sodium PCA, Sodium Chloride, Sodium Lactate, Trehalose, Allantoin, Sodium hyaluronate, Glucose Lara Care A-200 Galactoarabinan 0.3 Pemulen TR-2 Acrylates/C10-30 Alkyl 0.2 Acrylate Crosspolymer Sodium Hydroxide Sodium Hydroxide 0.4 (10% sol.) SymOcide PH Hydroxyacetophenone, 1.0 Phenoxyethanol, Caprylyl glycol, Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate Tocopheryl Acetate 0.5 Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00026 TABLE 26 Barrier repair cream Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.1 caprylate Glyceryl Glyceryl caprylate 0.1 monocaprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.1 nnonoundecylenate Abil 350 Dimethicone 0.5 Allantoin Allantoin 0.25 Ceramide BIO* Cetylhydroxyproline Palmitamide 0.5 Dracorin ® CE Glyceryl Stearate Citrate 1.5 Dragoxat ® 89 Ethylhexyl Ethylisononan-oate 2.0 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Extrapone ® Glycerin, Water (Aqua), Rosmarinus 0.5 Rosemary GW officinalis (Rosemary) Leaf Extract Perfume oil PO1, Fragrance 0.1 PO2, PO3, PO4, or PO5 Glycerol 85% Glycerin 3.0 Glyceryl Stearate Glyceryl Stearate 2.0 Hydroviton ® 24 Water, Glycerin, Sodium Lactate, 1.0 TEA Lactate, Serine, Lactic Acid, Urea, Sorbitol, Sodium Chloride, Lauryl Diethylenedi-anninoglycine, Lauryl Aminopropyl-glycine, Allantoin Isodragol ® Triisononanoin 3.0 Lanette O Cetearyl Alcohol 2.0 NaOH 10% sol. Sodium Hydroxide 0.3 Neutral Oil Caprylic/Capric Triglyceride 10.0 SymCalmin ® Pentylene Glycol, Butylene Glycol, 1.0 Hydroxyphenyl Propamidobenzoic Acid SymRepair ® 100 Hexyldecanol, Bisabolol, 2.0 Cetylhydroxyproline Palmitamide, Stearic Acid, Brassica Campestris (Rapeseed) Sterols SymTriol Caprylyl glycol, 1,2-Hexanediol, 1.0 Methylbenzyl alcohol Tegosoft PC 31 Polyglyceryl 3-Caprate 0.3 Tocopherol Acetate Tocopheryl Acetate 0.3 Water Water (Aqua) ad 100 (demineralized)

    TABLE-US-00027 TABLE 27 Skin soothing lotion Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate Glyceryl Glyceryl caprylate 0.05 monocaprylate 3-Hydroxypropyl Hydroxypropyl 0.2 undecylenate undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate Abil 350 Dimethicone 2.0 Allantoin Allantoin 0.2 Carbopol Ultrez-10 Carbomer 0.1 Ceramide BIO* Cetylhydroxyproline 0.1 Palmitamide Citric Acid 10% sol. Citric Acid 0.4 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Extrapone ® Green Glycerin, Water (Aqua), 0.2 Tea GW Camellia Sinensis Leaf Extract Extrapone ® Glycerin, Water (Aqua), 0.3 Rosemary GW Rosmarinus officinalis (Rosemary) Leaf Extract Perfume oil PO1, Fragrance 0.3 PO2, PO3, PO4, or PO5 Glycerol 85% Glycerin 2.0 Glyceryl Stearate Glyceryl Stearate 2.0 Isodragol ® Triisononanoin 2.0 Keltrol RD Xanthan Gum 0.1 Lanette O Cetearyl Alcohol 3.0 Neo PCL wssl. N Trideceth-9, PEG-5 1.0 Ethylhexanoate, Water PCL Liquid 100 Cetearyl Ethylhexanoate 5.0 PCL Solid Stearyl Heptanoate, Stearyl 2.0 Caprylate Propylene Glycol Propylene Glycol 5.0 Sodium Hydroxide Sodium Hydroxide 0.3 (10% sol.) SymCalmin ® Pentylene Glycol, Butylene 2.0 Glycol, Hydroxyphenyl Propamidobenzoic Acid SymMatrix ® Maltodextrin, Rubus 0.1 Fruticosus (Blackberry) Leaf Extract SymSave H Hydroxyacetophenone 0.4 2-Phenoxyethyl Phenoxyethanol 0.4 Alcohol SymSitive ® 1609 Pentylene Glycol, 4-t- 1.5 Butylcyclohexanol Water Water (Aqua) ad 100 (demineralized)

    TABLE-US-00028 TABLE 28 Baby Nappy Rash Cream w/o Ingredients Amount SymOcide PH Phenoxyethanol, Hydroxyacetophenone, 1 Caprylyl Glycol, Water (Aqua) Cupuaçu butter Theobroma Grandiflorum Seed Butter 1 Cutina HR Powder Hydrogenated Castor Oil 1.5 Dehymuls PGPH Polyglyceryl-2 Dipolyhydroxystearate 5 Glycerin Glycerin 5 Jojoba oil Simmondsia Chinensis (Jojoba) Seed Oil 5 Magnesium Sulfate Hepta Hydrate Magnesium Sulfate 0.5 Monomuls 90-O18 Glyceryl Oleate 1 Neutral oil Caprylic/capric triglyceride 8 PCL Liquid 100 Cetearyl Ethylhexanoate 5 SymCalmin Butylene Glycol, Pentylene Glycol, Hydroxyphenyl 1 Propamidobenzoic Acid Tamanu oil Calophyllum Inophyllum Seed Oil 0.2 Tetrasodium EDTA Tetrasodium EDTA 0.1 Titan dioxide Titan dioxide 4 Water Aqua ad 100 Wheat germ oil Triticum Vulgare (Wheat) Germ Oil 2 Zinc oxide Zinc oxide 10 3-Hydroxypropyl caprylate 0.3 3-Hydroxypropyl undecylenate 0.15

    TABLE-US-00029 TABLE 29 Skin lightening day cream o/w Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.1 caprylate Glyceryl Glyceryl caprylate 0.1 monocaprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate Abil 350 Dimethicone 0.5 Dracorin ® CE Glyceryl Stearate Citrate 2.5 Dracorin ® GOC Glyceryl Oleate Citrate, 0.5 Caprylic/Capric Triglyceride Drago-Beta-Glucan Water (Aqua), Butylene 0.3 Glycol, Glycerin, Avena Sativa (Oat), Kernel Extract Dragosantol ® 100* Bisabolol 0.2 Perfume oil PO1, Fragrance 0.1 PO2, PO3, PO4, or PO5 Frescolat ® MGA Menthone Glycerol Acetal 0.5 Glycerol 85% Glycerin 3.0 Isopropyl Palmitate Isopropyl Palmitate 4.0 Keltrol RD Xanthan Gum 0.2 Lanette 16 Cetyl Alcohol 1.0 Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 5.0 Neutral Oil Caprylic/Capric Triglyceride 6.0 PCL Liquid 100 Cetearyl Ethylhexoate 3.0 Sodium Benzoate Sodium Benzoate 0.1 Symdiol ® 68T 1,2-Hexanediol, Caprylylglycol, 0.5 Tropolone SymVital ® Zingiber Officinale (Ginger) 0.1 AgeRepair Root Extract SymWhite ® 377 Phenylethyl Resorcinol 0.5 Water Water (Aqua) ad 100 (demineralized)

    TABLE-US-00030 TABLE 30 Shampoo Ingredients Amount 4-Hydroxyacetophenone (SymSave H) Hydroxyacetophenone 0.3 Antil 127 PEG-120 Methyl Glucose Dioleate 0.5 Brazilian nut oil Bertholletia Excelsa Seed Oil 0.5 Cocamidopropyl Betaine 38% Cocamidopropyl Betaine 5 Octopirox Piroctone olamine 0.3 Dragoderm Glycerin, Triticunn Vulgare Gluten, Aqua 0.5 Fragrance Perfum 0.5 Glycerin Glycerin 0.5 Jojoba oil Simmondsia Chinensis (Jojoba) Seed Oil 0.5 Marlinat 242/90 M MIPA Laureth Sulfate, Propylene Glycol 15 Marlowet CG PEG-18 Castor Oil Dioleate 2 Plantacare 1200 UP Lauryl Glucoside 0.5 Polyquaternium-10 Polyquaternium-10 0.3 Sodium Chloride Sodium Chloride 1.5 SymCalmin Butylene Glycol, Pentylene Glycol, 1 Hydroxyphenyl Propamidobenzoic Acid SymOcide PS Phenoxyethanol, Decylene Glycol, 1,2-Hexanediol 0.8 3-Hydroxypropyl caprylate 0.4 3-Hydroxypropyl undecylenate 0.2 Water Aqua ad 100

    TABLE-US-00031 TABLE 31 Anti dandruff shampoo Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl 0.3 caprylate caprylate Glyceryl Glyceryl caprylate 0.2 monocaprylate 3-Hydroxypropyl Hydroxypropyl 0.15 undecylenate undecylenate Aloe Vera Gel Water (Aqua), Aloe 0.5 Concentrate 10/1 * Barbadensis Leaf Juice Avocado oil Persea Gratissima 0.5 (Avocado) Oil Citric Acid 10% sol. Citric Acid 0.3 Comperlan 100 Cocamide MEA 0.5 Crinipan AD Climbazole 0.2 Dragoderm ® Glycerin, Triticum 2.0 Vulgare (Wheat) Gluten, Water (Aqua) Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 Genapol LRO liquid Sodium Laureth Sulfate 37.0 Merquat 550 Polyquaternium-7 0.5 Sodium Chloride Sodium Chloride 1.0 SymSave ® H Hydroxyacetophenone 0.8 Tego Betain L7 Cocamidopropyl 6.0 Betaine Water Water (Aqua) ad 100 (demineralized)

    TABLE-US-00032 TABLE 32 2-in-1 Shampoo Ingredients INCI Name Amount Deionized water Water ad 100 Shea butter Butyrospermum Parkii 0.1 (Shea) Butter Plantacare PS 10 Sodium Laureth Sulfate, 20.0 Lauryl Glucoside Euperlan PK 771 Glycol Distearate, Sodium 6.0 Lauryl Sulfate, Cocamide MEA, Laureth-10 Sodium chloride Sodium Chloride 1.4 Citric acid Citric acid 0.1 monohydrate crystalline Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 Phenoxyethanol, Phenoxyethanol, Methylparaben, Methylparaben, 0.5 Ethylparaben Ethylparaben Zinc Omadine Zinc pyrithione 0.10 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate 3-Hydroxypropyl Hydroxypropyl 0.15 undecylenate undecylenate

    TABLE-US-00033 TABLE 33 Body wash Ingredients INCI Amount Lumerol K 28 Disodium Laureth 33.0 Sulfosuccinate, Cocamidopropyl Betaine, Magnesium Lauryl Sulfate Amphotensid B 4 Cocamidopropyl Betaine 10.0 Perlglanzmittel MIPA-Pareth-25 Sulfate, 4.0 GM 4055 Glycol Stearate Sodium Chloride Sodium Chloride 2.0 Avocado oil Persea Gratissima 3.0 (Avocado) Oil SymSave H Hydroxyacetophenone 0.8 Water Water ad 100 Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl caprylate 0.15 caprylate Glyceryl Glyceryl caprylate 0.15 monocaprylate 3-Hydroxypropyl Hydroxypropyl 0.1 undecylenate undecylenate Glyceryl Glyceryl undecylenate 0.1 monoundecylenate

    TABLE-US-00034 TABLE 34 Shower gel Ingredients INCI Amount Deionized water Water ad 100 Shea butter Butyrospermum Parkii 1.0 (Shea) Butter Plantacare PS 10 Sodium Laureth Sulfate, 20.0 Lauryl Glucoside Dehydroacetic acid Dehydroacetic acid 0.2 SymSave H Hydroxyacetophenone 0.3 Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric Acid 1.3 crystalline Perfume oil PO1, PO2, Fragrance 0.6 PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl 0.1 caprylate caprylate Glyceryl monocaprylate Glyceryl caprylate 0.3 3-Hydroxypropyl Hydroxypropyl 0.2 undecylenate undecylenate

    TABLE-US-00035 TABLE 35 Intimate wash Ingredients INCI Amount Tegobetaine HS Cocamidopropyl Betaine, 15.0 Glyceryl Laurate Tagat L 2 PEG-20 Glyceryl Laurate 2.0 Arlacide G Chlorhexidine Digluconate 0.1 Rewoquat B 50 Benzalkonium Chloride 0.1 Lactic Acid, 80% Lactic Acid 0.1 euxyl ® K700 Potassium Sorbate, Benzyl 0.3 Alcohol, Phenoxyethanol Water Water ad 100 Perfume oil PO1, Fragrance 0.2 PO2, PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate Glyceryl Glyceryl caprylate 0.1 monocaprylate 3-Hydroxypropyl Hydroxypropyl 0.1 undecylenate undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate

    TABLE-US-00036 TABLE 36 Liquid soap, transparent Ingredients INCI Amount Tagat O 2 PEG-20 Glyceryl Oleate 2.5 Coconut oil Cocamide DEA 5.0 diethanolamine condensate Abil B 8842 Cyclomethicone 0.5 Sodium Sodium Laureth Sulfate 35.0 laurylethersulfate, 28% Tego-Betaine L7 Cocamidopropyl Betaine 5.0 Soap, 25% Coconut acid, Potassium 20.0 salt, Potassium Oleate Perfume oil PO1, Fragrance 0.4 PO2, PO3, PO4, or PO5 Preservative DMDM Hydantoin 0.2 3-Hydroxypropyl Hydroxypropyl caprylate 0.15 caprylate Glyceryl Glyceryl caprylate 0.15 monocaprylate Water Water ad 100

    TABLE-US-00037 TABLE 37 Syndet soap, liquid Ingredients INCI Amount Elfan OS 46 Sodium Olefin C14-C16 35.5 Sulfonate Armoteric LB Lauryl Betaine 8.0 Euperlan PK 3000 Glycol Distearate, 10.0 OK Glycerin, Laureth-4, Cocamidopropyl Betaine Elfacos GT 282 L Talloweth-60 Myristyl 3.0 Glycol PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Perfume oil PO1, Fragrance 0.4 PO2, PO3, PO4, or PO5 SymSave H 4-Hydroxyacetophenone 0.6 3-Hydroxypropyl Hydroxypropyl 0.15 caprylate caprylate 3-Hydroxypropyl Hydroxypropyl 0.25 undecylenate undecylenate Water Water ad 100

    TABLE-US-00038 TABLE 38 Anti-acne wash Ingredients Amount Water (Aqua) ad 100 Polyquaternium-7 0.5 Cocamidopropyl Betaine 9.0 Coco Glucoside 2.0 Polysorbate 80, Glycerol, Gossypium 1.0 Herbaceum, (Cotton) Seed Oil, Water (Aqua) Trideceth-9, PEG-5 Ethylhexanoate, 1.0 Water (Aqua) Glycereth-90 Isostearate, Laureth-2 0.5 Sodium Laureth Sulfate 37.0 Glycerol, Triticum Vulgare (Wheat) Gluten, 1.0 Water (Aqua) Sodium Chloride 0.3 Perfume oil PO1, PO2, PO3, PO4, or PO5 1.0 SymOcide BHO (Hydroxyacetophenone, 1.0 Benzyl alcohol, Caprylyl glycol, Water) 3-Hydroxypropyl caprylate 0.25 3-Hydroxypropyl undecylenate 0.15

    TABLE-US-00039 TABLE 39 Mineral wash and cleaning gel Ingredients INCI Amount Water Water (Aqua) ad 100 Pionier ® NP 37 G Sodium Carbomer 1.5 SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 5.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Hydroviton ® 24 Water (Aqua), Pentylene Glycol, 1.0 Glycerol, Sodium Lactate, Lactic Acid, Serine, Urea, Sorbitol, Sodium Chloride, Allantoin Extrapone ® Silk GW Water (Aqua), Glycerol, Hydrolyzed Silk 1.0 Hydrolite ® 5 Pentylene Glycol 4.0 Actipearls Red Star # Water (Aqua), Propylene Glycol, Algin, 1.0 DH10402/6 Gellan Gum, Xanthan Gum, CalciumChloride, CI 12490 (Pigment Red 5), Mica (CI 77019), Titanium Dioxide (CI 77891) Perfume oil PO1, PO2, Fragrance 0.5 PO3, PO4, or PO5 SymGuard CD Phenylpropanol, o-cymen-5-ol, 0.3 Decylene glycol 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

    TABLE-US-00040 TABLE 40 After Shave Tonic Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, SodiumOleate, Sodium Sulfate SymSitive ® 1609 Pentylene Glycol, 4-t- 1.0 Butylcyclohexanol Frescolat ® ML Menthyl Lactate 0.3 Glycerol 99,5 P. Glycerol 5.0 Water Water (Aqua) ad 100 Extrapone ® Glacier Water Glycerol, Water (Aqua) 1.0 GW SymCalmin ® Butylene Glycol, Pentylene Glycol, 0.5 Hydroxyphenyl Propamidobenzoic Acid Dragosine ® Carnosine 0.1 Hydrolite ® 5 Pentylene Glycol 5.0 Ethanol 96% Alcohol Denat. 5.0 Colour Pigment Colour Pigment 0.05 Perfume oil PO1, PO2, PO3, Fragrance 0.15 PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate

    TABLE-US-00041 TABLE 41 Hair conditioner with Crinipan, rinse-off Ingredients INCI Amount Lanette ® O Cetearyl Alcohol 4.0 Dragoxat 89 Ethylhexyl Isononanoate 2.0 Genamin ® KDM-P Behentrimonium Chloride 1.0 SF 1550 Phenyl Trimethicone 0.1 Neo Heliopan ® BB Benzophenone-3 0.1 Crinipan ® AD Climbazole 0.4 Glycerol 99,5 P. Glycerol 6.0 Water Water (Aqua) ad 100 Actipone ® Alpha Pulp Water (Aqua), Butylene Glycol, Malic 0.5 Acid, Actinidia Chinensis (Kiwi) Fruit Juice, Citrus Aurantium Dulcis (Orange) Juice, Citrus Paradisi (Grapefruit) Juice, Pyrus Malus (Apple) Juice, Trideceth-9, Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract Extrapone ® Bamboo P Propylene Glycol, Water (Aqua), 0.5 Butylene Glycol, Bambusa Vulgaris Shoot Extract Sodium Hydroxide 10% Sodium Hydroxide 0.4 solution Colour I Colour 0.6 Colour II Colour 0.3 Perfume oil PO1, PO2, PO3, Fragrance 0.4 PO4, or PO5 Preservative Methylparaben 0.3 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate

    TABLE-US-00042 TABLE 42 Scalp soothing hair conditioner with UV-B/UV-A protection, rinse off Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1 Abil 350 Dimethicone 0.1 Dehyquart A CA Cetrimonium Chloride 0.5 Dehyquart SP Quaternium-52 4.0 Dracorin ® CE Glyceryl Stearate Citrate 1.0 EDETA BD Disodium EDTA 0.1 Extrapone ® Green Tea GW Glycerin, Water (Aqua), Camellia 0.7 Sinensis Leaf Extract Perfume oil PO1, PO2, PO3, Fragrance 0.5 PO4, or PO5 Lara Care A-200 Galactoarabinan 0.5 Neutral Oil Caprylic/Capric Triglyceride 1.0 PCL Liquid 100 Cetearyl Ethylhexoate 0.3 PCL Solid Stearyl Heptanoate, Stearyl Caprylate 3.0 SymOcide ®PS Phenoxyethanol, Decylene Glycol, 1.0 1,2-Hexanediol Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00043 TABLE 43 Hair conditioner with UV protection Ingredients INCI Amount Renex PEG 6000 PEG-150 2.5 Hair Conditioner Base Cetyl alcohol, behentrimonium 3.0 chloride, Triticum Vulgare (Wheat) bran extract, linoleic acid PCL-Solid Stearyl heptanoate, stearyl caprylate 0.5 Dow Corning 5200 Laurylmethicone copolyol 0.5 Natrosol 250 HR Hydroxyethylcellulose 0.5 Benzophenone-4 Benzophenone-4 1.0 Neo Heliopan AP Disodiumphenyldibenz-imidazole 1.0 tetrasulphonate Amino methyl propanol Amino methyl propanol 2.0 Dow Corning 949 cationic Amodimethicone, cetrimonium 2.0 emulsion chloride, trideceth-12 Perfume oil PO1, PO2, PO3, Fragrance 0.8 PO4, or PO5 1,2-Hexanediol 1,2-Hexanediol 0.5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Water Water (Aqua) ad 100

    TABLE-US-00044 TABLE 44 Hair conditioner, leave on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 Dehyquart A CA Cetrimonium Chloride 0.2 Dehyquart SP Quaternium-52 2.0 Dracorin ® CE Glyceryl Stearate Citrate 1.0 Drago-Calm Water, Glycerin, Avena Sativa (Oat) 2.0 Kernel Extract Farnesol Farnesol Perfume oil PO1, PO2, P03, Fragrance 0.5 PO4, or PO5 Lara Care A-200 Galactoarabinan 0.1 Polymer JR 400 Polyquaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 SymMollient ® WS Trideceth-9, PEG-5 Isononanoate, 1.0 Water SymSol ®PF3* Water, Pentylene Glycol, Sodium 1.5 Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate SymTriol ® Caprylyl Glycol, 1,2-Hexanediol, 1.0 Methylbenzyl Alcohol Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00045 TABLE 45 Anti-itch hair conditioner, leave on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate (-)-alpha Bisabolol Bisabolol 0.1 Dehyquart A CA Cetrimonium Chloride 0.5 Dehyquart SP Quaternium-52 4.0 Dracorin ® CE* Glyceryl Stearate Citrate 1.0 Drago-Oat-Active* Water (Aqua), Butylene Glycol, Avena 2.0 Sativa (Oat) Kernel Extract Perfume oil PO1, PO2, PO3, Fragrance 0.1 PO4, or PO5 Lara Care A-200 Galactoarabinan 1.5 Neutral Oil Caprylic/Capric Triglyceride 1.0 PCL Liquid 100* Cetearyl Ethylhexoate 0.3 Polymer JR 400 Polyquaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 SymGlucan ® Aqua, Glycerin, 1,2-Hexandiol, 5 Caprylyl Glycol, Beta-Glucan SymMollient ® W/S Trideceth-9, PEG-5 Isononanoate, 2.0 Water (Aqua) SymOcide ® PH Phenoxyethanol, 1.2 Hydroxyacetophenone, Caprylyl Glycol, Aqua SymSol ®PF3 * Water, Pentylene Glycol, Sodium 1.5 Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Water, demineral ized Water (Aqua) ad 100

    TABLE-US-00046 TABLE 46 Sprayable hair conditioner with zinc pyrithrione, leave-on Ingredients INCI Amount Monomuls 60-35 C Hydrogenated Palm Glycerides 1.7 Cetiol OE Dicaprylyl Ether 7.2 Abil 100 Dimethicone 3.6 Dehyquart F 75 Distearoylethyl Hydroxyethylmonium, 4.0 Methosulfate, Cetearyl Alcohol Eumulgin B1 Ceteareth-12 3.5 Cetiol S Diethylhexylcyclohe xane 7.2 D-Panthenol Panthenol 0.1 Glycerol 99,5 P. Glycerol 1.5 Water Water (Aqua) ad 100 Actipone ® Rosemary Water (Aqua), Propylene, Glycol, 0.1 Rosmarinus Officinalis, (Rosemary) Leaf Extract Frescolat ® ML Cryst. Menthyl Lactate 0.5 Dragosantol100 Bisabolol 0.1 Zinc Omadine Zinc pyrithione 0.1 Perfume oil PO1, PO2, PO3, Fragrance 0.4 PO4, or PO5 2-Phenoxyethyl alcohol Phenoxyethanol 0.4 SymSave H Hydroxyacetophenone 0.3 SymDiol 68 1,2-Hexanediol, Caprylyl glycol 0.3 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.4 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

    TABLE-US-00047 TABLE 47 Hair styling gel Ingredients Amount Water ad 100 PVM/MA Decadiene Crosspolymer 0.6 PVP 3.0 Isocetyl Stearate 4.0 Ethylhexyl Methoxycinnamate 0.5 Aminomethyl Propanol 0.4 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.6 SymDiol ® 68T (1,2-Hexanediol, 1,2-Octanediol, Tropolone) 0.4 Phenoxyethanol 0.3 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.1

    TABLE-US-00048 TABLE 48 Deodorant stick Ingredients Amount Sodium stearate 8.0 PPG-3 Myristyl ether 70.0 1,2-propylene glycol 10.0 1,1-dimethyl-3-phenylpropanol 0.2 2-butyloctanoic acid 0.2 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.6 Water ad 100 SymDeo Plus 0.5 (Jasmol (2-benzlheptanol), 1-Dodecanol (Lauryl Alcohol), 1,2- Decanediol (Decylene Glycol), 2-Phenoxyethyl Alcohol (Phenoxyethanol)) 3-Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate 0.15 3-Hydroxypropyl undecylenate 0.1

    TABLE-US-00049 TABLE 49 Zirconium suspensoid antiperspirant stick Ingredients INCI Amount PCL Liquid 100 Cetearyl ethylhexanonate ad 100 Silicone Fluid 345 Cyclomethicone 10.0 CRODACOL C90 Cetyl Alcohol 8.0 SYNCROWAX HGLC C18-36 Triglyceride 8.0 CRODAMOL PTC Pentaerythritol 5.0 Tetracaprylate/Caprate SYNCROWAX HRC Tribehenin 4.0 VOLPO N5 Oleth-5 1.0 Titanium Dioxide 1.0 Rezal 36GP Aluminium Tetrachlorohydrex GLY 20.0 Dry Flo C Aluminium Starch Octenyl Succinate 22.5 Preservative Phenoxyethanol 0.8 Perfume oil PO1, PO2, PO3, Fragrance 0.6 PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1

    TABLE-US-00050 TABLE 50 Antiperspirant/deodorant roll-on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Dragosantol ® 100* Bisabolol 0.1 Ethanol 96% Ethanol 30.0 Farnesol Farnesol 0.5 Perfume oil PO1, PO2, PO3, Fragrance 1.5 PO4, or PO5 Frescolat ®ML cryst. Menthyl Lactate 0.2 Irgasan DP 300 Triclosan 0.3 Natrosol 250 HHR Hydroxyethyl-cellulose 0.3 Solubilizer 611674 PEG-40 Hydrogenated Castor 2.0 Oil, Trideceth-9, Water (Aqua) SymDeo ® B125 2-Methyl 5-Cyclohexylpentanol 0.5 Water (demineralized) Water (Aqua) ad 100 Zirkonal L 450 Aluminium Zirconium 37.0 Pentachlorohydrate (40% aqueous solution)

    TABLE-US-00051 TABLE 51 Deodorant formulation in the form of a roll-on gel Ingredients Amount 1,3-butylene glycol 2.0 PEG-40-hydrogenated castor oil 2.0 Hydroxyethylcellulose 0.5 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 1,3-propanediol 0.5 SymGuard CD (3-Phenylpropanol, o-cymen-3-ol, 0.4 Decylene glycol) Ethylhexyl glycerin 0.1 3-Hydroxypropyl caprylate 0.3 Glyceryl monocaprylate 0.15 3-Hydroxypropyl undecylenate 0.1 Water ad 100

    TABLE-US-00052 TABLE 52 Clear deo anti-perspirant roll-on Ingredients INCI Amount Methocel E4M Premium Hydroxypropyl Methylcellulose 0.5 Water Water (Aqua) ad 100 Neo-PCL Water Soluble N Trideceth-9, PEG-5 Ethylhexanoate, 1.0 Water (Aqua) Solubilizer PEG-40 Hydrogenated Castor Oil, 3.0 Trideceth-9, Propylene Glycol, Water (Aqua) Deolite Dimethyl Phenylpropanol, Pentylene 0.5 Glycol Locron LW Aluminium Chlorohydrate 25.0 Aloe Vera Gel Concentrate Aloe Barbadensis Leaf Juice 1.0 10/1 1,2-Propylene Glycol 99 P Propylene Glycol 4.0 GC Ethanol 96% Alcohol Denat. 30.0 Perfume oil PO1, PO2, PO3, Fragrance 1.0 PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.3 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate

    TABLE-US-00053 TABLE 53 Deodorant pump spray with SymClariol Ingredients INCI Amount SymClariol ® Decylene Glycol 0.2 Solubilizer PEG-40 Hydrogenated Castor Oil, 4.0 Trideceth-9, Propylene Glycol, Water (Aqua) Neo-PCL Water Soluble N Trideceth-9, PEG-5 Ethylhexanoate, 1.5 Aqua SymRelief ® Bisabolol, Zingiber Officinale 0.1 (Ginger) Root Extract Water Water (Aqua) ad 100 1,2-Propylene Glycol Propylene Glycol 6.0 Perfume oil PO1, PO2, PO3, Perfume 0.4 PO4, or PO5 SymDiol ® 68 1,2-Hexanediol, Caprylyl Glycol 0.2 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

    TABLE-US-00054 TABLE 54 Deodorant spray Ingredients Amount PEG-40-hydrogenated castor oil 3.0 Ethylhexylglycerol (Octoxyglycerol) 0.2 Ethanol 40.0 Citrate buffer 0.5 1,2-Hexanediol, 1,2-Octanediol (1:1) 0.3 SymOcide C (o-cymen-5-ol) 0.05 2-Benzylheptan-1-ol (Jasmol) 0.1 Perfume oil PO1, PO2, PO3, 0.75 PO4, or PO5 Phenoxyethanol 0.4 3-Hydroxypropyl caprylate 0.2 Glyceryl monoundecylenate 0.1 Water ad 100

    TABLE-US-00055 TABLE 55 Sunscreen lotion (o/w, broadband protection) Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1 Carbopol Ultrez-10 Carbomer 0.2 Dow Corning 246 Fluid Cyclohexasiloxane and 2.0 Cyclopentasiloxane Dragosantol ® 100* Bisabolol 0.3 EDETA BD Disodium EDTA 0.1 Emulsiphos ® Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, PO3, Fragrance 0.4 PO4, or PO5 Frescolat ®MGA Menthone Glycerol Acetal 0.3 Glycerol 85% Glycerin 4.7 Keltrol RD Xanthan Gum 0.2 Lanette O Cetearyl Alcohol 1.0 Neo Heliopan ® 357 Butyl Methoxy-dibenzoyl-methane 1.0 Neo Heliopan ® AP Disodium Phenyl Dibenzimidazole 10.0 (10% as sodium salt) Tetrasulfonate Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 3.0 Neo Heliopan ® Hydro Phenylbenz-imidazole Sulfonic Acid 6.7 (15% as sodium salt) Neo Heliopan ® MBC 4-Methylbenzyl-idene Camphor 1.5 Neo Heliopan ® OS Ethylhexyl Salicylate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0 SymMatrix ® Maltodextrin, Rubus Fruticosus 0.3 (Blackberry) Leaf Extract SymOcide ® BHO Hydroxyacetophenone, Benzyl alcohol, Caprylyl glycol, Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate Tocopheryl Acetate 0.5 Triethanolamine, 99% Triethanolamine 0.5 Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00056 TABLE 56 Emulsion with UV-A/B-broadband protection Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 Abil 350 Dimethicone 0.3 Butylene Glycol Butylene Glycol 3.0 Carbopol Ultrez-10 Carbomer 0.2 Citric Acid 10% sol. Citric Acid 0.3 Dragosantol ® 100* Bisabolol 0.1 EDETA BD Disodium EDTA 0.1 Emulsiphos ® Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, PO3, Fragrance 0.1 PO4, or PO5 Frescolat ®X-COOL Menthyl Ethylamido Oxalate 1.0 Glyceryl Stearate Glyceryl Stearate 2.0 Keltrol RD Xanthan Gum 0.2 Lanette 16 Cetyl Alcohol 1.2 Lanette E Sodium Cetearyl Sulfate 0.7 Neo Heliopan ® AP (10% Disodium Phenyl Dibenzimidazole 22.0 as sodium salt) Tetrasulfonate Neo Heliopan ® HMS Homosalate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0 PCL Liquid 100 Cetearyl Ethylhexoate 3.0 Sodium Hydroxide (10% Sodium Hydroxide 2.8 sol.) Symdiol ®68 1,2-Hexanediol, Caprylylglycol 0.5 SymMollient ®S Cetearyl Nonanoate 1.5 SymSitive ® 1609 Pentylene Glycol, 4-t- 0.5 Butylcyclohexanol SymWhite ®377 Phenylethyl Resorcinol 0.5 Tocopherol Acetate Tocopheryl Acetate 0.5 Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00057 TABLE 57 Sun protection soft cream (w/o), SPF 40 Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 dipolyhydroxystearate 5.0 Copherol 1250 Tocopheryl acetate 0.5 Permulgin 3220 Ozocerite 0.5 Zinc stearate Zinc stearate 0.5 Tegosoft TN C12-15 Alkyl benzoate 10.0 Neo Heliopan ® E1000 Isoamyl-p-methoxycinnamate 2.0 Neo Heliopan ® 303 Octocrylene 5.0 Neo Heliopan ® MBC 4-Methylbenzylidene camphor 3.0 Zinc oxide, neutral Zinc oxide 5.0 Water, distilled Water (aqua) ad 100 EDETA BD Disodium EDTA 0.1 Glycerol Glycerol 4.0 Magnesium sulfate Magnesium sulfate 0.5 Perfume oil PO1, PO2, Fragrance 0.3 PO3, PO4, or PO5 Symdiol ® 68 1,2-Hexanediol, Caprylylglycol 0.3 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15

    TABLE-US-00058 TABLE 58 Sun protection milk (w/o) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 dipolyhydroxystearate 3.0 Beeswax 8100 Beeswax 1.0 Monomuls 90-0-18 Glyceryl oleate 1.0 Zinc stearate Zinc stearate 1.0 Cetiol SN Cetearyl isononanoate 5.0 Cetiol OE Dicaprylyl ether 5.0 Tegosoft TN C12-15 alkyl benzoate 4.0 Vitamin E Tocopherol 0.5 Neo Heliopan ® OS Ethylhexyl salicylate 5.0 Neo Heliopan ® AV Ethylhexyl methoxycinnamate 7.5 Uvinul ® T150 Ethylhexyl triazone 1.5 Water, distilled Water (Aqua) ad 100 Trilon BD Disodium EDTA 0.1 Glycerol Glycerol 5.0 Neo Heliopan ® AP 10% Disodium phenyl dibenzimidazole 15.0 solution, neutralized with tetrasulfonate NaOH Perfume oil PO1, PO2, Fragrance 0.25 PO3, PO4, or PO5 Alpha bisabolol Bisabolol 0.1 SymOcide ® PT Phenoxyethanol, Tropolone 0.25 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

    TABLE-US-00059 TABLE 59 Sun spray with UV-A/B-broadband protection with low oil content Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 Ethanol 96% Ethanol 13.0 Perfume oil PO1, PO2, PO3, Fragrance 0.5 PO4, or PO5 Glyceryl Stearate Glyceryl Stearate 4.0 Hydroviton ® PLUS Water, Pentylene Glycol, Glycerin, 1.0 Fructose, Urea, Citric Acid, Sodium Hydroxide, Maltose, Sodium PCA, Sodium Chloride, Sodium Lactate, Trehalose, Allantoin, Sodium hyaluronate, Glucose Isoadipate ® Diisopropyl Adipate 1.0 Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 25.0 Neo Heliopan ® MBC 4-Methylbenzyl-idene Camphor 33.3 Propylene Glycol Propylene Glycol 0.8 Tego Betain L7 Cocamidopropyl Betaine 1.0 Water (demineralized) Water (Aqua) ad 100

    TABLE-US-00060 TABLE 60 Sunscreen spray o/w, SPE 15-20 Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate, Caprylic/Capric 2.0 Triglyceride Corapan ® TQ Diethylhexyl 2,6-Naphthalate 3.0 Neo Heliopan ® HMS Homosalate 7.0 Neo Heliopan ® OS Ethylhexyl Salicylate 5.0 Neo Heliopan ® 357 Butyl Methoxydibenzoylmethane 3.0 Isoadipate Diisopropyl Adipate 6.0 Baysilone ® Oil M10 Dimethicone 1.0 Edeta ® BD Disodium EDTA 0.1 Vitamin E Acetate Tocopheryl Acetate 0.5 Dragosantol ® 100 Bisabolol 0.1 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate 0.25 Crosspolymer Water Water (Aqua) ad 100 Glycerol 99, 5 P. Glycerol 4.0 Butylene Glycol Butylene Glycol 5.0 Neo Heliopan ® Hydro Phenylbenzimidazole Sulfonic Acid 8.0 (103089), used as 25% aq. solution neutralized with Biotive ® L-Arginine Biotive ® L-Arginine Arginine 0.55 Perfume oil PO1, PO2, Fragrance 0.4 PO3, PO4, or PO5 SymOcide PS Phenoxyethanol, 1,2-Hexanediol, 0.8 Decylene glycol Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

    TABLE-US-00061 TABLE 61 After sun gel Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Glycerol 99, 5 P. Glycerol 5.0 SymHelios ® 1031 Benzylidene Dinnethoxydimethylin 0.1 danone Water Water (Aqua) ad 100 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate 1.0 Crosspolymer D-Panthenol 75 W Panthenol 0.5 SymFinity ® 1298 Echinacea Purpurea Extract 0.1 Extrapone ® Pearl GW Water (Aqua), Glycerol, Hydrolyzed 1.0 Pearl, Xanthan Gum Sodium Hydroxide 10% Sodium Hydroxide 2.5 solution Ethanol 96% Alcohol Denat. 15.0 Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 SymOcide ® PS Phenoxyethanol, 1,2-Hexanediol, 0.8 Decyleneglycol 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate

    TABLE-US-00062 TABLE 62 After sun lotion Ingredients Amount Acrylate/C10-30 alkylacrylate crosspolymer 0.4 Cetearylethyl hexanoate 15.0 Bisabolol 0.2 Tocopheryl acetate 1.0 Panthenol 1.0 Alcohol 15.0 Glycerol 3.0 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.30 1,2-Hexanediol 1.0 4-Hydroxyacetophenone 0.3 Pentylene glycol 4.0 Aqua dem. ad 100 Triethanolamine 0.2 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.1

    TABLE-US-00063 Example 63 Syndet antimicrobial soap bar Ingredients INCI Amount Zetesap 813 A Disodium Lauryl Sulfosuccinate, ad 100 Sodium Lauryl Sulfate, Corn Starch, Cetearyl Alcohol, Paraffin, Titanium Dioxide Amphotensid GB 2009 Disodium Cocoamphodiacetate 6.0 Allantoin Allantoin 1.0 Perfume oil PO1, PO2, Fragrance 1.0 PO3, PO4, or PO5 SymOcide C o-cymen-5-ol 0.1 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

    TABLE-US-00064 TABLE 64 Syndet soap bar Ingredients INCI Amount Fenopon AC-78 Sodium Cocoyl Isethionate 20.0 Natriumlaurylsulfoacetate Sodium Lauryl Sulfoacetate 16.0 Paraffin Paraffin 19.0 Wax, microcrystalline Microcrystalline Wax 1.0 Corn Starch Corn Starch 8.0 Coconut acid Coconut acid 2.0 Lauric acid diethanol amide Lauramide DEA 2.0 Dextrin Dextrin 21.0 Lactic acid, 88% Lactic Acid 1.0 SymGuard CD 3-Phenylpropanol, o-cymen-5-ol, 0.3 Decylene glycol Thymol Thymol 0.05 Water Water ad 100 Perfume oil PO1, PO2, Fragrance 1.0 PO3, PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

    TABLE-US-00065 TABLE 65 Antimicrobial toilet soap bar Ingredients Amount Sodium soap from tallow 60.0 Sodium soap from palm oil 27.0 Glycerol 2.0 Sodium Chloride 0.5 1-Hydroxyethane-1,1-diphosphonic acid, 0.3 tetrasodium salt Alpha-Tocopherol 0.1 Pigment Yellow 1 0.02 Water ad 100 Perfume oil PO1, PO2, PO3, PO4, or PO5 3.0 Farnesol 0.2 3-Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate 0.1 3-Hydroxypropyl undecylenate 0.05 Glyceryl monoundecylenate 0.05

    TABLE-US-00066 TABLE 66 Shaving foam Ingredients Amount Dem. Water ad 100 Triethanolamine 4.0 Edenor L2 SM (Stearinic acid, Palmitinic acid) (Cognis) 5.3 Laureth-23 3.0 Stearylalcohol 0.5 SymOcide BHO 1.0 (Hydroxacetophenone, Benzyl alcohol, Caprylyl glycol, Water) 3-Hydroxypropyl caprylate 0.2 Glyceryl monocaprylate 0.1 3-Hydroxypropyl undecylenate 0.1 Glyceryl monoundecylenate 0.05 Sodium lauryl sulfate 3.0 Extrapone Seaweed (water, propylene glycol, potassium iodide, 1.0 Fucus Vesiculosus Extract) Dragosantol (Bisabolol, Farnesol) 0.1 Perfume oil PO1, PO2, PO3, PO4, or PO5 1.0 propane, butane 4,2 Bar 4.0

    TABLE-US-00067 TABLE 67 Sprayable disinfecting gel Ingredients INCI Amount Water Water (Aqua) ad 100 Stabileze QM PVM/Ma Decadiene Crosspolymer 0.25 Sodium Hydroxide 10% Sodium Hydroxide 0.4 solution Coffein pure Caffeine 0.5 Extrapone ® Horse Chestnut Propylene Glycol, Water (Aqua), 1.0 Glucose, Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Lactic Acid Hydrolite ® 5 Pentylene Glycol 3.0 1,3 Butylene Glycol Butylene Glycol 5.0 Biotive ® Esculin Esculin 0.3 Sesquihydrate Ethanol 96% Alcohol Denat. 10.0 Solubilizer PEG-40 Hydrogenated Castor Oil, 0.5 Trideceth-9, Water (Aqua) Perfume oil PO1, PO2, PO3, Fragrance 0.2 PO4, or PO5 Octenidine dihydrochloride 0.1 Preservative Phenoxyethanol 0.7 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

    TABLE-US-00068 TABLE 68 Solution for wet wipes Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 2.0 Sodium Lauryl Sulfoacetate, SodiumOleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, SodiumOleate, Sodium Sulfate Dragosantol ® 100 Bisabolol 0.1 Glycerol 99, 5 P. Glycerol 5.0 Water Water (Aqua) ad 100 Hydrolite ® 5 Pentylene Glycol 5.0 D-Panthenol 75 W Panthenol 0.8 DragoCalm ® Water (Aqua), Glycerol, Avena Sativa 1.0 (Oat) Kernel Extract Witch Hazel-Distillate Hamamelis Virginiana (Witch Hazel) 1.0 Water, Water (Aqua), Alcohol Allplant Essence ® Org. Pelargonium Graveolens 1.0 Rose Geranium P Flower/Leaf/Stem Water Perfume oil PO1, PO2, Fragrance 0.1 PO3, PO4, or PO5 SymOcide BHO Benzyl alcohol, Hydroxyacetophenone, 0.8 Caprylyl glycol, Water 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1

    6. In Vivo Study

    [0120] An in vivo study was performed to investigate the potential of 3-hydroxypropyl caprylate for anti-dandruff efficacy on scalp. The efficacy was assessed based on the dandruff score according to Piérard-Franchimont, which evaluates the dandruff intensity on a scale from 0-10 (0=none; 1-2=mild; 3-4=moderate; 5-6=marked; 7-8=severe; 9-10=heavy) for 8 individual sections of the scalp. 22 participants with a visual dandruff score of 32 (sum of score over all 8 sections) were included in the study.

    [0121] The active ingredient was provided in a leave-on pump spray (formulation of 0.5 wt.-% of 3-hydroxypropyl caprylate in ethanol/water 70/30 vol/vol). After two weeks of wash out with an active free shampoo, the test product was applied once daily to the scalp (30 spray bursts, every evening, leave-on overnight) for four weeks, while washing with the active free shampoo continued as during the first two weeks of wash out.

    [0122] The dandruff scoring was performed after the two weeks of wash out with active free shampoo by a trained technician on day 1 (before first use of the active-containing leave on-pump spray) and day 29 of the treatment with the leave-on pump spray and is depicted in FIG. 5. As shown in FIG. 5, a significant reduction (p=0.004) of the average dandruff score according to Piérard-Franchimont from marked (4.78) to moderate (4.38) took place.