Topical compositions

Abstract

The present invention relates to topical compositions comprising erythrulose and a caprylate, characterized in that the amount of the caprylate in the composition is 5 higher than the amount of erythrulose.

Claims

1. A method of killing and/or inhibiting growth of Candida albicans and/or Propionibacterium acnes, wherein the method comprises contacting Candida albicans and/or Propionibacterium acnes with an antimicrobial composition comprising a mixture of erythrulose and glycerol caprylate in amounts effective to kill and/or inhibit growth of the Candida albicans and/or Propionibacterium acnes, wherein the mixture has a weight ratio (w/w) of the glycerol caprylate to the erythrulose of >1.

2. The method according to claim 1, wherein the weight ratio (w/w) of the caprylate to the erythrulose is 1.25 to 3.

3. The method according to claim 1, wherein the weight ratio(w/w) of the caprylate to the erythrulose is 1.5 to 2.5.

4. The method according to claim 1, wherein the erythrulose is present in an amount of about 0.01 to 3 wt. %, based on total weight of the composition.

5. The method according to claim 1, wherein the erythrulose is present in an amount of about 0.01 to 3 wt. %, based on total weight of the composition.

6. The method according to claim 1, wherein the erythrulose is present in an amount of about 0.025 to 2 wt. %, based on total weight of the composition.

7. The method according to claim 1, wherein the erythrulose is present in an amount of about 0.04 to 1 wt. %, based on total weight of the composition.

8. The method according to claim 1, wherein the erythrulose is present in an amount of about 0.04 to 0.75 wt. %, based on total weight of the composition.

9. The method according to claim 1, wherein the glyceryl caprylate is present in an amount of 0.1 to 2 wt. %, based on total weight of the composition.

10. The method according to claim 1, wherein the glyceryl caprylate is present in an amount of 0.2 to 1.5 wt. %, based on total weight of the composition.

11. The method according to claim 1, wherein the glyceryl caprylate is present in an amount of 0.3 to 1.0 wt. %, based on total weight of the composition.

12. The method according to claim 1, wherein the composition is a topical cosmetic or pharmaceutical composition.

13. The method according to claim 12, wherein the composition is a shampoo preparation, a hair conditioner, an O/W emulsion, a W/O emulsion or a gel.

14. The method according to claim 1, wherein the composition further comprises water and at least one agent selected from the group consisting of surfactants, emulsifiers, thickeners and oils.

Description

EXAMPLE 1: SYNERGISTIC AFFECT AGAINST MICROBES

(1) The antimicrobial efficacy is assessed in analogy to the regulatory challenge test method (NF EN ISO11930). Thus, solutions of the respective active(s) in ethanol are prepared and further dissolved in physiological serum with 0.85 wt.-% NaCl in the concentrations as outlined in table 1 under sterile conditions. The samples were solubilized in physiological serum supplemented with 1 wt.-% ethanol. A control was prepared under sterile condition based on a serum with 0.85 wt.-% NaCl and 1 wt.-% ethanol (C1).

(2) The control as well as the solutions of the active(s) were deposed in 96-deep well plates (1.6 ml/well). The wells are contaminated resulting in the initial contamination as outlined in table 1. After the contamination, each well was thoroughly mixed to ensure a homogeneous distribution of bacteria. Then each plate was incubated at 22° C. for 24 h. The counting of the (remaining) population is carried out 24 h after contamination.

(3) Protection Against Yeast

(4) TABLE-US-00001 TABLE 1 Results 0.1% Erythrulose (corresponds to 0.08% active) Candida albicans Time colony count Log Test solution [h] [cfu/ml] reduction 0.1 wt.-% erythrulose 0 25000 0.2 wt.-% glyceryl caprylate 24 100 2.4 0.2 wt.-% erythrulose 0 25000 0.1 wt.-% glyceryl caprylate 24 1000 1.4 C1 0 25000 24 5500 0.5

(5) As can be seen in the table above the combination of erythrulose and glyceryl caprylate shows a synergistic effect against Candida albicans. The combination of erythrulose <glyceryl caprylate performs best.

(6) Protection Against Acne

(7) TABLE-US-00002 TABLE 2 Results 0.1% Erythrulose (corresponds to 0.08% active) Propionibacterium Time acnes colony count Log Test solution [h] [cfu/ml] reduction 0.1 wt.-% erythrulose 0 310000 24 3300 2 0.2 wt.-% glyceryl caprylate 0 310000 24 260 3 0.1 wt.-% erythrulose 0 310000 0.2 wt.-% glyceryl caprylate 24 0 5.5 0.3 wt.-% erythrulose 0 310000 24 100 3.5 0.3 wt.-% glyceryl caprylate 0 310000 24 10 4.5 0.2 wt.-% erythrulose 0 310000 0.1 wt.-% glyceryl caprylate 24 26 4 C1 0 310000 24 31000 1

(8) As can be seen in the table above the combination of erythrulose and glyceryl caprylate shows a synergistic effect against Propionibacterium acnes. To reach germ-free conditions the combination of erythrulose <glyceryl caprylate performs best.