Liquid and transparent blend of UV filters

Abstract

Suggested is a liquid and transparent blend of UV filters, comprising, consisting or essentially consisting of (a) at least one solid UVA filter dissolved in (b) at least one liquid UVB filter exhibiting a linear UV absorbance curve with a variance of +/−10% in the range of 290 to 360 nm as measured from a solution containing 10 mg/l of said mixture in ethanol, wherein said solid UVA filters are selected from the group consisting of Avobenzone, Bemotrizinol and mixtures thereof.

Claims

1. A liquid and transparent blend of UV filters, of (a) at least one solid UVA filter dissolved in (b) at least one liquid UVB filter, said blend comprising (a1) about 9 to about 15 wt.-% avobenzone, (a2) about 12 to about 25 wt.-% bemotrizinol, (b1) about 20 to about 35 wt.-% octocrylene, (b2) about 9 to about 15 wt.-% octisalate, and (b3) about 9 to about 15 wt.-% homoslate, on condition the amounts add to 100 wt.-%.

2. A cosmetic, dermatological or pharmaceutical composition comprising the liquid and transparent blend of UV filters according to claim 1.

3. The composition of claim 2, further comprising at least one additional UVA filter selected from the group consisting of: terephthalylidenedibornanesulphonic acid and salts; hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate; menthyl anthranilate; 2,2′-(1,4-phenylene)bis-[1H-benzimidazole-4,5-disulfonic acid], disodium salt, and mixtures thereof.

4. The composition of claim 2, further comprising at least one additional UVB filter selected from the group consisting of: 2-ethylhexyl p-dimethylaminobenzoate; triethanolamine salicylate; 2-ethylhexyl p-methoxycinnamate; isoamyl p-methoxycinnamate; 2-phenylbenzimidazole sulfonic acid and its salts; 3-(4′-methylbenzylidene)-d,l-camphor; 4,4′-[(6-[4-(1,1-dimethyl)aminocarbonyl)phenylamino]-1,3,5-triazine-2,4-diyl)diimino]bis(benzoic acid 2-ethylhexyl ester); benzylidenemalonate-polysiloxane; tris(2-ethylhexyl)4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate); methoxy propylamino cyclohexenylidene ethoxyethyl cyanoacetate; and mixtures thereof.

5. The composition of claim 2, further comprising at least one additional broadband filter selected from the group consisting of: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid or its salts; 2-hydroxy-4-methoxybenzophenone; phenol,-(2H-benzotriazol-2-yl-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyanyl)propyl); 2,2′-methylenebis(6-(2H-benztriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)-phenol; tris-biphenyl triazine; (5,6,5′,6′-tetraphenyl-3,3′-(1,4-Phenylene)bis(1,2,4-triazine 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)bis(1,2,4-triazine); and mixtures thereof.

6. The composition of claim 2, further comprising at least one pigment selected from the group consisting of zinc oxide, titanium dioxide and mixtures thereof.

7. The composition of claim 2 exhibiting a sun protection factor (SPF) of at least 2.

8. The composition of claim 2, exhibiting a UVA protection factor of at least 370 nm, as measured by the Critical Wavelength Method for in vitro determination of UVA protection.

9. The composition of claim 2, exhibiting a UVA protection factor of at least one third of the SPF, as measured by ISO norm 24443:2012 for vitro determination of UVA protection.

10. The composition of claim 2, further comprising at least one 1,2-alkanediol having 5 to 12 carbon atoms.

11. The composition of claim 2, further comprising 4-hydroxyacetophenone, o-cymen-5-ol or mixtures thereof.

12. The composition of claim 2 which is photostable.

13. The composition of claim 2, wherein the composition is an oil in water emulsion.

14. The composition of claim 2, wherein the composition is a water in oil emulsion.

15. The composition of claim 2 representing an alcoholic spray.

16. The composition of claim 2, further comprising emulsifiers selected from the group consisting of alkyl phosphates, glyceryl oleate citrates, glycereyl stearate citrates, stearic acid esters, sorbitan esters, ethoxylated sorbitan esters, ethoxylated mono-, di- and tri glycerides, methyl glucose esters, and mixtures thereof.

17. The composition of claim 16, wherein the amount of emulsifier is in the range of about 1 to about 10 percent by weight, related to the composition.

18. The composition of claim 2 being obtained from a hot/hot, or cold/hot, or hot/cold or cold/cold manufacturing processes.

19. A non-therapeutic method for protecting human skin and hair against UV radiation comprising the following steps: (i) providing the blend of claim 1, and (ii) bringing said blend in contact with said human skin or hair.

20. The composition of claim 14, wherein said emulsion encompasses an oil phase comprising additives selected from the group consisting of hydrocarbon oils, waxes, silicone oils, natural oils, fatty acid esters, fatty alcohols, antioxidants, chelating agents, skin lightening agents, tan accelerating agents, insect repelling agents, moisturizing agents, water resistant polymers, and mixtures thereof.

21. The composition of claim 14, wherein said emulsion encompasses an aqueous phase comprising additives selected from the group consisting of antioxidants, preservation agents, chelating agents, and mixtures thereof.

22. A liquid and transparent blend of UV filters, consisting of (a) 13.5 wt.-percent butyl methoxydibenzoylmethane, (b) 27.0 wt.-percent octocrylene, (c) 27.0 wt.-percent homosalate, (d) 13.5 wt.-percent octisalate, and (e) 19.0 wt.-percent bemotrizinol.

Description

EXAMPLES

Preparation of a Blend “A” According to the Invention

(1) TABLE-US-00001 TABLE 1 Inventive Blend of UV filters (amounts in wt.-%) Ingredients Amount Butyl Methoxydibenzoylmethane 13.50 Octocrylene 27.00 Homosalate 27.00 Octisalate 13.50 Bemotrizinol 19.00 Total 100.00

(2) Add all of the components of table 1 to a suitable container and heat to 85° C. with continuous stirring until all the solids have dissolved. Cool down to ambient temperature and transfer to a holding vessel. The following formulation examples were prepared by incorporation of Blend A as explained above. All amounts are expressed in wt.-%.

FORMULATION EXAMPLES

Example 1

Sunscreen Lotion (O/W), Expected SPF 50+

(3) TABLE-US-00002 Phase Ingredient INCI or USAN name 1A 1B A Emulsiphos ® Potassium Cetyl Phosphate, 2.00 2.00 Hydrogenated Palm Glycerides Neo Heliopan ® 357 Butyl Methoxydibenzoylmethane 3.38 0.00 Neo Heliopan ® 303 Octocrylene 6.75 0.00 Neo Heliopan ® OS Ethylhexyl Salicylate 3.38 0.00 Neo Heliopan ® HMS Homosalate 6.75 0.00 Neo Heliopan ® BMT Bemotrizinol 4.75 0.00 Blend A Butyl Methoxydibenzoylmethane, 0.00 25.00 Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Cetyl Alcohol Cetyl Alcohol 1.00 1.00 PCL Liquid 100 Cetearyl 2-Ethylhexanoate 12.00 12.00 KP-545 L Dimethicone (and) Acrylates/ 1.00 1.00 Dimethicone Copolymer Edeta ® BD Disodium EDTA 0.10 0.10 B Aqua/Water Aqua/Water 53.49 53.49 Sodium Hydroxide, Aqua, Sodium Hydroxide 0.50 0.50 10% aq. Solution Glycerin 99% Glycerin Ad 00 Ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate 0.20 0.20 Crosspolymer Keltrol ® CG-BT Xanthan Gum 0.20 0.20 SymSave ® H Hydroxyacetophenone 0.50 0.50 Hydrolyte ® CG Caprylyl Glycol 0.25 0.25 C Fragrance Perfume qs qs In-Vitro SPF 55 71 In-Vitro UVA PF 32 32 Critical Wavelength (nm) 379 379

(4) Manufacturing Procedure

(5) Add all components of phases A and B together except for the Carbopol® and Keltrol® and heat with stirring to 80° C. Then add the Carbopol® and Keltrol® with stirring. Homogenize with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Cool down to ambient temperature while stirring and add Phase C with stirring.

(6) Alternative Manufacturing Procedure

(7) Add all components of phase A together and heat to 85° C. with stirring until homogeneous. Add all components of phase B together without Sodium Hydroxide solution with stirring while heating to 80° C. Add Sodium Hydroxide solution with stirring. Add phase B to phase A with stirring, and homogenize with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Cool down to ambient temperature while stirring and add Phase C with stirring.

(8) When 1.30 mg/cm.sup.2 of the emulsion was spread onto PMMA plates as described in ISO 24443:2012 Determination of Sunscreen UVA Protection in-vitro and the absorbance curves of formulations 1A and 1B measured we observe that shape of the absorbance curves are very similar to that shown in dilute solution but very surprisingly we observe that the absorbance curve of formula 1B, which has used the premixed combination of UV filters, is significantly higher than that of formula 1A (FIG. 2) in which the UV filters were added individually to the formulation, resulting in a significantly higher SPF.

Example 2

Sunscreen Lotions (O/W)—Expected SPF 10, 20, 30 and 50

(9) TABLE-US-00003 Phase Ingredient INCI or USAN name 2A 2B 2C 2D A Emulsiphos ® Potassium Cetyl Phosphate, 2.00 2.00 2.00 2.00 Hydrogenated Palm Glycerides Blend A Butyl Methoxydibenzoylmethane, 5.00 10.00 15.00 20.00 Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Cetyl Alcohol Cetyl Alcohol 1.00 1.00 1.00 1.00 PCL Liquid 100 Cetearyl 2-Ethylhexanoate 12.00 12.00 12.00 12.00 KP-545 L Dimethicone (and) Acrylates/ 1.00 1.00 1.00 1.00 Dimethicone Copolymer Edeta ® BD Disodium EDTA 0.10 0.10 0.10 0.10 B Aqua/Water Aqua/Water 73.49 68.49 63.49 58.49 Sodium Hydroxide, Aqua, Sodium Hydroxide 0.50 0.50 0.50 0.50 10% aq. Soln Glycerin 99% Glycerin Ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl Acrylate 0.20 0.20 0.20 0.20 Crosspolymer Keltrol ® CG-BT Xanthan Gum 0.20 0.20 0.20 0.20 SymSave ® H Hydroxyacetophenone 0.50 0.50 0.50 0.50 Hydrolyte ® CG Caprylyl Glycol 0.25 0.25 0.25 0.25 C Fragrance Perfume qs qs qs qs In-Vitro SPF 12 25 35 50 In-Vitro UVA PF 6 10 16 23 Critical Wavelength (nm) 373 375 376 378

(10) Manufacturing Procedure

(11) Add all components of phases A and B together except for the Carbopol® and Keltrol® and heat with stirring to 80° C. Then add the Carbopol® and Keltrol® with stirring. homogenise with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Cool down to ambient temperature while stirring and add Phase C with stirring.

Example 3

Cold-Cold Sunscreen Lotion (O/W)—Expected SPF 50

(12) TABLE-US-00004 Phase Ingredient INCI or USAN name 3 A Dracorin ® Gylceryl Oleate Citrate 2.50 GOC Described Butyl Methoxydibenzoylmethane, 25.00 Mixture Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol PCL Liquid Cetearyl 2-Ethylhexanoate 12.00 100 KP-545 L Dimethicone (and) Acrylates/ 1.00 Dimethicone Copolymer Edeta ® BD Disodium EDTA 0.10 B Aqua/Water Aqua/Water 54.20 Glycerin 99% Glycerin Ad 00 Aristoflex ® Polyacrylate Cross 0.80 Velvet Polymer 11 SymOcide ® Phenoxyethanol, Decylene 1.40 PS Glycol, 1,2-Hexanediol C Fragrance Perfume qs In-Vitro SPF 51 In-Vitro UVA PF 20 Critical Wavelength (nm) 379

(13) Manufacturing Procedure

(14) Add all components of phases A and B except for the Aristoflex® Velvet without heating. Then add the Aristoflex® with stirring, and homogenize with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Add Phase C with stirring.

Example 4

Very Low Viscosity Sunscreen Lotions (O/W)—Expected SPF 50

(15) TABLE-US-00005 Phase Ingredient INCI or USAN name 4A 4B 4C A Emulsiphos ® Potassium 2.00 2.00 1.50 Cetyl Phosphate, Hydrogenated Palm Glycerides SymMollient ® Propylenediol 7.00 7.00 7.00 PDCC Dicapylate Caprate Blend A Butyl Methoxy- 25.00 25.00 25.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Floraesters ® Hydrolysed Jojoba 0.50 0.50 0.50 K ester (and) Jojoba 100 Jojoba Esters (and) water (Aqua) KP-545L Dimethicone 0.00 0.00 1.00 (and) Acrylates/ Dimethicone Copolymer Edeta ® BD Disodium EDTA 0.10 0.10 0.10 B Aqua/Water Aqua/Water Ad 100 Sodium Aqua, Sodium 0.30 1.00 0.30 Hydroxide, Hydroxide 10% aq. Soln L-Arginine Arginine 0.00 1.00 0.00 Neo Phenylbenzimidazole 0.00 2.00 0.00 Heliopan ® Sulfonic Acid Hydro Keltrol ® Xanthan Gum 0.30 0.30 0.05 CC-BT Keltrol ® Xanthan Gum 0.05 0.05 0.30 CG-SFT SymSave ® Hydroxyacetophenone 0.50 0.50 0.50 H Hydrolyte ® Caprylyl Glycol 0.25 0.25 0.25 CG Hydrolyte ® 1,2-Pentylene Glycol 2.00 2.00 2.00 5 Green C Fragrance Parfum qs qs qs Vitacel Cellulose 0.00 1.00 1.00 CS 20 FC In-Vitro SPF 53 52 53 In-Vitro UVA PF 33 27 32 Critical Wavelength (nm) 379 375 379

(16) Manufacturing Procedure

(17) Add all components of phase A together and heat to 80° C. with stirring until homogeneous. Add the first four components of Phase B together with stirring until all of the Neo Heliopan Hydro® has dissolved. Add the rest of the components of phase B together with stirring while heating to 80° C. Add phase B to phase A with stirring, and homogenise with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Cool down to ambient temperature while stirring and add Phase C with stirring.

Example 5

Sunscreen Oils—Expected SPFs 50+ and 30

(18) TABLE-US-00006 Ingredient INCI or USAN name 5A 5B Blend A Butyl Methoxydibenzoylmethane, 25.00 15.00 Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Softisan ® 100 Hydrogenated Coco Glycerides 10.00 10.00 SymMollient ® Propylenediol Dicapylate Caprate 10.00 10.00 PDCC PCL Liquid 100 Cetearyl 2-Ethylhexanoate 10.00 10.00 Neutral Oil Capric Caprlyate Triglycerides 31.00 31.00 Isoadipate Isopropyl Adipate 5.00 10.00 Isodragol ® Triisononanoin 5.00 10.00 SymMollient ®S Cetearyl Nonanoate 3.00 3.00 Hydrolyte ® 5 1,2-Pentylene Glycol Ad 100 Ad 100 Green Fragrance Perfume qs qs In-Vitro SPF 90 43 In-Vitro UVA PF 25 15 Critical Wavelength (nm) 379 379

Example 6

Cold-Cold Manufacture of Sunscreen Lotions—Expected SPF 50 and 50+

(19) TABLE-US-00007 Phase Ingredient INCI or USAN name 6A 6B A Dracorin ® Gylceryl Oleate Citrate 2.00 2.00 GOC Blend A Butyl Methoxy- 25.00 30.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymMollient ® Propylenediol 7.00 7.00 PDCC Dicapylate Caprate Aristoflex ® Sodium Polyacryloyl- 0.60 0.60 Silk dimethyl Taurate KP-545 Cyclopentasiloxane, 1.00 1.00 Acrylates/ Dimethicone Copolymer Edeta ® BD Disodium EDTA 0.10 0.10 B Aqua/Water Aqua/Water Ad 100 Ad 100 Symocide ® PS Phenoxyethanol, 1.40 1.40 Caprylyl Glycol Glycerin 99% Glycerin 2.00 2.00 Hydrolyte ® 1,2-Pentylene Glycol 2.00 2.00 5 Green C Vitacel ® Cellulose 1.00 1.00 CS 20 FC Fragrance Perfume qs qs In-Vitro SPF 55 65 In-Vitro UVA PF 19 23 Critical Wavelength (nm) 379 379

(20) Manufacturing Procedure

(21) At ambient temperature mix the oils of phase A together with stirring until homogeneous. Then disperse the Aristoflex® and EDTA into the mix. At ambient temperature mix the components of phase B together with stirring until homogeneous and then add with stirring to phase A. Add phase C to phase A/B. Then homogenize with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion).

Example 7

Cold-Cold Manufacture of Sunscreen Balm—Expected SPF 50

(22) TABLE-US-00008 Phase Ingredient INCI or USAN name 7 A Aqua/Water Aqua/Water Ad 100 Neo Heliopan ® Phenylbenzimidazole 1.00 Hydro Sulfonic Acid L-Arginine Arginine 0.60 Hydrolyte ® 5 1,2-Pentylene Glycol 2.00 Green SymSave ® H Hydroxyacetophenone 0.50 Hydrolyte ® CG Caprylyl Glycol 0.25 Edeta ® BD Disodium EDTA 0.10 Hyaluronic Acid Hyaluronic Acid 0.10 Dragosine ® Carnosine 0.20 B Aristoflex ® Silk Sodium 1.10 Polyacryloyldimethyl Taurate C Blend A Butyl Methoxy- 25.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Dragoxat ®89 Ethylxyl Isononanoate 2.00 SymMollient ® Propylenediol 3.00 PDCC Dicapylate Caprate D Vitacel ® CS Cellulose 1.00 20 FC E Fragrance Perfume qs In-Vitro SPF 61 In-Vitro UVA PF 30

(23) Manufacturing Procedure

(24) Add the first three components of Phase A together with stirring until all of the Neo Heliopan Hydro® has dissolved. Add the rest of the components of phase A together with stirring until the solution get clear. Add phase B with stirring to phase A until a smooth gel has formed. Then add the components of phase C to the gel with stirring. Stir until homogeneous. Then add phase D with stirring, add phase E with stirring and then homogenize for 3 minutes at 10 000 rpm.

Example 8

Hot/Cold-Manufacture of Sunscreen Creams—Expected SPF 50 and 50+

(25) TABLE-US-00009 Phase Ingredient INCI or USAN name 8A 8B A Emulsiphos ® Potassium Cetyl 2.00 2.00 Phosphate, Hydrogenated Palm Glycerides Blend A Butyl Methoxy- 25.00 30.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymMollient ® Propylenediol 6.00 6.00 PDCC Dicapylate Caprate Lanette ®O Cetearyl Alcohol 2.00 2.00 Cutina ® GMS V Glyceryl Stearate 1.00 1.00 Dragoxat ®89 Ethylxyl Isononanoate 2.00 2.00 SymMollient ®S Cetearyl Nonanoate 2.00 2.00 Keltrol ® CC-BT Xanthan Gum 0.30 0.30 Carbopol ® Acrylates/C10-30 0.20 0.20 Ultrez 21 Alkyl Acrylate Crosspolymer Edeta ® BD Disodium EDTA 0.10 0.10 B Aqua/Water Aqua/Water Ad 100 Ad 100 Hydrolyte ® 1,2-Pentylene Glycol 2.00 2.00 5 Green SymSave ® H Hydroxyacetophenone 0.50 0.50 Hydrolyte ® CG Caprylyl Glycol 0.25 0.25 NaOH 10% aq Sodium Hydroxide, 0.50 0.50 Water (Aqua) C Fragrance Perfume qs qs In-Vitro SPF 53 93 In-Vitro UVA PF 20 30 Critical Wavelength (nm) 379 379

(26) Manufacturing Procedure

(27) Add all components of phases A together except for the Carbopol® and Keltrol® and heat with stirring to 80° C. Then add the Carbopol® and Keltrol® with stirring. Mix all of the components of phase B at ambient temperature together with stirring until a clear solution has been obtained. Then add to the hot phase A with stirring and homogenize. Allow to cool to room temperature and then add phase C with stirring.

Example 9

Antiaging Sunscreen Lotion (O/W)—Expected SPF 30

(28) TABLE-US-00010 Phase Ingredient INCI Name 9 A Emulsiphos ® Potassium Cetyl Phosphate, 3.80 Hydrogenated Palm Glycerides Lanette ® 16 Cetyl Alcohol 1.00 Blend A Butyl Methoxy- 15.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymMollient ® Propylenediol Dicapylate Caprate 5.00 PDCC SymUrban ® Benzylidene Dimethoxy- 0.50 dimethylindanone Silsoft ® 034 Caprylyl Methicone 3.00 Dragoxat ® 89 Ethylhexyl Isononanoate 3.00 Symsitive ®1609 Pentylene Glycol, 1.00 4-t-Butylcylcohexanol Antaron ® WP 660 Tricontanyl PVP 1.00 EDETA ® BD Disodium EDTA 0.10 Copherol ® 1250 Tocopheryl Acetete 0.50 Keltrol ® CG-T Xanthan Gum 0.40 Wacker- C26-28 Alkyl Dimethicone 1.00 Belsil ® CDM 3526 VP Hydrolite ®- Pentylene glycol 4.25 5 Green SymMollient ® S Cetearyl Nonanoate 1.00 B Water Aqua (Water) Ad 100 Glycerin 99% Glycerin 2.00 SymSave ® H Hydroxyacetophenone 0.50 C Symdiol ® 68 1,2-Hexanediol, Caprylyl Glycol 0.50 Dow Corning ® Dimethicone/Vinyl 0.50 9801 Dimethicone Crosspolymer, Cosmetic Powder Silica Fragrance Perfume 0.20 Dragosantol ® 100 Bisabalol 0.10 SymGlucan ® Aqua, Glycerin, Beta-Glucan, 1.00 1,2-Hexanediol, Caprylyl Glycol Orgasol ®Caresse Nylon 6/12 2.00

(29) Manufacturing Procedure

(30) Phase A: Mix the components without Keltrol® T to approx. 85° C. Homogenize for a short time with an Ultra Turrax®. Phase B: Mix the components and heat up to approx. 80° C. until dissolved. Add phase B to phase A while stirring. Cool down while stirring to 60° C. and homogenize with an Ultra Turrax®. Then cool down to ambient temperature while stirring. Phase C: Add all ingredients step by step and stir until homogeneous with an Ultra Turrax®.

Example 10

Sunscreen Spray—Expected SPF 50

(31) TABLE-US-00011 Phase Ingredient INCI Name 10 A Dracorin ® GOC Glyceryl Oleate Citrate, 2.00 Caprylic/Capric Triglyceride Blend A Butyl Methoxydibenzoyl- 25.00 methane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Neo Heliopan ® Ethylhexyl Methoxycinnamate 2.00 AV SymMollient ® Propylenediol Dicapylate Caprate 7.50 PDCC Dragoxat ® 89 Ethylhexyl Isononanoate 3.00 SymMollient ® S Cetearyl Nonanoate 2,00 EDTA ® BD Disodium EDTA 0.10 Copherol ® 1250 Tocopherolacetat-Alpha 0.50 Silcare ® Silicone Stearyl Dimethicone 1.00 41M65 Wacker C26-28 Alkyl Dimethicone 1.00 Belsil ® CMD 3526 VP Silsoft 034 Caprylyl Methicone 2.00 Pemulen TR 2 Acrylates/C10-30 Alkyl 0.20 Acrylate Crosspolymer B Water, dest. Water (Aqua) Ad 100 SymSol ® PF-3 Aqua, Pentylene Glycol, 3.00 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate Propylenglycol Propylene Glycol 5.00 EG 56 Polymer Bis-Methoxy PEG-13 0.20 Expert PEG-438/PPG-110 SMDI Copolymer SymSave ® H Hydroxyacetophenone 0.50 C Phenoxyethanol Phenoxyethanol 0.30 SymDiol ® 68 1,2 Hexanediol, Caprylylglycol 0.30 Dow Corning ® Dimethicone/Dimethiconol 1.00 1503 D Tapioca Pure Tapioca Starch 1.00 Perfume oil Fragrance (Parfum) 0.20

(32) Manufacturing Procedure

(33) Phase A: Mix the ingredients without Pemulen® TR2 to approx 60° C. with stirring. Add Pemulen® TR2 and homogenize for a short time, approx 0.5 min. with an Ultra Turrax® T25. Phase B: Dissolve ExpertGel® in water while stirring. When dissolved add the rest of the ingredients and stir until a clear solution is obtained. Heat slightly if necessary to solubilize SymSave® H. Add the water phase B without stirring to the warm oil phase A. Homogenize with an Ultra Turrax® for approximately 5 min. Stir to cool down. Phase C: Mix the ingredients stirring and then to phase A/B. Cool down while stirring. Phase D: Add these separately to phases A/B/C with stirring at ambient temperature. Then homogenize for a short time.

Example 11

Water Resistant Broad Spectrum O/W—Expected SPF 50+

(34) TABLE-US-00012 Phase Ingredients INCI 11 A Emulsiphos ® Potassium Cetyl Phosphate, 3.50 Hydrogenated Palm Glycerides Lanette ® O Cetearylalcohol 1.00 Blend A Butyl Methoxydibenzoyl- 20.00 methane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymMollient ® Propylenediol Dicapylate 5.00 PDCC Caprate Abil ® Wax 9801 Cetyl Dimethicone 1.00 Silcare ® Stearyl Dimethicone 1.00 Silicone 41M65 Baysilone ® oil Phenyl Trimethicone 2.00 PK 20 SymMollient ® Propylenediol Dicaprylate 2.00 PDCC Caprate Tocopherylacetat Tocopheryl Acetate 0.50 Antaron ® V216 VP/Hexadecene Copolymer 0.50 EDTA BD Disodium EDTA 0.10 Keltrol ® CG-T Xanthan Gum 0.50 B Water dem Water (Aqua) Ad 100 SymSave ® H Hydroxyacetophenone 0.50 Lara Care ® A-200 Galactoarabinan 0.25 Hydrolite ® 5 Pentylene Glycol 3.00 C Fragrance Perfume 0.30

(35) Manufacturing Procedure

(36) Phase A: Heat all components except for the Xanthan Gum to 85° C. Then add Xanthan Gum and homogenize. Phase B: Heat all components to 85° C. and add to Part A with stirring, stir to room temperature. Phase C: Add Part C to Parts A & B and homogenize.

Example 12

Sunscreen Lotion with Tanning Accelerator—Expected SPF 30

(37) TABLE-US-00013 Phase Ingredients INCI-Name 12 A Emulsiphos ® Potassium Cetyl Phosphate, 2.00 Hydrogenated Palm Glycerides Lanette 16 ® Cetyl Alcohol 1.00 Blend A Butyl Methoxy- 20.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymMollient ® Propylenediol 5.00 PDCC Dicapylate Caprate SymUrban ® Benzylidene Dimethoxy- 0.50 dimethylindanone Dragoxat ® 89 Ethylhexyl Isononanoate 3.00 SymMollient ® S Cetearyl Nonanoate 1.00 Dow Corning ® Dimethicone, Dimethiconol 0.50 DC 1503 Silcare ® Stearyl Dimethicone 1.00 Silicone 41M65 Silsoft ® 034 Caprylyl Methicone 1.50 EDETA ® BD Disodium EDTA 0.10 Vitamin E Acetate Tocopheryl Acetete 0.50 Keltrol ® CG-T Xanthan Gum 0.30 Aristoflex ® Polyacrylate 0.50 Velvet Crosspolymer-11 B Water dem Aqua (Water) Ad 100 C Neo Heliopan ® Phenylbenzimidazole 1.50 Hydro Sulfonic Acid Glycerin 99% Glycerin 3.00 Dragosine Carnosine 0.20 Biotive ® Arginine 1.00 L-Arginine Lanette ® E Sodium Cetearyl Sulfate 0.70 SymSave ® H Hydroxyacetophenone 0.50 SymDiol ® 68 1,2 Hexanediol, Caprylylglycol 0.50 D Fragrance Perfume 0.20 Tapioca Pure Tapioca Starch 2.00 SymBronze ® Caprylic/Capric Triglyceride, 2.00 Isochryris Galbana Extract

(38) Manufacturing Procedure

(39) Phase A: Mix ingredients to approx. 85° C. without Keltrol® and Aristoflex®, when all ingredients are dissolved add Keltrol® and Aristoflex® and homogenize with an Ultra Turrax® for a short time. Part B: Mix ingredients with stirring to approximately 80° C. Add the hot phase B to the hot phase A, cool down with stirring to 60° C. and start homogenizing with an Ultra Turrax®. Cool down to ambient temperature while stirring. Part C: Add the ingredients to parts A/B as listed with stirring and allow cooling to ambient temperature. Part D: Add the ingredients with stirring and homogenize for a short time.

Example 13

CC Cream—Expected SPF 50

(40) TABLE-US-00014 Phase Ingredients INCI-Name 13 A Cutina ® CP Cetyl Pamitate 1.00 Tegosoft MM Myristyl Myristate 1.00 Lanette ® O Cetearyl Alcohol 1.00 Blend A Butyl Methoxy- 25.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol SymUrban ® Benzylidene Dimethoxy- 0.30 dimethylindanone SymMollient ® Propylenediol 5.00 PDCC Dicapylate Caprate Dragoxat ® 89 Ethylhexyl Isononanoate 5.00 SymWhite ® 377 Phenylethyl Resorcinol 0.20 SymRepair ® 100 Hexyldecanol, Bisabolol, 1.00 Cetylhydroxyproline Palmitamide, Stearic Acid, Brassica Campestris Sterols A Symsitive ® 1609 Pentylene Glycol, 1.00 4-t-Butylcylcohexanol Dragoxat ® 89 Ethylhexyl Isononanoate 2.00 Silsoft 034 Caprylyl Methicone 3.00 Wacker-Belsil ® C26-28 Alkyl Dimethicone 1.00 CDM 3526 VP EDETA ® BD Disodium EDTA 0.10 Copherol ® 1250 Tocopheryl Acetate 0.50 Keltrol ® CG-BT Xanthan Gum 0.40 Aristoflex ® Velvet Polyacrylate Crosspolymer-11 0.50 B Water dem Aqua (Water) Ad 100 Neo Heliopan ® Phenylbenzimidazole 1.50 Hydro, Sulfonic Acid Glycerin 99% Glycerin 4.00 Dragosine ® Carnosine 0.20 SymSol ® PF3 Aqua, Pentylene 2.50 Glycol, Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate Biotive ® Arginine 1.00 L-Arginine NaOH 10% aq. Sodium Hydroxide 0.30 DragoColour ® Titanium Dioxide (CI 2.00 Brown 77891), Iron Oxides (CI 77492), Iron Oxides (CI 77491), Iron Oxides (CI 77499) SymSave ® H Hydroxyacetophenone 0.50 C SymDiol ® 68 1,2 Hexanediol, 0.50 Caprylylglycol D Tapioca pure Tapioca Starch 2.00 Orgasol ® Nylon 6/12 2.00 4000 EXD NAT COS Caresse SymGlucan ® Aqua, Glycerin, Beta- 1.00 Glucan, 1,2-Hexanediol, Caprylyl Glycol Fragrance Parfum 0.20

(41) Manufacturing Procedure

(42) Phase A: Mix ingredients to approx. 85° C. without Keltrol®, Aristoflex® when all ingredient are dissolved add Keltrol®, Aristoflex® and homogenize with an Ultra Turrax® for a short time. Phase B: Add the water and neutralization agents Biotive® L-Arginine and the sodium hydroxide solution and stir until homogeneous. Then add the Neo Heliopan® Hydro and stir until all has dissolved. Add the rest of ingredients without Dragocolor® to phase B and heat up to approximately 80° C., add Dragocolor® and homogenize for a short time then add the hot phase B to the hot phase A and start homogenizing with an Ultra Turrax® (13000 rpm/1 minutes per 100 g emulsion). Cool down to ambient temperature while stirring. Part C: Add the ingredients to parts A/B as listed with stirring and allow cooling to ambient temperature. Part D: Add the ingredients with stirring and homogenize for a short time.

Example 14

Sun Protection Sticks—Expected SPFs of 30 and 50+

(43) TABLE-US-00015 Phase Ingredients INCI name 14A 14B A Blend A Butyl Methoxy- 20.00 25.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol PCL Liquid 100 Cetearyl 2- 0.00 5.00 Ethylhexanoate SymUrban ® Benzylidene 0.50 0.50 Dimethoxy- dimethylindanone Copherol ® 1250 Tocopheryl Acetate 0.70 0.70 Dracorin ® GOC Glyceryl Oleate Citrate, 0.50 0.50 Caprylic/Capric Triglyceride Lanette ® O Cetearyl Alcohol 7.00 5.00 TeCe-Ozokerit ® Ozokerite 20.00 21.00 N 502 Candenilla Wax Candelilla (Euphorbia 2.00 3.00 LT 281 BI Cerifera) Wax Isoadipate Diisopropyl Adipate 5.00 2.00 Isopropylpalmitat Isopropyl Palmitate 8.20 3.00 PCL Liquid ® 100 Cetearyl Ethylhexanoate 2.00 5.20 SymMollient ® S Cetearyl Nonanoate 6.00 5.00 Wacker Belsil ® C26-28 Alkyl 2.00 2.00 CDM 3526 VP Dimethicone Silcare ® Silicone Stearyl Dimethicone 1.00 1.00 41 M45 Neutral oil Caprylic/Capric Ad 100 Ad 100 Triglyceride SymMollient ® Propylenediol 4.00 4.00 PDCC Dicaprylate Caprate Dragoxat 89 Ethylhexyl Isononanoate 2.00 1.00 Dragosantol ® 100 Bisabolol 0.10 0.10 B SymTio ® SP Titanium Dioxide, 5.00 5.00 Aluminum Hydroxide, Cetearyl Nonanoate Zinc Oxide PI Zinc Oxide 2.00 5.00 Dow Corning ® Dimethicone/ 2.00 2.00 Cosmetic Vinyl Dimethicone Powder 9701 Crosspolymer (and) Silica

(44) Manufacturing Procedure

(45) Phase A: Mix ingredients and heat with stirring to approx. 80° C. Hold the temperature. Phase B: Mix the ingredients then add phase B to phase A and homogenize. Hold the temperature. Stir slowly to let enclosed air escape from the mass. Transfer to the stick holders at 75-80° C.

Example 15

Sunscreen Cream (W/O)—Expected SPF 50, Water Resistant

(46) TABLE-US-00016 Phase Ingredients INCI Name 15 A Dehymuls ®PGPH Polyglyceryl-2 5.00 Dipolyhydroxystearate Copherol ®1250 Tocopheryl Acetate 0.50 Permulgin ® 3220 Ozokerite 0.50 Aluminium stearate Aluminium Stearate 0.50 Blend A Butyl Methoxy- 25.00 dibenzoylmethane, Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Tegosoft ® TN C12-15 Alkyl Benzoate 5.00 Neutral oil Caprylic/Capric Triglyceride 5.00 SymMollient ® Propylenediol 5.00 PDCC Dicaprylate Caprate Dragoxat 89 Ethylhexyl Isononanoate 5.00 EDETA ® BD Disodium EDTA 0.10 B Water, dist. Water (Aqua) Ad 100 Glycerol, 99% Glycerin 4.00 SymDiol ® 68 1,2 Hexanediol, 0.50 Caprylylglycol SymSave ® H Hydroxyacetophenone 0.50 Magnesium sulfate Magnesium Sulfate 0.50 C Perfume oil Perfume 0.30

(47) Manufacturing Procedure

(48) Part A: Mix the ingredients with stirring at about 50° C. Part B: Mix the ingredients with stirring at about 85° C. then add t A. Allow to cool with stirring then homogenize. Part C: Stir in at ambient temperature.

Example 16

Alcoholic Spray—Expected SPF 50

(49) TABLE-US-00017 Phase Ingredients INCI Name 16 A Blend A Butyl Methoxydibenzoylmethane, 30.00 Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Alcohol denat Alcohol Ad 100 Permulgin ® Ozokerite 0.50 3220 Aluminium Aluminium Stearate 0.50 stearate Butyloctyl Butyloctyl Salicylate 5.00 Salicylate SymMollient ® Propylenediol Dicaprylate Caprate 5.00 PDCC Dragoxat 89 Ethylhexyl Isononanoate 5.00 KP-545 Cyclopentasiloxane, 1.00 Acrylates/Dimethicone Copolymer Dermacryl ® 79 Acrylates/Octylacrylamide 2.00 Crosspolymer EDETA ® BD Disodium EDTA 0.10 B Vitamin E Tocopheryl Acetate 2.50 Acetate Vitamin E Tocopherol 0.10 Vitamin C Ascorbyl Palmitate 0.10 Palmitate Vitamin A Retinyl Palmitate 0.10 Palmitate Magnesium Magnesium Sulfate 0.50 sulfate C Perfume oil Perfume 0.30

(50) Manufacturing Procedure

(51) Part A: Disperse the Dermacryl and KP-545 into the alcohol and then mix in the other ingredients with stirring at about 50° C. and cool to ambient temperature. Part B: Mix the ingredients with stirring at ambient temperature then add to A with stirring then homogenize. Part C: Stir in at ambient temperature

Example 17

Antiaging Facial Lotion (O/W)—Expected SPF>50

(52) TABLE-US-00018 Phase Ingredients INCI Name 17 A Glyceryl Stearate Glyceryl Stearate 3.00 PEG-100 Stearate PEG-100 Stearate 1.00 Blend A Butyl Methoxydibenzoylmethane, 25.00 Octocrylene, Ethylhexyl Salicylate, Homosalate, Bemotrizinol Corapan ® TQ Diethylhexyl 2,6-Naphthalate 2.00 (182585) SymMollient ® Propylenediol Dicaprylate Caprate 5.00 PDCC SunSpheres ™ Styrene/Acylates Copolymer 2.00 Powder Pemulen ™ TR-2 Acrylates/C10-30 Alkyl Acrylate 1.00 Crosspolymer KP-545 Cyclopentasiloxane, 1.00 Acrylates/Dimethicone Copolymer Silica Silica 5.00 Beeswax Cera Alba 3.00 EDETA ® BD Disodium EDTA 0.10 B Water Aqua (Water) Ad 100 Ethylhexyl Ethylhexyl Glycerin 1.00 Glycerin Chlorphenesin Chlorphenesin 0.50 BHT Butyl Hydroxytoluene 0.10 Dipotassium Dipotassium glycyrrizate 0.10 glycyrrizate C Dragosantol ® Bisabalol 0.10 100 SymGlucan ® Aqua, Glycerin, Beta-Glucan, 1,2- 1.00 Hexanediol, Caprylyl Glycol Fragrance Perfume 0.20

(53) Manufacturing Procedure

(54) Phase A: Mix the components without silica and Pemulen to approx. 85° C., then add the other parts. Homogenize for a short time with an Ultra Turrax®. Phase B: Mix the components and heat up to approx. 50° C. until dissolved. Add phase B to phase A while stirring. Cool down while stirring to 30° C. and homogenize with an Ultra Turrax®. Then cool down to ambient temperature while stirring. Phase C: Add all ingredients step by step and stir until homogeneous with an Ultra Turrax®.