Pesticidal Mixtures

Abstract

Fungicidal mixtures comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one as compound I and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide as compound II.

Claims

1. A method for controlling a phytopathogenic pest, wherein the pest, its habitat, breeding grounds, its locus or the plant to be protected against pest attack, soil or plant propagation material is treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one (compound I) and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (compound II).

2. The method according to of claim 1 for controlling phytopathogenic fungi on cereals.

3. The method according to claim 2 wherein the phytopathogenic fungus is Microduchium nivale, Erysiphe graminis tritici, Septoria tritici, Phaeospheria nodorum, or Pyrenophera tritici on wheat.

4. The method according to claim 2 wherein the phytopathogenic fungus is Erysiphe graminis hordei, Pyrenophera teres, Ramularia collicygni, or Rynchosporium secalis on barley.

5. The method according claim 2 wherein the phytopathogenic fungus is Puccinia recondita (brown or leaf rust), Puccinia striiformis (stripe or yellow rust), or Puccinia graminis (stem or black rust) on wheat, barley or rye.

6. A method for improving the health of plant, wherein the plant, the locus where the plant is growing or is expected to grow or plant propagation material from which the plant grows is treated with an effective amount of a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one (compound I) and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (compound II).

7. A method for protecting plant propagation material from a pest comprising contacting the plant propagation material with a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one (compound I) and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (compound II).

8. The method as claimed in claim 7, wherein said fungicidal mixture is applied in an amount of from 0.01 g to 10 kg per 100 kg of plant propagation material.

9. The method as claimed in claim 1, wherein said fungicidal mixture is applied simultaneously, either jointly or separately, or in succession.

10. Plant propagation material, comprising a fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one (compound I) and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (compound II), for use in an amount of from 0.01 g to 10 kg per 100 kg of plant propagation material.

11. Fungicidal mixture comprising, as active components, 1) 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one (compound I) and 2)N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (compound II).

12. A fungicidal mixture as claimed in claim 11, wherein a ratio by weight of compound I and compound II is from 500:1 to 1:500.

13. A pesticidal composition, comprising a liquid or solid carrier and the fungicidal mixture as defined in claim 11.

Description

[0078] Experiments

[0079] Microtest

[0080] The active compounds were formulated separately as a stock solution having a concentration of 10000 ppm in dimethyl sulfoxide.

[0081] 1. Activity against Microdochium nivale (MONGNI) The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of Microdochium nivale in an aqueous biomalt or yeast-bactopeptone-glycerine or DOB solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18° C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation.

[0082] 2. Activity against leaf blotch on wheat caused by Septoria tritici (SEPTTR) The stock solutions were mixed according to the ratio, pipetted onto a micro titer plate (MTP) and diluted with water to the stated concentrations. A spore suspension of a Qoi resistant isolate of Septoria tritici in an aqueous biomalt or yeast-bactopeptone-glycerine or DOB solution was then added. The plates were placed in a water vapor-saturated chamber at a temperature of 18° C. Using an absorption photometer, the MTPs were measured at 405 nm 7 days after the inoculation.

[0083] The measured parameters were compared to the growth of the active compound-free control variant (100%) and the fungus-free blank value to determine the relative growth in % of the pathogens in the respective active compounds.

[0084] These percentages were converted into efficacies.

[0085] An efficacy of 0 means that the growth level of the pathogens corresponds to that of the untreated control; an efficacy of 100 means that the pathogens were not growing.

[0086] The expected efficacies of active compound mixtures were determined using Colby's formula [R. S. Colby, “Calculating synergistic and antagonistic responses of herbicide combinations”, Weeds 15, 20-22 (1967)] and compared with the observed efficacies.

TABLE-US-00002 MONGNI Calculated efficacy Active according compound/ Concentration Observed to Colby Synergism active mixture (Ppm) Mixture efficacy (%) (%) Metyltetraprol 0.016 — 32 Isoflucypram 0.063 — 40 Metyltetraprol 0.016 1:4 97 59 38 Isoflucypram 0.063

TABLE-US-00003 SEPTTR Qoi resistant Calculated efficacy according Active compound/ Concentration Observed to Colby Synergism active mixture (ppm) Mixture efficacy (%) (%) Metyltetraprol 0.063 — 1 0.016 — 0 Isoflucypram 0.063 34 0.016 — 5 0.004 — 0 Metyltetraprol 0.063 100 34 66 Isoflucypram 0.063 1:1 Metyltetraprol 0.063 4:1 98 6 92 Isoflucypram 0.016 Metyltetraprol 0.063 16:1  44 1 43 Isoflucypram 0.004 Metyltetraprol 0.016 1:4 79 34 45 Isoflucypram 0.063