MODULUS MODIFIERS AND FILMS THEREOF

Abstract

The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids and/or steroids. In particular, the composition can be a monomer, a polymer, or a copolymer derived from an amino acid dimer. Such compositions can optionally include a functionalized steroid.

Claims

1. A composition comprising a structure having formula (I): ##STR00086## or a salt thereof, wherein: each of G.sup.1 and G.sup.2 comprises, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; R.sup.g1 and G.sup.1, taken together with the nitrogen to which R.sup.g1 is bound, can optionally form an optionally substituted heterocyclyl; and R.sup.g2 and G.sup.2, taken together with the nitrogen to which R.sup.g2 is bound, can optionally form an optionally substituted heterocyclyl.

2. The composition of claim 1, wherein:
G.sup.1 is -L.sup.G1-R.sup.G1 and G.sup.2 is -L.sup.G2-R.sup.G2; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted amidoalkyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

3. The composition of claim 2, wherein the optionally substituted cyclic anhydride has a structure of: ##STR00087## and wherein each of a and b, independently, is an integer of from 0 to 3.

4. The composition of claim 2, wherein the optionally substituted cyclic imide has a structure of: ##STR00088## wherein each of a and b, independently, is an integer of from 0 to 3; and wherein R.sup.N1 is H, optionally substituted alkyl, optionally substituted aryl, or optionally substituted aralkyl.

5. The composition of claim 1, wherein the composition comprises a structure having formula (Ia): ##STR00089## or a salt thereof, wherein: each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

6. The composition of claim 1, wherein the composition comprises a structure having formula (Ib): ##STR00090## or a salt thereof, wherein: each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; each of Het.sup.G1 and Het.sup.G2 is, independently, optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

7. The composition of claim 1, wherein the composition comprises a structure having formula (Ic) ##STR00091## or a salt thereof, wherein: each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, carboxyl, amino, optionally substituted aminoalkyl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

8. (canceled)

9. (canceled)

10. (canceled)

11. A composition comprising a structure having formula (II): ##STR00092## or a salt thereof, wherein: each of G.sup.3 and G.sup.4 comprises, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 is, independently, H or optionally substituted alkyl; each of m and n is, independently, an integer of from 0 to 1; and o is an integer of from 0 to 2.

12. The composition of claim 11, wherein: G.sup.3 is -L.sup.G1-R.sup.G1 and G.sup.4 is -L.sup.G2-R.sup.G2; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted arylene, optionally substituted (aryl)(alkyl)ene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

13. A composition comprising a structure having formula (III): ##STR00093## or a salt thereof, wherein: each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; each of Ar.sup.G1 and Ar.sup.G2 is, independently, optionally substituted arylene or optionally substituted (aryl)(alky)lene; Het.sup.G1 is optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene; and at least one of Ar.sup.G1, Ar.sup.G2, or Het.sup.G1 comprises, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

14. A composition comprising a structure having formula (IV): ##STR00094## or a salt thereof, wherein: each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; each of L.sup.G1, L.sup.G2, and L.sup.G3 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or (heterocyclyl)(alkyl)ene; each of Ar.sup.G1 and Ar.sup.G2 is, independently, optionally substituted arylene or optionally substituted (aryl)(alkyl)ene; and at least one of L.sup.G1, L.sup.G2, L.sup.G3, Ar.sup.G1 or Ar.sup.G2 comprises, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

15. A composition comprising a structure having formula (VIII): ##STR00095## or a salt thereof, wherein: each of G.sup.L1 and G.sup.L2 comprises, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; Ar.sup.m is a polymer segment; R.sup.g1 and G.sup.1, taken together with the nitrogen to which R.sup.g1 is bound, can optionally form an optionally substituted heterocyclyl; and R.sup.g2 and G.sup.2, taken together with the nitrogen to which R.sup.g2 is bound, can optionally form an optionally substituted heterocyclyl.

16. The composition of claim 15, wherein Ar.sup.m comprises an imide subunit, an amic acid subunit, an amide subunit, an arylene subunit, an arylene ether subunit, an arylene ketone subunit, a urethane subunit, a phthalic anhydride subunit, an aliphatic subunit, a cycloalkyl subunit, an ether subunit, a thioether subunit, a perfluoroalkyl subunit, or a perfluoroalkoxy subunit.

17. The composition of claim 1, wherein the composition comprises a UV cutoff less than about 450 nm, an optical transmission of at least about 95% at 450 nm, a yellowness index less than about 2, a modulus less than about 12 GPa, and/or an elongation less than about 350%.

18. The composition of claim 17, wherein the composition is optionally soluble in an organic solvent.

19. The composition of claim 1, wherein the composition is configured to be biodegradable by one or more microbes.

20. A genetically modified organism configured to produce a composition of claim 1.

21. A film comprising a composition of claim 1.

22. (canceled)

23. A composite or bulk structure comprising a composition of claim 1.

24. A fiber or a particle comprising a composition of claim 1.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT(S)

[0087] The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids or steroids obtained from microbes (e.g., engineered microbes to overexpress desired biomolecules). Such bioreachable amino acids can be reacted to form a cyclic dimer or a cyclic derivative, which can be further chemically functionalized. In addition, steroids can be reacted to form a functionalized steroid. Such functionalized amino acids, cyclic dimers, and steroids can include, e.g., inclusion of one or more reactive moieties, polymerizable moieties, or others. In turn, such cyclic derivatives and/or functionalized steroids can be employed as a monomer, a polymer, or a copolymer.

[0088] In one aspect, the cyclic derivative can include a structure having formula (I), (Ia), (Ib), or (Ic):

##STR00014##

or a salt thereof. In some embodiments, each of G.sup.1, G.sup.2, R.sup.G1, and R.sup.G2 is or includes, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide. In some embodiments, each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl. In yet other embodiments, each of R and R.sup.g2 is, independently, H, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl. In particular embodiments, R.sup.g1 and G.sup.1, taken together with the nitrogen to which R.sup.g1 is bound; and/or R.sup.g2 and G.sup.2, taken together with the nitrogen to which R.sup.g2 is bound, can optionally form an optionally substituted heterocyclyl.

[0089] In some non-limiting embodiments, each of R.sup.g1 and R.sup.g2 is not H.

[0090] In other non-limiting embodiments, each of L.sup.G1 and L.sup.G2 does not comprise aryl or arylene. In other embodiments, at least one of G.sup.1, G.sup.2, R.sup.G1, and R.sup.G2 does not comprise aryl or arylene. In yet other embodiments, each of G.sup.1, G.sup.2, R.sup.G1, R.sup.G2 L.sup.G1, and L.sup.G2 does not comprise aryl or arylene.

[0091] In another aspect, the functionalized steroid can include a structure having formula (II), (IIa), or (IIb):

##STR00015##

or a salt thereof. In some embodiments, each of G.sup.3 and G.sup.4 is or includes, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide. In particular embodiments, each of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 is, independently, H or optionally substituted alkyl. In some embodiments, each of m and n is, independently, an integer of from 0 to 1; and o is an integer of from 0 to 2. In other embodiments, each of m, n, and o is 0. In yet other embodiments, each of m, n, and o is 1. In particular embodiments (e.g., in formula (II) or (IIa)), R.sup.12 is optionally substituted alkyl. In other embodiments (e.g., in formula (II) or (IIb)), each of R.sup.3, R.sup.4, R.sup.6, R.sup.8, R.sup.9, and R.sup.11 is optionally substituted alkyl.

[0092] As can be seen (e.g., in formulas (I), (Ia), (Ib), (Ic), (II), (IIa), or (IIb)), in some instances, G.sup.1, G.sup.2, G.sup.3, and G.sup.4 can include one or more reactive moieties, which in turn can provide a polymer when the cyclic derivative is employed as a monomer. Within a polymer, the same cyclic derivative can be employed, or two or more different cyclic derivatives may be employed. Illustrative reactive moieties include, e.g., those described herein for R.sup.G, R.sup.G1, or R.sup.G2, such as hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, halo, haloalkyl, carboxyl, optionally substituted carboxyalkyl, optionally substituted carboxyaryl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted amidoalkyl, optionally substituted alkyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0093] In some embodiments, one or more of G.sup.1, G.sup.2, G.sup.3, or G.sup.4 has a structure of -G.sup.aOH, in which Ga can be optionally substituted alkylene, optionally substituted arylene, or optionally substituted (aryl)(alkyl)ene. In one embodiment, Ga can be methylene, ethylene, n-propylene, isopropylene, n-butylene, 2-methylpropylene, n-pentylene, 2-methylbutylene, 2,3-dimethylpropylene, 1,4-phenylene, methylene-phenylene, para-methylene-phenylene, ethylene-phenylene, or para-ethylene-phenylene.

[0094] In some embodiments, one or more of G.sup.1, G.sup.2, G.sup.3, or G.sup.4 has a structure of R.sup.1OH, Ar.sup.1OH, R.sup.1NH.sub.2, Ar.sup.1NH.sub.2, R.sup.1R.sup.2NH, Ar.sup.1R.sup.1NH, Ar.sup.1Ar.sup.2NH,

##STR00016##

in which each of R.sup.1 and R.sup.2 includes any alkyl, olefin, or combinations thereof, in bivalent form; and each of Ar.sup.1 and Ar.sup.2 includes any aromatic ring, such as and not limited to benzene, naphthalene, anthracene, biphenyl, terphenyl, including bivalent forms thereof.

[0095] In some embodiments, each of G.sup.1, G.sup.2, G.sup.3, and G.sup.4 can include one or more linkers (e.g., L.sup.G, L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ak.sup.G1, Ak.sup.G3, Ar.sup.G1, Ar.sup.G2, Ar.sup.G3, Ar.sup.m, Het.sup.G1, or Het.sup.G2) attached to a reactive moiety (e.g., R.sup.G, R.sup.G1, or R.sup.G2). Illustrative linkers include, e.g., a covalent bond, an amide bond, —NR.sup.N1— (in which R.sup.N1 is H or optionally substituted alkyl), an ester bond, oxy, carbonyl, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted arylene, optionally substituted (aryl)(alkyl)ene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene, as well as combinations thereof. In particular embodiments, the linker does not include an aryl or arylene moiety. Yet other linkers can include -L.sup.G1-L.sup.G3-, -L.sup.G3-L.sup.G1-, -L.sup.G1-Ar.sup.G1—, -L.sup.G1-Het.sup.G1-, -Het.sup.G1-L.sup.G1-, -L.sup.G1-Ar.sup.G1-L.sup.G3-, -L.sup.G3-Ar.sup.G1-L.sup.G1-, -L.sup.G2-L.sup.G4-, -L.sup.G4-L.sup.G2-, -L.sup.G2-Ar.sup.G2—, -L.sup.G2Ar.sup.G2-L.sup.G4-, -L.sup.G2-Het.sup.G2-, -L.sup.G2-Ar.sup.G2-L.sup.G4-, -L.sup.G4-Het.sup.G1-, -Het.sup.G1-Ar.sup.G1-L.sup.G1-, -Het.sup.G2-Het.sup.G1-Ar.sup.G1-L.sup.G1-, -Ak.sup.G3-L.sup.G3-, Ar.sup.G1-L.sup.G1-, —Ar.sup.G3-L.sup.G3, Ar.sup.G1-L.sup.G1-, and —Ar.sup.m— for any L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ak.sup.G1, Ak.sup.G3, Ar.sup.G1, Ar.sup.G2, Ar.sup.m, Het.sup.G1, or Het.sup.G2 described herein.

[0096] For any compound herein (e.g., a cyclic derivative or a functionalized steroid), each of G.sup.1, G.sup.2, G.sup.3, and G.sup.4 can include -L.sup.G-R.sup.G, in which L.sup.G is a linker (e.g., L.sup.G1 or L.sup.G2) attached to a reactive moiety R.sup.G (e.g., R.sup.G1 or R.sup.G2). In some embodiments, L (e.g., L.sup.G1 or L.sup.G2) is a bond or optionally substituted alkylene; and R.sup.G (e.g., R.sup.G1 or R.sup.G2) is hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, optionally substituted carboxyalkyl, optionally substituted carboxyaryl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted amidoalkyl, optionally substituted cyclic anhydride, optionally substituted cyclic imide, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted epoxy, or optionally substituted (hetero)cycloalkyl (e.g., as for G.sup.1 and G.sup.2 in formula (I)). In particular embodiments, L.sup.G (e.g., L.sup.G1 or L.sup.G2) is a bond or optionally substituted alkylene; and R.sup.G (e.g., R.sup.G1 or R.sup.G2) is hydroxyl or amino (e.g., as for G.sup.3 and G.sup.4 in formula (II)).

[0097] For cyclic derivatives (e.g., as in formulas (I), (Ia), (Ib), or (Ic)), linkers and reactive moieties may be attached to a side chain present in the amino acid employed to form the cyclic dimer. Exemplary side chains can include, e.g., alkyl, amidoalkyl, aminoalkyl, carboxyalkyl, hydroxyalkyl, phenyl, aryl, aralkyl, hydroxyphenyl, hydroxyaryl, hydroxyaralkyl, or heterocyclyl. Accordingly, each of G.sup.1 and G.sup.2 can include any of such side chains that has been reacted to provide a linker (e.g., L.sup.G, L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ak.sup.G1, Ak.sup.G3, Ar.sup.G1, Ar.sup.G2, Het.sup.G1, or Het.sup.G2) attached to a reactive moiety (e.g., R.sup.G, R.sup.G1, or R.sup.G2).

[0098] For functionalized steroids (e.g., as in formulas (II), (IIa), or (IIb)), linkers and reactive moieties may be attached to a side chain present in the tetracyclic or pentacyclic structure of the steroid prior to functionalization. Exemplary side chains include, e.g., linear alkyl, branched alkyl, alkenyl, hydroxyl, hydroxyalkyl, etc. Accordingly, each of G.sup.3 and G.sup.4 can include any of such side chains that has been reacted to provide a linker (e.g., L.sup.G, L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ak.sup.G1, Ak.sup.G3, Ar.sup.G1, Ar.sup.G2, Het.sup.G1, or Het.sup.G2) attached to a reactive moiety (e.g., R.sup.G, R.sup.G1, or R.sup.G2).

[0099] In one embodiment, the reactive moiety is or includes an optionally substituted cyclic anhydride. Thus, G.sup.1, G.sup.2, G.sup.3, G.sup.4, G.sup.L1, G.sup.L2, R.sup.G, R.sup.G1, or R.sup.G2 can include such a reactive moiety.

[0100] In some embodiments, the optionally substituted cyclic anhydride has a structure of:

##STR00017##

where each of a and b, independently, is an integer of from 0 to 3. In particular embodiments, each of a and b is zero.

[0101] In one embodiment, the reactive moiety is or includes an optionally substituted cyclic imide. Thus, G.sup.1, G.sup.2, G.sup.3, G.sup.4, G.sup.L, G, R.sup.G, R.sup.G1, or R.sup.G2 can include such a reactive moiety. In some embodiments, the optionally substituted cyclic imide has a structure of:

##STR00018##

where each of a and b, independently, is an integer of from 0 to 3; and where R.sup.N1 is H, optionally substituted alkyl, optionally substituted aryl, or optionally substituted aralkyl. In particular embodiments, each of a and b is zero. In other embodiments, R.sup.N1 is H.

[0102] The cyclic derivatives and functionalized steroids can include any useful reactive moiety. In one embodiment, the reactive moiety is or includes hydroxyl, optionally substituted hydroxyalkyl, or optionally substituted hydroxyaryl. In particular embodiments, the cyclic derivative or the functionalized steroid can include a structure selected from the group of:

##STR00019##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 can be any described herein; m, n, and o can be any integer described herein; and L.sup.G1 and L.sup.G2 can be any linker described herein. In particular embodiments, each of R.sup.g1, R.sup.g2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 is, independently, H or optionally substituted alkyl. In other embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, -hAk-, -Ak-Ar—, -hAk-Ar—, —Ar-Ak-, or —Ar-hAk-, in which Ak is optionally substituted alkylene, hAk is optionally substituted heteroalkylene, and Ar is optionally substituted arylene. In some embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, or -hAk-.

[0103] In another embodiment, the reactive moiety is or includes amino, optionally substituted aminoalkyl, or optionally substituted aminoaryl. In particular embodiments, the cyclic derivative or the functionalized steroid can include a structure selected from the group of:

##STR00020##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.1, and R.sup.12 can be any described herein; m, n, and o can be any integer described herein; and L.sup.G1 and L.sup.G2 can be any linker described herein. In particular embodiments, each of R.sup.g1, R.sup.g2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 is, independently, H or optionally substituted alkyl. In other embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, -hAk-, -Ak-Ar—, -hAk-Ar—, —Ar-Ak-, or —Ar-hAk-, in which Ak is optionally substituted alkylene, hAk is optionally substituted heteroalkylene, and Ar is optionally substituted arylene. In some embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, or -hAk-.

[0104] In yet another embodiment, the reactive moiety is or includes optionally substituted cyclic anhydride or optionally substituted cyclic imide. In particular embodiments, the cyclic derivative can include a structure selected from the group of:

##STR00021##

or a salt thereof, in which R.sup.g1, R.sup.g2, and R.sup.N1 can be any described herein; and L.sup.G1 and L.sup.G2 can be any linker described herein. In particular embodiments, each of R.sup.g1, R.sup.g2, and R.sup.N1 is, independently, H or optionally substituted alkyl. In other embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, -hAk-, -Ak-Ar—, -hAk-Ar—, —Ar-Ak-, or —Ar-hAk-, in which Ak is optionally substituted alkylene, hAk is optionally substituted heteroalkylene, and Ar is optionally substituted arylene. In some embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, -Ak-, or -hAk-.

[0105] The compositions herein can be employed as a subunit within a polymer or a copolymer. Exemplary subunits can include a structure having formulas (III), (IIIa), (IV), (IVa), (IVb), (IVc), (V), (Va), (VI), (VIa), (VIb), (VIc), (VII), (VIIa), and (VIII). As can be seen, the subunit can have one or more linkers (e.g., L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ak.sup.G1, Ak.sup.G3, Ar.sup.G1, Ar.sup.G2, Ar.sup.G3, Ar.sup.m, Het.sup.G1, Het.sup.G2, G.sup.L1, and G.sup.L2), and the linker within the subunit can include a reaction product arising from reacting two or more reactive moieties (e.g., R.sup.G, R.sup.G1, or R.sup.G2). In one non-limiting embodiment, a first reactive moiety of a first cyclic derivative and a first reactive moiety of a second cyclic derivative can react to form a reaction product of an amide bond or an ester bond. In other instances, the reaction product can provide one or more of the following: hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, and optionally substituted cyclic imide.

[0106] In some embodiments, the subunit includes one or more heterocyclyl moieties within the linker. In particular embodiments, the subunit includes a structure of formula (III), (IIIa), (V), or (Va):

##STR00022##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.1, and R.sup.2 can be any described herein; and LG L.sup.G2, Ar.sup.G1, Ar.sup.G2, Ar.sup.m, Het.sup.G1, and Het.sup.G2 can be any linker described herein. In particular embodiments, each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, or optionally substituted alkylene; each of Ar.sup.G1 and Ar.sup.G2 is, independently, optionally substituted arylene or optionally substituted (aryl)(alky)lene; each of Het.sup.G1, and Het.sup.G2 is, independently, optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene; and Ar.sup.m is a polymer segment (e.g., any described herein). In other embodiments, at least one of Ar.sup.G1, Ar.sup.G2, Het.sup.G1, or Het.sup.G2 includes hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0107] In some embodiments, the subunit includes one or more aryl moieties within the linker. In particular embodiments, the subunit includes a structure of formula (IV), (IVa), (IVb), or (IVc):

##STR00023##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.1, and R.sup.2 can be any described herein; and L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ar.sup.G1, Ar.sup.G2, Ar.sup.G3, Ar.sup.G3, and Ar.sup.m can be any linker described herein. In particular embodiments, each of L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, and Ar.sup.G3 is, independently, a covalent bond, an amide bond, or optionally substituted alkylene; each of Ar.sup.G1, Ar.sup.G2, and Ar.sup.G3 is, independently, optionally substituted arylene or optionally substituted (aryl)(alky)lene; and Ar.sup.m is a polymer segment (e.g., any described herein). In other embodiments, at least one of L.sup.G3, L.sup.G4, Ar.sup.G3, Ar.sup.G1, Ar.sup.G2, or Ar.sup.G3 includes hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0108] The subunit can include any useful combination of linkers. In particular embodiments, the subunit includes a structure of formula (VI), (VIa), (VIb), or (VIc):

##STR00024##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.1, and R.sup.2 can be any described herein; and L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, Ar.sup.G1, Ar.sup.m, and Het.sup.G1 can be any linker described herein. In particular embodiments, each of L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, and Ak.sup.G1 is, independently, a covalent bond, an amide bond, or optionally substituted alkylene; Ar.sup.m is a polymer segment (e.g., any described herein); and Het.sup.G1 is optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene. In other embodiments, at least one of L.sup.G3, L.sup.G4, Ak.sup.G1, Het.sup.G1, or Ar.sup.m includes hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0109] The subunit can include a cyclic proline derivative. In particular embodiments, the subunit includes a structure of formula (VII) or (VIIa):

##STR00025##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.1, and R.sup.2 can be any described herein; and L.sup.G1, L.sup.G2, L.sup.G3, and L.sup.G4 can be any linker described herein. In other embodiments, at least one of L.sup.G1, L.sup.G3, or L.sup.G4 includes hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0110] The subunit can include any useful polymer segment. In particular embodiments, the subunit includes a structure of formula (VIII):

##STR00026##

or a salt thereof, in which R.sup.g1, R.sup.g2, R.sup.1, and R.sup.2 can be any described herein; G.sup.L1 and G.sup.L2 can be any linker described herein; and Ar.sup.m can be any polymer segment described herein. In some embodiments, each of G.sup.L1 and G.sup.L2 includes, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, optionally substituted cyclic imide, a carbamate bond (e.g., a —O—C(O)—NR.sup.N1— bond, in which R.sup.N1 is H or optionally substituted alkyl), or —NR.sup.N1— (in which R.sup.N1 is H or optionally substituted alkyl).

[0111] In any embodiment herein, the linker (e.g., L.sup.G1, L.sup.G2, L.sup.G3, L.sup.G4, G.sup.L, or G.sup.L2 in formula (Ia), (Ib), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), (IIc), (IId), (III), (IIIa), (IV), (IVa), (IVb), (IVc), (V), (Va), (VI), (VIa), (VIb), (VIc), (VII), (VIIa), or (VIII)) can be selected from any linker herein. Exemplary linkers include a covalent bond, an amide bond, —NR.sup.N1— (in which R.sup.N1 is H or optionally substituted alkyl), a carbamate bond (e.g., a —O—C(O)—NR.sup.N1— bond, in which R.sup.N1 is H or optionally substituted alkyl), an ester bond, oxy, carbonyl, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted arylene, optionally substituted (aryl)(alkyl)ene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene, as well as combinations thereof. In particular non-limiting embodiments, L.sup.G1, L.sup.G2, L.sup.G3, or L.sup.G4 is a covalent bond, an amide bond, —NR.sup.N1—, an ester bond, oxy, carbonyl, optionally substituted alkylene, or optionally substituted heteroalkylene. In other non-limiting embodiments (e.g., in formula (VIII)), each of G.sup.L1 and G.sup.L2 is or includes, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0112] In any embodiment herein, the linker can include an alkyl moiety. In some embodiments (e.g., in formula (IVb) or (VIb)), the linker is any described herein for Ak.sup.G1 or Ak.sup.G3, which can be optionally substituted alkylene or optionally substituted heteroalkylene. Exemplary linkers include -Ak-, -Ak-O—, —O-Ak-, -Ak.sup.a-O-Ak.sup.b-, -Ak-NR.sup.N1—, —NR.sup.N1-Ak-, or -Ak.sup.a-NR.sup.N1-Ak.sup.b-, in which each of Ak, Ak.sup.a, and Ak.sup.b is, independently, optionally substituted alkylene; and R.sup.N1 is H or optionally substituted alkyl.

[0113] In any embodiment herein, the linker can include an aryl moiety. In some embodiments (e.g., in formula (III), (IIIa), (IV), (IVa), (IVb), (IVc), (Va), (VIc), or (VIII)), the linker is any described herein for Ar.sup.G1, Ar.sup.G2, Ar.sup.G3, or Ar.sup.m, which can be optionally substituted arylene, optionally substituted (aryl)(alky)lene. Exemplary linkers include —(Ar).sub.a—, —(Ar).sub.a-(Ak).sub.c-, -(Ak).sub.c-(Ar).sub.a—, —(Ar).sub.a—C(O)—(Ar).sub.b—, —(Ar).sub.a—O—(Ar).sub.b—, —(Ar).sub.a—NR.sup.N1—(Ar).sub.b—, -(Ak).sub.c-C(O)—(Ar).sub.b—, -(Ak).sub.c-O—(Ar).sub.b—, -(Ak).sub.c-NR.sup.N1—(Ar).sub.b—, —(Ar).sub.a—C(O)-(Ak).sub.c-, —(Ar).sub.a—O-(Ak).sub.c-, —(Ar).sub.a—NR.sup.N1-(Ak).sub.c-, in which Ar is optionally substituted arylene; Ak is optionally substituted alkylene; R.sup.N1 is H or optionally substituted alkyl; each a and b is an integer of about 0 to 10 and at least one of a or b is 1 or more; and c is 0 or 1. In particular non-limiting embodiments, Ar is optionally substituted phenylene.

[0114] In any embodiment herein, the linker can include a heterocyclyl moiety. In some embodiments (e.g., in formula (Ib), III), (IIIa), (V), (Va), or (VIa)), the linker is any described herein for Het.sup.G1 or Het.sup.G2, which can be optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene. Exemplary linkers include optionally substituted 2,5-dioxo-1,3-pyrrolidinediyl, optionally substituted 2,5-diketo-3,6-piperazinediyl, optionally substituted 1,3-dioxo-2,3-dihydro-1H-isoindole-2,5-diyl, or optionally substituted 2,8-diketo-1,7-diazatricyclo[7.3.0.03,7]dodecane-4,10-diyl.

[0115] In any embodiment herein, the linker can include a polymer segment (e.g., Ar.sup.m, as in formula (VIII)). In some embodiments (e.g., in formula (VIII)), the linker is any described herein for Ar.sup.m, which can be optionally substituted arylene, optionally substituted (aryl)(alky)lene, an imide subunit, an amic acid subunit, an amide subunit, an arylene subunit, an arylene ether subunit, an arylene ketone subunit, a urethane subunit, a phthalic anhydride subunit, an aliphatic subunit, a cycloalkyl subunit, an ether subunit, or a thioether subunit.

[0116] Further exemplary polymer segments include optionally substituted arylene (e.g., —(Ar).sub.a—, —(Ar).sub.a—C(O)—(Ar).sub.b—, —(Ar).sub.a—O—(Ar).sub.b—, or —(Ar).sub.a—NR.sup.N1—(Ar).sub.b—); optionally substituted (aryl)(alky)lene (e.g., —(Ar).sub.a-(Ak).sub.c-, -(Ak).sub.c-(Ar).sub.a—, -(Ak).sub.c-C(O)—(Ar).sub.b—, -(Ak).sub.c-O—(Ar).sub.b—, -(Ak).sub.c-NR.sup.N1—(Ar).sub.b—, —(Ar).sub.a—C(O)-(Ak).sub.c-, —(Ar).sub.a—O-(Ak).sub.c-, or —(Ar).sub.a—NR.sup.N1-(Ak).sub.c-); an imide subunit (e.g., a subunit including an imide bond, such as —[C(O)].sub.d—NR.sup.Na—[C(O)].sub.e— or

##STR00027##

where R′ is an aliphatic or aromatic tetravalent organic moiety that is optionally substituted with a substituent described herein for aryl); an amic acid subunit (e.g., a subunit including (i) a carboxylic acid unit or an ester bond, as defined herein and (ii) a carboxamide unit or an amide bond, as defined herein); an amide subunit (e.g., a subunit including an amide bond, as defined herein); an arylene subunit (e.g., a subunit including an optionally substituted arylene, as defined herein); an arylene ether subunit (e.g., a subunit including an optionally substituted arylene and oxy bonds, such as —(Ar).sub.a—O—(Ar).sub.b—); an arylene ketone subunit (e.g., —(Ar).sub.a—C(O)—(Ar).sub.b—); a urethane subunit (e.g., a subunit including a carbamate bond, such as a —O—C(O)—NR.sup.N1— bond); a phthalic anhydride subunit (e.g., a subunit including an anhydride of phthalic acid, such as optionally substituted, multivalent form of 1,3-dioxo-isobenzofuran); an aliphatic subunit (e.g., a subunit including non-aromatic organic moieties, such as optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, etc.); a cycloalkyl subunit (e.g., a subunit including cycloalkyl moieties, including bivalent, trivalent, or tetravalent forms thereof); an ether subunit (e.g., a subunit including oxy, as defined herein, such as -Ak-O-Ak- or -Ak-O—Ar); a thioether subunit (e.g., a subunit including thio, as defined herein, such as -Ak-S-Ak- or -Ak-S—Ar); a perfluoroalkyl subunit (e.g., —(CF.sub.2).sub.f1—); or a perfluoroalkoxy subunit (e.g., —O(CF.sub.2).sub.f1—, —(CF.sub.2).sub.f1O—, —O(CF.sub.2).sub.f1CF(CF.sub.2).sub.f2—, or >CFO(CF.sub.2).sub.f1CF(CF.sub.2).sub.f2). For any of these linkers, Ar is optionally substituted arylene; Ak is optionally substituted alkylene; R.sup.N1 is H or optionally substituted alkyl; each a and b is an integer of about 0 to 10 and at least one of a or b is 1 or more; c is 0 or 1; R.sup.Na is H, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, optionally substituted aralkyl, or optionally substituted heterocyclyl; and each f1 and f2 is, independently, an integer of 1 to about 16. In addition, an aliphatic or aromatic tetravalent organic moiety can be, e.g., optionally substituted alkane-tetrayl, optionally substituted benzene-1,2,4,5-tetrayl, optionally substituted naphthalene-2,3,6,7-tetrayl, optionally substituted anthracene-2,3,6,7-tetrayl, optionally substituted phenanthrene-1,8,9,10-tetrayl, >Ar*—Ar*<, >Ar*—O—Ar*<, >Ar*—C(O)—Ar*<, >Ar*—S—Ar*<, >Ar*—S(O).sub.2—Ar*<, >Ar*—Si(CH.sub.3).sub.2-Ar*<, >Ar*—O—Ar—O—Ar—O—Ar*<, >Ar*—O—Ar—C(O)—Ar—O—Ar*<, >Ar*—O—Ar—S—Ar—O—Ar*<, >Ar*—O—Ar—S(O).sub.2—Ar—O—Ar*<, or >Ar*—O—Ar—Si(CH.sub.3).sub.2—Ar—O—Ar*<, in which Ar* is an optionally substituted trivalent arylene, such as benzene-1,3,4-triyl, and in which Ar is optionally substituted divalent arylene).

[0117] Reactive moieties can also be characterized as a polymerizable group. A polymerizable group includes groups that form homopolymers or copolymers. In a first embodiment, the polymerizable group can form predominately homopolymers, meaning that the compound A forms polymers symbolized as -(A-A-A)X—, wherein x is an integer. These groups are defined as homopolymerizable. Examples of such groups are unsaturated groups, such as vinyl and allyl groups, oxiranes (ethylene oxides or epoxides), aziridines (ethylene imines), oxetanes. In another embodiment, the polymerizable group is copolymerizable, i.e., a second compound B is required to form polymers -(A-B-A-B)X—, wherein x is an integer. Examples of such groups are carboxylic acids, hydroxyl groups, amino groups, and thiol groups; and examples for the respective copolymer monomer would be diols or diamines, diacids, diacid anhydrides, isocyanates, and di-isocyanates.

[0118] In one embodiment, the polymerizable group can be selected from a vinyl group, an allyl group, hydroxyl, carboxyl, amino, cyclic anhydride, cyclic imide, or a combination thereof.

[0119] In another embodiment, at least 35 wt. %, such as at least 40 wt. %, at least 45 wt. %, at least 50 wt. %, at least 55 wt. %, at least 60 wt. %, at least 65 wt. %, at least 70 wt. %, at least 75 wt. %, at least 80 wt. %, or at least 85 wt. % of the compound or the composition is comprised by the moiety. In another embodiment, not more than 98 wt. %, such as not more than 96 wt. %, not more than 95 wt. %, not more than 94 wt. %, not more than 92 wt. %, or not more than 90 wt. % of the compound or the composition are comprised by the moiety. In yet one further embodiment, the moiety of the compound or the composition has weight percentage in the range between 30 wt. % to 99.5 wt. %, such as 40 wt. % to 98 wt. %, or even 50.5 wt. % to 96 wt. %.

[0120] In yet one further embodiment, at least 60 wt. %, at least 65 wt. %, at least 70 wt. %, at least 75 wt. %, at least 80 wt. %, at least 85 wt. %, or at least 88 wt. % of the compound or the composition are comprised by the sum of weight percentages of the moiety and the polymerizable group. In another embodiment, not more than 99.9 wt. %, such as not more than 99 wt. %, not more than 98 wt. %, not more than 96 wt. %, not more than 94 wt. %, not more than 92 wt. %, not more than 90 wt. %, not more than 85 wt. %, or not more than 80 wt. % of the compound or the composition are comprised by the sum of weight percentages of the moiety and the polymerizable group. In yet one further embodiment, the sum of weight percentages of the moiety and the polymerizable group can range between 55 wt. % to 99.99 wt. %, such as 65 wt. % to 99 wt. %, or 75 wt. % to 98 wt. %.

[0121] In any of the formulas herein, R.sup.g1 and R.sup.g2 can be H, optionally substituted alkyl, haloalkyl, alkoxyalkyl, or any combination thereof. Other non-limiting R.sup.g1 and R.sup.g2 groups include, independently for each occasion, hydrogen or C.sub.1-20 straight or branched alkyl chains, such as methyl, ethyl, n-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl, pentyl, 2-methylbutyl, 2,2-dimethylpropyl, hexyl, 2-methylpentyl, 3-methylpentyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, heptyl, 2-methylhexyl, 3-methylhexyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, 2,4-dimethylpentyl, 3,3-dimethylpentyl, 3-ethylpentyl, 2,2,3-trimethylbutyl, octyl, 2-methylheptyl, 3-methylheptyl, 4-methylheptyl, 5-methylheptyl, 6-methylheptyl, 2-ethylhexyl, 3-ethylhexyl, 4-ethylhexyl, 2,3-dimethylhexyl, 2,4-dimethylhexyl, 2,5-dimethylhexyl, 3,4-dimethylhexyl, 3,5-dimethylhexyl, 4,5-dimethylhexyl, 2-propylpentyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, and icosyl.

[0122] In a further embodiment, the foregoing compound or composition has a bio-based carbon content of at least 10%, such as at least 15%, at least 20%, at least 25%, at least 30%, or at least 35% as determined by ASTM D6866. Bio-based carbon content as defined herein is the percentage of carbons from renewable or biogenic sources, such as plants or animals over the total number of carbons in the compound.

[0123] For example, the following cyclic derivative is prepared from bio-sourced tyrosine and petrochemically epichlorohydrin:

##STR00028##

Then, 16 carbon atoms are bio-based and 6 carbon atoms are petrochemically sourced. Upon analysis according to ASTM D6866, this compound has a bio-based carbon content of 16/(16+6)=72.7%.

[0124] Additional cyclic derivatives and functionalized steroids are provided below in Table 1.

TABLE-US-00001 TABLE 1 Non-limiting cyclic derivatives and functionalized steroids Compound No. Structure I-1 [00029] I-2 [00030] I-3 [00031] I-4 [00032] I-5 [00033] I-6 [00034] I-7 [00035] I-8 [00036] I-9 [00037]  I-10 [00038]  I-11 [00039] II-1  [00040] II-2  [00041] II-3  [00042] II-4  [00043]

[0125] The cyclic derivatives herein can be prepared in any useful manner, such as by providing a first biomolecule and a second biomolecule and forming a dimer between the first and second biomolecules. The first and second biomolecules can be any herein, including, e.g., amino acids, such as glycine, vinylglycine, 2-allylglycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, 4-aminophenylalanine, tyrosine, tryptophan, serine, threonine, asparagine, glutamine, cystine, homocystine, cysteine, homocysteine, selenocysteine, proline, hydroxyproline, arginine, histidine, lysine, aspartic acid, glutaminic acid, 4-(2-amino-2-carboxyethyl)-1,2-benzenedicarboxylic acid, 1-aminopropane-1,2,3-tricarboxylic acid, 4-amino-1,2,4-butanetricarboxylic acid, and well as any of these including an optionally substituted alkenyl, amino, and/or hydroxyl. Additional non-limiting biomolecules are further described herein.

[0126] The dimer can be further functionalized (e.g., to include one or more linkers and/or reactive moieties). The methods herein can further include hydroaminating an alkenyl group in the presence of a nitrogen-containing reactant (e.g., an amine, such as NR.sup.N1R.sup.N2R.sup.N3, in which each of R.sup.N1, R.sup.N2, and R.sup.N3 is, independently, H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or a leaving group, such as an ester group).

[0127] In yet other embodiments, the cyclic derivatives herein can be prepared by processes analogous to those established in the art, for example, by the reaction sequences shown in Schemes 1-2.

##STR00044##

[0128] As seen in Scheme 1, amino acids (1a, 1b) can be provided, in which R.sup.1 and R.sup.2 can be H, alkyl, any described herein for R.sup.1 and R.sup.2; and in which A.sup.1 and A.sup.2 can be an amino acid side chain or a functionalized form thereof. Substituents within the amino acid can be optionally protected with a protecting group (e.g., an N-protecting group for amino or an O-protecting group for hydroxyl) or can be optionally functionalized to provide a better leaving group (e.g., an alkylating agent for oxygen to provide an alkoxy leaving group). Amino acids (1a, 1b) can be the same or different. Furthermore, such amino acids can be optionally provided by a biological resource.

[0129] Cyclic amino acids (2) can be provided by dimerization and cyclization of the amino acids (1a, 1b) in the presence of a solvent (e.g., ethylene glycol). If desired, dimers can first be formed to promote internal cyclization within the dimer. Dimerization can be performed in any useful manner (e.g., with use of protecting groups); and subsequent cyclization can optionally be performed under catalytic conditions (e.g., with subsequent deprotection chemistry to remove protecting groups).

[0130] Reactive moieties can be provided within the side chains of A.sup.1 and A.sup.2 of amino acids (1a, 1b, respectively), prior to dimerization. Alternatively, cyclic amino acid (2) can be functionalized with R.sup.G-LG to provide a cyclic derivative (3), in which R.sup.G is or includes a reactive moiety (e.g., any described herein, such as for R.sup.G, R.sup.G1, or R.sup.G2) and LG is a leaving group (e.g., halo).

[0131] Further functionalization of compound (3) can provide another cyclic derivative (4), in which nitrogen atoms of the diketopiperazine can include be further substituted. Here, compound (3) can be functionalized with R.sup.8-LG to provide cyclic derivative (4), in which R.sup.g can be any described herein (e.g., such as for R.sup.g1 and R.sup.g2).

##STR00045##

[0132] As seen in Scheme 2, proline derivatives (5a, 5b) can be provided, in which A and A.sup.2 can be an amino acid side chain or a functionalized form thereof. In one instance, A and A.sup.2 includes hydroxyl for a hydroxyproline derivative (e.g., 4-hydroxyproline). Amino acids (5a, 5b) can be the same or different and can be optionally provided by a biological resource.

[0133] Cyclic amino acids (6) can be provided by dimerization and cyclization of the amino acids (5a, 5b) in the presence of a solvent (e.g., ethylene glycol). Reactive moieties can be provided within the side chains of A.sup.1 and A.sup.2 of proline derivatives (5a, 5b, respectively), prior to dimerization. Alternatively, reactive moieties can be provided by functionalizing the cyclic amino acid (6) with R.sup.G-LG to provide a cyclic derivative (7), in which R.sup.G is or includes a reactive moiety (e.g., any described herein, such as for R.sup.G, R.sup.G1, or R.sup.G2) and LG is a leaving group (e.g., halo).

[0134] The cyclic derivatives herein can be prepared in any useful manner, such as by providing a first biomolecule and a second biomolecule and forming a dimer between the first and second biomolecules. The first and second biomolecules can be any herein, including, e.g., amino acids, such as glycine, vinylglycine, 2-allylglycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, 4-aminophenylalanine, tyrosine, tryptophan, serine, threonine, asparagine, glutamine, cystine, homocystine, cysteine, homocysteine, selenocysteine, proline, hydroxyproline, arginine, histidine, lysine, aspartic acid, glutaminic acid, 4-(2-amino-2-carboxyethyl)-1,2-benzenedicarboxylic acid, 1-aminopropane-1,2,3-tricarboxylic acid, 4-amino-1,2,4-butanetricarboxylic acid, and well as any of these including an optionally substituted alkenyl, amino, and/or hydroxyl. Additional non-limiting biomolecules are further described herein.

[0135] As described herein, cyclic derivatives can be employed as a subunit within a polymer or copolymer. Non-limiting structures of subunits are provided below in Table 2 (e.g., in which n is any integer, such as from 1 to 100). Such subunits can provide any useful polymer or copolymer, such as a polyamic acid, a polyimide, a polyamide, a polyester, a polyurethane, or combinations thereof.

TABLE-US-00002 TABLE 2 Non-limiting subunits Compound No. Structure VIII-1 [00046] VIII-2 [00047] VIII-3 [00048] VIII-4 [00049] VIII-5 [00050] VIII-6 [00051] VIII-7 [00052] VIII-8 [00053] VIII-9 [00054]

[0136] Methods of preparing polymers having a subunit (e.g., any described herein) can include reacting a cyclic derivative (e.g., any described herein) with any useful monomer (e.g., a petroleum-based monomer or another cyclic derivative, such as any herein). Non-limiting monomers include a diamine (e.g., a petroleum-based diamine) with any cyclic derivative herein (e.g., a cyclic derivative including an optionally substituted cyclic anhydride, optionally substituted cyclic imide, or other reactive group); a diacid (e.g., a petroleum-based diacid) or a tetraacid (e.g., a petroleum-based diacid or tetraacid) with any cyclic derivative herein (e.g., a cyclic derivative including an optionally substituted cyclic anhydride, optionally substituted cyclic imide, or other reactive group); a dianhydride (e.g., a petroleum-based dianhydride) with any cyclic derivative herein (e.g., a cyclic derivative with amino, hydroxyl, or other reactive group); or a first cyclic derivative (e.g., any herein) including an optionally substituted cyclic anhydride or an optionally substituted cyclic imide, which is reacted with a second cyclic derivative (e.g., any herein) including hydroxyl, carboxyl, or amino.

[0137] Non-limiting diamines include, e.g., NR.sup.N1R.sup.N2-Ak-NR.sup.N3R.sup.N4, NR.sup.N1R.sup.N2-Cy-NR.sup.N3R.sup.N4, NR.sup.N1R.sup.N2—Ar—NR.sup.N3R.sup.N4, or NR.sup.N1R.sup.N2—[Ar—X].sub.r—Ar—NR.sup.N3R.sup.N4, in which each Ak is, independently, optionally substituted alkylene; Cy is a multivalent (e.g., bivalent) form of a cycloalkyl group, as described herein; each Ar is, independently, optionally substituted arylene; each X is, independently, a covalent bond, oxy, thio, alkylene, or carbonyl; each of R.sup.N1, R.sup.N2, R.sup.N3, and R.sup.N4 is, independently, H, optionally substituted alkyl, or an N-protecting group; and r is an integer from 0 to 4.

[0138] Examples of diamines include 4,4′-oxydianiline (4,4′-ODA); 3,4′-oxydianiline (3,4′-ODA); 4,4′-(4,4′-isopropylidenediphenyl-1,1′-diyldioxy)dianiline; m-phenylenediamine (MPD); p-phenylenediamine (PPD); 2,2-bis[4-(4-aminophenoxy)phenyl] propane (BAPP); 4,4′-methylene dianiline (MDA); 4,4′-(4-aminophenoxy)biphenyl (4BPDA); 2,2-bis[4-(4-aminophenoxy)phenyl]-hexafluoropropane (BDAF); 4,4′-[1,3-phenylenebis(1-methyl-ethylidene)] bisaniline (Bisaniline-M); 4,4′-[1,4-phenylenebis(1-methyl-ethylidene)] bisaniline (Bisaniline-P); 1,2-diaminoethane (1,2-DAE); 1,3-diaminopropane (1,3-DAP); 1,4-diaminobutane (1,4-DAB); 1,5-diaminopentane (1,5-DAP); 1,6-diaminohexane (1,6-HMDA), 1,7-diaminoheptane; 1,8-diaminooctane; 1,9-diaminononane; 1,10-diaminodecane; 1,11-diaminoundecane; 1,12-diaminododecane; N-(3-aminopropyl)-1,4-butadiamine; N,N′-bis(3-aminopropyl)-1,4-butanediamine; N-(3-aminopropyl)-1,3-propanediamine; N1-(3-(3-aminopropylamino)propyl)butane-1,4-diamine; 1,4-diamino-2-methylcyclohexane; 1,4-diamino-2-ethylcyclohexane; 1,4-diamino-2-n-propylcyclohexane; 1,4-diamino-2-isobutylcyclohexane; and 1,4-diamino-2-tert-butylcyclohexane. Yet other diamines include, e.g., a cyclic derivative having a structure of formula (I), in which both G.sup.1 and G.sup.2 is or includes amino, optionally substituted aminoalkyl, or optionally substituted aminoaryl.

[0139] Non-limiting diacids and tetraacids include HOC(O)-Ak-C(O)OH or

##STR00055##

in which Ak is optionally substituted alkylene and R′ is an aliphatic or aromatic tetravalent organic moiety that is optionally substituted with a substituent described herein for aryl. Examples of aliphatic or aromatic tetravalent groups include optionally substituted alkane-tetrayl (a tetravalent form of alkyl), optionally substituted benzene-1,2,4,5-tetrayl, optionally substituted naphthalene-2,3,6,7-tetrayl, optionally substituted anthracene-2,3,6,7-tetrayl, optionally substituted phenanthrene-1,8,9,10-tetrayl, >Ar*—Ar*<, >Ar*—O—Ar*<, >Ar*—C(O)—Ar*<, >Ar*—S—Ar*<, >Ar*—S(O).sub.2—Ar*<, >Ar*—Si(CH.sub.3).sub.2—Ar*<, >Ar*—O—Ar—O—Ar—O—Ar*<, >Ar*—O—Ar—C(O)—Ar—O—Ar*<, >Ar*—O—Ar—S—Ar—O—Ar*<, >Ar*—O—Ar—S(O).sub.2—Ar—O—Ar*<, or >Ar*—O—Ar—Si(CH.sub.3).sub.2—Ar—O—Ar*<, in which Ar* is an optionally substituted trivalent arylene, such as benzene-1,3,4-triyl, and in which Ar is optionally substituted divalent arylene.

[0140] Examples of diacids and tetraacids include 1,4-butanedioic acid (succinic acid), 1,6-hexanedioic acid (adipic acid), 1,7-heptanedioic acid (pimelic acid), 1,8-octanedioic acid (suberic acid), 1,9-nonanedioic acid (azelaic acid), 1,10-decanedioic acid (sebacic acid), 1,11-undecanedioic acid, 1,12-dodecanedioic acid (1,10-decanedicarboxylic acid), 1,13-tridecanedioic acid (brassylic acid) 1,14-tetradecanedioic acid (1,12-dodecanedicarboxylic acid), 1,4-cyclohexanedicarboxylic acid (CHDA), 1,3-cyclohexanedicarboxylic acid (CHDA), and phthalic acid. Yet other diacids include, e.g., a cyclic derivative having a structure of formula (I), in which both G.sup.1 and G.sup.2 is or includes carboxyl, optionally substituted carboxyalkyl, or optionally substituted carboxyaryl.

[0141] Non-limiting dianhydrides include

##STR00056##

where R′ is an aliphatic or aromatic tetravalent organic moiety, as provided herein for a tetraacid. Examples of dianhydrides include, e.g., 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA); 2,2′,4,4′-biphenyltetracarboxylic acid dianhydride (BPDA); 2,3,3′,4′-biphenyltetracarboxylic acid dianhydride (a-BPDA); 4,4′-oxydiphthalic anhydride (ODPA); pyromellitic dianhydride (PMDA); benzophenone-3,3′,4,4′-tetracarboxylic dianhydride (BTDA); isophthaloyl bisphthalic dianhydride (IPDA); 4,4′-(hexafluoroisopropylidene) diphthalic anhydride (6FDA); naphthalenetetracarboxylic dianhydride (NTDA); triptycene tetracarboxylic dianhydride (TDA and TPDA); 3,3′,4,4′-diphenylsulfone tetracarboxylic dianhydride (DSDA); 4,4′-bisphenol A dianhydride or 4,4′-(4,4′-isopropylidenediphenoxy) bis(phthalic anhydride) (BPADA); hydroquinone diphthalic anhydride (HQDEA); 2,3,4,5-tetrahydrofurantetracarboxylic dianhydride; 5-(2,5-dioxotetrahydrofural)-3-methyl-3-cyclohexane-1,2-dicarboxylic dianhydride; 1,2,4,5-cyclohexanetetracarboxylic acid dianhydride (H-PMDA); 3,4-dicarboxy-1,2,3,4-tetrahydro-1-naphthalenesuccinic acid; 3,3′,4,4′-bicyclohexyltetracarboxylic acid dianhydride (H-BPDA); 3,3′,4,4′-diphenylsulphone tetracarboxylic dianhydride; 3,3′,4,4′-diphenylpropane 2,2-tetracarboxylic dianhydride; 2,2-bis(3,4-dicarboxyphenyl)propane dianhydride; 1,4-bis(3,4-dicarboxybenzoyl)benzene dianhydride; 1,3-bis(3,4-dicarboxybenzoyl)benzene dianhydride; bis(3,4-dicarboxyphenyl) thioether dianhydride; spiro bisindane diether anhydride; bis-phenol A bisether-4-phthalic dianhydride; 1,4,5,8-naphthalenetetracraboxylic dianhydride; 2,3,6,7-naphthalenetetracarboxylic dianhydride; 3,3′,4,4′-dimethyldiphenylsilanetetracarboxylic dianhydride; 3,3′,4,4′-tetraphenyl silanetetracarboxylic dianhydride; p-phenylene-bis(triphenylphthalic acid)dianhydride; and m-phenylene-bis(triphenylphthalic acid)dianhydride. Yet other dianhydrides include, e.g., a cyclic derivative having a structure of formula (I), in which both G.sup.1 and G.sup.2 is or includes optionally substituted cyclic anhydride.

Biomolecules, Including Amino Acids, Steroids, and Derivatives Thereof

[0142] As described herein, the compositions and methods herein can employ biomolecules, which can be further undergo dimerization, cyclization, and/or functionalization. Non-limiting biomolecules include amino acids, such as glycine, vinylglycine, allylglycine, alkenylglycine, tyrosine, O-allyltyrosine, O-alkenyltryrosine, tryptophan, allyltryptophan, alkenyltryptophan, phenylalanine, allylphenylalanine, alkenylphenylalanine, proline, hydroxyproline (e.g., 4-hydroxyproline), serine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, 4-aminophenylalanine, threonine, asparagine, glutamine, cystine, homocystine, cysteine, homocysteine, selenocysteine, arginine, histidine, lysine, aspartic acid, glutaminic acid, 4-(2-amino-2-carboxyethyl)-1,2-benzenedicarboxylic acid, 1-aminopropane-1,2,3-tricarboxylic acid, and 4-amino-1,2,4-butanetricarboxylic acid. Other non-limiting biomolecules include steroids, such as betulin, pregnane, and others.

[0143] Yet other non-limiting biomolecules can include, e.g., derivatives of any amino acids including an alkenyl, amino, carboxyl, or hydroxyl moiety. In particular embodiments, the biomolecule is an L-amino acid or a functionalized L-amino acid having an alkenyl, amino, carboxyl, or hydroxyl moiety.

[0144] Biomolecules can be formed in any useful manner. In one instance, the biomolecules are produced from yeast, gram positive bacteria, gram negative bacteria, or fungi. In other embodiments, amino acids, as well as derivatives thereof and/or dimers thereof, and steroids are produced biologically by way of fermentation. In yet other embodiments, amino acid dimers are produced by chemical means using petro-based starting materials.

Applications

[0145] The compositions herein can be employed as ingredients and/or monomers in any useful application. Exemplary, non-limiting applications include adhesives, coatings, films, and plastics. Such applications can include materials for use in constructing electronics, industrial adhesives, architectural adhesives and coatings, civil engineering adhesives and coatings, transportation adhesives and coatings, handheld devices, electronic devices, energy storage devices, energy generation devices, personal electronics (e.g., smart phones, laptops, or tablets), displays, sensors, semi-conductor materials (e.g., such as in chip patterning, manufacturing, and packaging), packages, and the like.

[0146] In some embodiments, the compositions described herein can be used in electronics applications, such as, but not limited to microelectronic components or electronic displays. For example, the composition can be used as a transparent base material in the display. In various embodiments, the compositions can be used in waveguides, organic light emitting diodes, electronic paper, liquid crystal displays, electroluminescent display, thin film transistors, flexible electronics, wearable electronics, and as a dielectric material. In certain embodiments, the compositions described herein can be used in solar cells, e.g., where the composition is a transparent substrate in the solar cell.

[0147] In particular embodiments, the compositions are used as, or incorporated into, a film that has a thickness between 10 nm and 1 cm (inclusive). In various embodiments, the film thickness is on the order of 10, 50, 100, 200, 300, 400, 500 600, 700, 800, or 900 nm, or 1, 10, 50, 100, 200, 300, 400, 500, 600, 700, 800, or 900 mm, or 1 cm. In some embodiments, the film thickness falls within a range bounded by any of these values, e.g., 50 nm to 900 mm, 200 nm to 700 mm, 500 nm to 500 mm (including the endpoints).

[0148] Yet other applications include use of the composition as a polymer curative, a resin, a monomer for a polymer or a copolymer, and the like. The composition can be provided in any useful form, such as a film, a composite structure, a bulk structure, a fiber, or a particle. The composition can optionally include one or more hardeners for use with the cyclic derivatives. Non-limiting hardeners include, e.g., diamines (such as 1,4-diamino butane (DAB), 1,13-diamino-4,7,10-trioxatridecane (TDD), or any herein). If desired, the composition can also include an accelerator, such as tris(dimethylaminomethyl)phenol, or other additives (e.g., resorcinol diglycidyl ether).

[0149] In particular embodiments, the compositions herein can undergo bio-triggered degradation for debonding of adhesives, coatings, and composites. Degradation can be triggered, e.g., by employing one or more proteases, hydrolases, peptidases, and the like. Such degradation can be promoted by providing a microbe or a supernatant derived from such microbes (e.g., such as Streptomyces flavovirens, Paenibacillus chibensis, Leifsonia sp., Bacillus sp., Rhizobium sp., Paenibacillus sp., and Microbacterium sp.). In use, the final enzymatic breakdown product can be the starting amino acid, such that the cyclic derivatives, as well as any composition including such derivatives, can exhibit biodegradability. In one non-limiting instance, a cyclic derivative (e.g., any herein) can be employed as a film, a coating, or an adhesive, which can be de-bonded on demand with an engineered microbe and be reverted back to benign starting materials (amino acids).

[0150] In some embodiments, the present disclosure encompasses methods for manufacturing any use herein (e.g., an adhesive, a coating, a film, a plastic, a composite, an electronic device, an energy storage device, an energy generation device, and the like) by applying a composition herein (e.g., any foregoing compound) in the assembly of the adhesive, the coating, the film, the plastic, the composite, the electronic device, the energy storage device, or the energy generation device. In other embodiments, the composition is provided as a polymer curative.

[0151] The composition can possess any useful property. In one embodiment, the optical transmittance of the composition is at least 60% at 290 nm, 300 nm, 350 nm, 400 nm, 450 nm, 550 nm, and above. In various embodiments, the composition has an optical transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 550 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 500 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 450 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 400 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 350 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 300 nm and above. In various embodiments, such compositions have a transmittance of at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99% at 270 nm and above.

[0152] In various embodiments, the compositions described herein have a birefringence in the range of −0.005 and +0.005, −0.002 and +0.002, −0.001 and +0.001, or −0.0005 and +0.0005 (inclusive of these endpoints).

[0153] In particular embodiments, the composition is optically clear and perceived visually to be devoid of color. In some embodiments, the composition has a UV cutoff less than about 450 nm, 400 nm, 350 nm, 300 nm, 270 nm, or lower. In other embodiments, the composition has a yellowness index less than about 2, 1.8, 1.6, 1.5. 1.4, or 1. In yet other embodiments, the composition has a modulus less than about 12 GPa, 10 GPa, or less. In some embodiments, the composition has an elongation less than about 350%, 300%, 250%, 200%, 150%, or less.

[0154] In other embodiments, the composition is soluble in an organic solvent (e.g., an organic polar solvent, such as N-methyl-2-pyrrolidone (NMP), N,N-dimethylacetamide (DMAc), cyclopentanone, chloroform, and combinations thereof). In particular, the composition can be dissolved in the solvent to produce a solution that is processed into a material (e.g., a film, a fiber, a coating, an adhesive, a composite, a bulk structure, or a particle). Processing can include solution cast lines, ink jetting, dip coating, spraying, spin coating, casting, blow molding, extrusion, pultrusion, injection molding, melt-processing, and/or electrospinning.

[0155] Many different aspects and embodiments are possible. Some of those aspects and embodiments are described herein. After reading this specification, skilled artisans will appreciate that those aspects and embodiments are only illustrative and do not limit the scope of the present invention. Embodiments may be in accordance with any one or more of the items as listed below.

[0156] Embodiment 1. A composition including a structure having formula (I):

##STR00057##

or a salt thereof, wherein: each of G.sup.1 and G.sup.2 includes, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; R.sup.g1 and G.sup.1, taken together with the nitrogen to which R.sup.g1 is bound, can optionally form an optionally substituted heterocyclyl; and R.sup.g2 and G.sup.2, taken together with the nitrogen to which R.sup.g2 is bound, can optionally form an optionally substituted heterocyclyl.

[0157] Embodiment 2. The composition of embodiment 1, wherein: G.sup.1 is -L.sup.G1-R.sup.G1 and G.sup.2 is -L.sup.G2-R.sup.G2; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted amidoalkyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0158] Embodiment 3. The composition of embodiment 2, wherein the optionally substituted cyclic anhydride has a structure of:

##STR00058##

and wherein each of a and b, independently, is an integer of from 0 to 3.

[0159] Embodiment 4. The composition of embodiment 2, wherein the optionally substituted cyclic imide has a structure of:

##STR00059##

wherein each of a and b, independently, is an integer of from 0 to 3; and wherein R.sup.N1 is H, optionally substituted alkyl, optionally substituted aryl, or optionally substituted aralkyl.

[0160] Embodiment 5. The composition of embodiment 1, wherein the composition includes a structure having formula (Ia):

##STR00060##

or a salt thereof, wherein: each of L.sup.G1 and L.sup.G2 s independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0161] Embodiment 6. The composition of embodiment 1, wherein the composition includes a structure having formula (Ib):

##STR00061##

or a salt thereof, wherein: each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; each of Het.sup.G1 and Het is, independently, optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0162] Embodiment 7. The composition of embodiment 1, wherein the composition includes a structure having formula (Ic):

##STR00062##

or a salt thereof, wherein: each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, carboxyl, amino, optionally substituted aminoalkyl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0163] Embodiment 8. A method of making a composition of embodiment 1, the method including: providing a first amino acid and a second amino acid, wherein the first and second amino acids are selected from the group consisting of glycine, vinylglycine, 2-allylglycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, 4-aminophenylalanine, tyrosine, tryptophan, serine, threonine, asparagine, glutamine, cystine, homocystine, cysteine, homocysteine, selenocysteine, proline, hydroxyproline, arginine, histidine, lysine, aspartic acid, glutaminic acid, 4-(2-amino-2-carboxyethyl)-1,2-benzenedicarboxylic acid, 1-aminopropane-1,2,3-tricarboxylic acid, and 4-amino-1,2,4-butanetricarboxylic acid; and forming a dimer between the first and second amino acids.

[0164] Embodiment 9. The method of embodiment 8, wherein the first and second amino acids are selected from the group consisting of tyrosine, serine, threonine, and hydroxyproline.

[0165] Embodiment 10. A method of making a composition of embodiment 1, the method including: providing a first amino acid and a second amino acid, wherein the first and second amino acids are selected from the group consisting of vinylglycine and 2-allylglycine; forming a dimer between the first and second amino acids; and hydroaminating a vinyl group present on the first and second amino acids.

[0166] Embodiment 11. A composition including a structure having formula (II):

##STR00063##

or a salt thereof, wherein: each of G.sup.3 and G.sup.4 includes, independently, hydroxyl, carboxyl, amino, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12 is, independently, H or optionally substituted alkyl; each of m and n is, independently, an integer of from 0 to 1; and o is an integer of from 0 to 2.

[0167] Embodiment 12. The composition of embodiment 11, wherein: G.sup.3 is -L.sup.G1-R.sup.G1 and G.sup.4 is -L.sup.G2-R.sup.G2; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted arylene, optionally substituted (aryl)(alkyl)ene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; and each of R.sup.G1 and R.sup.G2 is, independently, hydroxyl, optionally substituted hydroxyalkyl, optionally substituted hydroxyaryl, carboxyl, amino, optionally substituted aminoalkyl, optionally substituted aminoaryl, amido, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0168] Embodiment 13. A composition including a structure having formula (III):

##STR00064##

or a salt thereof, wherein: each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; each of L.sup.G1 and L.sup.G2 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heterocyclyldiyl, or optionally substituted (heterocyclyl)(alkyl)ene; each of Ar.sup.G1 and Ar.sup.G2 is, independently, optionally substituted arylene or optionally substituted (aryl)(alky)lene; Het.sup.G1 is optionally substituted heterocyclyldiyl or optionally substituted (heterocyclyl)(alkyl)ene; and at least one of Ar.sup.G1, Ar.sup.G2, or Het.sup.G1 includes, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0169] Embodiment 14. A composition including a structure having formula (IV):

##STR00065##

or a salt thereof, wherein: each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; each of L.sup.G1, L.sup.G2, and L.sup.G3 is, independently, a covalent bond, an amide bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted heteroalkylene, optionally substituted heterocyclyldiyl, or (heterocyclyl)(alkyl)ene; each of Ar.sup.G1 and Ar.sup.G2 is, independently, optionally substituted arylene or optionally substituted (aryl)(alkyl)ene; and at least one of L.sup.G1 L.sup.G2 L.sup.G3, Ar.sup.G1 or Ar.sup.G2 includes, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide.

[0170] Embodiment 15. A composition including a structure having formula (VIII):

##STR00066##

or a salt thereof, wherein: each of G.sup.L1 and G.sup.L2 includes, independently, hydroxyl, carboxyl, amino, amido, an amide bond, an ester bond, oxy, carbonyl, optionally substituted cyclic anhydride, or optionally substituted cyclic imide; each of R.sup.1 and R.sup.2 is, independently, H or optionally substituted alkyl; each of R.sup.g1 and R.sup.g2 is, independently, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkaryl, or optionally substituted aralkyl; Ar.sup.m is a polymer segment; R.sup.g1 and G.sup.1, taken together with the nitrogen to which R.sup.g1 is bound, can optionally form an optionally substituted heterocyclyl; and R.sup.g2 and G.sup.2, taken together with the nitrogen to which R.sup.g2 is bound, can optionally form an optionally substituted heterocyclyl.

[0171] Embodiment 16. The composition of embodiment 15, wherein Ar.sup.m includes an imide subunit, an amic acid subunit, an amide subunit, an arylene subunit, an arylene ether subunit, an arylene ketone subunit, a urethane subunit, a phthalic anhydride subunit, an aliphatic subunit, a cycloalkyl subunit, an ether subunit, a thioether subunit, a perfluoroalkyl subunit, or a perfluoroalkoxy subunit.

[0172] Embodiment 17. The composition of embodiments 1-7 and 11-16, wherein the composition includes a UV cutoff less than about 450 nm, an optical transmission of at least about 95% at 450 nm, a yellowness index less than about 2, a modulus less than about 12 GPa, and/or an elongation less than about 350%.

[0173] Embodiment 18. The composition of embodiment 17, wherein the composition is optionally soluble in an organic solvent.

[0174] Embodiment 19. The composition of embodiments 1-7 and 11-18, wherein the composition is configured to be biodegradable by one or more microbes.

[0175] Embodiment 20. A genetically modified organism configured to produce a composition of embodiments 1-7 and 11-19.

[0176] Embodiment 21. A film including a composition of embodiments 1-7 and 11-19.

[0177] Embodiment 22. The film of embodiment 21, wherein the film is an adhesive or a coating.

[0178] Embodiment 23. A composite or bulk structure including a composition of embodiments 1-7 and 11-19.

[0179] Embodiment 24. A fiber or a particle including a composition of embodiments 1-7 and 11-19.

[0180] The following examples are provided to better disclose and teach processes and compositions of the present invention. They are for illustrative purposes only, and it must be acknowledged that minor variations and changes can be made without materially affecting the spirit and scope of the invention as recited in the claims that follow.

EXAMPLES

Example 1: Polymers and Copolymers from Amino Acid Dimers

[0181] The composition herein can be employed to provide a polymer or copolymer. In one instance, amino acids are employed to provide cyclic derivatives, which can be further functionalized with a reactive group containing hydroxy, amino, cyclic anhydride, or cyclic imide.

[0182] In one instance, the copolymer results from reaction between (i) a cyclic derivative having amino reactive groups and (ii) a dianhydride or a diacid. In another instance, the copolymer results from reaction between (i) a cyclic derivative having cyclic anhydride reactive groups and (ii) a diamine. In yet another instance, the copolymer results from reaction between (i) a cyclic derivative having cyclic anhydride reactive groups and (ii) a cyclic derivative having amino reactive groups. Resulting copolymers can have or include structures of compound nos. VIII-1 to VIII-9 in Table 2, as well as structures of formulas (III), (IIIa), (IV), (IVa), (IVb), (IVc), (V), (Va), (VI), (VIa), (VIb), (VIc), (VII), (VIIa), and (VIII).

Example 2: Non-Limiting Synthesis of Tyrosine Dimer

[0183] ##STR00067##

[0184] In a 3 L two-neck round bottom flask equipped with magnetic stirrer and overhead condenser, 200 g of Tyr-OH and 800 ml of ethylene glycol were mixed, and the flask was placed in silicon oil bath. The oil bath was heated to 190° C., and the reaction mixture was stirred for 7 hours (h). The conversion of starting material was followed up by HPLC. After 7 h, the reaction mixture was cooled down to room temperature, and the precipitated solid was filtered and washed with ethanol (2×200 ml). The solid was then dried in vacuum oven and used as is for the next step. (Yield: 64%)

Example 3: Non-Limiting Synthesis of 4-Hydroxy-Proline Dimer

[0185] ##STR00068##

[0186] In a two-neck 1 L round bottom flask equipped with magnetic stirrer and overhead condenser, 100 g of trans-4-hydroxy-L-proline and 200 ml of ethylene glycol were mixed, and the flask was placed in silicon oil bath. The oil bath was heated to 190° C., and the reaction mixture was stirred for 7 h. After 7 h, the reaction mixture was cooled down to room temperature, and the precipitated solid was filtered and washed with acetone (2×100 ml). The solid was then dried in vacuum oven. (Yield: 44%, isolated 37.95 grams of product) NMR .sup.1H NMR (D.sub.2O): 4.75 (d, 1H), 4.63 (d, 1H), 3.69 (d, 1H), 3.537 (d, 1H), 2.33 (d, 1H), 2.20 (d, 1H).

Example 4: Non-Limiting Stepwise Synthesis of Tyrosine Dimer

[0187] The following route could be applicable for dimers from different amino acids.

##STR00069##

Step 1: Preparation of (S)-methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl) propanamido)-3-(4-hydroxyphenyl)propanoate

[0188] A 1 L reactor equipped with a magnetic stirrer, temperature probe, and nitrogen inlet was charged with ((S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid (33.2 g, 118 mmol), (S)-methyl 2-amino-3-(4-hydroxyphenyl)propanoate (20 g, 102 mmol), hexafluorophosphate benzotriazole tetramethyl uronium (“HBTU,” 48.3 g, 127 mmol) and DMF (120 mL). The solution was stirred for 15 minutes and then cooled to 0° C. Triethylamine (42.6 mL, 306 mmol) was added to the mixture over 15 minutes. After the addition was completed, the cooling bath was removed, and the reaction was stirred overnight. After 18 h, the HPLC of the aliquot showed complete conversion of the starting materials. One hundred mL of water was slowly added to the reaction at 0° C. After stirring for 30 minutes (min), the mixture was diluted with EtOAc (150 mL), and the layers were separated. The organic layer was washed with aqueous sodium carbonate (10%, 3×50 mL) and finally with brine (50 mL). The organic layer was then dried over anhydrous sodium sulfate, filtered, and concentrated to dryness to afford the desired product as a thick oil. The product was used in the next step without further purification.

##STR00070##

Step 2: Preparation of 3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione

[0189] A 3 L single-neck reactor was charged with (S)-methyl 2-((R)-2-((tertbutoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoate (42 g, 91.6 mmol) and formic acid (420 mL), the mixture was stirred at ambient temperature for 5 h, and the formic acid and s-butanol were removed under reduced pressure. The residue was dissolved in sec-butanol (1600 mL) and toluene (400 mL), and the solution was refluxed for 3 h. The reaction was monitored by HPLC and, after the reaction was completed, the reaction mixture was concentrated to yield the crude material as an off-white solid. The crude material was dissolved in 5% NaOH in water at 5° C. and extracted with 250 ml of ethyl acetate. The aqueous layer was acidified to pH 3 by the slow addition of 10% HCl (aq). The solid material was separated by filtration, washed with water, and dried under vacuum. The solid was suspended in 200 ml of acetonitrile and filtered again and dried to get a white solid as a pure product. (Yield: 22 g, 73%). NMR H NMR (DMSO): 9.20 (s, 1H), 7.76 (s, 1H), 6.84 (d, J=8.4 Hz, 2H), 6.67 (d, J=8.5 Hz, 2H), 3.85 (s, 1H), 2.55-2.51 (m, 1H), 2.12 (d, J=6.6 Hz, 1H).

Example 5: Non-Limiting Stepwise Synthesis of p-Hydroxyphenyl-Glycine Dimer

[0190] ##STR00071##

[0191] (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid (1.00 eq, 1.00 g, 5.98 mmol) was dissolved in 1,4-dioxane (24 mL), water (24 ml), and 12.5 ml of an aqueous 2M NaOH solution in a 100 ml 2 neck flask under nitrogen. Di-tert-butyl dicarbonate (1.00 eq, 1.31 g, 5.98 mmol) was added to the solution dropwise, and the reaction was allowed to stir for 16 hours at room temperature. The reaction mixture was concentrated then acidified to pH 2 with 5M HCl, then extracted with ethyl acetate, and washed with a 5% sodium carbonate solution and brine. The organic layers were dried over magnesium sulfate, filtered, then concentrated in vacuo. Finally, 2-(tert-butoxycarbonylamino)-2-(4-hydroxyphenyl)acetic acid [4-HPG N-Boc](1.08 g, 4.03 mmol, 67.36% yield) was isolated as a pink tacky solid and used in the next step without further purification.

##STR00072##

[0192] rac-(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid (1.00 eq, 1.00 g, 5.98 mmol) was dissolved in 20 ml of 1.25M HCl in methanol and stirred at 70° C. for 3 hours. Then, the solvent was evaporated on a rotovap to yield 1.064 g of crude pink-white solid. This solid was washed with 250 ml of saturated sodium carbonate and extracted with ethyl acetate (4×100 ml) to provide 4-hydroxyphenyl-glycine methyl ester [4-HPG OMe]. (Yield: 33.766%, isolated 0.366 g of product).

##STR00073##

[0193] 4-hydroxyphenyl-glycine methyl ester (4-HPG OMe), 4-HPG N-Boc, HBTU, and DMAc were added to a 25 ml 2 neck round bottom flask and stirred for 15 min at room temperature under nitrogen. The reaction was cooled to 0° C., and trimethylamine (0.70 ml) was added dropwise over 15 min and then allowed to stir overnight. The reaction was then quenched with 2 ml of ice cold water, stirred for 10 mins and extracted 3× with EtoAc (2 ml). The organic layers were washed with 5% sodium carbonate and then brine, dried, and concentrated.

##STR00074##

[0194] A 3 L single-neck reactor was charged with the foregoing dipeptide peptide (0.31 g) and formic acid (2.1 mL), and the mixture was stirred at ambient temperature for 5 h. Formic acid was removed under reduced pressure by azeotropic distillation with toluene. The residue was dissolved in sec-butanol (7.5 mL) and toluene (2.5 mL), and the solution was refluxed for 3 hours. The reaction mixture was concentrated to yield the crude material as a yellow-white solid.

Example 6: Non-Limiting Stepwise Synthesis of 3,20-Diamino-Pregnane

[0195] ##STR00075##

[0196] Progesterone (1 g, 3.1 mmol) and Raney nickel (1 g) were added to a 100 ml high pressure hydrogenation apparatus and the vessel was charged with liquid ammonia (25 ml) and the vessel was sealed. The total vessel pressure was then increased to 25 atmospheres and the reaction vessel was heated at 200° C. for 20 h. The vessel was subsequently cooled and the pressure released. Upon evaporation of the ammonia, the mixture was dissolved in methanol and the catalyst removed. The reside was purified by column chromatography to afford 70% yield of the target 3,20-diamino pregnane (700 mg).

Example 7: Non-Limiting Stepwise Synthesis of 4-Aminoproline Dimer

[0197] ##STR00076##

[0198] The 4-hydroxy-proline dimer (20 g, 88 mmol) was suspended in pyridine (60 ml) and a catalytic amount of dimethyl aminopyridine (600 mg) was added. The mixture was cooled to −10° C. and Methanesulfonyl chloride (16 ml, 200 mmol) was added dropwise. The mixture was allowed to warm to room temperature and was stirred for 20 h at 20° C. before being poured over dilute HCl in ice water. The resulting solid was collected and dried under vacuum to give 81% yield (27 g) of the target dimesyl-4-hydroxy proline dimer.

##STR00077##

[0199] The dimesyl-4-hydroxy proline dimer (25 g, 65 mmol) was dissolved in DMF (250 ml) and cooled to 0° C. Sodium azide (21.5 g, 327 mmol) was added slowly and the reaction mixture was heated to 75° C. and stirred under a nitrogen atmosphere for 72 h. The mixture was cooled, diluted with ethyl acetate (500 ml), filtered, and concentrated to give 17.5 g of crude diazide for the next step.

##STR00078##

[0200] The hydroxy-proline dimer based diazide (10 g, 36 mmol) was dissolved in methanol (100 ml) and added to palladium on carbon (1 g) in a hydrogenation reactor. The atmosphere was replaced with hydrogen and the reactor was charged to 5 atmospheres of pressure. The mixture was allowed to stir under hydrogen atmosphere for 4 hours. The pressure was released, the catalysts filtered through celite and the solvent was removed in vacuo to afford the target 4-amino-proline dimer in 96% yield (7.7 g).

Example 8: Non-Limiting Stepwise Synthesis of 4-Amino-Phenylalanine Dimer

[0201] ##STR00079##

[0202] 4-Nitrophenylalanine methyl ester (14.3 g, 64 mmol) and 4-nitro-N-(tert-Butoxycarbonyl)-phenylalanine (20 g, 64 mmol) were combined in DMF (500 ml). HBTU (29 g, 77 mmol) was added and the mixture was stirred for 15 min and cooled to 0° C. Triethylamine (50 ml) was added slowly at 0° C. and the mixture was allowed to warm to room temperature and stirred for 20 h. The reaction mixture was quenched with cold water and the target dipeptide extracted using ethyl acetate and used for the subsequent step without purification.

##STR00080##

[0203] The dinitro-dipeptide (34 g, 66 mmol) was suspended in formic acid (300 ml) and stirred for 18 h at room temperature. Then 2-butanol (3.5 L) and toluene (850 ml) were added and the temperature was raised to 100° C. and the mixture was stirred for 4 h. The mixture was then cooled and the resulting nitro-phenylalanine dimer was filtered off and washed with methanol and dried to give the target compound in 72% yield (18 g).

##STR00081##

[0204] The nitro-phenylalanine dimer (12 g, 31 mmol) and palladium on carbon (1.2 g) was suspended in 10% HCl in methanol (1 L) in a hydrogenation vessel. The vessel was charged to 50 psi and the mixture was stirred for 8 hours. The pressure was then released and the mixture filtered to remove the catalyst. The solvent volume was reduced and the solid isolated and treated with base to generate the target molecule.

Example 9: Non-Limiting Stepwise Synthesis of 3-Aminophenyl-Glycine Dimer

[0205] ##STR00082##

[0206] The phenyl-glycine dimer (39 g, 25 mmol) was suspended in Sulfuric acid (50 ml) and cooled to 10° C. To this was added a 1:1 mixture of fuming nitric acid and sulfuric acid (50 ml) dropwise. The mixture was allowed to stir for 4 hours and then was poured over ice. The resulting solid was filtered to give 50 g of solid that was washed copiously with methanol.

##STR00083##

[0207] The nitro-phenyl-glycine dimer (12 g, 34 mmol) and palladium on carbon (1 g) was suspended in ethanol (50 ml) containing 10% HCl. This mixture was added to a hydrogenation vessel and the system was charged to 50 psi and allowed to stir for 20 h. After the pressure was released, the catalyst was filtered off and the neutralization of the filtrate gave 7.9 g of the meta-amino-phenylglycine as a solid. The resulting compound was recrystallized from DMF.

Example 10: Non-Limiting Stepwise Synthesis Diamino-Estrane

[0208] ##STR00084##

[0209] Estrone (15 g, 56 mmol) and potassium carbonate (15 g, 110 mmol) were suspended in ethanol (50 ml), hydroxylamine hydrochloride (5.5 g, 80 mmol) was added in small portions and the mixture was allowed to stir for 2 hours before being dumped over ice water. The resulting solid was filtered to 11 g of intermediate for the next step. The oxamine intermediate (9 g, 32 mmol) was dissolved in 25% ammonia in methanol (300 ml) and Raney Nickel (5 g) was added and the mixture was transferred to a hydrogenation vessel. The system was then charged to 50 atmospheres and stirred at 40° C. for 20 hours. The mixture was then cooled, the pressure released, and the catalyst filtered away to give the hydroxy-amino-estrone intermediate in 93% yield (8 g).

##STR00085##

[0210] The hydroxy-amino-estrone (2.2 g, 8.2 mmol) produced in the previous step was charged into a hydrogenation vessel with Raney Nickel (2 g) and liquid ammonia (20 ml) was added. The vessel pressure was increased to 50 atmospheres with hydrogen and the system was heated to 200° C. for 20 h. Upon cooling, the pressure was released and the mixture was dissolved in methanol and the catalyst was removed using filtration and evaporation gave the target compound in 84% yield as a mixture of isomers (1.7 g).

OTHER EMBODIMENTS

[0211] While the invention has been described in connection with specific embodiments thereof, it will be understood that it is capable of further modifications and this application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure that come within known or customary practice within the art to which the invention pertains and may be applied to the essential features hereinbefore set forth, and follows in the scope of the claims.

[0212] Other embodiments are within the claims.