MEDICINAL PLANT PHYTOCHEMICAL EXTRACTS FOR COUGH REMEDY

Abstract

The subject invention refers to the process of extracting phytochemicals and mixing of their active material composition from leaves, roots and fruits of several plants to formulate a cough syrup for the relief and treatment of mild & severe respiratory disorders brought about by bacteria and viruses, dust and pollens that may lead to difficulty in breathing resulting among others to coughs, allergies, colds, nasal congestions, pharyngitis, laryngitis, asthma and sneezing. The efficacy of the mixture of tropical plants having polyphenolic flavonoidal compounds derived from the basic below formula has yielded an effective remedy with little known side effects. I claim the formulations referred to as follows, but not limited thereto: Psidium guajava 25%, Zingiber officinale 30%, Curcuma longa 20%, Euphorbia hirta 10%, Adhatoda vasica 5%, and Citrofortunella microcarpa 3%.

Claims

1. I claim the formulations referred to as follows, but not limited thereto. TABLE-US-00009 Quantity Botanical Name: in % 1. Psidium Guajava 25 2. Zingiber Officinale 30 3. Curcuma Longa 20 4. Euphorbia Hirta 10 5. Adhatoda Vasica 5 6. Citrofortunella Microcarpa 3

2. The discovery of a mixture of various polyphenolic phytochemical from plants when combined through some basic processes of extraction of certain parts of the plant and on the mixed proportion of ingredients by weight can provide relief remedy for mild and severe cough that maybe due to bacteria, viruses, dust, fungus, pollens, allergies and asthma and minimize if not eliminate their symptoms altogether.

3. The syrup or elixir has a broad application that it can relieve, mild and severe cough, itchy throat, shortness of breathing and sore throat related to bacterial, fungal, viral and or allergies due to dust or pollens. Very little side effects are known since individually the compounds and their polyphenolic phytochemicals and some derivatives components are edible and non-toxic to humans and are used traditionally as medicines. The formulations have efficacies as antitussive, anti-inflammatory, analgesic, bronchodilator, mucolytic and expectorant.

Description

DETAILED DESCRIPTION OF INVENTION

[0025] The preparation of the extracted polyphenolic phytochemicals herbal mixture involves the sorting, cutting, washing, convection drying, filtering, pulverizing or grinding each herb specimen at the desired temperature and cleaving to achieve a fine powdered form in concentrate and the extract's component or ingredient for each herb. After the pulverized elements have been achieved to each desired mesh and size to make the solid particles easy to bind when mixed with aqueous or ethanolic solutions, the pulverized herbal components in powdered form shall then be mixed with purified water, xanthan gum and 95% ethanolic solutions, thereafter, sorbitol and other flavorings of tropical fruits and acceptable pharmaceutical grade preservative for longer stability and shelf life shall be added to make the syrup as a palatable cough remedy. The tropical herb compound formula will give instant respiratory and immediate relief to the patient arising from bacteria, viruses, dust and pollens resulting in mild to severe cough and colds, difficulty in breathing from allergies, asthma and sore throats.

TECHNICAL DESCRIPTION

[0026] The subject invention refers to the extraction of active polyphenolic compound from tropical herbal composition: Psidium guajava 25%, Zingiber officinale 30%, Curcuma longa 20%, Euphorbia hirta 10%, Adhatoda vasica 5%, and Citrofortunella microcarpa 3%, for the relief and treatment of mild and severe coughs brought about by bacteria, viruses, dust and pollens that may lead to difficulty in breathing resulting among others in coughing, sneezing due to allergies, colds, nasal congestions, pharyngitis, laryngitis, asthma and other forms of bronchial, nasal and or certain respiratory ailments. The formulation shall result in an effective cough syrup remedy as an anti-tussive, anti-inflammatory, analgesic, bronchodilator, mucolytic and expectorant.

Ingredients

[0027] Each 15 ml comprises of extracts derived from the following herbs:

TABLE-US-00001 Active Quantity Plant Phytochemicals & percentage Quantity per Ingredients Parts Derivatives per 15 ml unit per 15 ml (1) Psidium Guajava Leaves Quercetin 25 250 mg (2) Zingiber Officinale Rhizome Curcumin I, II, III 30 300 mg (3) Curcuma Longa Rhizome Gingerols/Shogaols 20 200 mg (4) Euphorbia Hirta Leaves Quercetin 10 100 mg (5) Adhatoda Vasica Leaves Quercetin 5 50 mg (6) Citrofortunella Microcarpa Fruit Citric Acid 3 30 mg

Process Flow to Obtain Plant Extracts' Polyphenolic Phytochemical and Other Derivatives

[0028] Sorting: The herb materials from leaves and rhizomes shall be sorted out as to remove impurities and non-essential plant parts. The leaves shall be freshly harvested and free from any pesticides or harmful chemicals. Rhizome parts shall be similarly be classified as to eliminate the presence of fungus or any other root crop pests or infestations.

[0029] Steaming and Boiling: The leaves of Psidium guajava shall be steamed in a steamer to soften plant tissue and to denature some flavonoids present in the herbs. This is also to reduce the amount of bitterness when used for the cough syrup from its powdered form. The Euphorbia hirta shall be washed and immersed in boiling or steamed water for 20 minutes as the leaves are thin and the liquid from the leaves contain the most essential ingredients which need to be extracted. Adhatoda vasica leaves shall be cleaned similarly with the Euphorbia hirta to be soaked 3 times in warm purified water.

[0030] The rhizomes of the Zingiber officinale and Curcuma longa shall be washed, scraped, brushed and cleaned with warm water to remove all dirt and impurities. Thereafter, rhizomes should be soaked in mild chlorinated water for two hours. Water should be changed twice after every two hours, thereafter, running water should remove the remaining dirt or impurities. The juice of the fruit of Citrofortunella microcarpa will be extracted by simple juicer equipment, thereby obtaining the main ingredient.

[0031] Cutting: The leaves shall be ready for drying and the rhizomes shall be cut into thin slices to reduce the size and in preparation for drying.

[0032] Drying (Artificial Drying in a Convection Oven): For the leaves' components, convection air dry for one hour at 40° C. until moisture content is reduced to a minimum of 90%. The rhizomes shall be convection dried at 50° C. for four hours until moisture content is reduced by 90%. For the leafy herbs convection drying shall result in a yellow dry leaf color at a 40° C. temperature and for at least one hour. The rhizomes, when dried, will turn into brownish color at four hours convection dried and 50° C. temperature.

[0033] Grinding and Pulverizing: After drying the leaves and rhizomes, the leaves shall be put in a grinding machine reduce in powdered form at least 297 μm (microns) or 0.297 mm mesh. After achieving the desired mesh, the powdered herbs shall be prepared for mixing.

[0034] Mixing: The pulverized herbs from the leaves and rhizomes shall be mixed in a stainless-steel cylinder together with the excipients, ethanol, sorbitol, sodium benzoate and Citrofortunella microcarpa flavoring and other inert ingredient to achieve a stable cough remedy solution ready for bottling in a 100 mL, 120 mL and 200 mL cough remedy pharmaceutical bottle.

SUMMARY OF THE INVENTION

[0035] The claimed invention is on the discovery of the extraction and mixture of plants' and herbs' polyphenolic compounds when combined through same basic processes of extraction and mixing of certain parts of the plant and on the mixed proportion of ingredients by weight synergistically can provide relief and remedy for mild and severe cough that maybe due to bacteria, viruses, dust fungus, pollens, allergies and asthma and eliminate their symptoms thereof.

[0036] The syrup or elixir has a broad application that it can relieve, mild and severe cough, itchy throat, shortness of breathing and sore throat related to bacterial, fungal, viral and or allergies due to dust or pollens. Very little side effects are known since individually the polyphenolic compounds and their components are edible and non-toxic to humans and are used traditionally as medicines or food. The formulations have efficacies as antitussive, anti-inflammatory, analgesic, bronchodilator, mucolytic and expectorant.

[0037] The syrup does not contain regulated drugs like codeine or ephedrine which are known for serious side effects that may cause addictions.

[0038] The formulations of the compound's ingredients are all based on the therapeutic value of each plant and their active polyphenolic materials which have been extracted and are mixed into a cough syrup as follows:

TABLE-US-00002 Therapeutic Active Botanical Name: Properties: Phytochemicals (1) Psidium Guajava Antibacterial for gram Quercetin positive bacteria cereus and staphylococcus aureus (2) Curcuma Longa Analgesic, Anti- Curcumin I, II, III inflammatory (3) Zingiber Officinale Anti-inflammatory, Gingerols/Shogaols Antibacterial, Mucolytic (4) Euphorbia Hirta Anti-asthma, Quercetin Anti-allergy (5) Adhatoda Vasica Anti-mucolytic or Quercetin Expectorant, Bronchodilator (6) Citrofortunella Microcarpa Anti-inflammatory, Citric Acid Bronchodilator, Expectorant

[0039] The extracted active polyphenolic materials and mixtures from various tropical herbs from leaves, fruits and roots provide instant relief for some respiratory ailments and act as antitussive, anti-inflammatory, analgesic, bronchodilator, mucolytic and expectorant.

[0040] Examples 1 to 5 of the ingredients per 15 ml or one tablespoon. Formulations claimed from tropical plants extracts for every 15 ml are composed of the following elements and materials:

TABLE-US-00003 Example 1 Botanical Name Qty in % Psidium Guajava 24.73 Zingiber Officinale 30.22 Curcuma Longa 20.25 Euphorbia Hirta 9.8 Adhatoda Vasica 5.35 Citrofotunella Microcarpa 3.2

[0041] Compositions of the tropical plant extracts as in claim 1 have the following elements and materials for every 15 ml.

TABLE-US-00004 Example 2 Botanical Name Qty in % Psidium Guajava 10.23 Zingiber Officinale 24.89 Curcuma Longa 19.81 Euphorbia Hirta 30.20 Adhatoda Vasica 3.45 Citrofotunella Microcarpa 4.32

[0042] Compositions of the tropical plant extracts as in claim 1 have the following elements and materials for every 15 ml.

TABLE-US-00005 Example 3 Botanical Name Qty in % Psidium Guajava 14.97 Zingiber Officinale 25.30 Curcuma Longa 4.79 Euphorbia Hirta 20.32 Adhatoda Vasica 4.89 Citrofotunella Microcarpa 15.23

[0043] Compositions of the tropical plant extracts as in claim 1 have the following elements and materials for every 15 ml.

TABLE-US-00006 Example 4 Botanical Name Qty in % Psidium Guajava 29.69 Zingiber Officinale 20.14 Curcuma Longa 14.97 Euphorbia Hirta 10.46 Adhatoda Vasica 4.89 Citrofotunella Microcarpa 9.98

[0044] Compositions of the tropical plant extracts as in claim 1 have the following elements and materials for every 15 ml.

TABLE-US-00007 Example 5 Botanical Name Qty in % Psidium Guajava 15.27 Zingiber Officinale 19.83 Curcuma Longa 20.22 Euphorbia Hirta 10.26 Adhatoda Vasica 4.89 Citrofotunella Microcarpa 14.88

[0045] Compositions of the tropical plant extracts as in claim 1 have the following elements and materials for every 15 ml.

[0046] Inert Ingredients and excipients such as ethanol, sorbitol, flavorings and preservatives will remain constant for every 15 ml dosage on all the seven examples and on claim 1 as follows:

[0047] Excipients and inert ingredients per 15 ml dose:

TABLE-US-00008 Excipient Qty % 1. Sorbitol 600 mg 26 2. Ethanol 95% 1500 mg 65 3. Sodium Benzoate 10 mg .40 4. Glycerin 100 mg 4.3 5. Flavorants 100 mg 4.3 6. Purified Water q.s Total Excipients & Inert 2,310 mg 100 Ingr. (Excluding purified water)

[0048] The combinations of the efficacy of the syrup of the subject invention shall be adjusted for applications on different levels of target ailments based on the following examples. The main ingredients may be increased or decreased depending on the application of the invention such as formulations for dry cough, too much phlegm, sneezing, clogged nose or runny nose, whooping cough and itchy throat.

[0049] Therefore, different amounts of the main active ingredients shall be subject to adjustments. To blend the ingredients into a syrup form, excipients shall be added such as ethanol, glycerin and sorbitol. Optional ingredients maybe added for flavoring aromatics and sweetener to tone down the bitter taste of the syrup. The excipients preferred are sucrose, honey, sorbitol or coconut-based sugar. For added flavorings, methyl salicylate, peppermint, lemon grass or Pandan leaves. Sodium Benzoate as preservative is more preferred. Other miscellaneous excipients maybe added.