Injection nozzle for a needleless injection device

Abstract

An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).

Claims

1. A needleless injection device comprising: a gas generator; a plunger arranged to be actuated by the gas generator; a reservoir configured to receive a fluid to be injected, the plunger configured to eject the fluid out of the reservoir; and at least one injection nozzle fluidly connected to the reservoir and configured to guide the fluid out of the needleless injection device, the at least one injection nozzle comprising: at least one monolithic outlet conduit configured to let the fluid pass when expelled, the at least one outlet conduit extending parallel to an injection axis, the at least one outlet conduit comprising: a first conduit portion having a first section; a second conduit portion integral with the first conduit portion and having a second section, the first section having a first fluid flow area that is larger than a second fluid flow area of the second section; and a connecting portion between the first conduit portion and the second conduit portion, the connecting portion is inclined at an angle comprised between 70° and 90° with respect to the injection axis, wherein the gas generator extends along an axis that is offset from the injection axis, and wherein the needleless injection device further includes a cap mounted about the injection axis between a closure position in which the cap is locked on the needleless injection device and an open position in which access is allowed to the nozzle to carry out an injection, the cap including a passage at least partially receiving the at least one injection nozzle and closed by a removable disk.

2. The needleless injection device according to claim 1, wherein the reservoir and the plunger are disposed parallel to the injection axis.

3. The needleless injection device according to claim 1, wherein the fluid contained in the reservoir comprises an active ingredient selected from the group consisting of Methotrexate, Adrenaline, Sumatriptan, Hydrocortisone, Naloxone, Midazolam, Apomorphine, Ethylnatrexone bromide, Phytomenadione, Chlorpromazine hydrochloride, Zuclopenthixol acetate, Danaparoid sodium, Enoxaparin sodium, Estradiol cypionate, Medroxyprogesterone acetate, Medroparin calcium, Methylprednisolone acetate, Heparin calcium, and Terbuline.

4. The injection nozzle according to claim 1, wherein the connecting portion is inclined at an angle between 80° and 90° with respect to the injection axis.

5. The injection nozzle according to claim 1, wherein the connecting portion is perpendicular to the injection axis.

6. The injection nozzle according to claim 1, wherein the connecting portion forms a shoulder between the first conduit portion and the second conduit portion.

7. The injection nozzle according to claim 1, wherein the first section of the first conduit portion has a diameter between 0.8 and 1 millimeter.

8. The injection nozzle according to claim 7, wherein the diameter of the first section is 1 millimeter.

9. The injection nozzle according to claim 1, wherein the second section of the second conduit portion has a diameter between 0.3 and 0.45 millimeter.

10. The injection nozzle according to claim 9, wherein the diameter of the second section is 0.4 millimeter.

11. The injection nozzle according to claim 1, wherein a ratio of diameters of the second section to the first section is between 0.35 and 0.45.

12. The injection nozzle according to claim 11, wherein the ratio of diameters is equal to 0.4.

13. The injection nozzle according to claim 1, wherein a length of the second conduit portion is between 0.5 and 1.5 millimeter.

14. The injection nozzle according to claim 1 further comprising a support configured to receive the at least one outlet conduit.

Description

DRAWINGS

(1) In order that the disclosure may be well understood, there will now be described various forms thereof, given by way of example, reference being made to the accompanying drawings, in which:

(2) FIG. 1 is an axially exploded perspective view, which illustrates a needleless injection device according to the present disclosure;

(3) FIG. 2 is a perspective detail view of FIG. 1, which illustrates an injection nozzle comprising outlet conduits according to the present disclosure;

(4) FIG. 3 is an axial sectional view of the injection device according to the present disclosure;

(5) FIG. 4 represents a bottle-like shaped profile of an outlet conduit according to the prior art; and

(6) FIG. 5 represents a profile of an outlet conduit according to the present disclosure.

(7) The drawings described herein are for illustration purposes only and are not intended to limit the scope of the present disclosure in any way.

DETAILED DESCRIPTION

(8) The following description is merely exemplary in nature and is not intended to limit the present disclosure, application, or uses. It should be understood that throughout the drawings, corresponding reference numerals indicate like or corresponding parts and features.

(9) In the present disclosure, in order to clarify the description and the claims, the terms longitudinal, vertical and transverse will be used in a non-limiting manner with reference to the trihedron L, V, T indicated in the figures.

(10) It should be noted that in the present patent application, the terms “upstream” and “downstream” should be understood with respect to the circulation of the active ingredient inside the injection device, along an injection direction.

(11) In addition, in the present application, the terms “top,” “bottom,” “upper,” “lower,” “horizontal,” “vertical,” and their derivatives refer to the position or to the orientation of an element or of a component, this position or this orientation being considered with reference to the orientation of the device in the Figures, without reference to Earth's gravity.

(12) There is represented in FIG. 1 a needleless injection device 10, or needleless syringe, which includes a U-shaped body 12 successively comprising a striker device 14, a primer 16, a pyrotechnic charge 18, these three elements constituting a gas generator 20, an expansion chamber 22, a reservoir 24 containing a fluid comprising an active ingredient 26 and an injection system 28.

(13) The gas generator 20 constitutes a linear first subset of the body 12 which extends axially along a vertical first axis A, and the reservoir 24 containing the liquid active ingredient 26 and the injection system 28 form a linear second subset of the body 12 which extends axially along a vertical second injection axis B.

(14) These two subsets are connected to each other by the expansion chamber 22 which has an axis perpendicular to the axes A, B of the subsets.

(15) The reservoir 24 is constituted by a glass tube 30 plugged by an upstream cap-plunger 32 and a downstream cap-plunger 34 between which the liquid active ingredient 26 is contained, the cap-plungers being made of an elastomer-based elastically-deformable material.

(16) The reservoir 24 is inserted into the body 12 and is blocked vertically, on the one hand, at its upstream portion by the body 12, via a cylindrical part 36 made of a flexible material, such as rubber, and provided with a central opening leading onto an elastic pouch 37. The elastic pouch is in fluid communication with the expansion chamber, the gas is then arranged to penetrate into the pouch which then extends by elasticity and thus allows displacing the upstream cap-plunger 32. Thus, the gas does not come into communication with the active ingredient. On the other hand, the reservoir 24 is blocked vertically at its downstream portion by an injection nozzle 38.

(17) The nozzle 38, shown in more detail in FIG. 2, has a cylindrical shape along the injection axis B which is delimited by a peripheral cylindrical face 40 provided with a tapping, the tapping being intended to cooperate with a complementary thread formed on the inner wall of the downstream end of the body 12.

(18) In addition, the nozzle 38 comprises from one to three outlet conduit(s) 42, parallel to the injection axis B and formed in a support 39.

(19) According to FIG. 3, the body 12 is wrapped by a hollow cover 46 which delimits a lower opening closed by a horizontal pad 48 forming a cover bottom.

(20) The pad 48 delimits a circular passage 50 around the injection axis B which is adapted for the passage of the injection nozzle 38 and of the downstream end of the body 12, so that the nozzle 38 includes a lower segment 52 projecting vertically downwards out of the cover 46.

(21) Also, the injection device 10 is equipped with a cap 54 which is delimited vertically by an open upper face 56 bearing on the pad 48 of the cover 46, and a generally planar closed lower face 58.

(22) The cap 54 delimits a generally tubular housing which extends axially along the injection axis B and which opens into the lower face 58 of the cap 54 by forming a circular passage 60 closed by a removable bottom disk 62.

(23) The bottom disk 62 includes six clamping feet 64 which extend axially parallel to the injection axis B, from an upper face 66 of the disk 62.

(24) In addition, in order to enable fastening of the disk 62 on the cap 54, the disk 62 includes four elastically-deformable teeth 68 each adapted to cooperate with an inner annular groove 70 formed by the cap 54.

(25) According to another aspect, the cap 54 is pivotally mounted about the injection axis B between a closure position in which the cap 54 is positioned in the continuation of the cover 46, so that the cap 54 and the cover 46 form a homogeneous shell devoid of any asperity, and an opening position in which the cap 54 is angularly pivoted by about 60 degrees about the injection axis B.

(26) In its closure position, the cap 54 is locked on the rest of the injection device 10. Conversely, in its opening position, the cap 54 is adapted to be removed from the rest of the device 10 to enable access to the nozzle 38 and to carry out an injection.

(27) For this purpose, the injection device 10 includes a first bayonet-type locking device adapted to lock the cap 54 on the body 12 of the device 10, during the driving of the cap 54 between its opening position and its closure position.

(28) As represented in FIG. 5, the outlet conduits 42 comprising a first conduit portion 90 with a first section 91 and a second conduit portion 92 with a second section 93. The first section 91 being larger than the second section 93. The conduits 42 further comprise a connecting portion 94 between the first conduit portion 90 and the second conduit portion 92. The connecting portion 94 is substantially transversal, that is to say it has an inclination with respect to the injection axis B comprised between 70° and 90°, and in one form is between 80° and 90°. In another form, the connecting portion 94 is perpendicular to the injection axis B.

(29) Thus, coherence length of the active ingredient jet is improved. Indeed, the current lines are oriented so as to be substantially parallel to each other over a longer distance, enabling a better penetration and propagation of the product in human tissues. The speed of the active ingredient at the outlet is higher by substantially 10% in comparison with a bottle-like shape, represented in FIG. 4, for the same pressure. Indeed, the bottle-like shape generally allows limiting pressure drops and therefore improving the fluid speed. The consequences of a manufacturing defect are also limited. Furthermore, a connecting portion 94 that is significantly inclined with respect to the injection axis B is more easy to make and less expensive.

(30) Thus, it is possible to obtain a better performance of the jet at the outlet of the injection nozzle with an identical pressure generated by the gas generator or to preserve identical performances while reducing the pressure to be exerted by the gas generator, and thus save energy.

(31) The connecting portion 94 forms a shoulder between the first conduit portion 90 and the second conduit portion 92. A shoulder is less sensitive to manufacturing defects than the bottle-like shape.

(32) The first section 91 has a diameter comprised between 0.8 and 1 millimeter, and in one form the diameter is 1 mm. Thus, the diameter of the first section 91 allows proper operation of the injection device 10 while limiting the bulk in the injection device 10.

(33) The second section 93 has a diameter comprised between 0.3 and 0.45 millimeters, and in one form the diameter is 0.4 millimeter. These arrangements allow for an enhanced ratio between the first section 91 and the second section 93.

(34) The length of the second conduit portion 92 is comprised between 0.5 and 1.5 millimeter. This arrangement allows for a length which is long enough to straighten the current lines of the fluid and short enough to not generate any pressure drop.

(35) For example, the conduits 42 are made of polycarbonate.

(36) As regards the operation of the injection device 10 briefly described later on, this is similar to the operation of the device described in the document FR-A-2815544, which is incorporated by reference herein in its entirety.

(37) The user unlocks the injection device 10 by removing the cap 54 through a rotation in either direction. The user applies the free end of the nozzle 38 against the skin of the patient to be treated and, by pressing with a finger, the user pushes in the cover 46 which slides along the body 12 until triggering of the gas generator 20. The pressure exerted by the gas generator is comprised between 100 and 300 bars.

(38) The generated gases overwhelm the expansion chamber 22 and, when the pressure is sufficient, exert a push on the liquid column constituted by the two cap-plungers 32, 34 and the liquid active ingredient 26, the liquid active ingredient 26 is then expelled by the nozzles 42.

(39) The description of the present disclosure is provided as a non-limiting example.

(40) Unless otherwise expressly indicated herein, all numerical values indicating mechanical/thermal properties, compositional percentages, dimensions and/or tolerances, or other characteristics are to be understood as modified by the word “about” or “approximately” in describing the scope of the present disclosure. This modification is desired for various reasons including industrial practice, manufacturing technology, and testing capability.

(41) As used herein, the phrase at least one of A, B, and C should be construed to mean a logical (A OR B OR C), using a non-exclusive logical OR, and should not be construed to mean “at least one of A, at least one of B, and at least one of C.”

(42) The description of the disclosure is merely exemplary in nature and, thus, variations that do not depart from the substance of the disclosure are intended to be within the scope of the disclosure. Such variations are not to be regarded as a departure from the spirit and scope of the disclosure.