PLASTER PREPARATION, POLYMER FILM, SPRAY PLASTER SPRAY DEVICE, METHOD FOR PRODUCING A POLYMER FIBER NONWOVEN MATERIAL, POLYMER FIBER NONWOVEN MATERIAL, AND USES OF THE PLASTER PREPARATION

Abstract

A plaster preparation includes (a) at least one resorbable polymer made of at least three monomer units, in particular a terpolymer, having monomers selected from the group consisting of trimethylene carbonate, glycolide, lactide (in particular DL-lactide), p-dioxanone, ε-caprolactone and/or butyrolactone; (b) at least one readily vaporizable organic solvent; and (c) at least one propellant. The plaster preparation additionally relates to a polymer film, to a spray plaster spray device, to a method for producing polymer fiber nonwoven materials, to a polymer fiber nonwoven material, and to uses of the plaster preparation.

Claims

1. A plaster preparation, comprising: a) at least one resorbable polymer made of at least 3 monomer units, being a terpolymer, comprising monomers selected from the group consisting of: trimethylene carbonate; glycolide; lactide; p-dioxanone; ε-caprolactone and/or butyrolactone; and b) at least one readily vaporizable organic solvent.

2. The plaster preparation according to claim 1, wherein the lactide is D,L-lactide.

3. The plaster preparation according to claim 1, wherein the plaster preparation is a spray plaster preparation with at least one propellant.

4. The plaster preparation according to claim 1, wherein the resorbable polymer consists of: lactide being D,L-lactide, ε-caprolactone and trimethylene carbonate.

5. The plaster preparation according to claim 1, wherein the resorbable polymer consists of 60 to 90% w/w D,L-lactide, 5 to 35% w/w ε-caprolactone and 5 to 35% w/w trimethylene carbonate.

6. The plaster preparation according to claim 1, wherein the resorbable polymer consists of 70 to 85% w/w D,L-lactide, 5 to 20% w/w ε-caprolactone and 5 to 20% w/w trimethylene carbonate.

7. The plaster preparation according to claim 5, wherein the resorbable polymer has an inherent viscosity between 0.5 and 2.5 dl/g.

8. The plaster preparation according to claim 5, wherein the resorbable polymer has an inherent viscosity between 0.5 and 1.6 dl/g.

9. The plaster preparation according to claim 5, wherein the resorbable polymer has an inherent viscosity between 0.9 and 1.6 dl/g.

10. The plaster preparation according to claim 1, wherein the terpolymer has a monomer content between 0.5 and 10% w/w.

11. The plaster preparation according to claim 1, wherein the terpolymer has a monomer content between 3 and 8% w/w.

12. The plaster preparation according to claim 1, additionally comprising: at least one further resorbable polymer from the group consisting of poly-s-caprolactone, polylactide, polyglycolide, polyethylene glycol and poloxamer; and/or at least one non-resorbable polymer from the group consisting of polyacrylates, polycyanoacrylates, and polyurethanes; wherein the non-resorbable polymers are admixed as a blend.

13. The plaster preparation according to claim 1, additionally comprising: at least one further resorbable polymer from the group consisting of poly-E-caprolactone, polylactide, polyglycolide and polyethylene glycol; and/or at least one monomer, being cyanoacrylate, which polymerizes out on the skin to a non-resorbable polymer and yields a polymer blend of a resorbable polymer and a non-resorbable polymer.

14. The plaster preparation according to claim 1, wherein the organic solvent is selected from the group consisting of acetone, methyl acetate, ethyl acetate, halogenated hydrocarbons, DMSO, N-pyrrolidone, cyclopentane and/or mixtures thereof with cyclopentane.

15. The plaster preparation according to claim 1, wherein the terpolymer is present dissolved in the organic solvent.

16. The plaster preparation according to claim 1, wherein the propellant is dimethyl ether, methane, propane, butane, pentane, butene, low-boiling halogenated hydrocarbons, noble gases, air and/or CO2.

17. The plaster preparation according to claim 1, wherein the plaster preparation contains 5 to 30% w/w terpolymer and 70-95% w/w organic solvent.

18. The plaster preparation according to claim 1, wherein the plaster preparation contains 2.8 to 7% w/w terpolymer, 31.5 to 64.4% w/w organic solvent and 30 to 65% w/w propellant.

19. The plaster preparation according to claim 1, wherein the plaster preparation additionally has at least one disinfectant, being an antibacterial active substance, selected from the group consisting of polyhexanide, phenoxyethanol, iodine, peroxides, and/or silver.

20. The plaster preparation according to claim 1, wherein the plaster preparation additionally contains UVA and/or UVB filters, cytokines, growth factors being TGF-ß, local anesthetics, hemostatic or antibacterial active substances and/or biologically inactive additives being dyes or cyanoacrylates.

21. A polymer film produced by means of applying or spraying of the plaster preparation according to claim 1.

22. The polymer film according to claim 21, wherein the polymer film has an E-modulus between 1.5 and 1000 N/mm.sup.2.

23. The polymer film according to claim 21, wherein the polymer film has an E-modulus between 1.7 and 450 N/mm.sup.2.

24. The polymer film according to claim 21, wherein the polymer film has a monomer content of <10% w/w.

25. The polymer film according to claim 21, wherein the polymer film has an extensibility between 100 to 1500%.

26. The polymer film according to claim 21, wherein the polymer film has an extensibility between 250 and 600%.

27. The polymer film according to claim 21, wherein the polymer film has a strength between 0.1 and 30 N/mm.sup.2.

28. The polymer film according to claim 21, wherein the polymer film has a strength between 1 and 20 N/mm.sup.2.

29. The polymer film according to claim 21, wherein the polymer film has a thickness between 5 and 30 pm.

30. A spray plaster spray device for spraying the plaster preparation according to claim 3, comprising a housing with a spray head for initiating the spraying process, being a cylindrical housing, having a longitudinal axis, the housing comprising: a reservoir for the plaster preparation, a propellant channel for a propellant of the plaster preparation with a diameter d.sub.1, wherein the propellant channel extends in a first area in axial direction in the housing as a riser tube and extends in a second area in the spray head angled radially between the geodesic face side of the riser tube and a spray opening of the spray head; wherein the second area has a diameter d.sub.2 which is smaller than the diameter d.sub.1 of the first area; wherein the second area opens into a mixing area with a diameter d.sub.3 which is smaller than the diameter d.sub.2; wherein the mixing area is radially adjacent to the second area and connects the second area to the spray opening; wherein a reservoir channel with a diameter d.sub.4 extends in the direction of the longitudinal axis and opens into the mixing area and wherein the diameter d.sub.4 is larger than the diameter d.sub.3, and wherein the spray opening has a relief area expanding in an expansion cone-shaped manner, which extends in a radial direction between the mixing area and the spray opening.

31. A method for producing a polymer fiber nonwoven material comprising polymer fibers, wherein the spray plaster preparation is sprayed by means of the spray plaster spray device in accordance to claim 30, wherein the propellant of the spray plaster preparation is forced at high velocity into the mixing area of the propellant channel; and wherein the terpolymer of the spray plaster preparation and the solvent of the spray plaster preparation are transported into the mixing area by means of the reservoir channel and mixed with the propellant flowing at high speed; and wherein the mixture obtained is transported into a relief space of the spray opening, wherein the solvent is vaporized as it exits the spray opening, wherein polymer fibers are formed, and wherein a polymer fiber nonwoven material having the polymer fibers is deposited on a surface, the surface being a human or animal skin surface.

32. A polymer fiber nonwoven material produced by the method according to claim 31.

33. The polymer fiber nonwoven material according to claim 32, wherein the polymer fiber nonwoven material has a water vapor permeability between 80 and 200 g/m.sup.2/h.

34. A use of the plaster preparation according to claim 1 for topical treating of human or animal skin for wound treatment of epidermal and dermal wounds being abrasions, cuts, burn wounds, chronic wounds and ulcer wounds.

35. A use of the plaster preparation according to claim 1 for external application in the case of reddening of the skin, sunburn, sun protection, cosmetic applications, camouflage and/or as a resorbable adhesive.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0070] In the drawings:

[0071] FIG. 1 shows schematically the structure of a plaster spraying device in accordance with an embodiment;

[0072] FIG. 2 shows images of polymer fibers of polymer fiber nonwoven material produced according to Example 5, wherein the polymer fibers were produced from plaster preparations (A) and (C) by spraying by means of a plaster spraying device according to the invention;

[0073] FIG. 3 shows scanning electron micrographs of polymer fibers of a polymer fiber nonwoven material produced from plaster preparations (A), (B) and (C) according to Example 5 by means of the plaster spray device shown in FIG. 1; and

[0074] FIG. 4 shows scanning electron micrographs of polymer fiber nonwoven materials according to example 6 which were produced by means of a spray fiber spray device according to the invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0075] In the figures, identical or similar components are each numbered with the same reference numerals. The embodiments shown in the figures are merely exemplary for the description of the invention and are not to be understood as limiting.

[0076] FIG. 1 schematically shows the structure of a pressurized spray plaster spray device 10 for spraying a plaster preparation according to the invention, in particular, for producing of polymer fiber nonwoven material of the plaster preparation according to a method for producing the polymer fiber nonwoven material according to the invention.

[0077] The spray plaster spray device 10 comprises a housing 12 with a movably arranged spray head 14 for initiating the spraying process. In particular, the housing 12 may be cylindrical or may have another shape. The housing 12 has a longitudinal axis L and comprises a reservoir 16 for the plaster preparation, a propellant channel 18 for a propellant T of the plaster preparation. The propellant 18 extends in a first area 20 in the direction of the longitudinal axis L in the housing as a riser tube 22 and extends in a second area 24 in the spray head 14 angled in a radial direction between the geodesic face side of the riser tube 22 and a spray opening 26 of the spray head 14. The first area 20 has an inner diameter d.sub.1. The second area 24 has an inner diameter d.sub.2, which is smaller than the diameter d.sub.1 of the first area 20.

[0078] The second area 24 opens into a mixing area 28 having a diameter d.sub.3, which is preferably less than or equal to the diameter d.sub.2. The mixing area 28 connects in a radial direction to the second area 24 and fluidically connects the second area 24 to the spray opening 26.

[0079] A channel 30 of the reservoir 16 with a diameter d.sub.4 extends in the axial direction and opens into the mixing area 28. Here, the diameter d.sub.4 is larger than the diameter d.sub.3 and the diameter d.sub.2. Actuating the spray head creates a fluidic connection between the propellant T stored in the housing 12 and the spray opening 26. The remaining plaster preparation disposed in the housing 12 is drawn into the mixing area 28 by a subatmospheric suction mediated by the outflowing propellant.

[0080] The spray opening 26 has a relief area 32 expanding in an expansion cone-shaped manner, which extends in a direction radial to the longitudinal axis L between the mixing area 28 and the spray opening 26. The spray opening has a maximum inner diameter d.sub.5 (=opening width).

[0081] FIG. 2 shows photographic images of a polymer fiber nonwoven material 100 comprising a plurality of polymer fibers 102 produced according to Example 5 discussed above.

[0082] The polymer fibers 102 were produced by spraying plaster preparations: A, shown in the top row of images, and C, shown in the bottom row of images, by means of a spray fiber spray device 10 according to the invention in accordance with FIG. 1 onto a glass plate (not shown in FIG. 2) with a spraying distance of 30 cm. The polymer fibers 102 of the polymer fiber nonwoven materials 100 are clearly visible.

[0083] FIG. 3 shows scanning electron micrographs of polymer fiber nonwoven materials 100 each comprising polymer fibers 102 produced according to Example 5. The polymer fibers 102 were produced by spraying the plaster preparations A, B and C by means of the spray fiber spray device 10 in accordance with FIG. 1.

[0084] The left figure shows polymer fibers 102 produced from plaster preparation A. The middle figure shows polymer fibers 102 of plaster preparation B and the right figure shows polymer fibers 102 of plaster preparation C. All images are at a scale of 50 pm, i.e., a 1 cm section in the image corresponds to 50 pm in real life. The polymer fibers 102 exhibit a form fit typical of nonwoven materials as sheet materials by entanglement, cohesion, and/or adhesion.

[0085] FIG. 4 shows scanning electron micrographs of polymer fiber nonwoven materials 100 according to example 6 described above, which were produced by means of a spray fiber spray device 10 according to the invention in accordance with FIG. 1. The scale is 50 μm. The polymer solutions were each sprayed at an internal pressure of the spray fiber spray device 10 of approximately 8 bar. The polymer concentrations were varied. Image A shows a polymer fiber nonwoven material 100 of solution A, image B shows a polymer fiber nonwoven material 100 of solution B, image C shows a polymer fiber nonwoven material 100 of solution C. The polymer fibers 102 or respectively polymer fiber nonwoven materials 100 exhibit adhesion to human skin sufficient even for wound closure.